Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets

Clonal hematopoiesis and inflammation: Partners in leukemogenesis and comorbidity

(2020) Elina K. Cook et al.   EXPERIMENTAL HEMATOLOGY

Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs

(2020) Tomoya Muto et al.   NATURE IMMUNOLOGY

Immunogenomic Landscape of Hematological Malignancies

(2020) Olli Dufva et al.   CANCER CELL

Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells

(2020) Josephine Wesely et al.   Cell Reports

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

(2019) Peter van Galen et al.   CELL

The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes

(2019) David A. Sallman et al.   BLOOD

Genetics of MDS

(2019) Seishi Ogawa   BLOOD

U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies

(2019) Molly A. Smith et al.   NATURE CELL BIOLOGY

FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation

(2019) Kihyun Lee et al.   Cell Reports

Overcoming adaptive therapy resistance in AML by targeting immune response pathways

(2019) Katelyn Melgar et al.   Science Translational Medicine

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis

(2019) Akihide Yoshimi et al.   NATURE

Clonal hematopoiesis in human aging and disease

(2019) Siddhartha Jaiswal et al.   SCIENCE

Environmental influences on clonal hematopoiesis

(2019) Katherine Y. King et al.   EXPERIMENTAL HEMATOLOGY

Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations

(2018) Andrea Pellagatti et al.   BLOOD

An inflammatory environment containing TNFα favors Tet2 -mutant clonal hematopoiesis

(2018) Samuel O. Abegunde et al.   EXPERIMENTAL HEMATOLOGY

IL1RAP potentiates multiple oncogenic signaling pathways in AML

(2018) Kelly Mitchell et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes

(2018) Mona M. Hosseini et al.   LEUKEMIA

Mechanism of ubiquitin transfer promoted by TRAF6

(2018) Tian-Min Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

(2018) Bradleigh Whitton et al.   Cancer Medicine

Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs

(2018) Chan-Jung Chang et al.   Stem Cell Reports

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

(2018) Zhigang Cai et al.   Cell Stem Cell

Functional genomic landscape of acute myeloid leukaemia

(2018) Jeffrey W. Tyner et al.   NATURE

Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level

(2018) Jiahao Chen et al.   NATURE MEDICINE

Immune Escape of Relapsed AML Cells after Allogeneic Transplantation

(2018) Matthew J. Christopher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage

(2018) Jung Wook Park et al.   SCIENCE

Epigenetic plasticity and the hallmarks of cancer

(2017) William A. Flavahan et al.   SCIENCE

Clonal evolution in myelodysplastic syndromes

(2017) Pedro da Silva-Coelho et al.   Nature Communications

Splicing factor gene mutations in hematologic malignancies

(2016) Borja Saez et al.   BLOOD

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia

(2016) Noemi A. Zambetti et al.   Cell Stem Cell

Progress towards generation of human haematopoietic stem cells

(2016) Lara Wahlster et al.   NATURE CELL BIOLOGY

Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution

(2016) M Ryan Corces et al.   NATURE GENETICS

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia

(2016) Jing Fang et al.   NATURE IMMUNOLOGY

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9

(2016) Rebekka K Schneider et al.   NATURE MEDICINE

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emerging therapeutic drugs for AML

(2015) E. M. Stein et al.   BLOOD

Xenograft models for normal and malignant stem cells

(2015) S. Goyama et al.   BLOOD

Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells

(2015) Xiongwei Cai et al.   Cell Stem Cell

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells

(2015) Andriana G Kotini et al.   NATURE BIOTECHNOLOGY

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

(2015) Mami Matano et al.   NATURE MEDICINE

Myeloid Malignancies with Chromosome 5q Deletions Acquire a Dependency on an Intrachromosomal NF-κB Gene Network

(2014) Jing Fang et al.   Cell Reports

Clinical and biological implications of driver mutations in myelodysplastic syndromes

(2013) E. Papaemmanuil et al.   BLOOD

Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome

(2013) Garrett W. Rhyasen et al.   CANCER CELL

Induction of myelodysplasia by myeloid-derived suppressor cells

(2013) Xianghong Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

FIMO: scanning for occurrences of a given motif

(2011) Charles E. Grant et al.   BIOINFORMATICS

AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3

(2010) M Wunderlich et al.   LEUKEMIA

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE