Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction

Albumin in decompensated cirrhosis: new concepts and perspectives

(2020) Mauro Bernardi et al.   GUT

Cirrhosis as new indication for statins

(2020) Jaime Bosch et al.   GUT

Toll-like receptor 4 is a therapeutic target for prevention and treatment of liver failure

(2020) Cornelius Engelmann et al.   JOURNAL OF HEPATOLOGY

Epigenetic basis for monocyte dysfunction in patients with severe alcoholic hepatitis

(2020) Laura Weichselbaum et al.   JOURNAL OF HEPATOLOGY

Recombinant Alkaline Phosphatase Prevents Acute on Chronic Liver Failure

(2020) Cornelius Engelmann et al.   Scientific Reports

Targeted lipidomics reveals extensive changes in circulating lipid mediators in patients with acutely decompensated cirrhosis

(2020) Cristina López-Vicario et al.   JOURNAL OF HEPATOLOGY

Non-selective beta-blockers impair global circulatory homeostasis and renal function in cirrhotic patients with refractory ascites

(2020) Luis Téllez et al.   JOURNAL OF HEPATOLOGY

Cardiodynamic state is associated with systemic inflammation and fatal acute‐on‐chronic liver failure

(2020) Michael Praktiknjo et al.   LIVER INTERNATIONAL

Acute-on-Chronic Liver Failure

(2020) Vicente Arroyo et al.   NEW ENGLAND JOURNAL OF MEDICINE

LPS Induces Active HMGB1 Release From Hepatocytes Into Exosomes Through the Coordinated Activities of TLR4 and Caspase-11/GSDMD Signaling

(2020) Wenbo Li et al.   Frontiers in Immunology

Leucocyte ratios are biomarkers of mortality in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure

(2020) Christine Bernsmeier et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Amino Assets: How Amino Acids Support Immunity

(2020) Beth Kelly et al.   Cell Metabolism

Effect of poorly absorbable antibiotics on hepatic venous pressure gradient in cirrhosis: A systematic review and meta-analysis

(2020) Yuly P. Mendoza et al.   DIGESTIVE AND LIVER DISEASE

Serum Levels of Metabolites Produced by Intestinal Microbes and Lipid Moieties Independently Associated With Acute on Chronic Liver Failure and Death in Patients With Cirrhosis

(2020) Jasmohan S. Bajaj et al.   GASTROENTEROLOGY

The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology

(2020) Jonel Trebicka et al.   JOURNAL OF HEPATOLOGY

Hepatic inflammasome activation as origin of Interleukin-1α and Interleukin-1β in liver cirrhosis

(2020) Michael Praktiknjo et al.   GUT

An evolutionary perspective on immunometabolism

(2019) Andrew Wang et al.   SCIENCE

Reduced Serum Sphingolipids Constitute a Molecular Signature of Malnutrition in Hospitalized Patients With Decompensated Cirrhosis

(2019) Vikrant Rachakonda et al.   Clinical and Translational Gastroenterology

Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation

(2019) Katharina Maria Schwarzkopf et al.   PLoS One

Prognostic Role of Ammonia in Patients With Cirrhosis

(2019) Shalimar et al.   HEPATOLOGY

Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance

(2019) Kirthana Ganeshan et al.   CELL

Organ dysfunction in cirrhosis

(2019) Anderson Brito-Azevedo et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt

(2019) Michael Praktiknjo et al.   Clinical and Translational Gastroenterology

News in Pathophysiology, Definition and Classification of Hepatorenal Syndrome: a step beyond the International Club of Ascites (ICA) Consensus document

(2019) Paolo Angeli et al.   JOURNAL OF HEPATOLOGY

Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF

(2019) Richard Moreau et al.   JOURNAL OF HEPATOLOGY

The gut-liver axis in liver disease: pathophysiological basis for therapy

(2019) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

Characteristics and outcomes of critically ill patients with severe hyperammonemia

(2019) Katherine J. Jacoby et al.   JOURNAL OF CRITICAL CARE

Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?

(2018) Lise Van Wyngene et al.   EMBO Molecular Medicine

Cell death markers in patients with cirrhosis and acute decompensation

(2018) Stewart Macdonald et al.   HEPATOLOGY

Cardiopulmonary hemodynamics and C-reactive protein as prognostic indicators in compensated and decompensated cirrhosis

(2018) Laura Turco et al.   JOURNAL OF HEPATOLOGY

Low subcutaneous adiposity associates with higher mortality in female patients with cirrhosis

(2018) Maryam Ebadi et al.   JOURNAL OF HEPATOLOGY

Abnormal neutrophil traps and impaired efferocytosis contribute to liver injury and sepsis severity after binge alcohol use

(2018) Terence Ndonyi Bukong et al.   JOURNAL OF HEPATOLOGY

Novel perspectives in the management of decompensated cirrhosis

(2018) Mauro Bernardi et al.   Nature Reviews Gastroenterology & Hepatology

Macrophage polarization and meta-inflammation

(2018) Chuan Li et al.   Translational Research

The soluble guanylate cyclase stimulator riociguat reduces fibrogenesis and portal pressure in cirrhotic rats

(2018) Philipp Schwabl et al.   Scientific Reports

Oxidized albumin triggers a cytokine storm in leukocytes through p38 MAP kinase: role in systemic inflammation in decompensated cirrhosis

(2018) José Alcaraz-Quiles et al.   HEPATOLOGY

M1-/M2-macrophage Polarization-based Hepatotoxicity in d-galactosamine-induced Acute Liver Injury in Rats

(2018) Nahid Rahman et al.   TOXICOLOGIC PATHOLOGY

Butyrate Protects Mice Against Methionine–Choline-Deficient Diet-Induced Non-alcoholic Steatohepatitis by Improving Gut Barrier Function, Attenuating Inflammation and Reducing Endotoxin Levels

(2018) Jianzhong Ye et al.   Frontiers in Microbiology

Loss of paraspinal muscle mass is a gender-specific consequence of cirrhosis that predicts complications and death

(2018) Cornelius Engelmann et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Simvastatin Prevents Progression of Acute on Chronic Liver Failure in Rats With Cirrhosis and Portal Hypertension

(2018) Dinesh Mani Tripathi et al.   GASTROENTEROLOGY

Hepatic microcirculation and mechanisms of portal hypertension

(2018) Jordi Gracia-Sancho et al.   Nature Reviews Gastroenterology & Hepatology

RAMP1 in Kupffer cells is a critical regulator in immune-mediated hepatitis

(2018) Tomoyoshi Inoue et al.   PLoS One

Disorganized Gut Microbiome Contributed to Liver Cirrhosis Progression: A Meta-Omics-Based Study

(2018) Li Shao et al.   Frontiers in Microbiology

Left ventricular systolic function is associated with sympathetic nervous activity and markers of inflammation in cirrhosis

(2017) Raquel Yotti et al.   HEPATOLOGY

Effects of an intensive lifestyle intervention program on portal hypertension in patients with cirrhosis and obesity: The SportDiet study

(2017) Annalisa Berzigotti et al.   HEPATOLOGY

NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice

(2017) Alexander Wree et al.   HEPATOLOGY

Targeting hepatic macrophages to treat liver diseases

(2017) Frank Tacke   JOURNAL OF HEPATOLOGY

Macrophage Phenotype in Liver Injury and Repair

(2017) Y.-Y. Sun et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Gut microbiome and liver disease

(2017) Naga S. Betrapally et al.   Translational Research

Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease

(2017) Veronika B. Dubinkina et al.   Microbiome

Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis

(2017) Susen Becker et al.   PLoS One

Emerging therapies for portal hypertension in cirrhosis

(2016) Harikumar Nair et al.   EXPERT OPINION ON EMERGING DRUGS

Addition of Simvastatin to Standard Therapy for the Prevention of Variceal Rebleeding Does Not Reduce Rebleeding but Increases Survival in Patients With Cirrhosis

(2016) Juan G. Abraldes et al.   GASTROENTEROLOGY

Portal hypertensive bleeding in cirrhosis: Risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseases

(2016) Guadalupe Garcia-Tsao et al.   HEPATOLOGY

Hyperoxidized albumin modulates neutrophils to induce oxidative stress and inflammation in severe alcoholic hepatitis

(2016) Sukanta Das et al.   HEPATOLOGY

Systemic inflammation in decompensated cirrhosis: Characterization and role in acute-on-chronic liver failure

(2016) Joan Clària et al.   HEPATOLOGY

Ammonia produces pathological changes in human hepatic stellate cells and is a target for therapy of portal hypertension

(2016) Rajiv Jalan et al.   JOURNAL OF HEPATOLOGY

Enoxaparin reduces hepatic vascular resistance and portal pressure in cirrhotic rats

(2016) Federica Cerini et al.   JOURNAL OF HEPATOLOGY

Role of ammonia, inflammation, and cerebral oxygenation in brain dysfunction of acute-on-chronic liver failure patients

(2016) Rohit Sawhney et al.   LIVER TRANSPLANTATION

Ammonia toxicity: from head to toe?

(2016) Srinivasan Dasarathy et al.   METABOLIC BRAIN DISEASE

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

Changes in the Microbiome in Cirrhosis and Relationship to Complications: Hepatic Encephalopathy, Spontaneous Bacterial Peritonitis, and Sepsis

(2016) Jatinder Lachar et al.   SEMINARS IN LIVER DISEASE

Low expression of CXCR1/2 on neutrophils predicts poor survival in patients with hepatitis B virus-related acute-on-chronic liver failure

(2016) Ruonan Xu et al.   Scientific Reports

Albumin Homodimers in Patients with Cirrhosis: Clinical and Prognostic Relevance of a Novel Identified Structural Alteration of the Molecule

(2016) Maurizio Baldassarre et al.   Scientific Reports

Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization

(2015) Kun Liu et al.   Autophagy

A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses

(2015) Marielle S. Köberlin et al.   CELL

Depletion of Kupffer cells attenuates systemic insulin resistance, inflammation and improves liver autophagy in high-fat diet fed mice

(2015) Tian-shu Zeng et al.   ENDOCRINE JOURNAL

Clinical Course of acute-on-chronic liver failure syndrome and effects on prognosis

(2015) Thierry Gustot et al.   HEPATOLOGY

Molecular pathophysiology of portal hypertension

(2015) Mercedes Fernandez   HEPATOLOGY

Development of hyperdynamic circulation and response to β-blockers in compensated cirrhosis with portal hypertension

(2015) Càndid Villanueva et al.   HEPATOLOGY

Evolution in the understanding of the pathophysiological basis of portal hypertension: How changes in paradigm are leading to successful new treatments

(2015) Jaume Bosch et al.   JOURNAL OF HEPATOLOGY

Ischaemia-modified albumin: a marker of bacterial infection in hospitalized patients with cirrhosis

(2015) Ferdinando A. Giannone et al.   LIVER INTERNATIONAL

Mechanism of cell death in acute-on-chronic liver failure: a clinico-pathologic-biomarker study

(2015) Danielle Adebayo et al.   LIVER INTERNATIONAL

Inflammasome activation and function in liver disease

(2015) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

Serum Sphingolipid Variations Associate with Hepatic Decompensation and Survival in Patients with Cirrhosis

(2015) Georgios Grammatikos et al.   PLoS One

Boosting pigment epithelial-derived factor: a promising approach for the treatment of early portal hypertension

(2014) Umberto Vespasiani-Gentilucci et al.   GUT

Antiangiogenic and antifibrogenic activity of pigment epithelium-derived factor (PEDF) in bile duct-ligated portal hypertensive rats

(2014) Marc Mejias et al.   GUT

KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins

(2014) Giusi Marrone et al.   GUT

Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats

(2014) Laura Coch et al.   HEPATOLOGY

Posttranscriptional changes of serum albumin: Clinical and prognostic significance in hospitalized patients with cirrhosis

(2014) Marco Domenicali et al.   HEPATOLOGY

Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure

(2014) Rajiv Jalan et al.   JOURNAL OF HEPATOLOGY

A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease

(2014) Taichiro Nishikawa et al.   JOURNAL OF HEPATOLOGY

Alterations of the human gut microbiome in liver cirrhosis

(2014) Nan Qin et al.   NATURE

Nucleotide signalling during inflammation

(2014) Marco Idzko et al.   NATURE

Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2

(2014) Alastair J O'Brien et al.   NATURE MEDICINE

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases

(2013) Matthew Spite et al.   Cell Metabolism

Microcirculatory Alterations in Patients With Severe Sepsis

(2013) Daniel De Backer et al.   CRITICAL CARE MEDICINE

Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis

(2013) Richard Moreau et al.   GASTROENTEROLOGY

Albumin: Pathophysiologic basis of its role in the treatment of cirrhosis and its complications

(2013) Rita Garcia-Martinez et al.   HEPATOLOGY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Oxidative albumin damage in chronic liver failure: Relation to albumin binding capacity, liver dysfunction and survival

(2013) Karl Oettl et al.   JOURNAL OF HEPATOLOGY

Cerebral oedema is rare in acute-on-chronic liver failure patients presenting with high-grade hepatic encephalopathy

(2013) Deepak Joshi et al.   LIVER INTERNATIONAL

A Unified Theory of Sepsis-Induced Acute Kidney Injury

(2013) Hernando Gomez et al.   SHOCK

Cardiovascular Risk Factors and Systemic Endothelial Function in Patients With Cirrhosis

(2012) Annalisa Berzigotti et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Positive cardiac inotropic effect of albumin infusion in rodents with cirrhosis and ascites: molecular mechanisms

(2012) Alessia Bortoluzzi et al.   HEPATOLOGY

Inhibition of mammalian target of rapamycin aggravates the respiratory burst defect of neutrophils from decompensated patients with cirrhosis

(2012) Loïc Rolas et al.   HEPATOLOGY

Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression

(2012) Naina Shah et al.   JOURNAL OF HEPATOLOGY

LEFT ventricular function assessed by echocardiography in cirrhosis: Relationship to systemic hemodynamics and renal dysfunction

(2012) André Nazar et al.   JOURNAL OF HEPATOLOGY

Increased renal expression and urinary excretion of TLR4 in acute kidney injury associated with cirrhosis

(2012) Naina Shah et al.   LIVER INTERNATIONAL

Muscle depletion increases the risk of overt and minimal hepatic encephalopathy: results of a prospective study

(2012) Manuela Merli et al.   METABOLIC BRAIN DISEASE

Obesity is an independent risk factor for clinical decompensation in patients with cirrhosis

(2011) Annalisa Berzigotti et al.   HEPATOLOGY

Endogenous Angiogenesis Inhibitor Vasohibin1 Exhibits Broad-Spectrum Antilymphangiogenic Activity and Suppresses Lymph Node Metastasis

(2010) Takahiro Heishi et al.   AMERICAN JOURNAL OF PATHOLOGY

A Central Role for CD68(+) Macrophages in Hepatopulmonary Syndrome

(2010) Thenappan Thenappan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver

(2010) J. Gracia-Sancho et al.   GUT

Bacterial DNA translocation is associated with systemic circulatory abnormalities and intrahepatic endothelial dysfunction in patients with cirrhosis

(2010) Pablo Bellot et al.   HEPATOLOGY

Interorgan ammonia metabolism in liver failure: the basis of current and future therapies

(2010) Gavin Wright et al.   LIVER INTERNATIONAL

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Management of Varices and Variceal Hemorrhage in Cirrhosis

(2010) Guadalupe Garcia-Tsao et al.   NEW ENGLAND JOURNAL OF MEDICINE

NEUTROPHIL PARALYSIS IN SEPSIS

(2010) José C. Alves-Filho et al.   SHOCK

Bedside Sublingual Video Imaging of Microcirculation in Assessing Bacterial Infection in Cirrhosis

(2009) Muhammad Y. Sheikh et al.   DIGESTIVE DISEASES AND SCIENCES

Alterations in the functional capacity of albumin in patients with decompensated cirrhosis is associated with increased mortality

(2009) Rajiv Jalan et al.   HEPATOLOGY

Segment-specific proximal tubule injury in tripterygium glycosides intoxicated rats

(2009) Hong Dan et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

A study of muscle tissue oxygenation and peripheral microcirculatory dysfunction in cirrhosis using near infrared spectroscopy

(2009) Sam J. Thomson et al.   LIVER INTERNATIONAL

The spectrum of renal lesions in patients with cirrhosis: a clinicopathological study

(2009) Jean-Marie Trawalé et al.   LIVER INTERNATIONAL

Emerging roles for lipids in shaping membrane-protein function

(2009) Rob Phillips et al.   NATURE

Oxidative damage of albumin in advanced liver disease

(2008) Karl Oettl et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pathogenetic mechanisms of hepatic encephalopathy

(2008) D Haussinger et al.   GUT

Ammonia impairs neutrophil phagocytic function in liver disease

(2008) Debbie L. Shawcross et al.   HEPATOLOGY

Muscle circulation contributes to hyperdynamic circulatory syndrome in advanced cirrhosis

(2008) Paolo Caraceni et al.   JOURNAL OF HEPATOLOGY

The management of portal hypertension: Rational basis, available treatments and future options

(2008) Jaime Bosch et al.   JOURNAL OF HEPATOLOGY

Hepatopulmonary Syndrome — A Liver-Induced Lung Vascular Disorder

(2008) Roberto Rodríguez-Roisin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Presence of bacterial-DNA in cirrhosis identifies a subgroup of patients with marked inflammatory response not related to endotoxin

(2007) José M. González-Navajas et al.   JOURNAL OF HEPATOLOGY