Modulation of cell signaling pathways by Phyllanthus amarus and its major constituents: potential role in the prevention and treatment of inflammation and cancer

Protective Effects of Phyllanthus amarus Against Lipopolysaccharide-Induced Neuroinflammation and Cognitive Impairment in Rats

(2019) Akilandeshwari Alagan et al.   Frontiers in Pharmacology

Geraniin promotes osteoblast proliferation and differentiation via the activation of Wnt/β-catenin pathway

(2018) Kejia Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Anti-Inflammatory Effects of Hypophyllanthin and Niranthin Through Downregulation of NF-κB/MAPKs/PI3K-Akt Signaling Pathways

(2018) Hemavathy Harikrishnan et al.   INFLAMMATION

Neuroprotective mechanisms of rutin for spinal cord injury through anti-oxidation and anti-inflammation and inhibition of p38 mitogen activated protein kinase pathway

(2018) Bin Ning et al.   Neural Regeneration Research

Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways

(2018) Ashley B. Ward et al.   World Journal of Surgical Oncology

Geraniin promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) via activating β-catenin: a comparative study between BMSCs from normal and osteoporotic rats

(2018) Jiao Mo et al.   Journal of Natural Medicines

Phyllanthin from Phyllanthus amarus inhibits LPS-induced proinflammatory responses in U937 macrophages via downregulation of NF-κB/MAPK/PI3K-Akt signaling pathways

(2018) Hemavathy Harikrishnan et al.   PHYTOTHERAPY RESEARCH

Rutin protects against lipopolysaccharide-induced mastitis by inhibiting the activation of the NF-κB signaling pathway and attenuating endoplasmic reticulum stress

(2018) Siyi Su et al.   INFLAMMOPHARMACOLOGY

Inhibitory Effects of Emodin, Thymol, and Astragalin on Leptospira interrogans-Induced Inflammatory Response in the Uterine and Endometrium Epithelial Cells of Mice

(2017) Wenlong Zhang et al.   INFLAMMATION

Astragalin Inhibits Allergic Inflammation and Airway Thickening in Ovalbumin-Challenged Mice

(2017) Yun-Ho Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Rutin attenuates isoflurane-induced neuroapoptosis via modulating JNK and p38 MAPK pathways in the hippocampi of neonatal rats

(2017) Wei Li et al.   Experimental and Therapeutic Medicine

Ursolic acid inhibits proliferation and induces apoptosis by inactivating Wnt/β-catenin signaling in human osteosarcoma cells

(2016) Ran-Xi Zhang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Protective Role of Corilagin on Aβ25–35-Induced Neurotoxicity: Suppression of NF-κB Signaling Pathway

(2016) Kumju Youn et al.   JOURNAL OF MEDICINAL FOOD

Lupeol inhibits LPS-induced NF-kappa B signaling in intestinal epithelial cells and macrophages, and attenuates acute and chronic murine colitis

(2016) Changhyun Lee et al.   LIFE SCIENCES

Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway

(2015) Peng Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Rutin ameliorates cyclophosphamide induced oxidative stress and inflammation in Wistar rats: Role of NFκB/MAPK pathway

(2015) Sana Nafees et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Antimicrobial Activity of Oleanolic and Ursolic Acids: An Update

(2015) Jéssica A. Jesus et al.   Evidence-based Complementary and Alternative Medicine

Geraniin suppresses RANKL-induced osteoclastogenesis in vitro and ameliorates wear particle-induced osteolysis in mouse model

(2015) Fei Xiao et al.   EXPERIMENTAL CELL RESEARCH

Astragalin inhibits IL-1β-induced inflammatory mediators production in human osteoarthritis chondrocyte by inhibiting NF-κB and MAPK activation

(2015) Zhiqiang Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Dietary Flavonoid Kaempferol Mediates Anti-Inflammatory Responses via the Src, Syk, IRAK1, and IRAK4 Molecular Targets

(2015) Shi Hyoung Kim et al.   MEDIATORS OF INFLAMMATION

Anticancer and apoptotic activities of oleanolic acid are mediated through cell cycle arrest and disruption of mitochondrial membrane potential in HepG2 human hepatocellular carcinoma cells

(2015) YUE-YONG ZHU et al.   Molecular Medicine Reports

Quercetin induces human colon cancer cells apoptosis by inhibiting the nuclear factor-kappa B Pathway

(2015) Xiang-An Zhang et al.   Pharmacognosy Magazine

Clinical perspectives on reperfusion injury in acute myocardial infarction

(2014) Kevin R. Bainey et al.   AMERICAN HEART JOURNAL

Rutin inhibits UVB radiation-induced expression of COX-2 and iNOS in hairless mouse skin: p38 MAP kinase and JNK as potential targets

(2014) Ki-Seok Choi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Ellagic acid, an NF-κB inhibitor, ameliorates renal function in experimental diabetic nephropathy

(2014) Amjid Ahad et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Rutin decreases lipopolysaccharide-induced acute lung injury via inhibition of oxidative stress and the MAPK–NF-κB pathway

(2014) Chung-Hsin Yeh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective Effect of Kaempferol on LPS plus ATP-Induced Inflammatory Response in Cardiac Fibroblasts

(2014) Xi-lan Tang et al.   INFLAMMATION

Oleanolic acid modulates the immune-inflammatory response in mice with experimental autoimmune myocarditis and protects from cardiac injury. Therapeutic implications for the human disease

(2014) R. Martín et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inhibitory effects of astragalin on lipopolysaccharide-induced inflammatory response in mouse mammary epithelial cells

(2014) Fengyang Li et al.   JOURNAL OF SURGICAL RESEARCH

Corilagin Protects Against HSV1 Encephalitis Through Inhibiting the TLR2 Signaling Pathways In Vivo and In Vitro

(2014) Yuan-Jin Guo et al.   MOLECULAR NEUROBIOLOGY

Phyllanthin inhibits CCl4-mediated oxidative stress and hepatic fibrosis by down-regulating TNF-α/NF-κB, and pro-fibrotic factor TGF-β1 mediating inflammatory signaling

(2014) Rajesh Krithika et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling

(2014) In-Hee Cho et al.   BMC Pulmonary Medicine

Development and Characterisation of Ursolic Acid Nanocrystals Without Stabiliser Having Improved Dissolution Rate and In Vitro Anticancer Activity

(2013) Ju Song et al.   AAPS PHARMSCITECH

Quercetin and lithium chloride modulate Wnt signaling in pluripotent embryonal carcinoma NT2/D1 cells

(2013) Mojsin Marija et al.   Archives of Biological Sciences

Rutin inhibits B[a]PDE-induced cyclooxygenase-2 expression by targeting EGFR kinase activity

(2013) Seunghwan Choi et al.   BIOCHEMICAL PHARMACOLOGY

A potential anti-tumor herbal medicine, Corilagin, inhibits ovarian cancer cell growth through blocking the TGF-β signaling pathways

(2013) Luoqi Jia et al.   BMC Complementary and Alternative Medicine

Geraniin induces apoptotic cell death in human lung adenocarcinoma A549 cells in vitro and in vivo

(2013) Jia Li et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK–p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

(2013) Xin Wang et al.   CARCINOGENESIS

Geraniin down regulates gamma radiation-induced apoptosis by suppressing DNA damage

(2013) So Jin Bing et al.   FOOD AND CHEMICAL TOXICOLOGY

Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells

(2013) Mehari Endale et al.   IMMUNOBIOLOGY

Anti-inflammatory effects of rutin on HMGB1-induced inflammatory responses in vitro and in vivo

(2013) Hayoung Yoo et al.   INFLAMMATION RESEARCH

Astragalin suppresses inflammatory responses via down-regulation of NF-κB signaling pathway in lipopolysaccharide-induced mastitis in a murine model

(2013) Fengyang Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Oleanolic acid improves hepatic insulin resistance via antioxidant, hypolipidemic and anti-inflammatory effects

(2013) Xin Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Astragalin attenuates lipopolysaccharide-induced inflammatory responses by down-regulating NF-κB signaling pathway

(2012) Lanan Wassy Soromou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Geraniin and amariin, ellagitannins from Phyllanthus amarus, protect liver cells against ethanol induced cytotoxicity

(2012) Jayant S. Londhe et al.   FITOTERAPIA

Anti-inflammatory activities of oleanolic acid on HMGB1 activated HUVECs

(2012) Eun-Ju Yang et al.   FOOD AND CHEMICAL TOXICOLOGY

Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways

(2012) Ching-Lung Liao et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-inflammatory Effects of Oleanolic Acid on LPS-Induced Inflammation In Vitro and In Vivo

(2012) Wonhwa Lee et al.   INFLAMMATION

Kaempferol regulates MAPKs and NF-κB signaling pathways to attenuate LPS-induced acute lung injury in mice

(2012) Xiaojun Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells

(2012) Roberto Gambari et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gallic acid, a natural polyphenolic acid, induces apoptosis and inhibits proinflammatory gene expressions in rheumatoid arthritis fibroblast-like synoviocytes

(2012) Chong-Hyeon Yoon et al.   JOINT BONE SPINE

Gallic acid inhibits gastric cancer cells metastasis and invasive growth via increased expression of RhoB, downregulation of AKT/small GTPase signals and inhibition of NF-κB activity

(2012) Hsieh-Hsun Ho et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Simultaneous analysis of six bioactive lignans inPhyllanthusspecies by reversed phase hyphenated high performance liquid chromatographic technique

(2011) K. Shanker et al.   ACTA CHROMATOGRAPHICA

Inhibitory effect of astragalin on expression of lipopolysaccharide-induced inflammatory mediators through NF-κB in macrophages

(2011) Mi-Sun Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

(2011) M.A. Rosillo et al.   BIOCHEMICAL PHARMACOLOGY

Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells

(2011) SE Park et al.   BRITISH JOURNAL OF PHARMACOLOGY

Astragalin heptaacetate-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway

(2011) Olga Burmistrova et al.   CANCER LETTERS

Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells

(2011) Kuo-Ching Liu et al.   ENVIRONMENTAL TOXICOLOGY

Ellagic acid coordinately attenuates Wnt/β-catenin and NF-κB signaling pathways to induce intrinsic apoptosis in an animal model of oral oncogenesis

(2011) Prabukumar Anitha et al.   EUROPEAN JOURNAL OF NUTRITION

Phyllanthus amarus: Ethnomedicinal uses, phytochemistry and pharmacology: A review

(2011) Jay Ram Patel et al.   JOURNAL OF ETHNOPHARMACOLOGY

A Review on the Dietary Flavonoid Kaempferol

(2011) J. M. Calderon-Montano et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Gallic acid, a histone acetyltransferase inhibitor, suppresses β-amyloid neurotoxicity by inhibiting microglial-mediated neuroinflammation

(2011) Mi-Jeong Kim et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Antimetastatic Effects of Phyllanthus on Human Lung (A549) and Breast (MCF-7) Cancer Cell Lines

(2011) Sau Har Lee et al.   PLoS One

Kaempferol modulates pro-inflammatory NF-κB activation by suppressing advanced glycation endproducts-induced NADPH oxidase

(2010) Ji Min Kim et al.   AGE

Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity

(2010) Kyung Mi Lee et al.   BIOCHEMICAL PHARMACOLOGY

Induction of apoptosis by lupeol in human epidermoid carcinoma A431 cells through regulation of mitochondrial, Akt/PKB and NF-kappaB signaling pathways

(2010) Sahdeo Prasad et al.   CANCER BIOLOGY & THERAPY

Phosphatidylinositol 3-kinase, a novel target molecule for the inhibitory effects of kaempferol on neoplastic cell transformation

(2010) Kyung Mi Lee et al.   CARCINOGENESIS

Radioprotective effect of geraniin via the inhibition of apoptosis triggered by γ-radiation-induced oxidative stress

(2010) Kyoung Ah Kang et al.   CELL BIOLOGY AND TOXICOLOGY

Antioxidant activities of oleanolic acid in vitro: Possible role of Nrf2 and MAP kinases

(2010) Xin Wang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cyclooxygenase-2 in oncogenesis

(2010) Maria Teresa Rizzo   CLINICA CHIMICA ACTA

Effect of Corilagin on anti-inflammation in HSV-1 encephalitis and HSV-1 infected microglias

(2010) Yuan-Jin Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Gallic acid suppresses cell viability, proliferation, invasion and angiogenesis in human glioma cells

(2010) Yong Lu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hairy root extract of Phyllanthus amarus induces apoptotic cell death in human breast cancer cells

(2010) Gauri Abhyankar et al.   Innovative Food Science & Emerging Technologies

Protective Effect of Quercetin against Arsenite-Induced COX-2 Expression by Targeting PI3K in Rat Liver Epithelial Cells

(2010) Kyung Mi Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Flavonoids and antioxidant activity of Rosa agrestis leaves

(2010) Leyla Bıtıs et al.   NATURAL PRODUCT RESEARCH

Quercetin Modulates NF-κ B and AP-1/JNK Pathways to Induce Cell Death in Human Hepatoma Cells

(2010) Ana Belén Granado-Serrano et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Antifungal Activity of Securinine against Some Plant Pathogenic Fungi

(2010) Ashok K. Singh et al.   MYCOBIOLOGY

The Biological Functions of NF-κB1 (p ) and its Potential as an Anti-Cancer Target

(2009) Yonghui Yu et al.   CURRENT CANCER DRUG TARGETS

Transcriptional regulation of cytokines and oxidative stress by gallic acid in human THP-1 monocytes

(2009) Gokulakrishnan Kuppan et al.   CYTOKINE

Phyllanthus amarus Inhibits Cell Growth and Induces Apoptosis in Dalton's Lymphoma Ascites Cells Through Activation of Caspase-3 and Downregulation of Bcl-2

(2009) Kuzhuvelil B. Harikumar et al.   INTEGRATIVE CANCER THERAPIES

Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-α-induced upregulation of matrix metalloproteinase-9: Its direct inhibition by quercetin

(2009) Mun Kyung Hwang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Radioprotective Properties of Polyphenols from Phyllanthus amarus Linn

(2009) Jayant S. LONDHE et al.   JOURNAL OF RADIATION RESEARCH

Gallic Acid Suppresses Lipopolysaccharide-Induced Nuclear Factor- B Signaling by Preventing RelA Acetylation in A549 Lung Cancer Cells

(2009) K.-C. Choi et al.   MOLECULAR CANCER RESEARCH

Naturally occurring flavonoids attenuate high glucose-induced expression of proinflammatory cytokines in human monocytic THP-1 cells

(2009) Chi-Hao Wu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-α by inhibiting activation of NF-κB

(2008) Tae-Wook Kyung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The triterpenoid lupeol attenuates allergic airway inflammation in a murine model

(2008) J.F. Vasconcelos et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Preliminary exploration on anti-inflammatory mechanism of Corilagin (beta-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose) in vitro

(2008) Lei Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells

(2008) Jang-Chang Lee et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Time-course regulation of quercetin on cell survival/proliferation pathways in human hepatoma cells

(2008) Ana Belén Granado-Serrano et al.   MOLECULAR NUTRITION & FOOD RESEARCH

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Ellagic acid induces apoptosis through inhibition of nuclear factor kB in pancreatic cancer cells

(2008) Mouad Edderkaoui et al.   WORLD JOURNAL OF GASTROENTEROLOGY