Article
Chemistry, Multidisciplinary
Man-Di Wang, Gan-Tian Lv, Hong-Wei An, Ni-Yuan Zhang, Hao Wang
Summary: This study reports a programmable peptide molecule that enables specific and efficient assembly by binding to targeting receptor proteins. By designing different peptide sequences and receptor bindings, it is possible to promote oligomerization and functional regulation of protein complexes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Nanoscience & Nanotechnology
X. Shi, L. Shu, Y. Qiao, J. Yao, H. Xie, L. Zhou, H. Wang, S. Zheng
Summary: STAT3 is a key converging point of multiple oncogenic pathways and is constitutively activated in various cancer cells. Stattic, a selective inhibitor of STAT3, has shown promising potential for targeted cancer therapy and has been formulated in nanoparticles to enhance its therapeutic effects against tumor growth and metastasis.
MATERIALS TODAY NANO
(2022)
Review
Pharmacology & Pharmacy
Hannah S. Newton, Marina A. Dobrovolskaia
Summary: Pharmaceutical products can activate, suppress, or modify immune responses. Nanoparticles, depending on their physicochemical properties, can have immunostimulatory, immunosuppressive, or immunomodulatory effects. Immunophenotyping is a valuable method for evaluating immune cell changes and activation status.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Tongyu Li, Xiaona Chen, Jianqin Wan, Xiaoxiao Hu, Wanzhi Chen, Hangxiang Wang
Summary: This study demonstrates that combining cabazitaxel nanotherapeutics with a pan-Akt inhibitor MK-2206 sensitizes resistant cancer cells, reduces systemic toxicity, and maximizes efficacy in vitro and in an animal model. The nanoparticle formulation also shows higher tolerance compared to free cabazitaxel agent.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Medicine, Research & Experimental
Xiaona Chen, Binbin Xie, Lingling Huang, Jianqin Wan, Yuchen Wang, Xiaowei Shi, Yiting Qiao, Haihan Song, Hangxiang Wang
Summary: A new class of self-assembled drug cocktails, formed through a one-pot process, shows promising therapeutic synergy in preclinical cancer models, producing durable recession in tumor growth. The self-assembled CD NAs offer a scalable and cost-effective methodology for drug delivery without the need for carrier matrices.
Review
Engineering, Biomedical
Yu Chen, Yue Pan, Danrong Hu, Jinrong Peng, Ying Hao, Meng Pan, Liping Yuan, Yongyang Yu, Zhiyong Qian
Summary: Cabazitaxel, a second-generation taxane, shows potential to overcome taxane resistance but its clinical use is restricted due to high systemic toxicity, hydrophobicity, and instability. Nanomedicine is believed to offer solutions to these limitations and help surmount taxane resistance.
BIOMEDICAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Boyang Sun, Shuai Shao, Sanjana Ghosh, Jiexin Li, Xiaojie Wang, Changning Li, Breandan Quinn, Paschalis Alexandridis, Jonathan F. Lovell, Yumiao Zhang
Summary: The study demonstrates the development of a simple formulation methodology for Cabazitaxel (CTX) to produce a lyophilized drug product with a high drug-to-excipient ratio. The drug and excipient can be dissolved together in a mixed solvent system, allowing for sterile filtration, lyophilization, and reconstitution. The size of the reconstituted nanoparticles can be adjusted by tuning the solvent ratio and the ratio of excipient to drug.
SCIENCE CHINA-MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zhengqing Guo, Hui He, Yi Zhang, Jiaming Rao, Tao Yang, Ting Li, Lu Wang, Mengke Shi, Mengya Wang, Shihong Qiu, Xue Song, Hengte Ke, Huabing Chen
Summary: This study demonstrates the use of self-assembled micellar nanoarchitecture for potent phototherapy against triple-negative breast cancer, showing efficient suppression against primary, metastatic, and recurrent TNBC through tunable photoconversion and cytoplasmic translocation.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Zijian Zhou, Chao Du, Qianyu Zhang, Guocan Yu, Fuwu Zhang, Xiaoyuan Chen
Summary: By modulating the self-assembly of drug amphiphiles EB-CPT with the anticancer drug PTX, ultrahigh quality nanovesicles (NVs) were produced with high drug loading efficiency and content. The ECX NVs with EB-CPT:PTX weight ratio of 1:2 exhibited remarkable anticancer activity against cancer cells and improved tumor inhibition effect in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Multidisciplinary
Yi Lai, Fenglin Li, Zhifeng Zou, Madiha Saeed, Zhiai Xu, Haijun Yu
Summary: This article explores the development and applications of amyloid polypeptide-based nanostructures in biotechnological applications. It emphasizes the importance of thermodynamic and kinetic factors in self-assembly and summarizes cutting-edge advances and challenges in engineering amyloid peptide nanomaterials.
APPLIED MATERIALS TODAY
(2021)
Article
Engineering, Biomedical
Hao Zhang, Zhilong Wang, Tongxin Gao, Zhongyan Wang, Chunhua Ren, Jianfeng Liu
Summary: By using an in situ enzyme-instructed self-assembly system, the targeted inhibition of lactate efflux and consumption was achieved, inducing tumor acidosis apoptosis for cancer selective therapy.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Physical
Zsombor Miskolczy, Monika Megyesi, Gyorgy Lendvay, Laszlo Biczok
Summary: The self-association of three biologically active natural quaternary benzo[c]phenanthridine alkaloids, nitidine, sanguinarine, and chelerythrine, was studied. Nitidine showed changes in fluorescence properties and enthalpy-controlled self-binding. Nitidine dimerization was the most exothermic process with an equilibrium constant about 5 times higher than the other two alkaloids. The results of quantum chemical calculations were in agreement with experimental data and provided information on the structural features of the dimers.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
Jing Sun, Julian Vogel, Lisa Chen, A. Lennart Schleper, Tim Bergner, Alexander J. C. Kuehne, Max von Delius
Summary: In this study, we synthesized ribose- and ribonucleotide-based amphiphiles and investigated their self-assembly and reactivity. We found that these amphiphiles can form various types of aggregates with aggregation-induced emission properties in both solution and solid state. Additionally, we discovered that the addition of a specific reagent can promote rapid dimerization of the amphiphiles, reducing their critical aggregation concentration. These findings may have implications for simulating the formation of primitive compartments under prebiotic conditions.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Anouk Martin, Pierre Lalanne, Amelie Weber-Vax, Angela Mutschler, Sebastien Lecommandoux
Summary: The self-assembly of PEG-b-PTMC copolymers into vesicles, also known as polymersomes, was evaluated using microfluidic systems. Two microfluidic chips with different flow regimes were used to investigate the impact of process conditions on vesicle formation. A solvent exchange approach was developed to allow direct use of the polymersomes in biological evaluation. The size of the polymersomes was influenced by the total flow rate and copolymer concentration, but not by the organic/aqueous solvent ratio.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Zhen Zou, Libei He, Xiangxi Deng, Huangxiang Wang, Ziyun Huang, Qian Xue, Zhihe Qing, Yanli Lei, Ronghua Yang, Juewen Liu
Summary: The study reports the formation of Zn2+-driven RNA self-assembly forming spherical nanoparticles, while preserving the integrity and biological function of RNA, with excellent RNA-loading efficiency, pharmacokinetics, and bioavailability.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Jiaguo Huang, Shiyun Xian, Yi Liu, Xiaona Chen, Kanyi Pu, Hangxiang Wang
Summary: A new activatable polymeric nanoprobe (APN(SO)) for real-time in vivo near-infrared fluorescence imaging and urinalysis of hepatic ischemia-reperfusion injury (IRI) is reported, which can detect IRI at least 7 hours earlier than typical clinical assays in a mouse model.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Physical
Xinting Han, Lulu Ren, Yan Ma, Xiao Gong, Hangxiang Wang
Summary: In this study, a self-repairing superhydrophobic coating with good anti-corrosion and photothermal properties was fabricated by the spaying method. The coating exhibited excellent corrosion resistance and was capable of self-repairing under sunlight. This research provides a new idea for the application of superhydrophobic coatings.
Article
Chemistry, Physical
Jiaguo Huang, Xiaona Chen, Yuyan Jiang, Chi Zhang, Shasha He, Hangxiang Wang, Kanyi Pu
Summary: This study develops activatable polyfluorophore nanosensors that can react with disease-associated proteases to produce fluorescent signals for non-invasive disease diagnosis. These nanosensors show promising results in detecting tumors and diagnosing acute liver allograft rejection in rodent models.
Article
Nanoscience & Nanotechnology
X. Shi, L. Shu, Y. Qiao, J. Yao, H. Xie, L. Zhou, H. Wang, S. Zheng
Summary: STAT3 is a key converging point of multiple oncogenic pathways and is constitutively activated in various cancer cells. Stattic, a selective inhibitor of STAT3, has shown promising potential for targeted cancer therapy and has been formulated in nanoparticles to enhance its therapeutic effects against tumor growth and metastasis.
MATERIALS TODAY NANO
(2022)
Correction
Chemistry, Multidisciplinary
Qiong Bian, Lingling Huang, Yihua Xu, Ruxuan Wang, Yueting Gu, Anran Yuan, Xiaolu Ma, Jingyi Hu, Yuefeng Rao, Donghang Xu, Hangxiang Wang, Jianqing Gao
Article
Nanoscience & Nanotechnology
Xiao Gong, Zheng Xiong, Xiaona Chen, Fanchao Meng, Hangxiang Wang
Summary: A facile method is reported to prepare multifunctional cotton fabrics with high flame retardancy, high electrical conductivity, superamphiphobicity, and high electromagnetic shielding. This was achieved by modifying the cotton fabric surface with phytic acid, coating with tannic acid and 3-aminopropyltriethoxysilane, and reducing the surface energy with fluorine-containing molecules. The resulting composite cotton fabric exhibited excellent properties in all these aspects.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Kangkang Ying, Yifeng Zhu, Jianqin Wan, Chenyue Zhan, Yuchen Wang, Binbin Xie, Peirong Xu, Hongming Pan, Hangxiang Wang
Summary: This study describes a novel therapeutic strategy that utilizes polymeric prodrug design and cell membrane cloaking to create a highly effective and low-toxicity treatment. In animal model experiments, this biomimetic therapy exhibited a higher level of tumor accumulation and effectively suppressed tumor growth and metastasis.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Physical
Xiao Gong, Qingqing Xu, Xiaona Chen, Fanchao Meng, Hangxiang Wang
Summary: This paper reports the synthesis of carbon nanodots that can efficiently absorb UV and high-energy blue light. These carbon nanodots can be easily synthesized in large scale and embedded in cellulose films, resulting in ultrahigh efficient UV and blue light shielding with guaranteed visible light transmission rate.
Article
Pharmacology & Pharmacy
Shiyun Xian, Jiabin Zhu, Yuchen Wang, Haihan Song, Hangxiang Wang
Summary: This study developed an oral liposome called budsomes to deliver the anti-inflammatory drug budesonide for the treatment of inflammatory bowel disease (IBD). The budsomes showed high stability in the stomach and released active budesonide after accumulation in inflamed intestinal tissues. Compared to free budesonide treatment, budsomes exhibited higher therapeutic efficiency and induced remission of acute colitis without adverse side effects.
Article
Multidisciplinary Sciences
Jianqin Wan, Lulu Ren, Xiaoyan Li, Shasha He, Yang Fu, Peirong Xu, Fanchao Meng, Shiyun Xian, Kanyi Pu, Hangxiang Wang
Summary: A photoactivatable toll-like receptor 7/8 (TLR7/8) nanoagonist system is developed to induce near-infrared light-induced immunogenic cell death (ICD) in dying tumor cells and release a potent immunoadjuvant. In mouse models, this system effectively eliminates tumors, suppresses tumor recurrence and metastasis, and activates tumor-specific T cells. This study provides a simple and cost-effective approach to generate in situ cancer vaccines for the photodynamic immunotherapy of metastatic cancers.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Xiaowei Shi, Liwei Shu, Minwen Wang, Jie Yao, Qigu Yao, Suchen Bian, Xiaona Chen, Jianqin Wan, Fu Zhang, Shusen Zheng, Hangxiang Wang
Summary: Immune checkpoint blockade therapies have made a significant impact on cancer treatment, but many patients do not respond to these therapies. Researchers have developed a combination chemoimmunotherapy nanosystem that includes a gemcitabine prodrug nanoparticle decorated with an anti-PD-L1 antibody and a STING agonist. This nanosystem enhances drug delivery to ICB-refractory tumors, activates CD8+ T cell responses, and transforms low-immunogenic tumors into inflamed tumors. In multiple mouse tumor models, the triple-combination nanovesicles induce a strong antitumor immune response and result in regression of large tumors and reduction in metastatic burden. These findings provide a basis for developing chemoimmunotherapeutic strategies for treating ICB-nonresponsive tumors.
Article
Multidisciplinary Sciences
Xiaona Chen, Fanchao Meng, Yiting Xu, Tongyu Li, Xiaolong Chen, Hangxiang Wang
Summary: The authors developed esterase-activatable pro-drugs based on STING agonist MSA-2 that are incorporated into liposomal vesicles for targeted intravenous administration. These pro-drugs, delivered via liposomes (SAProsomes), show enhanced pharmacokinetic properties and immune stimulatory capacity. The best candidate, SAProsome-3, effectively stimulates secretion of inflammatory cytokines and creates a tumoricidal immune landscape, leading to durable remission and decreased metastatic burden in breast cancer and melanoma mouse models.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Jian Wang, Peirong Xu, Yeyong Zhang, Shuai Han, Gongteng Wang, Hangxiang Wang, Haihan Song, Shufeng Li
Summary: The study develops injectable anticancer nanoassemblies through self-assembly technique, which exhibit tumor-restricted pharmacology and can be self-activated without exogenous stimuli. The anticancer agent cabazitaxel is covalently dimerized to form the prodrug diCTX, which is further coassembled with an ROS generator diDHA. The refined nanoparticles show durable antitumor efficacy in a preclinical model and lower toxicity compared to free drug combinations, suggesting great potential for clinical translation.
Article
Medicine, General & Internal
Zhentao Yang, Haiyang Xie, Jianqin Wan, Yuchen Wang, Liang Zhang, Ke Zhou, Hong Tang, Wentao Zhao, Hangxiang Wang, Penghong Song, Shusen Zheng
Summary: A nanotherapeutic strategy was developed to deliver rapamycin and 7-ethyl-10-hydroxycamptothecin in a nanoparticle, which exhibited synergistic effects against hepatocellular carcinoma and alleviated drug resistance.
Article
Engineering, Biomedical
Tongyu Li, Weiwei Shi, Jie Yao, Jingyun Hu, Qiong Sun, Jing Meng, Jian Wan, Haihan Song, Hangxiang Wang
Summary: This study presents a strategy to integrate multiple structurally disparate drugs into a self-assembling nanococktail platform. In vitro and in vivo assays demonstrate that this nanococktail therapy can effectively mitigate chemoresistance and improve the therapeutic efficacy in lung cancer. The findings suggest the potential of this approach in synergistically treating chemoresistant cancers.
BIOMATERIALS RESEARCH
(2022)