Nanoparticle-Mediated Targeted Drug Delivery to Remodel Tumor Microenvironment for Cancer Therapy

Bifunctional Janus Particles as Multivalent Synthetic Nanoparticle Antibodies (SNAbs) for Selective Depletion of Target Cells

(2021) Jiaying Liu et al.   NANO LETTERS

An injectable hydrogel using an immunomodulating gelator for amplified tumor immunotherapy by blocking the arginase pathway

(2021) Xiaomeng Ren et al.   Acta Biomaterialia

Recent trends in bioresponsive linker technologies of Prodrug-Based Self-Assembling nanomaterials

(2021) Anne Nguyen et al.   BIOMATERIALS

Engineering of a dual-modal phototherapeutic nanoplatform for single NIR laser-triggered tumor therapy

(2021) Mengzhu Zhang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Tumor Microenvironment

(2020) Borros Arneth   Medicina-Lithuania

Mild Acid-Responsive “Nanoenzyme Capsule” Remodeling of the Tumor Microenvironment to Increase Tumor Penetration

(2020) Hanchun Yao et al.   ACS Applied Materials & Interfaces

Quinacrine based gold hybrid nanoparticle caused apoptosis through modulating replication fork in oral cancer stem cells

(2020) Krushna Chandra Hembram et al.   MOLECULAR PHARMACEUTICS

An Attempt to Polarize Human Neutrophils Toward N1 and N2 Phenotypes in vitro

(2020) Mareike Ohms et al.   Frontiers in Immunology

Transforming a toxic drug into an efficacious nanomedicine using a lipoprodrug strategy for the treatment of patient-derived melanoma xenografts

(2020) Linlin Shi et al.   JOURNAL OF CONTROLLED RELEASE

Adenosine A2A Receptor Antagonists for Cancer Immunotherapy

(2020) Fazhi Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dimerization-induced self-assembly of a redox-responsive prodrug into nanoparticles for improved therapeutic index

(2020) Liqian Zhou et al.   Acta Biomaterialia

Mechanism Investigation of Hyaluronidase-Combined Multistage Nanoparticles for Solid Tumor Penetration and Antitumor Effect

(2020) Enrui Chen et al.   International Journal of Nanomedicine

Anti‑CD206 antibody‑conjugated Fe3O4‑based PLGA nanoparticles selectively promote tumor‑associated macrophages to polarize to the pro‑inflammatory subtype

(2020) Yun Zhou et al.   Oncology Letters

Legumain protease-activated tuftsin-functionalized nanoparticles for dual-targeting TAMs and cancer chemotherapy

(2020) Hui Peng et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Exosome-mediated miR-33 transfer induces M1 polarization in mouse macrophages and exerts antitumor effect in 4T1 breast cancer cell line

(2020) Maryam Moradi-Chaleshtori et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Target-oriented delivery of self-assembled immunosuppressant cocktails prolongs allogeneic orthotopic liver transplant survival

(2020) Haiyang Xie et al.   JOURNAL OF CONTROLLED RELEASE

Tuft and Cancer Stem Cell Marker DCLK1: A New Target to Enhance Anti-Tumor Immunity in the Tumor Microenvironment

(2020) Zhiyun Cao et al.   Cancers

Cu-MOF chemodynamic nanoplatform via modulating glutathione and H2O2 in tumor microenvironment for amplified cancer therapy

(2020) Hailong Tian et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Enhanced Drug Delivery by Nanoscale Integration of a Nitric Oxide Donor To Induce Tumor Collagen Depletion

(2019) Xiao Dong et al.   NANO LETTERS

Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy

(2019) Marta Truffi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosome-orchestrated hypoxic tumor microenvironment

(2019) Wanrong Meng et al.   Molecular Cancer

Tumor microenvironment targeted nanotherapeutics for cancer therapy and diagnosis: A review

(2019) Shreya Thakkar et al.   Acta Biomaterialia

Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy

(2019) Maria Teresa Masucci et al.   Frontiers in Oncology

Preclinical Assessment with Clinical Validation of Selinexor with Gemcitabine and Nab-Paclitaxel for the Treatment of Pancreatic Ductal Adenocarcinoma

(2019) Asfar S. Azmi et al.   CLINICAL CANCER RESEARCH

Synthetic Polymeric Mixed Micelles Targeting Lymph Nodes Trigger Enhanced Cellular and Humoral Immune Responses

(2018) Chenxi Li et al.   ACS Applied Materials & Interfaces

Nanocarrier-Mediated Chemo-Immuno Therapy Arrested Cancer Progression and Induced Tumor Dormancy in Desmoplastic Melanoma

(2018) Qi Liu et al.   ACS Nano

Nanoparticles Targeting and Remodeling Tumor Microenvironment for Cancer Theranostics

(2018) Gan Lin et al.   Journal of Biomedical Nanotechnology

Regulatory T cell-targeted hybrid nanoparticles combined with immuno-checkpoint blockage for cancer immunotherapy

(2018) Wenquan Ou et al.   JOURNAL OF CONTROLLED RELEASE

Exosomal miR-9 inhibits angiogenesis by targeting MDK and regulating PDK/AKT pathway in nasopharyngeal carcinoma

(2018) Juan Lu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Current status and future directions of cancer immunotherapy

(2018) Hongming Zhang et al.   Journal of Cancer

Role of tumor microenvironment in cancer stem cell chemoresistance and recurrence

(2018) Madhurima Das et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sequential delivery of VEGF siRNA and paclitaxel for PVN destruction, anti-angiogenesis, and tumor cell apoptosis procedurally via a multi-functional polymer micelle

(2018) Yanfang Yang et al.   JOURNAL OF CONTROLLED RELEASE

The Long Noncoding RNA MALAT1 Induces Tolerogenic Dendritic Cells and Regulatory T Cells via miR155/Dendritic Cell-Specific Intercellular Adhesion Molecule-3 Grabbing Nonintegrin/IL10 Axis

(2018) Jian Wu et al.   Frontiers in Immunology

Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression

(2018) Christopher Groth et al.   BRITISH JOURNAL OF CANCER

Role of Extracellular Matrix in Development and Cancer Progression

(2018) Cameron Walker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation

(2017) Bryan Vander Lugt et al.   JOURNAL OF CELL BIOLOGY

In This Issue

(2017)   JOURNAL OF IMMUNOLOGY

Scavenger Receptor Type B1 and Lipoprotein Nanoparticle Inhibit Myeloid-Derived Suppressor Cells

(2017) Michael P. Plebanek et al.   MOLECULAR CANCER THERAPEUTICS

Protein Nanocage Mediated Fibroblast-Activation Protein Targeted Photoimmunotherapy To Enhance Cytotoxic T Cell Infiltration and Tumor Control

(2017) Zipeng Zhen et al.   NANO LETTERS

Exploring the Potential of Nanotherapeutics in Targeting Tumor Microenvironment for Cancer Therapy

(2017) Eameema Muntimadugu et al.   PHARMACOLOGICAL RESEARCH

IL-35 induces N2 phenotype of neutrophils to promote tumor growth

(2017) Jiu-Ming Zou et al.   Oncotarget

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Tumor-derived exosomes elicit tumor suppression in murine hepatocellular carcinoma models and humansin vitro

(2016) Quan Rao et al.   HEPATOLOGY

Pyropia yezoensis glycoprotein promotes the M1 to M2 macrophage phenotypic switch via the STAT3 and STAT6 transcription factors

(2016) Jeong-Wook Choi et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Comprehensively priming the tumor microenvironment by cancer-associated fibroblast-targeted liposomes for combined therapy with cancer cell-targeted chemotherapeutic drug delivery system

(2016) Binlong Chen et al.   JOURNAL OF CONTROLLED RELEASE

Vaccination with trifunctional nanoparticles that address CD8+dendritic cells inhibits growth of established melanoma

(2016) Limei Shen et al.   Nanomedicine

Tumor stromal disrupting agent enhances the anticancer efficacy of docetaxel loaded PEGylated liposomes in lung cancer

(2016) Ketan Patel et al.   Nanomedicine

Metastatic colonization by circulating tumour cells

(2016) Joan Massagué et al.   NATURE

Microenvironment-Responsive Three-Pronged Approach Breaking Traditional Chemotherapy to Target Cancer Stem Cells for Synergistic Inoperable Large Tumor Therapy

(2016) Yan Li et al.   Small

Expression of Th1- Th2- and Th17-associated cytokines in laryngeal carcinoma

(2016) Xiaoqun Xu et al.   Oncology Letters

Pancreatic Cancer Cell Exosome-Mediated Macrophage Reprogramming and the Role of MicroRNAs 155 and 125b2 Transfection using Nanoparticle Delivery Systems

(2016) Mei-Ju Su et al.   Scientific Reports

miR-181a Induces Macrophage Polarized to M2 Phenotype and Promotes M2 Macrophage-mediated Tumor Cell Metastasis by Targeting KLF6 and C/EBPα

(2016) Jia Bi et al.   Molecular Therapy-Nucleic Acids

Chitosan-Decorated Doxorubicin-Encapsulated Nanoparticle Targets and Eliminates Tumor Reinitiating Cancer Stem-like Cells

(2015) Wei Rao et al.   ACS Nano

Cancer-associated fibroblasts: A multifaceted driver of breast cancer progression

(2015) Haojun Luo et al.   CANCER LETTERS

TGF-β Regulates Hepatocellular Carcinoma Progression by Inducing Treg Cell Polarization

(2015) Yinan Shen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Nanoparticle modulation of the tumor microenvironment enhances therapeutic efficacy of cisplatin

(2015) Lei Miao et al.   JOURNAL OF CONTROLLED RELEASE

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

(2015) Miranda Y. Fong et al.   NATURE CELL BIOLOGY

Prognostic Implication of M2 Macrophages Are Determined by the Proportional Balance of Tumor Associated Macrophages and Tumor Infiltrating Lymphocytes in Microsatellite-Unstable Gastric Carcinoma

(2015) Kyung-Ju Kim et al.   PLoS One

Metastatic Stem Cells: Sources, Niches, and Vital Pathways

(2014) Thordur Oskarsson et al.   Cell Stem Cell

Improving the distribution of Doxil® in the tumor matrix by depletion of tumor hyaluronan

(2014) Aditya G. Kohli et al.   JOURNAL OF CONTROLLED RELEASE

Intracellular autofluorescence: a biomarker for epithelial cancer stem cells

(2014) Irene Miranda-Lorenzo et al.   NATURE METHODS

Cancer-Induced Alterations of NK-Mediated Target Recognition: Current and Investigational Pharmacological Strategies Aiming at Restoring NK-Mediated Anti-Tumor Activity

(2014) Anne-Sophie Chretien et al.   Frontiers in Immunology

Development of Y-shaped peptide for constructing nanoparticle systems targeting tumor-associated macrophages in vitro and in vivo

(2014) Lu Yan et al.   Materials Research Express

In Vivo Targeting of Intratumor Regulatory T Cells Using PEG-Modified Single-Walled Carbon Nanotubes

(2013) Cristiano Sacchetti et al.   BIOCONJUGATE CHEMISTRY

Modulation of Treg cells/T effector function by GITR signaling is context-dependent

(2013) Amal Ephrem et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization

(2013) H. Cucak et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hybrid Nanoparticles for Detection and Treatment of Cancer

(2012) Michael J. Sailor et al.   ADVANCED MATERIALS

Transtumoral targeting enabled by a novel neuropilin-binding peptide

(2011) L Roth et al.   ONCOGENE

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

(2011) Shom Goel et al.   PHYSIOLOGICAL REVIEWS

The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by Tumor-Vascular Disrupting Agents

(2010) Dietmar W. Siemann   CANCER TREATMENT REVIEWS

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

(2009) M. K. Srivastava et al.   CANCER RESEARCH

Tim-2 is the receptor for H-ferritin on oligodendrocytes

(2008) Bozho Todorich et al.   JOURNAL OF NEUROCHEMISTRY