Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK–NRF2 pathway

MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study

(2016) Christine von Toerne et al.   DIABETOLOGIA

The Keap1–Nrf2 system and diabetes mellitus

(2015) Akira Uruno et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

In vitro use of free fatty acids bound to albumin: A comparison of protocols

(2015) Ana F Oliveira et al.   BIOTECHNIQUES

JunB protects β-cells from lipotoxicity via the XBP1–AKT pathway

(2014) D A Cunha et al.   CELL DEATH AND DIFFERENTIATION

BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic  -Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2

(2014) L. Marroqui et al.   DIABETES

Prevention and management of type 2 diabetes: dietary components and nutritional strategies

(2014) Sylvia H Ley et al.   LANCET

Current understanding of the thrombospondin-1 interactome

(2014) Andrea Resovi et al.   MATRIX BIOLOGY

Nova1 is a master regulator of alternative splicing in pancreatic beta cells

(2014) Olatz Villate et al.   NUCLEIC ACIDS RESEARCH

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity

(2014) J A Wali et al.   Cell Death & Disease

Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study

(2014) Nita G Forouhi et al.   Lancet Diabetes & Endocrinology

Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation

(2013) Ping Kong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

(2013) C. Atkins et al.   CANCER RESEARCH

A Novel Mechanism by Which SDF-1  Protects Cardiac Cells From Palmitate-Induced Endoplasmic Reticulum Stress and Apoptosis via CXCR7 and AMPK/p38 MAPK-Mediated Interleukin-6 Generation

(2013) Y. Zhao et al.   DIABETES

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

(2013) Miriam Cnop et al.   DIABETES

Nrf2 Protects Pancreatic  -Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice

(2013) Y. Yagishita et al.   DIABETES

Thrombospondin 1 Mediates High-Fat Diet-Induced Muscle Fibrosis and Insulin Resistance in Male Mice

(2013) Mayumi Inoue et al.   ENDOCRINOLOGY

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

(2013) Steven E Kahn et al.   LANCET

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

(2013) Tatiane C. Nogueira et al.   PLoS Genetics

A Thrombospondin-Dependent Pathway for a Protective ER Stress Response

(2012) Jeffrey M. Lynch et al.   CELL

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress-Mitochondrial Dialog Triggering Lipotoxic Rodent and Human  -Cell Apoptosis

(2012) D. A. Cunha et al.   DIABETES

Sustained Beta-Cell Dysfunction but Normalized Islet Mass in Aged Thrombospondin-1 Deficient Mice

(2012) Carl Johan Drott et al.   PLoS One

Thrombospondin-1: An Islet Endothelial Cell Signal of Importance for  -Cell Function

(2011) J. Olerud et al.   DIABETES

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic  -Cell Apoptosis via Regulation of the BH3-Only Protein Bim

(2011) I. Santin et al.   DIABETES

Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade

(2010) W. Roberts et al.   BLOOD

p53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic β-Cell Apoptosis Induced by Proinflammatory Cytokines and Endoplasmic Reticulum Stress

(2010) Esteban N. Gurzov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT1 Is a Master Regulator of Pancreatic β-Cell Apoptosis and Islet Inflammation

(2010) Fabrice Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

(2009) Daniel A. Cunha et al.   DIABETES

Regulation of Nrf2-dependent gene expression by 15-deoxy-Δ12,14-prostaglandin J2

(2009) Emilia Kansanen et al.   FREE RADICAL BIOLOGY AND MEDICINE

The interaction of Thrombospondins with extracellular matrix proteins

(2009) Kemin Tan et al.   Journal of Cell Communication and Signaling

An update on lipotoxic endoplasmic reticulum stress in pancreatic β-cells

(2008) Miriam Cnop et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets

(2008) J. Olerud et al.   DIABETES

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death

(2008) Changhong Xing et al.   JOURNAL OF NEUROCHEMISTRY