Article
Genetics & Heredity
Liu Ye, Xin Liu, Kai Jin, Yingjie Niu, Qisheng Zuo, Jiuzhou Song, Wei Han, Guohong Chen, Bichun Li
Summary: This study demonstrates that insulin reduces apoptosis and ferroptosis and enhances cell proliferation in a dose-dependent manner via the PI3K-AKT-mTOR signaling pathway in PGCs.
Article
Pathology
Zhaohui Liu, Zheng Hu, Xingdong Cai, Shengming Liu
Summary: SLC39A5 is upregulated in lung adenocarcinoma (LUAD), correlated with poor patient survival, promotes LUAD cell proliferation by activating the PI3K/AKT signaling pathway, and may serve as a novel prognostic biomarker and therapeutic target for LUAD.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Agriculture, Multidisciplinary
Xiaoya Li, Huali Chen, Zelin Zhang, Dejun Xu, Jiaxin Duan, Xiaodi Li, Li Yang, Rongmao Hua, Jianyong Cheng, Qingwang Li
Summary: Isorhamnetin regulates steroidogenesis in ovarian granulosa cells by activating PI3K/Akt signaling pathway, promoting proliferation, inhibiting apoptosis, and alleviating oxidative stress.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Zongkui Wang, Peng Jiang, Fengjuan Liu, Xi Du, Li Ma, Shengliang Ye, Haijun Cao, Pan Sun, Na Su, Fangzhao Lin, Rong Zhang, Changqing Li
Summary: This study reveals that GDF11 negatively regulates neurogenesis by activating the ALK5-dependent PI3K-Akt signaling pathway in neural stem cells, inhibiting cell proliferation and migration while promoting differentiation and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Rongrong Huang, Yunbiao Lu, Zhifei Xie, Xuegan Yang, Yu Ou
Summary: This study demonstrates that LGP9 can ameliorate pancreatic beta cell injury in diabetic patients through the IRS2/PI3K/Akt signaling pathway, offering important clinical implications.
Article
Oncology
Mengmeng Wang, Mingjun Gao, Yong Chen, Jun Wu, Xiaolin Wang, Yusheng Shu
Summary: This study found that PLCD3 is highly expressed in ESCC tissues and cell lines, and its expression is correlated with pathological stage and lymphatic metastasis. PLCD3 knockdown inhibits cell proliferation, migration, and invasion, promotes apoptosis, and arrests the cell cycle in the G1 phase. PLCD3 overexpression, on the other hand, promotes cell proliferation, migration, and invasion. Xenograft models also suggest that PLCD3 promotes tumorigenesis in ESCC. Finally, overexpression of PLCD3 activates the PI3K/AKT/P21 signaling pathway.
Article
Oncology
Wacili Da, Lin Tao, Yue Zhu
Summary: This study demonstrates that CTAB inhibits the proliferation and metastasis of osteosarcoma cells, induces apoptosis through the PI3K/AKT signaling pathway, and does not inhibit the growth of human osteoblasts.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Cell Biology
Yanyi Xiao, Yilong Liu, Zhiwei Gao, Xian Li, Min Weng, Chenghao Shi, Cheng Wang, Linxiao Sun
Summary: Pancreatic cancer is a highly malignant tumor with increasing chemotherapeutic resistance, posing a challenge in clinical treatment. Fisetin, extracted from vegetables and fruits, shows potential as an anti-cancer agent for pancreatic cancer by targeting the PI3K/AKT/mTOR signaling cascade. Further research is needed to better understand the molecular mechanisms underlying fisetin's anti-cancer effects on pancreatic cancer.
Article
Pharmacology & Pharmacy
Xiongjie Huang, Habu Jiwa, Jingtao Xu, Jun Zhang, Yanran Huang, Xiaoji Luo
Summary: This study investigated the effect of Genipin on osteosarcoma and its potential mechanism. The results showed that Genipin significantly inhibited the proliferation, migration, and invasion of osteosarcoma cells, and promoted apoptosis. Animal experiments confirmed the anti-tumor effect of Genipin in vivo. The mechanism may be related to the regulation of the PI3K/AKT signaling pathway.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Biochemistry & Molecular Biology
Chen Xue, Ganglei Li, Juan Lu, Lanjuan Li
Summary: Circular RNAs (circRNAs) are covalently closed noncoding RNAs that regulate target gene expression and play important roles in cancer progression through the circRNA/PI3K/AKT axis. Aberrant regulation of circRNA expression is significantly associated with clinicopathological characteristics and plays crucial roles in biological functions.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Oncology
Mengya Zhong, Xingfeng Qiu, Yu Liu, Yan Yang, Lei Gu, Chenxi Wang, Huiyu Chen, Zhongchen Liu, Jiayin Miao, Guohong Zhuang
Summary: The study revealed that both TIPE and DcR3 are highly expressed in colorectal cancer (CRC) patients with their levels showing a positive correlation. DcR3 was found to be highly expressed in the plasma of cancer patients. TIPE regulates the expression of DcR3 by activating the PI3K/AKT signaling pathway in CRC, promoting cell proliferation and migration while inhibiting apoptosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Developmental Biology
Jose Esteban-Collado, Montserrat Corominas, Florenci Serras
Summary: The study showed that in Drosophila wing, PI3K Akt signaling is crucial for Ask1 to activate p38, but not JNK. Nutrient restriction or mutations targeting specific residues of Drosophila Ask1 protein can block regeneration, which can be reversed by ectopic activation of p38.
Article
Oncology
Mujie Ye, Jiajun He, Jingjing Zhang, Baihui Liu, Xiangqi Liu, Lulu Xie, Meng Wei, Rui Dong, Kai Li, Duan Ma, Kuiran Dong
Summary: The study found that USP7 is highly expressed in hepatoblastoma and both knockdown and overexpression of USP7 significantly affect cell proliferation, migration, and invasion. USP7 may influence HB tumorigenesis through the PI3K/AKT signaling pathway, with potential implications for future treatment.
Article
Anesthesiology
Guoping Yin, Jia Wang, Yanling Zhong, Weidong Wu
Summary: This study found that propofol inhibits the proliferation, migration, and invasive potential of ADSCs, while promoting apoptosis and arresting cells in the G0/G1 phase. These effects are dose-dependent and mediated by the PI3K/AKT-Wnt pathway.
BMC ANESTHESIOLOGY
(2022)
Article
Plant Sciences
Meng-Lian Zhu, Jian-Chun Li, Lu Wang, Xia Zhong, Yu-Wei Zhang, Rui-Zhi Tan, Hong-Lian Wang, Jun-Ming Fan, Li Wang
Summary: The study found that decursin can induce apoptosis, inhibit cell proliferation and migration in HeLa cells, and also inhibit tumor growth in vivo, possibly through the regulation of Akt activation. These findings may have implications for novel therapeutic strategies for cervical cancer.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Wu He, Gang Yuan, Yu Han, Yongcui Yan, Gen Li, Chengcheng Zhao, Jingshan Shen, Xiangrui Jiang, Chen Chen, Li Ni, Dao Wen Wang
Summary: Long-term continuous use of glimepiride is associated with better survival, fewer hospitalizations and emergency visits for heart failure, and fewer hospitalizations for acute myocardial infarction or stroke. High-dose glimepiride has greater cardiovascular protective advantages than low-dose glimepiride. The cardiovascular protective effect of glimepiride may be related to the increase in epoxyeicosatrienoic acid levels through soluble epoxide hydrolase inhibition.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jianing Gao, Yanghui Chen, Huiqing Wang, Xin Li, Ke Li, Yangkai Xu, Xianwei Xie, Yansong Guo, Nana Yang, Xinhua Zhang, Dong Ma, Hong S. Lu, Ying H. Shen, Yong Liu, Jifeng Zhang, Y. Eugene Chen, Alan Daugherty, Dao Wen Wang, Lemin Zheng
Summary: This study investigates the role of GSDMD in vascular smooth muscle cell phenotypic alteration and abdominal aortic aneurysm (AAA) formation. Gsdmd is found to be upregulated in aortic VSMCs in Ang II-induced AAA. VSMC-specific Gsdmd deletion ameliorates AAA formation. Untargeted metabolomic analysis reveals a significant reduction of putrescine in GSDMD-deficient mice.
Review
Biology
Xiang Nie, Jiahui Fan, Dao Wen Wang
Summary: Cardiac fibrosis is a significant issue in cardiovascular diseases, with molecular mechanisms involving TGF-beta signaling, extracellular matrix synthesis and degradation, and non-coding RNAs. Long noncoding RNAs play a crucial role in myocardial fibrosis and can regulate fibrosis by affecting miRNA expression, TGF-beta signaling, and ECM synthesis. Understanding these mechanisms can guide the development of novel therapeutic strategies to prevent or reverse cardiac fibrosis.
Article
Biochemistry & Molecular Biology
Jiali Nie, Yu Han, Zhiyuan Jin, Weijian Hang, Hongyang Shu, Zheng Wen, Li Ni, Dao Wen Wang
Summary: Editing MYBPC3 gene using CRISPR/Cas9 system in vivo can rescue the phenotype of rats with hypertrophic cardiomyopathy. The editing corrected some mutations, restored MYBPC3 protein expression, and normalized the HCM phenotype.
Article
Cardiac & Cardiovascular Systems
Chen Chen, Wu He, Dao Wen Wang
Summary: In November 2019, Wuhan became the epicenter of the COVID-19 outbreak caused by the novel SARS-CoV-2 infection. The emergence of new strains and mutations of the virus posed a serious global health threat. COVID-19-associated cardiac injury, ranging from mild cases to fulminant myocarditis, is not uncommon, and the overactivated immune response and inflammatory storm play a crucial role in its pathogenesis. Early identification and diagnosis are crucial for the treatment of COVID-19-associated myocarditis.
Article
Oncology
Hong Yang, Rui Li, Fei Ma, Yujian Liu, Xingwei He, Qiao Yang, Dao Wen Wang, Hesong Zeng, Hong Wang
Summary: This study aimed to explore and determine whether echocardiographic phenotype provides value for further risk stratification and guiding treatment in AL patients with heart failure. The results showed that right ventricular wall thickness (RVT), relative wall thickness (RWT), and left ventricular ejection fraction (LVEF) < 50% were independently associated with survival. Survival was significantly reduced in the presence of RVT >= 6.5 mm or LVEF < 50%. Echocardiographic phenotype has incremental value beyond rMayo staging for predicting survival and guiding treatment in AL patients with heart failure.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Jiang He, Nanxiang Ouyang, Xiaofan Guo, Guozhe Sun, Zhao Li, Jianjun Mu, Dao Wen Wang, Lixia Qiao, Liying Xing, Guocheng Ren, Chunxia Zhao, Ruihai Yang, Zuyi Yuan, Chang Wang, Chuning Shi, Songyue Liu, Wei Miao, Guangxiao Li, Chung-Shiuan Chen, Yingxian Sun
Summary: This study tested the effectiveness of a non-physician community health-care provider-led intervention for hypertension. The results showed that this intervention can effectively reduce the risk of cardiovascular disease and death.
Review
Biology
Wu He, Ling Zhou, Ke Xu, Huihui Li, James Jiqi Wang, Chen Chen, DaoWen Wang
Summary: Myocarditis is an inflammatory cardiac disease that causes the destruction of myocardial cells, infiltration of inflammatory cells, and fibrosis, and is becoming a major public health concern. The aetiology of myocarditis is expanding with the emergence of new pathogens and drugs. The relationship between immune checkpoint inhibitors, severe acute respiratory syndrome coronavirus 2, vaccines against coronavirus disease-2019, and myocarditis is gaining attention. Immunopathological processes play a significant role in the development and prognosis of myocarditis. Excessive immune activation can cause severe myocardial injury, while chronic inflammation can result in cardiac remodelling and dilated cardiomyopathy. The use of immunosuppressive treatments, particularly cytotoxic agents, for myocarditis remains controversial, and immunomodulatory therapy is the general trend. This review focuses on the current understanding of the aetiology and immunopathogenesis of myocarditis and provides new perspectives on immunomodulatory therapies.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jiabing Zhan, Kunying Jin, Nan Ding, Yufei Zhou, Guo Hu, Shuai Yuan, Rong Xie, Zheng Wen, Chen Chen, Huaping Li, Dao Wen Wang
Summary: Intensive glycemic control is insufficient for reducing the risk of heart failure in patients with diabetes mellitus. MiR-320 and CD36 mutually enhance each other's expression, forming a positive feedback loop that sustains a hyperlipidemic state in the heart.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Medicine, Research & Experimental
Rong Xie, Jiahui Fan, Jianpei Wen, Kunying Jin, Jiabing Zhan, Shuai Yuan, Yuyan Tang, Xiang Nie, Zheng Wen, Huaping Li, Chen Chen, Dao Wen Wang
Summary: Diabetes can directly cause cardiac injury, leading to cardiomyopathy. In this study, the protective role of ZNF593-AS in diabetic cardiomyopathy was identified. ZNF593-AS attenuated cardiomyocyte apoptosis and inflammation by suppressing the phosphorylation and activation of IRF3, suggesting that ZNF593-AS may be a potential therapeutic target for diabetic cardiomyopathy.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Oncology
Jiaqi Dai, Tao Wang, Ke Xu, Yang Sun, Zongzhe Li, Peng Chen, Hong Wang, Dongyang Wu, Yanghui Chen, Lei Xiao, Hao Liu, Haoran Wei, Rui Li, Liyuan Peng, Ting Yu, Yan Wang, Zhongsheng Sun, Dao Wen Wang
Summary: Previous studies have identified differences in symptom severity and prognosis among patients with hypertrophic cardiomyopathy (HCM), suggesting the presence of potential HCM subtypes. In this study, consensus clustering was performed on echocardiography features of 793 HCM patients to identify potential subtypes. Machine learning modeling and interactome network detection techniques were used to explore the relationship between phenotype and genotype based on whole-exome sequencing data. Two subtypes were identified: subtype 2 characterized by stable course with asymmetric septal hypertrophy, and subtype 1 characterized by aggressive progression and left ventricular systolic dysfunction. Machine learning modeling based on personal whole-exome data accurately predicted subtype propensities using 46 genes with high mutation burden. Another cohort replicated the findings, showing increased left ventricular end-diastolic diameter and reduced ejection fraction in patients predicted as subtype 1. Echocardiography and genetic screening for the 46 genes can be used to classify HCM into two subtypes with distinct clinical outcomes.
FRONTIERS OF MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Zuowen He, Xin Xu, Qu Zhao, Hu Ding, Dao Wen Wang
Summary: This article summarizes the characteristics, etiology, diagnosis, and treatment of vasospastic angina (VSA), with a focus on the role of inflammation. It provides new insights into the understanding of VSA.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cell Biology
Huihui Li, Mingzhi Zhang, Quanyi Zhao, Wanqing Zhao, Yan Zhuang, Jin Wang, Weijian Hang, Zheng Wen, Li Wang, Chen Chen, Dao Wen Wang
Summary: This study reveals the pathogenesis of fulminant myocarditis (FM) and suggests potential therapeutic strategies. Healthy cardiomyocytes lose their function and differentiate into pro-angiogenic and pro-inflammatory cells in FM. Neutrophils, after migrating to the heart, continuously attract peripheral neutrophils via specific signals, resulting in their acute accumulation in the heart. Moreover, neutrophils can amplify the inflammatory response by recruiting and activating pro-inflammatory cells. Blockade of the self-recruiting loop of neutrophils substantially alleviates FM in mice.
Article
Cardiac & Cardiovascular Systems
Mei-Yan Dai, Yong-Cui Yan, Lu-Yun Wang, Chun-Xia Zhao, Dao-Wen Wang, Jian-Gang Jiang
Summary: Retrospective analysis of 150 patients with fulminant myocarditis revealed marked ECG abnormalities, including significantly decreased QRS amplitudes and various arrhythmias, which can serve as preliminary clues for the diagnosis of this condition.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Yanru Zhao, Huaping Li, Hengzhi Du, Zhongwei Yin, Mengying He, Jiahui Fan, Xiang Nie, Yang Sun, Huiying Hou, Beibei Dai, Xudong Zhang, Yuanyuan Cai, Kunying Jin, Nan Ding, Zheng Wen, Jiang Chang, Chen Chen, Dao Wen Wang
Summary: This study found that KSHV infection is a risk factor for dilated cardiomyopathy, and the KSHV-encoded miRNA kshv-miR-K12-1-5p may be involved in the development of heart disease.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)