Shortcomings in the Current Amyotrophic Lateral Sclerosis Trials and Potential Solutions for Improvement
Published 2017 View Full Article
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Title
Shortcomings in the Current Amyotrophic Lateral Sclerosis Trials and Potential Solutions for Improvement
Authors
Keywords
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Journal
Frontiers in Neurology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2017-09-29
DOI
10.3389/fneur.2017.00521
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Note: Only part of the references are listed.- From animal models to human disease: a genetic approach for personalized medicine in ALS
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