Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia

Loss ofTifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor–TRAF6 signaling

(2015) Melinda E. Varney et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells

(2014) H Dolatshad et al.   LEUKEMIA

Starvation actively inhibits splicing of glucose-6-phosphate dehydrogenase mRNA via a bifunctional ESE/ESS element bound by hnRNP K

(2013) T.J. Cyphert et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome

(2013) Garrett W. Rhyasen et al.   CANCER CELL

Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation

(2013) Justin J.-L. Wong et al.   CELL

Dendritic Cell Expression of the Signaling Molecule TRAF6 Is Critical for Gut Microbiota-Dependent Immune Tolerance

(2013) Daehee Han et al.   IMMUNITY

hnRNP A1: The Swiss Army Knife of Gene Expression

(2013) Jacques Jean-Philippe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Crystal Structures and RNA-binding Properties of the RNA Recognition Motifs of Heterogeneous Nuclear Ribonucleoprotein L

(2013) Wenjuan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of myelodysplasia by myeloid-derived suppressor cells

(2013) Xianghong Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitative Phosphoproteomics Using Acetone-Based Peptide Labeling: Method Evaluation and Application to a Cardiac Ischemia/Reperfusion Model

(2013) Aruna B. Wijeratne et al.   JOURNAL OF PROTEOME RESEARCH

Toll-like receptor alterations in myelodysplastic syndrome

(2013) Y Wei et al.   LEUKEMIA

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing

(2013) Maria Carolina Florian et al.   NATURE

A compendium of RNA-binding motifs for decoding gene regulation

(2013) Debashish Ray et al.   NATURE

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

(2013) Alex K. Shalek et al.   NATURE

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Stem cell origin of myelodysplastic syndromes

(2013) H K Elias et al.   ONCOGENE

Overexpression of the Toll-Like Receptor (TLR) Signaling Adaptor MYD88, but Lack of Genetic Mutation, in Myelodysplastic Syndromes

(2013) Sophie Dimicoli et al.   PLoS One

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS

(2012) L. Barreyro et al.   BLOOD

Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1

(2012) J. Fang et al.   BLOOD

Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation

(2012) Maria Carolina Florian et al.   Cell Stem Cell

hnRNP A1 Proofreads 3′ Splice Site Recognition by U2AF

(2012) Joao Paulo Tavanez et al.   MOLECULAR CELL

Combined Chromatin and Expression Analysis Reveals Specific Regulatory Mechanisms within Cytokine Genes in the Macrophage Early Immune Response

(2012) Maria Jesus Iglesias et al.   PLoS One

Integrative Genome-wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins

(2012) Stephanie C. Huelga et al.   Cell Reports

SpliceTrap: a method to quantify alternative splicing under single cellular conditions

(2011) Jie Wu et al.   BIOINFORMATICS

TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer

(2011) Daniel T. Starczynowski et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic Immune Stimulation Might Act As a Trigger for the Development of Acute Myeloid Leukemia or Myelodysplastic Syndromes

(2011) Sigurdur Y. Kristinsson et al.   JOURNAL OF CLINICAL ONCOLOGY

Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells

(2011) B. L. Esplin et al.   JOURNAL OF IMMUNOLOGY

Quaking Regulates Hnrnpa1 Expression through Its 3′ UTR in Oligodendrocyte Precursor Cells

(2011) N. Ruth Zearfoss et al.   PLoS Genetics

Motif Enrichment Analysis: a unified framework and an evaluation on ChIP data

(2010) Robert C McLeay et al.   BMC BIOINFORMATICS

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

(2010) Megan T. Baldridge et al.   NATURE

AltAnalyze and DomainGraph: analyzing and visualizing exon expression data

(2010) Dorothea Emig et al.   NUCLEIC ACIDS RESEARCH

Lysine 63-linked Polyubiquitination of TAK1 at Lysine 158 Is Required for Tumor Necrosis Factor α- and Interleukin-1β-induced IKK/NF-κB and JNK/AP-1 Activation

(2009) Yihui Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

(2009) Daniel T Starczynowski et al.   NATURE MEDICINE

FIRMA: a method for detection of alternative splicing from exon array data

(2008) E. Purdom et al.   BIOINFORMATICS

Myelodysplastic syndromes

(2008) S. D. Nimer   BLOOD

A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators

(2008) P. Stoilov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA