Tuft and Cancer Stem Cell Marker DCLK1: A New Target to Enhance Anti-Tumor Immunity in the Tumor Microenvironment
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Title
Tuft and Cancer Stem Cell Marker DCLK1: A New Target to Enhance Anti-Tumor Immunity in the Tumor Microenvironment
Authors
Keywords
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Journal
Cancers
Volume 12, Issue 12, Pages 3801
Publisher
MDPI AG
Online
2020-12-18
DOI
10.3390/cancers12123801
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Note: Only part of the references are listed.- Cancer Stem Cell Marker DCLK1 Correlates with Tumorigenic Immune Infiltrates in the Colon and Gastric Adenocarcinoma Microenvironments
- (2020) Xiangyan Wu et al. Cancers
- LncRNA SNHG1 promotes EMT process in gastric cancer cells through regulation of the miR-15b/DCLK1/Notch1 axis
- (2020) Zhi-Qi Liu et al. BMC GASTROENTEROLOGY
- DCLK1-isoform2 alternative splice variant promotes pancreatic tumor immunosuppressive M2-macrophage polarization
- (2020) Parthasarathy Chandrakesan et al. MOLECULAR CANCER THERAPEUTICS
- Discovery of a selective inhibitor of doublecortin like kinase 1
- (2020) Fleur M. Ferguson et al. Nature Chemical Biology
- Systemic Therapy of Extensive Stage Small Cell Lung Cancer in the Era of Immunotherapy
- (2020) Meera Ragavan et al. CURRENT TREATMENT OPTIONS IN ONCOLOGY
- Synthesis and Structure–Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one Scaffold
- (2020) Fleur M. Ferguson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Interplay of EMT and CSC in Cancer and the Potential Therapeutic Strategies
- (2020) Shihori Tanabe et al. Frontiers in Pharmacology
- Advances in Therapeutic Targeting of Cancer Stem Cells within the Tumor Microenvironment: An Updated Review
- (2020) Kevin Dzobo et al. Cells
- DCLK1, a promising colorectal cancer stem cell marker, regulates tumor progression and invasion through miR-137 and miR-15a dependent manner
- (2020) Sepideh Razi et al. CLINICAL AND EXPERIMENTAL MEDICINE
- DCLK1, a putative novel stem cell marker in human cholangiocarcinoma
- (2020) Lorenzo Nevi et al. HEPATOLOGY
- Expression of PD-L1, cancer stem cell and epithelial–mesenchymal transition phenotype in non-small cell lung cancer
- (2020) Young Wha Koh et al. PATHOLOGY
- EMT is associated with an epigenetic signature of ECM remodeling genes
- (2019) Paul Peixoto et al. Cell Death & Disease
- Lineage tracing and targeting of IL17RB+tuft cell-like human colorectal cancer stem cells
- (2019) Norihiro Goto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tumor-induced escape mechanisms and their association with resistance to checkpoint inhibitor therapy
- (2019) Michael Friedrich et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- The Histone Demethylase KDM3A, Increased in Human Pancreatic Tumors, Regulates Expression of DCLK1 in and Promotes Tumorigenesis in Mice
- (2019) Prasad Dandawate et al. GASTROENTEROLOGY
- Overexpression of DCLK1-AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer
- (2019) Dongfeng Qu et al. Journal of Oncology
- Inhibition of DCLK1 down-regulates PD-L1 expression through Hippo pathway in human pancreatic cancer
- (2019) Rui Yan et al. LIFE SCIENCES
- DCLK1 Monoclonal Antibody-Based CAR-T Cells as a Novel Treatment Strategy against Human Colorectal Cancers
- (2019) Sripathi M. Sureban et al. Cancers
- Role of the Microenvironment in Gastrointestinal Tumors
- (2019) Nathaniel Weygant et al. Journal of Oncology
- Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling
- (2018) Ming Luo et al. Cell Metabolism
- Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells
- (2018) Yu Zhang et al. GASTROENTEROLOGY
- Intestinal Epithelial Wnt Signaling Mediates Acetylcholine-Triggered Host Defense against Infection
- (2018) Sid Ahmed Labed et al. IMMUNITY
- Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit
- (2018) Marija S. Nadjsombati et al. IMMUNITY
- DCLK1 promotes epithelial-mesenchymal transition via the PI3K/Akt/NF-κB pathway in colorectal cancer
- (2018) Weiying Liu et al. INTERNATIONAL JOURNAL OF CANCER
- Alternative splice variants of DCLK1 mark cancer stem cells, promote self-renewal and drug-resistance, and can be targeted to inhibit tumorigenesis in kidney cancer
- (2018) Yang Ge et al. INTERNATIONAL JOURNAL OF CANCER
- Understanding the tumor immune microenvironment (TIME) for effective therapy
- (2018) Mikhail Binnewies et al. NATURE MEDICINE
- TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
- (2018) Sanjeev Mariathasan et al. NATURE
- Analysis of the clinical significance of DCLK1+ colorectal cancer using novel monoclonal antibodies against DCLK1
- (2018) Tianqi Dai et al. OncoTargets and Therapy
- Cancer stem cells as targets for DC-based immunotherapy of colorectal cancer
- (2018) Magdalena Szaryńska et al. Scientific Reports
- Dclk1 Inhibition Cancels 5-FU-induced Cell-cycle Arrest and Decreases Cell Survival in Colorectal Cancer
- (2018) YUKI SUEHIRO et al. ANTICANCER RESEARCH
- Dclk1 in tuft cells promotes inflammation-driven epithelial restitution and mitigates chronic colitis
- (2018) Jun Yi et al. CELL DEATH AND DIFFERENTIATION
- DCLK1 is correlated with MET and ERK5 expression, and associated with prognosis in malignant pleural mesothelioma
- (2017) Hui Wang et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Up-regulation of glycolysis promotes the stemness and EMT phenotypes in gemcitabine-resistant pancreatic cancer cells
- (2017) Hengqiang Zhao et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- A single-cell survey of the small intestinal epithelium
- (2017) Adam L. Haber et al. NATURE
- Enhancement of cytotoxic effects of gemcitabine by Dclk1 inhibition through suppression of Chk1 phosphorylation in human pancreatic cancer cells
- (2017) Daichi Kawamura et al. ONCOLOGY REPORTS
- Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine
- (2017) Bola Aladegbami et al. Scientific Reports
- Doublecortin-like kinase 1-positive enterocyte - a new cell type in human intestine
- (2016) Joni Leppänen et al. APMIS
- Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis
- (2016) C. Benedikt Westphalen et al. Cell Stem Cell
- CD44+ Cells in Head and Neck Squamous Cell Carcinoma Suppress T-Cell-Mediated Immunity by Selective Constitutive and Inducible Expression of PD-L1
- (2016) Y. Lee et al. CLINICAL CANCER RESEARCH
- Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma
- (2016) Y. Lou et al. CLINICAL CANCER RESEARCH
- DCLK1 phosphorylates the microtubule-associated protein MAP7D1 to promote axon elongation in cortical neurons
- (2016) Hiroyuki Koizumi et al. Developmental Neurobiology
- A novel double-targeted nondrug delivery system for targeting cancer stem cells
- (2016) Shupei Qiao et al. International Journal of Nanomedicine
- Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors
- (2016) Gao Zhang et al. JOURNAL OF CLINICAL INVESTIGATION
- Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites
- (2016) François Gerbe et al. NATURE
- Dominant Expression of DCLK1 in Human Pancreatic Cancer Stem Cells Accelerates Tumor Invasion and Metastasis
- (2016) Hiromitsu Ito et al. PLoS One
- Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury
- (2016) Parthasarathy Chandrakesan et al. Scientific Reports
- Epithelial-to-mesenchymal transition (EMT) induced by inflammatory priming elicits mesenchymal stromal cell-like immune-modulatory properties in cancer cells
- (2015) M Ricciardi et al. BRITISH JOURNAL OF CANCER
- GALNT1-Mediated Glycosylation and Activation of Sonic Hedgehog Signaling Maintains the Self-Renewal and Tumor-Initiating Capacity of Bladder Cancer Stem Cells
- (2015) C. Li et al. CANCER RESEARCH
- The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?
- (2015) Vicki Plaks et al. Cell Stem Cell
- Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
- (2015) Kari R. Fischer et al. NATURE
- Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism
- (2015) Sripathi M. Sureban et al. Oncotarget
- Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122
- (2015) Kyoungsub Song et al. Oncotarget
- DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma
- (2015) Nathaniel Weygant et al. Oncotarget
- Dclk1+ small intestinal epithelial tuft cells display the hallmarks of quiescence and self-renewal
- (2015) Parthasarathy Chandrakesan et al. Oncotarget
- Chemical coding and chemosensory properties of cholinergic brush cells in the mouse gastrointestinal and biliary tract
- (2015) Burkhard Schütz et al. Frontiers in Physiology
- Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis
- (2015) Dongfeng Qu et al. PLoS One
- XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism
- (2014) Sripathi M. Sureban et al. CANCER LETTERS
- Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile
- (2014) Cristina Oliveras-Ferraros et al. CELL CYCLE
- Long-lived intestinal tuft cells serve as colon cancer–initiating cells
- (2014) C. Benedikt Westphalen et al. JOURNAL OF CLINICAL INVESTIGATION
- Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1
- (2014) Nathaniel Weygant et al. Molecular Cancer
- Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
- (2014) Andrea Viale et al. NATURE
- Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism
- (2014) Jianqun Liao et al. PLoS One
- Targeting Unique Metabolic Properties of Breast Tumor Initiating Cells
- (2014) Weiguo Feng et al. STEM CELLS
- Intestinal stem cells and the colorectal cancer microenvironment
- (2014) Bryan A Ong WORLD JOURNAL OF GASTROENTEROLOGY
- Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
- (2014) Limo Chen et al. Nature Communications
- Cancer Stem Cell Immunology: Key to Understanding Tumorigenesis and Tumor Immune Escape?
- (2014) Valentin S. Bruttel et al. Frontiers in Immunology
- Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment
- (2014) Theerawut Chanmee et al. Cancers
- PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress
- (2013) Francisca Vazquez et al. CANCER CELL
- DCLK1 Marks a Morphologically Distinct Subpopulation of Cells With Stem Cell Properties in Preinvasive Pancreatic Cancer
- (2013) Jennifer M. Bailey et al. GASTROENTEROLOGY
- The secretome of colon cancer stem cells contains drug-metabolizing enzymes
- (2013) Benjamin L Emmink et al. Journal of Proteomics
- DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer
- (2013) Sripathi M. Sureban et al. PLoS One
- Brief Report: Dclk1 Deletion in Tuft Cells Results in Impaired Epithelial Repair After Radiation Injury
- (2013) Randal May et al. STEM CELLS
- Altered expression of a putative progenitor cell marker DCAMKL1 in the rat gastric mucosa in regeneration, metaplasia and dysplasia
- (2012) Miho Kikuchi et al. BMC GASTROENTEROLOGY
- Molecular Pathways: Targeting the TGF- Pathway for Cancer Therapy
- (2012) A. L. Smith et al. CLINICAL CANCER RESEARCH
- Cholinergic chemosensory cells in the auditory tube
- (2012) G. Krasteva et al. HISTOCHEMISTRY AND CELL BIOLOGY
- Dclk1 distinguishes between tumor and normal stem cells in the intestine
- (2012) Yuki Nakanishi et al. NATURE GENETICS
- DCAMKL-1 Regulates Epithelial-Mesenchymal Transition in Human Pancreatic Cells through a miR-200a-Dependent Mechanism
- (2011) S. M. Sureban et al. CANCER RESEARCH
- Metabolic Alterations in Highly Tumorigenic Glioblastoma Cells
- (2011) Yunfei Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of the putative intestinal stem cell marker doublecortin and CaM kinase-like-1 in Barrett's esophagus and esophageal adenocarcinoma
- (2011) Kenneth J Vega et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism
- (2011) Sripathi M Sureban et al. JOURNAL OF NANOBIOTECHNOLOGY
- Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas
- (2010) Randal May et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- K-ras Mutation Targeted to Gastric Tissue Progenitor Cells Results in Chronic Inflammation, an Altered Microenvironment, and Progression to Intraepithelial Neoplasia
- (2010) T. Okumura et al. CANCER RESEARCH
- Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
- (2010) Johanna Chiche et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- CD13 is a therapeutic target in human liver cancer stem cells
- (2010) Naotsugu Haraguchi et al. JOURNAL OF CLINICAL INVESTIGATION
- The diffuse chemosensory system: Exploring the iceberg toward the definition of functional roles
- (2010) Andrea Sbarbati et al. PROGRESS IN NEUROBIOLOGY
- DCAMKL-1 Expression Identifies Tuft Cells Rather Than Stem Cells in the Adult Mouse Intestinal Epithelium
- (2009) François Gerbe et al. GASTROENTEROLOGY
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