Review of recent data on the metabolism, biological effects, and toxicity of resveratrol in humans

The journey of resveratrol from yeast to human

(2016) Silvie Timmers et al.   Aging-US

Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer

(2016) Randall F Holcombe et al.   Cancer Management and Research

One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease

(2012) João Tomé-Carneiro et al.   AMERICAN JOURNAL OF CARDIOLOGY

Effect of the Intake of Resveratrol, Resveratrol Phosphate, and Catechin-Rich Grape Seed Extract on Markers of Oxidative Stress and Gene Expression in Adult Obese Subjects

(2012) Donat De Groote et al.   ANNALS OF NUTRITION AND METABOLISM

Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance

(2012) Jun Yoshino et al.   Cell Metabolism

High-Dose Resveratrol Supplementation in Obese Men: An Investigator-Initiated, Randomized, Placebo-Controlled Clinical Trial of Substrate Metabolism, Insulin Sensitivity, and Body Composition

(2012) M. M. Poulsen et al.   DIABETES

Distribution of Resveratrol Metabolites in Liver, Adipose Tissue, and Skeletal Muscle in Rats Fed Different Doses of This Polyphenol

(2012) Cristina Andres-Lacueva et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance

(2012) Jill P. Crandall et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A triple-blind, 6-month follow-up, placebo-controlled, randomized trial

(2012) Joao Tomé-Carneiro et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Trans-Resveratrol Alters Mammary Promoter Hypermethylation in Women at Increased Risk for Breast Cancer

(2012) Weizhu Zhu et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus

(2012) Jayesh Kumar Bhatt et al.   NUTRITION RESEARCH

High urinary levels of resveratrol metabolites are associated with a reduction in the prevalence of cardiovascular risk factors in high-risk patients

(2012) Raul Zamora-Ros et al.   PHARMACOLOGICAL RESEARCH

Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats

(2012) Pankaj K. Bagul et al.   PHARMACOLOGICAL RESEARCH

Chemoprevention in experimental animals

(2011) Nalini Namasivayam   Annals of the New York Academy of Sciences

Resveratrol modulates astroglial functions: neuroprotective hypothesis

(2011) André Quincozes-Santos et al.   Annals of the New York Academy of Sciences

Resveratrol in cardiovascular health and disease

(2011) Goran Petrovski et al.   Annals of the New York Academy of Sciences

Resveratrol in cancer management: where are we and where we go from here?

(2011) Mary Ndiaye et al.   Annals of the New York Academy of Sciences

Anti-diabetic effects of resveratrol

(2011) Tomasz Szkudelski et al.   Annals of the New York Academy of Sciences

Chemopreventive effects of resveratrol and resveratrol derivatives

(2011) Thomas Szekeres et al.   Annals of the New York Academy of Sciences

Neuroprotective properties of resveratrol and derivatives

(2011) Tristan Richard et al.   Annals of the New York Academy of Sciences

Clinical trials of resveratrol

(2011) Ketan R. Patel et al.   Annals of the New York Academy of Sciences

Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease

(2011) Anna Csiszar   Annals of the New York Academy of Sciences

Antioxidant effects of resveratrol and other stilbene derivatives on oxidative stress and NO bioavailability: Potential benefits to cardiovascular diseases

(2011) Matthieu Frombaum et al.   BIOCHIMIE

Phase I Randomized, Double-Blind Pilot Study of Micronized Resveratrol (SRT501) in Patients with Hepatic Metastases--Safety, Pharmacokinetics, and Pharmacodynamics

(2011) L. M. Howells et al.   Cancer Prevention Research

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Calorie restriction and prevention of age-associated chronic disease

(2011) Daniela Omodei et al.   FEBS LETTERS

Piceatannol is more effective than resveratrol in restoring endothelial cell dimethylarginine dimethylaminohydrolase expression and activity after high-glucose oxidative stress

(2011) Matthieu Frombaum et al.   FREE RADICAL RESEARCH

Effect of food on the pharmacokinetic profile of trans-resveratrol

(2011) M. Vaz-da-Silva et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

A Resveratrol and Polyphenol Preparation Suppresses Oxidative and Inflammatory Stress Response to a High-Fat, High-Carbohydrate Meal

(2011) Husam Ghanim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Administration of resveratrol: What formulation solutions to bioavailability limitations?

(2011) A. Amri et al.   JOURNAL OF CONTROLLED RELEASE

Resveratrol and health - A comprehensive review of human clinical trials

(2011) James M. Smoliga et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Biological activity of piceatannol: Leaving the shadow of resveratrol

(2011) Hanna Piotrowska et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment

(2011) Keisuke Fujitaka et al.   NUTRITION RESEARCH

Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation

(2010) David O Kennedy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Pleiotropic mechanisms facilitated by resveratrol and its metabolites

(2010) Barbara Calamini et al.   BIOCHEMICAL JOURNAL

Resveratrol Modulates Drug- and Carcinogen-Metabolizing Enzymes in a Healthy Volunteer Study

(2010) H.-H. S. Chow et al.   Cancer Prevention Research

Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis

(2010) V. A. Brown et al.   CANCER RESEARCH

Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients

(2010) K. R. Patel et al.   CANCER RESEARCH

Steady-State Pharmacokinetics and Tolerability of Trans-Resveratrol 2000 mg Twice Daily with Food, Quercetin and Alcohol (Ethanol) in Healthy Human Subjects

(2010) Charles la Porte et al.   CLINICAL PHARMACOKINETICS

Resveratrol commonly displays hormesis: Occurrence and biomedical significance

(2010) Edward J Calabrese et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract ofPolygonum CuspidatumContaining Resveratrol

(2010) Husam Ghanim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Selective Synthesis and Biological Evaluation of Sulfate-Conjugated Resveratrol Metabolites

(2010) Juma Hoshino et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reduction of blood cholesterol and ischemic injury in the hypercholesteromic rabbits with modified resveratrol, logevinex

(2010) Bela Juhaz et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure

(2010) R.H.X. Wong et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Protective effect of post-ischemic treatment with trans-resveratrol on cytokine production and neutrophil recruitment by rat liver

(2009) Sahar Hassan-Khabbar et al.   BIOCHIMIE

Matrix effects on the bioavailability of resveratrol in humans

(2009) Jordi Ortuño et al.   FOOD CHEMISTRY

Pharmacokinetics ofTrans-resveratrol Following Repeated Administration in Healthy Elderly and Young Subjects

(2009) Teresa Nunes et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Quantification of trans-resveratrol and its metabolites in rat plasma and tissues by HPLC

(2009) M. Emília Juan et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers

(2009) Luis Almeida et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol bioavailability and toxicity in humans

(2009) Charles-Henry Cottart et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Antitumor Activity of Resveratrol and its Sulfated Metabolites against Human Breast Cancer Cells

(2009) Michaela Miksits et al.   PLANTA MEDICA

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Postischemic treatment bytrans-resveratrol in rat liver ischemia-reperfusion: A possible strategy in liver surgery

(2008) Sahar Hassan-Khabbar et al.   LIVER TRANSPLANTATION

Quantification of free and protein-boundtrans-resveratrol metabolites and identification oftrans-resveratrol-C/O-conjugated diglucuronides – Two novel resveratrol metabolites in human plasma

(2008) Alexander Burkon et al.   MOLECULAR NUTRITION & FOOD RESEARCH