Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS

Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis

(2021) Teng Gao et al.   Nature Communications

Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets

(2021) Tiansu Wang et al.   Cell Stem Cell

Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms

(2021) Debra Van Egeren et al.   Cell Stem Cell

60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations

(2020) Sami Ayachi et al.   EXPERIMENTAL HEMATOLOGY

Integrating the “Immunome” in the Stratification of Myelodysplastic Syndromes and Future Clinical Trial Design

(2020) Susann Winter et al.   JOURNAL OF CLINICAL ONCOLOGY

Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes

(2020) Pierre Fenaux et al.   NEW ENGLAND JOURNAL OF MEDICINE

TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis

(2020) Madeline Niederkorn et al.   Cell Reports

Mouse Models of Myeloid Malignancies

(2020) Faisal Basheer et al.   Cold Spring Harbor Perspectives in Medicine

Altered microRNA expression links IL6 and TNF-induced inflammaging with myeloid malignancy

(2020) Jennifer Margaret Grants et al.   BLOOD

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

Myelodysplastic syndrome patient-derived xenografts: from no options to many

(2020) Christophe Côme et al.   HAEMATOLOGICA

The Nlrp3 inflammasome as a “rising star” in studies of normal and malignant hematopoiesis

(2020) Mariusz Z. Ratajczak et al.   LEUKEMIA

Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs

(2020) Tomoya Muto et al.   NATURE IMMUNOLOGY

IL-6 blockade reverses bone marrow failure induced by human acute myeloid leukemia

(2020) Tian Yi Zhang et al.   Science Translational Medicine

TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98–HOXD13 mouse model of MDS

(2020) Darlene A. Monlish et al.   EXPERIMENTAL HEMATOLOGY

Contribution of Aberrant Toll Like Receptor Signaling to the Pathogenesis of Myelodysplastic Syndromes

(2020) Luana Chiquetto Paracatu et al.   Frontiers in Immunology

Hand in hand: intrinsic and extrinsic drivers of aging and clonal hematopoiesis

(2020) Jennifer M. SanMiguel et al.   EXPERIMENTAL HEMATOLOGY

Myelodysplastic Syndromes

(2020) Mario Cazzola   NEW ENGLAND JOURNAL OF MEDICINE

Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

(2020) Simona Valletta et al.   Nature Communications

Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome

(2019) Flavia Ribezzo et al.   LEUKEMIA

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging

(2019) Hanzhi Luo et al.   Cell Reports

The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes

(2019) David A. Sallman et al.   BLOOD

Genetics of MDS

(2019) Seishi Ogawa   BLOOD

Flaming and fanning: The Spectrum of inflammatory influences in myelodysplastic syndromes

(2019) Titas Banerjee et al.   BLOOD REVIEWS

Clonal haematopoiesis and risk of acute myeloid leukemia.

(2019) Andrew L. Young et al.   HAEMATOLOGICA

Transforming growth factor (TGF)-β pathway as a therapeutic target in lower risk myelodysplastic syndromes

(2019) Jan Philipp Bewersdorf et al.   LEUKEMIA

U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies

(2019) Molly A. Smith et al.   NATURE CELL BIOLOGY

Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia

(2019) Emmalee R Adelman et al.   Cancer Discovery

Hippo Kinase Loss Contributes to Del(20q) Hematologic Malignancies through Chronic Innate Immune Activation

(2019) Samuel A. Stoner et al.   BLOOD

Author Correction: Metastatic-niche labelling reveals parenchymal cells with stem features

(2019) Luigi Ombrato et al.   NATURE

Clonal hematopoiesis in human aging and disease

(2019) Siddhartha Jaiswal et al.   SCIENCE

Myeloid cell–targeted miR-146a mimic inhibits NF-κB–driven inflammation and leukemia progression in vivo

(2019) Yu-Lin Su et al.   BLOOD

Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients

(2019) Christine R.C. Zhang et al.   EXPERIMENTAL HEMATOLOGY

Loss of Toll-like receptor 2 results in accelerated leukemogenesis in theNUP98-HOXD13mouse model of MDS

(2018) Darlene A. Monlish et al.   BLOOD

An inflammatory environment containing TNFα favors Tet2 -mutant clonal hematopoiesis

(2018) Samuel O. Abegunde et al.   EXPERIMENTAL HEMATOLOGY

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

(2018) Soichi Sano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Evolutionary Origins of Toll-like Receptor Signaling

(2018) Joseph J Brennan et al.   MOLECULAR BIOLOGY AND EVOLUTION

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

(2018) Marlies Meisel et al.   NATURE

Somatic mutations precede acute myeloid leukemia years before diagnosis

(2018) Pinkal Desai et al.   NATURE MEDICINE

miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling

(2018) Jeffrey Lam et al.   Nature Communications

Disordered Immune Regulation and its Therapeutic Targeting in Myelodysplastic Syndromes

(2018) Kathryn S. Ivy et al.   Current Hematologic Malignancy Reports

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines

(2018) Irene Maeve Rea et al.   Frontiers in Immunology

SKI controls MDS-associated chronic TGFβ signaling, aberrant splicing, and stem cell fitness

(2018) David E. Muench et al.   BLOOD

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

(2018) Stanley Chun-Wei Lee et al.   CANCER CELL

Age-related clonal hematopoiesis

(2018) Sagi Abelson et al.   CURRENT OPINION IN HEMATOLOGY

Understanding early TLR signaling through the Myddosome

(2018) Katherine R. Balka et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Increased Ripk1-mediated bone marrow necroptosis leads to myelodysplasia and bone marrow failure in mice

(2018) Patrice N. Wagner et al.   BLOOD

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

(2018) Zhigang Cai et al.   Cell Stem Cell

Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level

(2018) Jiahao Chen et al.   NATURE MEDICINE

Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age

(2018) Mati Mann et al.   Cell Reports

Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure

(2018) Lena Dorsheimer et al.   JAMA Cardiology

Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS

(2017) Y Mei et al.   LEUKEMIA

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

(2017) Michalis Agathocleous et al.   NATURE

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dnmt3arestrains mast cell inflammatory responses

(2017) Cristina Leoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

(2017) José J. Fuster et al.   SCIENCE

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

(2016) A. A. Basiorka et al.   BLOOD

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

(2016) D. A. Arber et al.   BLOOD

Apoptosis in human myelodysplastic syndrome CD34+ cells is modulated by the upregulation of TLRs and histone H4 acetylation via a β-arrestin 1 dependent mechanism

(2016) Qing Zeng et al.   EXPERIMENTAL CELL RESEARCH

Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome

(2016) M E Varney et al.   LEUKEMIA

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Erratum: Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity.

(2016) Xia Li et al.   NATURE IMMUNOLOGY

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia

(2016) Jing Fang et al.   NATURE IMMUNOLOGY

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9

(2016) Rebekka K Schneider et al.   NATURE MEDICINE

Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells

(2016) Shailaja Akunuru et al.   TRENDS IN MOLECULAR MEDICINE

Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation

(2016) Katie A. Matatall et al.   Cell Reports

The Role of Toll-Like Receptors in Hematopoietic Malignancies

(2016) Darlene A. Monlish et al.   Frontiers in Immunology

Unraveling the Pathogenesis of MDS: The NLRP3 Inflammasome and Pyroptosis Drive the MDS Phenotype

(2016) David A. Sallman et al.   Frontiers in Oncology

Revisiting the case for genetically engineered mouse models in human myelodysplastic syndrome research

(2015) T. Zhou et al.   BLOOD

MDS-associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance

(2015) B. Kwok et al.   BLOOD

Deconstructing innate immune signaling in myelodysplastic syndromes

(2015) Melinda E. Varney et al.   EXPERIMENTAL HEMATOLOGY

Loss ofTifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor–TRAF6 signaling

(2015) Melinda E. Varney et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

(2015) I Gañán-Gómez et al.   LEUKEMIA

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

(2015) Qian Zhang et al.   NATURE

Supramolecular organizing centers (SMOCs) as signaling machines in innate immune activation

(2015) Qi Qiao et al.   Science China-Life Sciences

Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal

(2014) Deqiang Sun et al.   Cell Stem Cell

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Myeloid Malignancies with Chromosome 5q Deletions Acquire a Dependency on an Intrachromosomal NF-κB Gene Network

(2014) Jing Fang et al.   Cell Reports

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome

(2013) Garrett W. Rhyasen et al.   CANCER CELL

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome

(2013) T. Fernandes-Alnemri et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor alterations in myelodysplastic syndrome

(2013) Y Wei et al.   LEUKEMIA

M-CSF instructs myeloid lineage fate in single haematopoietic stem cells

(2013) Noushine Mossadegh-Keller et al.   NATURE

Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications

(2013) Amélie Bonnefond et al.   NATURE GENETICS

Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes

(2013) W. W. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revised International Prognostic Scoring System for Myelodysplastic Syndromes

(2012) P. L. Greenberg et al.   BLOOD

Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome

(2011) M. S. Kumar et al.   BLOOD

miR-146ais a significant brake on autoimmunity, myeloproliferation, and cancer in mice

(2011) Mark P. Boldin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells

(2011) B. L. Esplin et al.   JOURNAL OF IMMUNOLOGY

NF- B dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies

(2011) J. L. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced SMAD7 Leads to Overactivation of TGF-  Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-  Receptor I Kinase

(2010) L. Zhou et al.   CANCER RESEARCH

Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses

(2010) Li-Fan Lu et al.   CELL

Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1

(2010) Grant A. Challen et al.   Cell Stem Cell

Innate Immune Signaling in the Myelodysplastic Syndromes

(2010) Daniel T. Starczynowski et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells

(2010) A Pellagatti et al.   LEUKEMIA

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

(2010) Megan T. Baldridge et al.   NATURE

Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

(2009) Daniel T Starczynowski et al.   NATURE MEDICINE

Myelodysplastic syndromes

(2008) S. D. Nimer   BLOOD