Article
Agriculture, Multidisciplinary
Yi-Ju Lee, Sin-Rong Chen, Ping-En Ko, Mon-Yuan Yang, Meng-Hsuin Yu, Chau-Jong Wang, Huei-Jane Lee
Summary: Neurogenesis is crucial for maintaining synaptic plasticity and normal function. Miquelianin has been found to have protective effects against neurodegenerative diseases and can promote neurogenesis by upregulating the TrkR and PI3K/Akt signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Yi-Ju Lee, Sin-Rong Chen, Ping-En Ko, Mon-Yuan Yang, Meng-Hsuin Yu, Chau-Jong Wang, Huei-Jane Lee
Summary: Neurogenesis is crucial for synaptic plasticity and normal function, and its impairment in the adult hippocampus may lead to neurodegenerative diseases. This study found that quercetin-3-O-beta-d-glucuronide (Q3GA), a constituent of the nuciferine leaf polyphenol extract (NLPE), can promote neurogenesis by upregulating TrkR and the PI3K/Akt signaling pathway. This suggests that NLPE containing Q3GA could be a potential alternative treatment strategy for neurodegeneration.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Bingting Chen, Yilzera Abaydula, Delong Li, Huiwen Tan, Xiaoli Ma
Summary: The study showed that taurine can alleviate insulin resistance in HepG2 cells and improve blood glucose levels and oxidative stress in T2DM rats. Taurine's effects are partly attributed to its activation of the PI3K/Akt/GLUT4 pathway, suggesting potential benefits in treating diabetes-related dysfunction.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Oncology
Yutao Guan, Qianlong Wu, Miaomiao Li, Danyang Chen, Jingyao Su, Liandong Zuo, Bing Zhu, Yinghua Li
Summary: This study evaluated the cytotoxic and anti-cancer mechanisms of Epigallocatechin-3-gallate (EGCG) in HepG2 cells. The results showed that EGCG induced apoptosis in HepG2 cells by activating the AKT, JNK, and p53 signaling pathways. Therefore, EGCG may be a suitable candidate for cancer chemotherapy.
CURRENT CANCER DRUG TARGETS
(2023)
Article
Pharmacology & Pharmacy
Peng Tang, Yong Tang, Yan Liu, Bing He, Xin Shen, Zhi-Jie Zhang, Da-Lian Qin, Ji Tian
Summary: Quercetin glycoside (QAG) extracted from Eucommia ulmoides leaves (EUOL) can significantly improve insulin resistance (IR) by increasing glucose uptake and glycogen production through the IRS-1/PI3K/Akt/GSK-3β signaling pathway.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Agriculture, Dairy & Animal Science
Manman Shen, Tao Li, Yuan Feng, Ping Wu, Boris Ramos Serrano, Adileidys Ruiz Barcenas, Liang Qu, Weiguo Zhao
Summary: This study found that the flavonoid quercetin has a regulatory effect on granulosa cells (GCs) in the prehierarchical follicles of chickens. Specifically, at appropriate concentrations, quercetin can promote cell proliferation and progesterone secretion, which is beneficial for follicle development and selection.
Article
Biochemistry & Molecular Biology
Qirong Lu, Lang Zhou, Ziyue Wang, Xiaomin Li, Li Ding, Yinsheng Qiu, Pu Guo, Chun Ye, Shulin Fu, Zhongyuan Wu, Yu Liu
Summary: This study demonstrated for the first time that baicalin exerted an anti-apoptotic effect in porcine peritoneal mesothelial cells (PPMC) infected with Glaesserella parasuis (GPS) by inhibiting the activation of the PKC-MAPK pathway, suggesting it as a potential therapeutic option for GPS infection-induced apoptosis.
Article
Biotechnology & Applied Microbiology
Haitao Tu, Duanhua Ma, Yuanyuan Luo, Shuifu Tang, Ying Li, Gangyi Chen, Liangliang Wang, Zhengkun Hou, Chuangpeng Shen, Huan Lu, Xun Zhuang, Liangyou Zhang
Summary: This study demonstrates the significant therapeutic effect of Quercetin on chronic renal failure (CRF) by regulating the PI3K/Akt pathway to reduce cell apoptosis, water retention, and toxin accumulation. Quercetin, as the main ingredient of SQJZJN, may minimize renal fibrosis and apoptosis in CRF rats through targeting PIK3R1.
Article
Biotechnology & Applied Microbiology
Xiao Wang, Na Xu, Qinglin Li, Shengqi Chen, Hui Cheng, Mo Yang, Ting Jiang, Jun Chu, Xiaojing Ma, Dengke Yin
Summary: Lactonic sophorolipids (LSL) has the potential to inhibit proliferation and induce apoptosis in HepG2 cells, possibly through regulating the expression of genes and proteins associated with apoptosis via the Caspase-3 pathway. These findings suggest that LSL could be a potential drug candidate for liver cancer treatment.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Plant Sciences
Ya Hou, Yating Zhang, Shengnan Jiang, Na Xie, Yi Zhang, Xianli Meng, Xiaobo Wang
Summary: This study aimed to investigate the mechanisms by which Salidroside enhances mitochondrial function in CoCl2-induced HT22 hypoxic injury. The results showed that Salidroside can reduce oxidative damage, decrease ROS and Ca2+ levels, and enhance mitochondrial membrane potential and cell viability.
Article
Food Science & Technology
Jing Wang, Meiling Fan, Shuhe Yin, Xiaohao Xu, Baoyu Fu, Rui Jiang, Liwei Sun
Summary: The research shows that ginseng oligosaccharide extract (GSO) has the potential for clinical treatment in alleviating allergies by inhibiting multiple immune response pathways.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Neurosciences
Yanfeng Huang, Xie Zhang, Yidan Zou, Qiuju Yuan, Yan-Fang Xian, Zhi-Xiu Lin
Summary: This study provides evidence that quercetin can alleviate pain hypersensitivity following brachial plexus avulsion in rats by suppressing inflammation and oxidative stress. These results suggest that quercetin has the potential to be further developed as a therapeutic method for the treatment of neuropathic pain.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhan-Long Li, Jia Mi, Lu Lu, Qing Luo, Xi Liu, Ya-Mei Yan, Bo Jin, You-Long Cao, Xiao-Xiong Zeng, Lin-Wu Ran
Summary: The main anthocyanin monomer Pt3G of Lycium ruthenicum Murray inhibits cell proliferation and induces apoptosis in prostate cancer DU-145 cells, potentially through the regulation of the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway.
Article
Immunology
Wanvisa Udomsinprasert, Tachatra Ungsudechachai, Supawit Wunthong, Supakorn Yuttanarad, Jiraphun Jittikoon, Sittisak Honsawek
Summary: This study investigated the clinical and pathological effects of Galectin-3 on inflammation in knee osteoarthritis (OA). The results showed increased levels of Galectin-3 in the synovial fluid and plasma of knee OA patients, which were significantly associated with disease severity and indicators of body composition, physical performance, knee pain, and disability. Further analysis revealed that Galectin-3 exerted an inflammatory action in knee OA synoviocytes, stimulating the production of inflammatory factors and regulating gene expressions related to inflammation and cartilage degeneration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rania Alaaeldin, Iman A. M. Abdel-Rahman, Heba Ali Hassan, Nancy Youssef, Ahmed E. Allam, Sayed F. Abdelwahab, Qing-Li Zhao, Moustafa Fathy
Summary: The study investigated the potential antidiabetic activity of carpachromene on glucose metabolism and insulin signaling, revealing its impact on cell metabolism and signaling pathways through various mechanisms.
Article
Biochemistry & Molecular Biology
Raquel Mateos, Joaquin Garcia-Cordero, Laura Bravo-Clemente, Beatriz Sarria
Summary: This study compared the effects of a combination of decaffeinated green coffee bean extract and two types of oat beta-glucans on overweight/obese subjects, finding that the 5g - 70% BG nutraceutical was most effective in aiding weight loss.
Article
Biochemistry & Molecular Biology
Esther Garcia-Diez, Maria Elvira Lopez-Oliva, Alicia Caro-Vadillo, Francisco Perez-Vizcaino, Jara Perez-Jimenez, Sonia Ramos, Maria Angeles Martin
Summary: Diabetic cardiomyopathy is a major cause of death among diabetic patients. Oxidative stress and inflammation play key roles in its development. Dietary flavonoids have strong antioxidant and anti-inflammatory activities, and their combination with antidiabetic drugs has potential benefits. This study found that a cocoa-carob blend diet, rich in flavonoids, can prevent cardiac remodeling and dysfunction in diabetic animals, and its effects are further improved when used in combination with metformin.
Article
Food Science & Technology
Joaquin Garcia-Cordero, Jose Luis Sierra-Cinos, Miguel A. Seguido, Susana Gonzalez-Ramila, Raquel Mateos, Laura Bravo-Clemente, Beatriz Sarria
Summary: The study investigated the effects of regularly consuming supplements containing green coffee polyphenols, beta-glucans, or their combination on body composition in overweight/obese subjects without changing their dietary and physical activity habits. The results showed that there were no changes in body composition parameters with any of the supplements, indicating that regular intake of these supplements without lifestyle changes is not an effective weight loss strategy.
Article
Food Science & Technology
Esther Garcia-Diez, Helena Senchez-Ayora, Maria Blanch, Sonia Ramos, Maria Angeles Martin, Jara Perez-Jimenez
Summary: Evidence suggests that combining carob with cocoa can result in a blend with high dietary fiber, methylxanthines, and polyphenols, and less bitterness compared to pure cocoa. This blend may serve as a suitable alternative to commercial sugar-rich soluble cocoa powders.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Miguel Angel Seguido, Rosa Maria Tarradas, Susana Gonzalez-Ramila, Joaquin Garcia-Cordero, Beatriz Sarria, Laura Bravo-Clemente, Raquel Mateos
Summary: This study investigated the effects of regularly consuming a green coffee phenolic extract (GCPE) on the bioavailability and metabolism of coffee (poly)phenols. The results showed that sustained consumption of GCPE produced certain changes in the excretion of phenolic metabolites, but had a small overall effect on the bioavailability of (poly)phenols.
Article
Food Science & Technology
Susana Gonzalez-Ramila, Raquel Mateos, Joaquin Garcia-Cordero, Miguel A. Seguido, Laura Bravo-Clemente, Beatriz Sarria
Summary: The study found that regular consumption of olive pomace oil (OPO) can reduce total cholesterol, LDL cholesterol, and waist circumference. It also found that malondialdehyde levels decreased after OPO intake in healthy subjects. In contrast, the consumption of sunflower oil led to an increase in apolipoprotein B and the apolipoprotein B/Apo A ratio. OPO intake may improve cardiometabolic risk in both healthy and hypercholesterolemic subjects.
Article
Nutrition & Dietetics
Susana Gonzalez-Ramila, Beatriz Sarria, Miguel A. Seguido, Joaquin Garcia-Cordero, Raquel Mateos, Laura Bravo
Summary: This study found that dietary consumption of olive pomace oil may have a hypolipidemic effect, contributing to cardiovascular disease prevention.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Susana Gonzalez-Ramila, Beatriz Sarria, Miguel Angel Seguido, Joaquin Garcia-Cordero, Laura Bravo-Clemente, Raquel Mateos
Summary: The study found that long-term consumption of olive pomace oil may help reduce visceral fat and potentially have a positive effect on cardiovascular metabolism and vascular tone. However, it did not have a significant impact on markers such as lipid profile, blood pressure, and endothelial function.
Article
Nutrition & Dietetics
Elisa Fernandez-Millan, Sonia Ramos, David Alvarez-Cilleros, Sara Samino, Nuria Amigo, Xavier Correig, Monica Chagoyen, Carmen Alvarez, Maria Angeles Martin
Summary: This study used metabolomics tools to investigate the metabolic impact of cocoa in type 2 diabetes. The results showed that cocoa supplementation decreased blood glucose levels, improved glucose metabolism, and produced significant changes in urinary metabolites. Pathway analysis revealed the involvement of branched-chain amino acids and ketone bodies in the beneficial impact of cocoa on diabetes.
Review
Food Science & Technology
Stefano Quarta, Marika Massaro, Maria Annunziata Carluccio, Nadia Calabriso, Laura Bravo, Beatriz Sarria, Maria-Teresa Garcia-Conesa
Summary: This review critically examines data on TNF-alpha levels in different weight groups and the effects of food intervention, showing high variability and uncertainty in the effects of different dietary approaches on TNF-alpha levels, with no clear relationship between TNF-alpha responses and body weight changes.
Article
Nutrition & Dietetics
Paula Martinez-Oca, Claudio Alba, Alicia Sanchez-Roncero, Tamara Fernandez-Marcelo, Maria Angeles Martin, Fernando Escriva, Juan Miguel Rodriguez, Carmen Alvarez, Elisa Fernandez-Millan
Summary: This study suggests that maternal malnutrition during lactation can impact the microbial composition of mother's milk and offspring gut colonization. These microbial changes compromise the correlations between milk and fecal samples and lead to increased offspring gut permeability and altered expression of goblet cell markers.
Article
Biochemistry & Molecular Biology
Esther Garcia-Diez, Maria Elvira Lopez-Oliva, Francisco Perez-Vizcaino, Jara Perez-Jimenez, Sonia Ramos, Maria Angeles Martin
Summary: In this study, it was shown that a cocoa-carob blend rich in polyphenols improved gut health and gut microbiota composition in diabetic rats. The blend regulated the levels of mucin and tight-junction proteins, reduced oxidative stress and inflammation, and modulated the composition of gut bacteria. Several phenolic metabolites in the blend were found to be associated with specific changes in gut bacteria composition.
Article
Biochemistry & Molecular Biology
Esther Garcia-Diez, Maria Elvira Lopez-Oliva, Jara Perez-Jimenez, Maria Angeles Martin, Sonia Ramos
Summary: This study demonstrates that epicatechin and 2,3-dihydroxybenzoic acid can modulate energy metabolism and insulin signaling in cardiac cells through the activation of AKT and AMPK pathways.
