Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS

Autoimmune diseases and myelodysplastic syndromes

(2016) Rami S. Komrokji et al.   AMERICAN JOURNAL OF HEMATOLOGY

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

(2016) A. A. Basiorka et al.   BLOOD

Erythropoietin-regulated oxidative stress negatively affects enucleation during terminal erythropoiesis

(2016) Baobing Zhao et al.   EXPERIMENTAL HEMATOLOGY

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia

(2016) Jing Fang et al.   NATURE IMMUNOLOGY

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9

(2016) Rebekka K Schneider et al.   NATURE MEDICINE

Reduction of MDSCs with All-trans Retinoic Acid Improves CAR Therapy Efficacy for Sarcomas

(2016) A. H. Long et al.   Cancer Immunology Research

Bone Marrow Immunity and Myelodysplasia

(2016) Claude Lambert et al.   Frontiers in Oncology

DAMPs, ageing, and cancer: The ‘DAMP Hypothesis’

(2015) Jin Huang et al.   AGEING RESEARCH REVIEWS

Human and murine erythropoiesis

(2015) Xiuli An et al.   CURRENT OPINION IN HEMATOLOGY

Loss ofTifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor–TRAF6 signaling

(2015) Melinda E. Varney et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RECENT ADVANCES IN THE 5Q- SYNDROME

(2015) Andrea Pellagatti et al.   Mediterranean Journal of Hematology and Infectious Diseases

Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS

(2014) G. Keerthivasan et al.   BLOOD

Quantitative analysis of murine terminal erythroid differentiation in vivo: novel method to study normal and disordered erythropoiesis

(2013) J. Liu et al.   BLOOD

Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus

(2013) S. Gardenghi et al.   BLOOD

Induction of myelodysplasia by myeloid-derived suppressor cells

(2013) Xianghong Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Large-scale gene function analysis with the PANTHER classification system

(2013) Huaiyu Mi et al.   Nature Protocols

Role of DNA Methylation in the Pathogenesis and Treatment of Myelodysplastic Syndromes

(2013) Hina Khan et al.   SEMINARS IN HEMATOLOGY

miR-146acontrols the resolution of T cell responses in mice

(2012) Lili Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miR-146ais a significant brake on autoimmunity, myeloproliferation, and cancer in mice

(2011) Mark P. Boldin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular Dissection of the 5q Deletion in Myelodysplastic Syndrome

(2011) Benjamin L. Ebert   SEMINARS IN ONCOLOGY

Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation

(2010) S. Millot et al.   BLOOD

Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses

(2010) Li-Fan Lu et al.   CELL

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pro-Inflammatory Cytokine-Mediated Anemia: Regarding Molecular Mechanisms of Erythropoiesis

(2010) F. Morceau et al.   MEDIATORS OF INFLAMMATION

Progressive Chromatin Repression and Promoter Methylation of CTNNA1 Associated with Advanced Myeloid Malignancies

(2009) Y. Ye et al.   CANCER RESEARCH

Eosinophils Oxidize Damage-Associated Molecular Pattern Molecules Derived from Stressed Cells

(2009) R. Lotfi et al.   JOURNAL OF IMMUNOLOGY

Is there a role for all-trans retinoic acid in combination with recombinant erythropoetin in myelodysplastic syndromes? A report on 59 cases

(2009) R Itzykson et al.   LEUKEMIA

Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

(2009) Daniel T Starczynowski et al.   NATURE MEDICINE

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity

(2008) K. Movahedi et al.   BLOOD

BMP4/Smad5 dependent stress erythropoiesis is required for the expansion of erythroid progenitors during fetal development

(2008) Prashanth Porayette et al.   DEVELOPMENTAL BIOLOGY