Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy

Nanoplatform Assembled from a CD44-Targeted Prodrug and Smart Liposomes for Dual Targeting of Tumor Microenvironment and Cancer Cells

(2018) Yaqi Lv et al.   ACS Nano

Dual pH-responsive multifunctional nanoparticles for targeted treatment of breast cancer by combining immunotherapy and chemotherapy

(2018) Yuanyuan Liu et al.   Acta Biomaterialia

LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody–Drug Conjugates

(2018) James W. Purcell et al.   CANCER RESEARCH

CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

(2018) Shicheng Su et al.   CELL

CXCR4/CXCL12 Signaling and Protumor Macrophages in Primary Tumors and Sentinel Lymph Nodes Are Involved in Luminal B Breast Cancer Progression

(2018) Carlotta Raschioni et al.   DISEASE MARKERS

A peek into cancer-associated fibroblasts: origins, functions and translational impact

(2018) Valerie S. LeBleu et al.   Disease Models & Mechanisms

Fibroblasts in the Tumor Microenvironment: Shield or Spear?

(2018) Twana Alkasalias et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Photosensitizer-Encapsulated Ferritins Mediate Photodynamic Therapy against Cancer-Associated Fibroblasts and Improve Tumor Accumulation of Nanoparticles

(2018) Lu Li et al.   MOLECULAR PHARMACEUTICS

Remodeling the Tumor Microenvironment with Emerging Nanotherapeutics

(2018) Qin Chen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cancer-associated fibroblasts induce antigen-specific deletion of CD8+ T Cells to protect tumour cells

(2018) Matthew A. Lakins et al.   Nature Communications

Multivalent exposure of trastuzumab on iron oxide nanoparticles improves antitumor potential and reduces resistance in HER2-positive breast cancer cells

(2018) Marta Truffi et al.   Scientific Reports

Local Blockade of Interleukin 10 and C-X-C Motif Chemokine Ligand 12 with Nano-Delivery Promotes Antitumor Response in Murine Cancers

(2018) Limei Shen et al.   ACS Nano

Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment

(2018) Bing Feng et al.   ADVANCED MATERIALS

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway

(2018) Jianqin Lu et al.   ACS Nano

Half-Chain Cetuximab Nanoconjugates Allow Multitarget Therapy of Triple Negative Breast Cancer

(2018) Miriam Colombo et al.   BIOCONJUGATE CHEMISTRY

Nanoparticle-Mediated Combination Therapy: Two-in-One Approach for Cancer

(2018) Sangiliyandi Gurunathan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nano-targeted relaxin impairs fibrosis and tumor growth in pancreatic cancer and improves the efficacy of gemcitabine in vivo

(2018) Deby F. Mardhian et al.   JOURNAL OF CONTROLLED RELEASE

Recent Development of pH-Responsive Polymers for Cancer Nanomedicine

(2018) Houliang Tang et al.   MOLECULES

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Curcumin in combination with anti-cancer drugs: A nanomedicine review

(2018) Harshul Batra et al.   PHARMACOLOGICAL RESEARCH

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

(2018) Michael Bartoschek et al.   Nature Communications

Progress in nonviral gene therapy for breast cancer and what comes next?

(2017) Giulia Bottai et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Nanomedicine applications in the treatment of breast cancer: current state of the art

(2017) Di Wu et al.   International Journal of Nanomedicine

Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy

(2017) Fotios Mpekris et al.   JOURNAL OF CONTROLLED RELEASE

Tumor-induced Stromal STAT1 Accelerates Breast Cancer via Deregulating Tissue Homeostasis

(2017) Victoria R. Zellmer et al.   MOLECULAR CANCER RESEARCH

Protein Nanocage Mediated Fibroblast-Activation Protein Targeted Photoimmunotherapy To Enhance Cytotoxic T Cell Infiltration and Tumor Control

(2017) Zipeng Zhen et al.   NANO LETTERS

Nano-targeting of mucosal addressin cell adhesion molecule-1 identifies bowel inflammation foci in murine model

(2017) Marta Truffi et al.   Nanomedicine

Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now?

(2017) Andrew L. Mellor et al.   Frontiers in Immunology

Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment

(2016) Genichiro Ishii et al.   ADVANCED DRUG DELIVERY REVIEWS

Tumor microenvironment-mediated chemoresistance in breast cancer

(2016) Kobra velaei et al.   BREAST

FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling

(2016) Xuguang Yang et al.   CANCER RESEARCH

Targeting Tumor-Associated Fibroblasts for Therapeutic Delivery in Desmoplastic Tumors

(2016) Lei Miao et al.   CANCER RESEARCH

Enhanced stimulation of anti-breast cancer T cells responses by dendritic cells loaded with poly lactic-co-glycolic acid (PLGA) nanoparticle encapsulated tumor antigens

(2016) Soodabeh Iranpour et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy

(2016) Hua Gong et al.   NANO LETTERS

Hyaluronidase Embedded in Nanocarrier PEG Shell for Enhanced Tumor Penetration and Highly Efficient Antitumor Efficacy

(2016) Hao Zhou et al.   NANO LETTERS

A tenascin C targeted nanoliposome with navitoclax for specifically eradicating of cancer-associated fibroblasts

(2016) Binlong Chen et al.   Nanomedicine-Nanotechnology Biology and Medicine

Ferritin nanocages: A biological platform for drug delivery, imaging and theranostics in cancer

(2016) Marta Truffi et al.   PHARMACOLOGICAL RESEARCH

Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

(2016) Aixiu Qiao et al.   Frontiers of Medicine

Breast Cancer-Associated Fibroblasts: Where We Are and Where We Need to Go

(2016) Rachel Buchsbaum et al.   Cancers

Peptide Assembly Integration of Fibroblast-Targeting and Cell-Penetration Features for Enhanced Antitumor Drug Delivery

(2015) Tianjiao Ji et al.   ADVANCED MATERIALS

Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation

(2015) Tianjiao Ji et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanomedicines Targeting the Tumor Microenvironment

(2015) Rong Tong et al.   CANCER JOURNAL

Cancer-associated fibroblasts: A multifaceted driver of breast cancer progression

(2015) Haojun Luo et al.   CANCER LETTERS

Preclinical Mouse Cancer Models: A Maze of Opportunities and Challenges

(2015) Chi-Ping Day et al.   CELL

Randomized, Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed

(2015) Herbert I. Hurwitz et al.   JOURNAL OF CLINICAL ONCOLOGY

Nanoparticle modulation of the tumor microenvironment enhances therapeutic efficacy of cisplatin

(2015) Lei Miao et al.   JOURNAL OF CONTROLLED RELEASE

3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation

(2015) Pallavi Sethi et al.   Nanomedicine-Nanotechnology Biology and Medicine

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

(2014) Ruth Scherz-Shouval et al.   CELL

Effects of Tumor Microenvironment Heterogeneity on Nanoparticle Disposition and Efficacy in Breast Cancer Tumor Models

(2014) G. Song et al.   CLINICAL CANCER RESEARCH

Sulfatide-containing lipid perfluorooctylbromide nanoparticles as paclitaxel vehicles targeting breast carcinoma

(2014) Xiao Li et al.   International Journal of Nanomedicine

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fibroblast Activation Protein (FAP) Is Essential for the Migration of Bone Marrow Mesenchymal Stem Cells through RhoA Activation

(2014) Kuei-Min Chung et al.   PLoS One

Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer

(2013) L. Bochet et al.   CANCER RESEARCH

Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma

(2013) Abasi Ene–Obong et al.   GASTROENTEROLOGY

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia

(2013) Edward W. Roberts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression

(2013) G Comito et al.   ONCOGENE

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

(2013) Vikash P. Chauhan et al.   Nature Communications

Stromal cells in tumor microenvironment and breast cancer

(2012) Yan Mao et al.   CANCER AND METASTASIS REVIEWS

CCL2 Mediates Cross-talk between Cancer Cells and Stromal Fibroblasts That Regulates Breast Cancer Stem Cells

(2012) A. Tsuyada et al.   CANCER RESEARCH

Therapeutic Effects of Deleting Cancer-Associated Fibroblasts in Cholangiocarcinoma

(2012) J. C. Mertens et al.   CANCER RESEARCH

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Photodynamic therapy of cancer: An update

(2011) Patrizia Agostinis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Interleukin 10 in the tumor microenvironment: a target for anticancer immunotherapy

(2011) Takami Sato et al.   IMMUNOLOGIC RESEARCH

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein- 

(2010) M. Kraman et al.   SCIENCE

Role of stromal myofibroblasts in invasive breast cancer: stromal expression of alpha-smooth muscle actin correlates with worse clinical outcome

(2010) Masako Yamashita et al.   Breast Cancer

Phase II Trial of Talabostat and Docetaxel in Advanced Non-small Cell Lung Cancer

(2009) R.M. Eager et al.   CLINICAL ONCOLOGY

CXCR4 and Matrix Metalloproteinase-1 Are Elevated in Breast Carcinoma-Associated Fibroblasts and in Normal Mammary Fibroblasts Exposed to Factors Secreted by Breast Cancer Cells

(2009) S. M. Eck et al.   MOLECULAR CANCER RESEARCH

Pten in stromal fibroblasts suppresses mammary epithelial tumours

(2009) Anthony J. Trimboli et al.   NATURE

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Regulation of In Situ to Invasive Breast Carcinoma Transition

(2008) Min Hu et al.   CANCER CELL