Gut microbiome and amyotrophic lateral sclerosis: A systematic review of current evidence

The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS)

(2021) Sarah L. Boddy et al.   BMC Medicine

Large-scale association analyses identify host factors influencing human gut microbiome composition

(2021) Alexander Kurilshikov et al.   NATURE GENETICS

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

(2021) Francesco Asnicar et al.   NATURE MEDICINE

Serum Creatinine Protects Against Amyotrophic Lateral Sclerosis: a Mendelian Randomization Study

(2021) Mengmeng Wang et al.   MOLECULAR NEUROBIOLOGY

Comparison between 16S rRNA and shotgun sequencing data for the taxonomic characterization of the gut microbiota

(2021) Francesco Durazzi et al.   Scientific Reports

Microbiome Metadata Standards: Report of the National Microbiome Data Collaborative’s Workshop and Follow-On Activities

(2021) Pajau Vangay et al.   mSystems

Life Course Adiposity and Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study

(2020) Linjing Zhang et al.   ANNALS OF NEUROLOGY

Establishing or Exaggerating Causality for the Gut Microbiome: Lessons from Human Microbiota-Associated Rodents

(2020) Jens Walter et al.   CELL

Comparing bioinformatic pipelines for microbial 16S rRNA amplicon sequencing

(2020) Andrei Prodan et al.   PLoS One

Bacterial DNA promotes Tau aggregation

(2020) George Tetz et al.   Scientific Reports

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

(2020) Timothy R Sampson et al.   eLife

C9orf72 suppresses systemic and neural inflammation induced by gut bacteria

(2020) Aaron Burberry et al.   NATURE

Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer’s transgenic mice

(2020) Hemraj B. Dodiya et al.   Scientific Reports

The Role of the Microbiota–Gut–Brain Axis and Antibiotics in ALS and Neurodegenerative Diseases

(2020) Mark Obrenovich et al.   Microorganisms

A prospective longitudinal study on the microbiota composition in amyotrophic lateral sclerosis

(2020) Diana Di Gioia et al.   BMC Medicine

The Microbiome as a Modifier of Neurodegenerative Disease Risk

(2020) P. Fang et al.   Cell Host & Microbe

Gut–Brain Axis and Neurodegeneration: State-of-the-Art of Meta-Omics Sciences for Microbiota Characterization

(2020) Bruno Tilocca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Causal Association of Leukocytes Count and Amyotrophic Lateral Sclerosis: a Mendelian Randomization Study

(2020) Chunyu Li et al.   MOLECULAR NEUROBIOLOGY

Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer

(2020) Winnie Fong et al.   ONCOGENE

The alteration of gut microbiome and metabolism in amyotrophic lateral sclerosis patients

(2020) Qianqian Zeng et al.   Scientific Reports

Progression and survival of patients with motor neuron disease relative to their fecal microbiota

(2020) Shyuan T. Ngo et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

ALS Genetics: Gains, Losses, and Implications for Future Therapies

(2020) Garam Kim et al.   NEURON

Trial of Sodium Phenylbutyrate–Taurursodiol for Amyotrophic Lateral Sclerosis

(2020) Sabrina Paganoni et al.   NEW ENGLAND JOURNAL OF MEDICINE

Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma

(2020) Gianluca Ianiro et al.   Nature Communications

Education, intelligence, and amyotrophic lateral sclerosis: A Mendelian randomization study

(2020) Linjing Zhang et al.   Annals of Clinical and Translational Neurology

Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study

(2019) JosÉ E. de la Rubia et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Understanding and overcoming the pitfalls and biases of next-generation sequencing (NGS) methods for use in the routine clinical microbiological diagnostic laboratory

(2019) Stefan A. Boers et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Smoking and amyotrophic lateral sclerosis: A mendelian randomization study

(2019) Yiqiang Zhan et al.   ANNALS OF NEUROLOGY

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis

(2019) Sara Bandres‐Ciga et al.   ANNALS OF NEUROLOGY

Antibiotics Use and Risk of Amyotrophic Lateral Sclerosis in Sweden

(2019) Jiangwei Sun et al.   EUROPEAN JOURNAL OF NEUROLOGY

Environmental risk factors and amyotrophic lateral sclerosis (ALS): A case-control study of ALS in China

(2019) Ling Lian et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes

(2019) Hemraj B. Dodiya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epidemiology of amyotrophic lateral sclerosis

(2019) Elisa Longinetti et al.   CURRENT OPINION IN NEUROLOGY

Potential roles of gut microbiome and metabolites in modulating ALS in mice

(2019) Eran Blacher et al.   NATURE

High BMI is associated with low ALS risk

(2019) Ola Nakken et al.   NEUROLOGY

Intestinal microbiota composition in patients with amyotrophic lateral sclerosis

(2019) Chao-Di Zhai et al.   CHINESE MEDICAL JOURNAL

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

FETR-ALS Study Protocol: A Randomized Clinical Trial of Fecal Microbiota Transplantation in Amyotrophic Lateral Sclerosis

(2019) Jessica Mandrioli et al.   Frontiers in Neurology

Temporal evolution of the microbiome, immune system and epigenome with disease progression in ALS mice

(2019) Claudia Figueroa-Romero et al.   Disease Models & Mechanisms

Fecal Microbiota Transplantation for Dysbiosis — Predictable Risks

(2019) Martin J. Blaser   NEW ENGLAND JOURNAL OF MEDICINE

Causal association of type 2 diabetes with amyotrophic lateral sclerosis: new evidence from Mendelian randomization using GWAS summary statistics

(2019) Ping Zeng et al.   BMC Medicine

Causal effects of serum metabolites on amyotrophic lateral sclerosis: A Mendelian randomization study

(2019) Lihong Yang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?

(2019) Rita Mejzini et al.   Frontiers in Neuroscience

Best practices for analysing microbiomes

(2018) Rob Knight et al.   NATURE REVIEWS MICROBIOLOGY

The fecal microbiome of ALS patients

(2018) David Brenner et al.   NEUROBIOLOGY OF AGING

Polygenic link between blood lipids and amyotrophic lateral sclerosis

(2018) Xu Chen et al.   NEUROBIOLOGY OF AGING

Microbiome Composition in Both Wild-Type and Disease Model Mice Is Heavily Influenced by Mouse Facility

(2018) Kristopher D. Parker et al.   Frontiers in Microbiology

Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians

(2018) Celeste Allaband et al.   Clinical Gastroenterology and Hepatology

Animal models of neurodegenerative diseases

(2018) Ted M. Dawson et al.   NATURE NEUROSCIENCE

Denoising the Denoisers: an independent evaluation of microbiome sequence error-correction approaches

(2018) Jacob T. Nearing et al.   PeerJ

Causal Effects of Blood Lipids on Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study

(2018) Ping Zeng et al.   HUMAN MOLECULAR GENETICS

The gut microbiome: Relationships with disease and opportunities for therapy

(2018) Juliana Durack et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Assessment of variation in microbial community amplicon sequencing by the Microbiome Quality Control (MBQC) project consortium

(2017) Rashmi Sinha et al.   NATURE BIOTECHNOLOGY

Shotgun metagenomics, from sampling to analysis

(2017) Christopher Quince et al.   NATURE BIOTECHNOLOGY

Towards standards for human fecal sample processing in metagenomic studies

(2017) Paul I Costea et al.   NATURE BIOTECHNOLOGY

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microbiome Datasets Are Compositional: And This Is Not Optional

(2017) Gregory B. Gloor et al.   Frontiers in Microbiology

Correlation of Peripheral Immunity With Rapid Amyotrophic Lateral Sclerosis Progression

(2017) Benjamin J. Murdock et al.   JAMA Neurology

Shortcomings in the Current Amyotrophic Lateral Sclerosis Trials and Potential Solutions for Improvement

(2017) Nakul Katyal et al.   Frontiers in Neurology

Optimizing methods and dodging pitfalls in microbiome research

(2017) Dorothy Kim et al.   Microbiome

Normalization and microbial differential abundance strategies depend upon data characteristics

(2017) Sophie Weiss et al.   Microbiome

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

(2017) T. Harach et al.   Scientific Reports

Peripheral monocytes are functionally altered and invade the CNS in ALS patients

(2016) Lisa Zondler et al.   ACTA NEUROPATHOLOGICA

Compositional data analysis of the microbiome: fundamentals, tools, and challenges

(2016) Matthew C.B. Tsilimigras et al.   ANNALS OF EPIDEMIOLOGY

It's all relative: analyzing microbiome data as compositions

(2016) Gregory B. Gloor et al.   ANNALS OF EPIDEMIOLOGY

Physical and cognitive fitness in young adulthood and risk of amyotrophic lateral sclerosis at an early age

(2016) E. Longinetti et al.   EUROPEAN JOURNAL OF NEUROLOGY

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Immunometabolism of regulatory T cells

(2016) Ryan Newton et al.   NATURE IMMUNOLOGY

Population-level analysis of gut microbiome variation

(2016) Gwen Falony et al.   SCIENCE

Evaluation of the Microbial Diversity in Amyotrophic Lateral Sclerosis Using High-Throughput Sequencing

(2016) Xin Fang et al.   Frontiers in Microbiology

Novel perspectives on therapeutic modulation of the gut microbiota

(2016) Justin L. McCarville et al.   Therapeutic Advances in Gastroenterology

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

(2016) Myles R. Minter et al.   Scientific Reports

Neurofilament levels as biomarkers in asymptomatic and symptomatic familial amyotrophic lateral sclerosis

(2015) Patrick Weydt et al.   ANNALS OF NEUROLOGY

Regulation of Adaptive Immunity in Health and Disease by Cholesterol Metabolism

(2015) Michael B. Fessler   CURRENT ALLERGY AND ASTHMA REPORTS

How informative is the mouse for human gut microbiota research?

(2015) T. L. A. Nguyen et al.   Disease Models & Mechanisms

Association between diabetes and amyotrophic lateral sclerosis in Sweden

(2015) D. Mariosa et al.   EUROPEAN JOURNAL OF NEUROLOGY

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

(2015) Kristoffer Forslund et al.   NATURE

The dual roles of immunity in ALS: Injury overrides protection

(2015) Benjamin J. Murdock et al.   NEUROBIOLOGY OF DISEASE

Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants

(2015) Shahram Saberi et al.   NEUROLOGIC CLINICS

Mitochondrial dynamism and the pathogenesis of Amyotrophic Lateral Sclerosis

(2015) Mauro Cozzolino et al.   Frontiers in Cellular Neuroscience

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

(2015) Clovis S. Palmer et al.   Frontiers in Immunology

Conducting a Microbiome Study

(2014) Julia K. Goodrich et al.   CELL

Advances in motor neurone disease

(2014) Dirk Bäumer et al.   JOURNAL OF THE ROYAL SOCIETY OF MEDICINE

Publication bias in the social sciences: Unlocking the file drawer

(2014) A. Franco et al.   SCIENCE

Waste Not, Want Not: Why Rarefying Microbiome Data Is Inadmissible

(2014) Paul J. McMurdie et al.   PLoS Computational Biology

The epidemiology of ALS: a conspiracy of genes, environment and time

(2013) Ammar Al-Chalabi et al.   Nature Reviews Neurology

Ribosomal Database Project: data and tools for high throughput rRNA analysis

(2013) James R. Cole et al.   NUCLEIC ACIDS RESEARCH

The SILVA and “All-species Living Tree Project (LTP)” taxonomic frameworks

(2013) Pelin Yilmaz et al.   NUCLEIC ACIDS RESEARCH

Neuroimmunity dynamics and the development of therapeutic strategies for amyotrophic lateral sclerosis

(2013) Melissa Bowerman et al.   Frontiers in Cellular Neuroscience

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival

(2012) Jenny S. Henkel et al.   EMBO Molecular Medicine

A framework for human microbiome research

(2012)   NATURE

The role of regulatory T cells in neurodegenerative diseases

(2012) Feng He et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Premorbid body mass index and risk of amyotrophic lateral sclerosis

(2012) Éilis J. O'Reilly et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

(2011) David R. Beers et al.   BRAIN

An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea

(2011) Daniel McDonald et al.   ISME Journal

Human nutrition, the gut microbiome and the immune system

(2011) Andrew L. Kau et al.   NATURE

Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications

(2011) Pelin Yilmaz et al.   NATURE BIOTECHNOLOGY

The NCBI Taxonomy database

(2011) S. Federhen   NUCLEIC ACIDS RESEARCH

Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form

(2010) Aaron Kerman et al.   ACTA NEUROPATHOLOGICA

Energy metabolism in amyotrophic lateral sclerosis

(2010) Luc Dupuis et al.   LANCET NEUROLOGY

Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins

(2010) P. J. Turnbaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Getting to the core of the gut microbiome

(2009) Matthias H Tschöp et al.   NATURE BIOTECHNOLOGY

The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

(2009) Alessandro Liberati et al.   PLOS MEDICINE