Article
Medicine, Research & Experimental
Maiara Mikuska Cordeiro, Patricia Bubna Biscaia, Janaini Brunoski, Rosane Aparecida Ribeiro, Gilson Cesar Nobre Franco, Dionizia Xavier Scomparin
Summary: The study found that supplementing with vitamin D in western diet-induced obese rats can reduce weight gain, abdominal fat deposition, and improve plasma lipid profile. These effects may be mediated by reductions in leptin and TNF-alpha levels.
Article
Endocrinology & Metabolism
Erika Monelli, Pilar Villacampa, Amaia Zabala-Letona, Anabel Martinez-Romero, Judith Llena, Daniel Beiroa, Leonor Gouveia, Inigo Chivite, Sebastian Zagmutt, Pau Gama-Perez, Oscar Osorio-Conles, Laia Muixi, Ainara Martinez-Gonzalez, Sandra D. Castillo, Natalia Martin-Martin, Pau Castel, Lorea Valcarcel-Jimenez, Irene Garcia-Gonzalez, Josep A. Villena, Sonia Fernandez-Ruiz, Dolors Serra, Laura Herrero, Rui Benedito, Pablo Garcia-Roves, Josep Vidal, Paul Cohen, Ruben Nogueiras, Marc Claret, Arkaitz Carracedo, Mariona Graupera
Summary: Reciprocal interactions between endothelial cells and adipocytes play a crucial role in maintaining the homeostasis of adipose tissue. The production of polyamines in endothelial cells stimulates adipocyte lipolysis and regulates adipose tissue homeostasis.
Review
Pharmacology & Pharmacy
Ko Fujimori
Summary: Prostaglandins (PGs) are lipid-derived autacoids that regulate adipogenesis and obesity through G protein-coupled receptors.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Review
Endocrinology & Metabolism
Camille Lassale, Montserrat Fito, Maria Morales-Suarez-Varela, Andres Moya, Santiago F. Gomez, Helmut Schroder
Summary: Current evidence suggests a certain impact of adherence to the Mediterranean diet on adiposity markers and obesity in children and adolescents, but the majority of related studies are of low quality, with limited evidence supporting its positive effect on maintaining a healthy body weight. More high-quality intervention and longitudinal data are needed to form the base of large-scale health programs to prevent childhood obesity.
Review
Nutrition & Dietetics
Lucilla Crudele, Elena Piccinin, Antonio Moschetta
Summary: The prevalence of overweight and obesity has increased dramatically worldwide in recent years, leading to a higher risk of chronic diseases such as cancer. Strategies focused on limiting fat accumulation and lifestyle interventions are crucial to prevent cancer and reduce excess body weight.
Article
Psychiatry
Mari Archer, Onni Niemela, Mari Hamalainen, Eeva Moilanen, Esa Leinonen, Olli Kampman
Summary: This study found that adiposity may influence the IL-1Ra anti-inflammatory response in depressed patients, while the effect of alcohol consumption in these patients seems insignificant.
Article
Chemistry, Multidisciplinary
Yingkai Sun, Juan Zhang, Jie Hong, Zhongyun Zhang, Peng Lu, Aibo Gao, Mengshan Ni, Zhiyin Zhang, Huanjie Yang, Juan Shen, Jieli Lu, Wenzhi Xue, Qianqian Lv, Yufang Bi, Yi Arial Zeng, Weiqiong Gu, Guang Ning, Weiqing Wang, Ruixin Liu, Jiqiu Wang
Summary: Recent genetic evidence has shown that mutations in WNT downstream play a role in fat distribution. This study identified 12 obese patients with the same mutations in RSPO1, which is associated with human obesity. Overexpression of RSPO1 leads to obesity under a high-fat diet, while its ablation prevents diet-induced adiposity. The overexpression of RSPO1 inhibits adipocyte mitochondrial respiration and thermogenesis through the LGR4-Wnt/beta-catenin signaling pathway. Therefore, gain-of-function mutations and excessive expression of RSPO1 suppress fat thermogenesis and contribute to obesity in humans.
Article
Endocrinology & Metabolism
Bing Liu, Yi Zhong, Dandan Huang, Liuye Yang, Pengchao Wang, Liu Yang, Fengxiao Zhang, Xiaoguang Li, Minglu Liang, Kai Huang, Meng Du
Summary: This study identifies a long non-coding RNA NRON as an important regulator of glucose/lipid metabolism and whole-body energy expenditure. Depletion of Nron in obese mice leads to metabolic benefits, including reduced body weight and fat mass, improved insulin sensitivity and serum lipid parameters, attenuated hepatic steatosis, and enhanced adipose function. The mechanism involves the activation of specific signaling pathways and metabolic networks. Inhibition of Nron may have potential as a therapeutic approach for obesity.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Biochemistry & Molecular Biology
Mark B. Wiley, Nicholas DiPatrizio
Summary: The gut barrier is compromised in diet-induced obesity, and the dysregulated endocannabinoid system in the gut may play a role in this dysfunction. This study found that mice lacking cannabinoid receptor subtype-1 (CB1R) in intestinal epithelial cells had worsened gut barrier dysfunction when fed a high-fat/sucrose diet. The mice also showed reduced levels of endocannabinoids and altered gene expression for gut barrier components and inflammatory markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Klarissa R. Wilkinson, Larry A. Tucker, Lance E. Davidson, Bruce W. Bailey
Summary: Regular consumption of non-fat milk was associated with lower levels of abdominal adiposity, while no significant differences were found for full-fat milk drinkers or milk abstainers.
Article
Nutrition & Dietetics
Jingya Guo, Mengjie Li, Yuhan Zhao, Seong-Gook Kang, Kunlun Huang, Tao Tong
Summary: In this study, the preventive benefits of Cedryl acetate (CA) on obesity and obesity-related metabolic syndrome caused by a high-fat diet (HFD) were investigated. CA supplementation significantly reduced weight gain induced by an HFD, decreased the weight of the visceral fat pads, and prevented adipocyte hypertrophy in mice. Moreover, CA showed significant improvements in metabolic parameters and gene expression related to metabolism in the liver and white adipose tissues of mice fed an HFD.
Article
Genetics & Heredity
Phoebe Yam, Jody Albright, Melissa VerHague, Erik R. Gertz, Fernando Pardo-Manuel de Villena, Brian J. Bennett
Summary: This study analyzed the effects of different macronutrient diets on body composition and obesity-related traits in a genetically diverse mouse population, showing significant variation in phenotypic responses among different genetic strains. The findings underscore the importance of considering genetic diversity when making dietary recommendations for weight management.
FRONTIERS IN GENETICS
(2021)
Article
Psychology, Biological
Kadri Arumae, Rene Mottus, Uku Vainik
Summary: Various personality traits are differently associated with relative fat mass (RFM), body mass index (BMI), and basal metabolic rate (BMR). Openness and its facets are strongly associated with RFM, potentially influencing fat mass through eating habits; one facet of Extraversion is associated with both BMI and BMR, related to biological processes. BMI confounds associations of personality traits with both fat mass and lean mass.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Public, Environmental & Occupational Health
Matthew N. Ahmadi, Elif Inan-Eroglu, Gita D. Mishra, Amanda Salis, Emmanuel Stamatakis
Summary: This study examined the association between changes in physical activity and diet with obesity development and changes in body fat percentage, body mass index, and waist circumference. The results showed that increasing physical activity combined with improving diet was most effective in reducing the risk of obesity. Improvements in physical activity or diet mutually attenuated the deleterious associations of the other behavior's deterioration.
PREVENTIVE MEDICINE
(2023)
Article
Medicine, General & Internal
Hila Zelicha, Nora Kloting, Alon Kaplan, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Yoash Chassidim, Matthias Bluher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Rita Nana Quayson, Martin von Bergen, Beatrice Engelmann, Ulrike E. Rolle-Kampczyk, Sven-Bastiaan Haange, Kieran M. Tuohy, Camilla Diotallevi, Ilan Shelef, Frank B. Hu, Meir J. Stampfer, Iris Shai
Summary: Through an 18-month study, it was found that a green-MED diet, enriched with plant-based polyphenols and lower in red meat intake, may be a potent intervention to promote visceral adipose tissue regression.
Article
Gastroenterology & Hepatology
Cecile Vors, Laurie Joumard-Cubizolles, Manon Lecomte, Emmanuel Combe, Lemlih Ouchchane, Jocelyne Drai, Ketsia Raynal, Florent Joffre, Laure Meiller, Melanie Le Barz, Patrice Gaborit, Aurelie Caille, Monique Sothier, Carla Domingues-Faria, Adeline Blot, Aurelie Wauquier, Emilie Blond, Valerie Sauvinet, Genevieve Gesan-Guiziou, Jean-Pierre Bodin, Philippe Moulin, David Cheillan, Hubert Vidal, Beatrice Morio, Eddy Cotte, Francoise Morel-Laporte, Martine Laville, Annick Bernalier-Donadille, Stephanie Lambert-Porcheron, Corinne Malpuech-Brugere, Marie-Caroline Michalski
Article
Nutrition & Dietetics
Fabienne Laugerette, Cecile Vors, Maud Alligier, Gaelle Pineau, Jocelyne Drai, Carole Knibbe, Beatrice Morio, Stephanie Lambert-Porcheron, Martine Laville, Hubert Vidal, Marie-Caroline Michalski
Article
Endocrinology & Metabolism
Allan de Oliveira Lira, Jose Luiz de Brito Alves, Mariana Pinheiro Fernandes, Diogo Vasconcelos, David Filipe Santana, Joao Henrique da Costa-Silva, Beatrice Morio, Carol Gois Leandro, Luciano Pirola
WORLD JOURNAL OF DIABETES
(2020)
Article
Nutrition & Dietetics
Karla Fabiola Corral-Jara, Laura Cantini, Nathalie Poupin, Tao Ye, Jean Paul Rigaudiere, Sarah De Saint Vincent, Alexandre Pinel, Beatrice Morio, Frederic Capel
Article
Cell Biology
Beatrice Morio, Baptiste Panthu, Arthur Bassot, Jennifer Rieusset
Summary: The liver plays a crucial role in coordinating the metabolic flexibility of the body, with hepatocyte mitochondria being key partners in this process. This review covers the metabolic and signaling pathways carried by liver mitochondria, as well as their role in health and metabolic disorders associated with obesity.
Article
Nutrition & Dietetics
Alexandre Pinel, Jean Paul Rigaudiere, Chrystele Jouve, Christophe Montaurier, Celine Jousse, Marie LHomme, Beatrice Morio, Frederic Capel
Summary: Transgenerational and continuous intake of EPA may help reduce cardiovascular and metabolic risks related to an unbalanced diet by modulating insulin sensitivity, fatty acid metabolism, and fibrosis in skeletal muscle.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Multidisciplinary Sciences
G. J. P. Rautureau, B. Morio, S. Guibert, C. Lefevre, J. Perrier, A. Alves, M. A. Chauvin, C. Pinteur, M. A. Monet, M. Godet, A. M. Madec, J. Rieusset, A. Mey, Baptiste Panthu
Summary: Obesity is linked to respiratory diseases, affecting the lung and liver the most. High-fat high-sugar diet induces specific metabolic changes in various organs, with the lung showing the second most severe effects, including decreased one-carbon metabolism and increased lipid accumulation.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Aline Maria Nunes de Lira Gomes Bloise, Aiany Cibelle Simoes-Alves, Alves Debora Santos, Beatrice Morio, Joao Henrique Costa-Silva
Summary: Nutrition transition is a global phenomenon characterized by increased consumption of fat-rich diets and high prevalence of obesity. While reducing saturated fatty acids intake is a consensus in preventing metabolic diseases, fatty acids of different chain lengths may have different cardiometabolic effects. Short and medium-chain SFA may provide beneficial health effects in cardiometabolic prevention.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Jeremy Bellien, Erwan Bozec, Frederic Bounoure, Hakim Khettab, Julie Malloizel-Delaunay, Mohamed Skiba, Michele Iacob, Nathalie Donnadieu, Aude Coquard, Beatrice Morio, Brigitte Laillet, Jean-Paul Rigaudiere, Jean-Michel Chardigny, Christelle Monteil, Cathy Vendeville, Alain Mercier, Anne-Francoise Cailleux, Anne Blanchard, Jacques Amar, Leopold K. Fezeu, Bruno Pannier, Alessandra Bura-Riviere, Pierre Boutouyrie, Robinson Joannides
Summary: This study assessed the cardiovascular and metabolic effects of camelina oil in hypertensive patients with metabolic syndrome. The results showed that camelina oil supplementation did not improve vascular function but adversely affected glucose metabolism.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Arthur Bassot, Carina Prip-Buus, Anais Alves, Olivier Berdeaux, Johan Perrier, Veronique Lenoir, Jingwei Ji-Cao, Marie-Agnes Berger, Emmanuelle Loizon, Stephanie Cabaret, Baptiste Panthu, Jennifer Rieusset, Beatrice Morio
Summary: This study demonstrates the impact of Grp75 or Mfn2 silencing and overexpression on triglyceride accumulation and cholesterol storage in MAMs, promoting fatty liver through distinct cellular pathways. Both proteins play crucial roles in hepatic lipid and cholesterol metabolism in obesity and NAFLD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Biochemistry & Molecular Biology
Mauricio Castro-Sepulveda, Beatrice Morio, Mauro Tunon-Suarez, Sebastian Jannas-Vela, Francisco Diaz-Castro, Jennifer Rieusset, Hermann Zbinden-Foncea
Summary: This study aimed to investigate the mitochondrial dynamics response in human peripheral blood mononuclear cells during the metabolic transition from fasting to feeding. The results demonstrated that this transition reduces mitochondria-ER interactions, induces mitochondrial fission, and reduces mitochondrial cristae density in human PBMCs.
Review
Physiology
Morgane Couchet, Charlotte Breuillard, Christelle Corne, John Rendu, Beatrice Morio, Uwe Schlattner, Christophe Moinard
Summary: Ornithine transcarbamylase (OTC) is a widely distributed enzyme in organisms, catalyzing the production of L-citrulline and playing a crucial role in the urea cycle. OTC is mainly expressed in the liver and intestine in mammals, influencing amino acid homeostasis significantly.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alexandre Pinel, Jean-Paul Rigaudiere, Beatrice Morio, Frederic Capel
Summary: The study showed that continuous intake of EPA-rich fish oil for three generations could reduce activation of inflammatory processes, maintain metabolic homeostasis, and decrease dysregulation of cholesterol metabolism and mitochondrial functions in response to an obesogenic diet. Continuous intake of long chain n-3 PUFA may be beneficial in preventing the effects of energy-dense, nutrient-poor foods.
Article
Cardiac & Cardiovascular Systems
Vivien Chavanelle, Stephanie Chanon, Claudie Pinteur, Emmanuelle Loizon, Guillaume Vial, Yolanda E. Otero, Florian Le Joubioux, Thierry Maugard, Sebastien L. Peltier, Pascal Sirvent, Beatrice Morio
Summary: The study showed that TOTUM-63 significantly reduced food intake, limited weight gain, and improved glucose homeostasis in animal models of obesity, potentially through modulation of GLP-1 and PYY.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Nutrition & Dietetics
Anais Alves, Frederic Lamarche, Remy Lefebvre, Eva Drevet Mulard, Arthur Bassot, Stephanie Chanon, Emmanuelle Loizon, Claudie Pinteur, Aline Maria Nunes de Lira Gomes Bloise, Murielle Godet, Gilles J. P. Rautureau, Baptiste Panthu, Beatrice Morio
Summary: The interactions between mitochondria and the endoplasmic reticulum, known as MAMs, are altered in the liver in obesity, which leads to disruption of the insulin signaling pathway. The plasma level of glycine is decreased in obesity, and the decrease is strongly correlated with the severity of insulin resistance. Glycine supplementation can promote MAM integrity and improve insulin response in hepatocytes, but it does not have a beneficial effect on the overall metabolic profile in obese mice.