Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome

TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis

(2018) Jing Fang et al.   Cell Reports

Disordered Immune Regulation and its Therapeutic Targeting in Myelodysplastic Syndromes

(2018) Kathryn S. Ivy et al.   Current Hematologic Malignancy Reports

Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS

(2017) Y Mei et al.   LEUKEMIA

Increase of DNA damage and alteration of the DNA damage response in myelodysplastic syndromes and acute myeloid leukemias

(2017) Henning D. Popp et al.   LEUKEMIA RESEARCH

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia

(2016) Noemi A. Zambetti et al.   Cell Stem Cell

Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs

(2016) S Chen et al.   LEUKEMIA

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9

(2016) Rebekka K Schneider et al.   NATURE MEDICINE

Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche

(2016) Xingbin Hu et al.   Nature Communications

CSNK1A1mutations and gene expression analysis in myelodysplastic syndromes with del(5q)

(2015) Erica Bello et al.   BRITISH JOURNAL OF HAEMATOLOGY

Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms

(2015) Chantana Polprasert et al.   CANCER CELL

Loss ofTifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor–TRAF6 signaling

(2015) Melinda E. Varney et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Frequency and prognostic impact of casein kinase 1A1 mutations in MDS patients with deletion of chromosome 5q

(2015) M Heuser et al.   LEUKEMIA

Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

(2015) I Gañán-Gómez et al.   LEUKEMIA

Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice

(2014) A. Stoddart et al.   BLOOD

Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS

(2014) G. Keerthivasan et al.   BLOOD

Role of Casein Kinase 1A1 in the Biology and Targeted Therapy of del(5q) MDS

(2014) Rebekka K. Schneider et al.   CANCER CELL

Deletion 5q MDS: Molecular and therapeutic implications

(2013) Rami S. Komrokji et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Cell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc

(2013) A. Stoddart et al.   BLOOD

Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome

(2013) Garrett W. Rhyasen et al.   CANCER CELL

Overexpression of the Toll-Like Receptor (TLR) Signaling Adaptor MYD88, but Lack of Genetic Mutation, in Myelodysplastic Syndromes

(2013) Sophie Dimicoli et al.   PLoS One

Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors

(2011) Cornelis J.H. Pronk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miR-146ais a significant brake on autoimmunity, myeloproliferation, and cancer in mice

(2011) Mark P. Boldin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

(2011) Andrew Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NF- B dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies

(2011) J. L. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS

(2010) S. W. Lane et al.   BLOOD

Haploinsufficiency of Apc leads to ineffective hematopoiesis

(2010) J. Wang et al.   BLOOD

Innate Immune Signaling in the Myelodysplastic Syndromes

(2010) Daniel T. Starczynowski et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

(2009) Daniel T Starczynowski et al.   NATURE MEDICINE

5q– myelodysplastic syndromes: chromosome 5q genes direct a tumor-suppression network sensing actin dynamics

(2009) K M Eisenmann et al.   ONCOGENE

Myelodysplastic syndromes

(2008) S. D. Nimer   BLOOD

A critical role for Apc in hematopoietic stem and progenitor cell survival

(2008) Zhijian Qian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

(2008) Benjamin L. Ebert et al.   NATURE