Ammonia toxicity: from head to toe?

Ammonia produces pathological changes in human hepatic stellate cells and is a target for therapy of portal hypertension

(2016) Rajiv Jalan et al.   JOURNAL OF HEPATOLOGY

Metabolic and molecular responses to leucine-enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis

(2015) Cynthia Tsien et al.   HEPATOLOGY

Reactive Astrogliosis Causes the Development of Spontaneous Seizures

(2015) S. Robel et al.   JOURNAL OF NEUROSCIENCE

Management and Sequelae of a 41-Year-Old Jehovah’s Witness With Severe Anhydrous Ammonia Inhalation Injury

(2014) Shiara Ortiz-Pujols et al.   Journal of Burn Care & Research

Effects of short-term portacaval anastomosis on the peripheral and brain disposition of the blood–brain barrier permeability marker sodium fluorescein in rats

(2013) Imam H. Shaik et al.   BRAIN RESEARCH

Risk factors for hyperammonemia in pediatric patients with epilepsy

(2013) Yoshiaki Yamamoto et al.   EPILEPSIA

Didecyldimethylammonium chloride induces pulmonary fibrosis in association with TGF-β signaling in mice

(2013) Aya Ohnuma-Koyama et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Increased brain lactate is central to the development of brain edema in rats with chronic liver disease

(2013) Cristina R. Bosoi et al.   JOURNAL OF HEPATOLOGY

Hyperammonaemia induces hepatic injury with alteration of gene expression profiles

(2013) Bin Jia et al.   LIVER INTERNATIONAL

Cerebral oedema is rare in acute-on-chronic liver failure patients presenting with high-grade hepatic encephalopathy

(2013) Deepak Joshi et al.   LIVER INTERNATIONAL

Cerebral oedema is not responsible for motor or cognitive deficits in rats with hepatic encephalopathy

(2013) Omar Cauli et al.   LIVER INTERNATIONAL

Update on cerebral uptake of blood ammonia

(2013) Michael Sørensen   METABOLIC BRAIN DISEASE

Extracellular ammonia at sites of pulmonary infection with Coccidioides posadasii contributes to severity of the respiratory disease

(2013) Hua Zhang Wise et al.   MICROBIAL PATHOGENESIS

Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering

(2013) Vinita Rangroo Thrane et al.   NATURE MEDICINE

Aquaporin-4 deletion in mice reduces encephalopathy and brain edema in experimental acute liver failure

(2013) Kakulavarapu V. Rama Rao et al.   NEUROBIOLOGY OF DISEASE

Branched-chain amino acids and ammonia metabolism in liver disease: Therapeutic implications

(2013) Milan Holecek   NUTRITION

Hyperammonemia in cirrhosis induces transcriptional regulation of myostatin by an NF- B-mediated mechanism

(2013) J. Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis

(2012) Jia Qiu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ameliorative potential of alpha-ketoglutaric acid (AKG) on acute lung injuries induced by ammonia inhalation in rats

(2012) Rashid Ali et al.   EXPERIMENTAL LUNG RESEARCH

Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure

(2012) Cristina R. Bosoi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake

(2012) Gitte Dam et al.   HEPATOLOGY

Creatine and guanidinoacetate transport at blood-brain and blood-cerebrospinal fluid barriers

(2012) Olivier Braissant   JOURNAL OF INHERITED METABOLIC DISEASE

Ammonia toxicity to the brain

(2012) Olivier Braissant et al.   JOURNAL OF INHERITED METABOLIC DISEASE

In vivo studies of brain metabolism in animal models of Hepatic Encephalopathy using 1H Magnetic Resonance Spectroscopy

(2012) Cristina Cudalbu   METABOLIC BRAIN DISEASE

Real-time analysis of microglial activation and motility in hepatic and hyperammonemic encephalopathy

(2012) V. RANGROO THRANE et al.   NEUROSCIENCE

Oxidative stress and tissue pathology caused by subacute exposure to ammonium acetate in rats and their response to treatments with alpha-ketoglutarate and N-acetyl cysteine

(2012) RM Satpute et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Consilience in sarcopenia of cirrhosis

(2012) Srinivasan Dasarathy   Journal of Cachexia Sarcopenia and Muscle

Ammonia reduction with ornithine phenylacetate restores brain eNOS activity via the DDAH-ADMA pathway in bile duct-ligated cirrhotic rats

(2011) Vairappan Balasubramaniyan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts

(2011) A. Agusti et al.   GUT

Microglia activation in hepatic encephalopathy in rats and humans

(2011) Irina Zemtsova et al.   HEPATOLOGY

Late evening snack: Exploiting a period of anabolic opportunity in cirrhosis

(2011) Cynthia D Tsien et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy

(2011) Renata Leke et al.   JOURNAL OF NEUROCHEMISTRY

Exercise capacity and muscle strength in patients with cirrhosis

(2011) Jacqueline C. Jones et al.   LIVER TRANSPLANTATION

Neuroinflammation in acute liver failure: Mechanisms and novel therapeutic targets

(2011) Roger F. Butterworth   NEUROCHEMISTRY INTERNATIONAL

Neuropathology of acute liver failure

(2011) Kiran K. Thumburu et al.   NEUROCHEMISTRY INTERNATIONAL

Alterations of Blood Brain Barrier Function in Hyperammonemia: An Overview

(2011) Marta Skowrońska et al.   NEUROTOXICITY RESEARCH

Pharmacotherapy for Hepatic Encephalopathy

(2010) Paula V. Phongsamran et al.   DRUGS

Hyperammonemia Induces Neuroinflammation That Contributes to Cognitive Impairment in Rats With Hepatic Encephalopathy

(2010) Regina Rodrigo et al.   GASTROENTEROLOGY

Locomotor impairment and cerebrocortical oxidative stress in portal vein ligated rats in vivo

(2010) Jonathan Brück et al.   JOURNAL OF HEPATOLOGY

Sarcopenia associated with portosystemic shunting is reversed by follistatin

(2010) Srinivasan Dasarathy et al.   JOURNAL OF HEPATOLOGY

The myeloid cells of the central nervous system parenchyma

(2010) Richard M. Ransohoff et al.   NATURE

Hyperammonemia increases the expression and activity of the glutamine/arginine transporter y+LAT2 in rat cerebral cortex: Implications for the nitric oxide/cGMP pathway

(2010) Magdalena Zielińska et al.   NEUROCHEMISTRY INTERNATIONAL

Segment-specific proximal tubule injury in tripterygium glycosides intoxicated rats

(2009) Hong Dan et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Direct Evidence for Central Proinflammatory Mechanisms in Rats with Experimental Acute Liver Failure: Protective Effect of Hypothermia

(2009) Wenlei Jiang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline

(2009) Wenlei Jiang et al.   JOURNAL OF NEUROCHEMISTRY

Experimental models of hepatic encephalopathy: ISHEN guidelines

(2009) Roger F. Butterworth et al.   LIVER INTERNATIONAL

Plasma ammonia response to incremental cycling and walking tests in COPD

(2009) L.D. Calvert et al.   RESPIRATORY MEDICINE

MR Imaging Findings in Hepatic Encephalopathy

(2008) A. Rovira et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Gene expression profiling of astrocytes from hyperammonemic mice reveals altered pathways for water and potassium homeostasisin vivo

(2008) Uta Lichter-Konecki et al.   GLIA

Ammonium-evoked alterations in intracellular sodium and pH reduce glial glutamate transport activity

(2008) Tony Kelly et al.   GLIA

Ammonia impairs neutrophil phagocytic function in liver disease

(2008) Debbie L. Shawcross et al.   HEPATOLOGY

Pathophysiology of hepatic encephalopathy: The concept of synergism

(2008) Roger F. Butterworth   HEPATOLOGY RESEARCH

Na-K-Cl Cotransporter-1 in the Mechanism of Ammonia-induced Astrocyte Swelling

(2008) Arumugam R. Jayakumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling factors in the mechanism of ammonia neurotoxicity

(2008) M. D. Norenberg et al.   METABOLIC BRAIN DISEASE

Identifying the direct effects of ammonia on the brain

(2008) Cristina R. Bosoi et al.   METABOLIC BRAIN DISEASE

CNTF protects oligodendrocytes from ammonia toxicity: Intracellular signaling pathways involved

(2008) Laurène Cagnon et al.   NEUROBIOLOGY OF DISEASE