Roles of CCL2-CCR2 Axis in the Tumor Microenvironment

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Does C-C Motif Chemokine Ligand 2 (CCL2) Link Obesity to a Pro-Inflammatory State?

(2021) Sebastian Dommel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phase I dose‐escalation trial to repurpose propagermanium, an oral CCL2 inhibitor, in patients with breast cancer

(2020) Takaaki Masuda et al.   CANCER SCIENCE

Tumor Microenvironment

(2020) Borros Arneth   Medicina-Lithuania

CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis

(2020) Hui Yang et al.   Molecular Cancer

Cancer-associated fibroblasts promote immunosuppression by inducing ROS-generating monocytic MDSCs in lung squamous cell carcinoma

(2020) Handan Xiang et al.   Cancer Immunology Research

Tumor-Associated Macrophages Induce Migration of Renal Cell Carcinoma Cells via Activation of the CCL20-CCR6 Axis

(2020) Suguru Kadomoto et al.   Cancers

Schwann Cell-Derived CCL2 Promotes the Perineural Invasion of Cervical Cancer

(2020) Ting Huang et al.   Frontiers in Oncology

CCL2/CCR2 signaling in cancer pathogenesis

(2020) Qiongyu Hao et al.   Cell Communication and Signaling

Metastasis-associated fibroblasts promote angiogenesis in metastasized pancreatic cancer via the CXCL8 and the CCL2 axes

(2020) Thomas M. Pausch et al.   Scientific Reports

Chemokines and chemokine receptors: A new strategy for breast cancer therapy

(2020) Hui Liu et al.   Cancer Medicine

Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer

(2020) Pranabananda Dutta et al.   Cancers

Myeloid-derived suppressor cells are essential partners for immune checkpoint inhibitors in the treatment of cisplatin-resistant bladder cancer

(2020) Yuji Takeyama et al.   CANCER LETTERS

Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma

(2020) Kayla J Steinberger et al.   Cancer Prevention Research

The CCL20-CCR6 Axis in Cancer Progression

(2020) Suguru Kadomoto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting tumor cell-derived CCL2 as a strategy to overcome Bevacizumab resistance in ETV5+ colorectal cancer

(2020) Haoran Feng et al.   Cell Death & Disease

Is the C-C Motif Ligand 2–C-C Chemokine Receptor 2 Axis a Promising Target for Cancer Therapy and Diagnosis?

(2020) Hiroaki Iwamoto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bladder Cancer

(2020) Andrew T. Lenis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhibition of the CCL2 receptor, CCR2, enhances tumor response to immune checkpoint therapy

(2020) Megan M. Tu et al.   Communications Biology

Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma

(2019) Brian I. Rini et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fibroblast activation protein-positive fibroblasts promote tumor progression through secretion of CCL2 and interleukin-6 in esophageal squamous cell carcinoma

(2019) Nobuhide Higashino et al.   LABORATORY INVESTIGATION

Tumor-associated macrophages modulate resistance to oxaliplatin via inducing autophagy in hepatocellular carcinoma

(2019) Xiu-Tao Fu et al.   Cancer Cell International

Treatment of Advanced Prostate Cancer

(2019) Min Yuen Teo et al.   Annual Review of Medicine

Regulatory T (Treg) cells in cancer: can Treg cells be a new therapeutic target?

(2019) Yoshihiro Ohue et al.   CANCER SCIENCE

Targeting Tumor-Associated Macrophages in Cancer

(2019) Paulina Pathria et al.   TRENDS IN IMMUNOLOGY

Suppressive Role of Androgen/Androgen Receptor Signaling via Chemokines on Prostate Cancer Cells

(2019) Kouji Izumi et al.   Journal of Clinical Medicine

Targeting Treg cells in cancer immunotherapy

(2019) Atsushi Tanaka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Promotion of tumor-associated macrophages infiltration by elevated neddylation pathway via NF-κB-CCL2 signaling in lung cancer

(2019) Lisha Zhou et al.   ONCOGENE

Regulation of CCL2 expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA

(2019) Nadiya Khyzha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCL2 secreted from cancer-associated mesothelial cells promotes peritoneal metastasis of ovarian cancer cells through the P38-MAPK pathway

(2019) Hiroaki Yasui et al.   CLINICAL & EXPERIMENTAL METASTASIS

Non–Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment

(2019) Narjust Duma et al.   MAYO CLINIC PROCEEDINGS

Hedgehog signaling promotes tumor-associated macrophage polarization to suppress intratumoral CD8+ T cell recruitment

(2019) Amy J. Petty et al.   JOURNAL OF CLINICAL INVESTIGATION

Colorectal cancer

(2019) Evelien Dekker et al.   LANCET

MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis

(2019) Chaoyang Sun et al.   ONCOGENE

The global burden of urinary bladder cancer: an update

(2019) Anke Richters et al.   WORLD JOURNAL OF UROLOGY

PIPKIγ Regulates CCL2 Expression in Colorectal Cancer by Activating AKT-STAT3 Signaling

(2019) JunLi Xue et al.   Journal of Immunology Research

Interleukin‐33‐nuclear factor‐κB‐CCL2 signaling pathway promotes progression of esophageal squamous cell carcinoma by directing regulatory T cells

(2019) Ying Yue et al.   CANCER SCIENCE

Myeloid-Derived Suppressor Cells: Major Figures that Shape the Immunosuppressive and Angiogenic Network in Cancer

(2019) Eleni-Kyriaki Vetsika et al.   Cells

Androgen deprivation therapy-induced epithelial-mesenchymal transition of prostate cancer through downregulating SPDEF and activating CCL2

(2018) Yuan-Chin Tsai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MCP-1 is overexpressed in triple-negative breast cancers and drives cancer invasiveness and metastasis

(2018) Pranabananda Dutta et al.   BREAST CANCER RESEARCH AND TREATMENT

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally?

(2018) Teizo Yoshimura   Cellular & Molecular Immunology

Cancer-associated fibroblasts in tumor microenvironment – Accomplices in tumor malignancy

(2018) Zehuan Liao et al.   CELLULAR IMMUNOLOGY

Implications of macrophage polarization in autoimmunity

(2018) Samanta C. Funes et al.   IMMUNOLOGY

Resistance to Anti-Angiogenic Therapy in Cancer—Alterations to Anti-VEGF Pathway

(2018) Yoshiro Itatani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211): a multicentre, open-label, phase 3 randomised controlled trial

(2018) Thomas Powles et al.   LANCET

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma

(2018) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

CCL2 influences the sensitivity of lung cancer A549 cells to docetaxel

(2018) Ting Wang et al.   Oncology Letters

The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma

(2018) Irene Soncin et al.   Nature Communications

LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment

(2018) Changhao Chen et al.   Nature Communications

Myeloid-derived suppressor cell accumulation in renal cell carcinoma is correlated with CCL2, IL-17 and IL-18 expression in blood and tumors

(2018) XIAODONG GUAN et al.   Advances in Clinical and Experimental Medicine

CCL2 induces resistance to the antiproliferative effect of cabazitaxel in prostate cancer cells

(2018) Ariunbold Natsagdorj et al.   CANCER SCIENCE

Monocytes in rheumatoid arthritis: Circulating precursors of macrophages and osteoclasts and, their heterogeneity and plasticity role in RA pathogenesis

(2018) Amit Kumar Rana et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chemokines and Chemokine Receptors: Orchestrating Tumor Metastasization

(2018) Elisabetta Marcuzzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Tumor-associated macrophages: implications in cancer immunotherapy

(2017) Amy J Petty et al.   Immunotherapy

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Breast cancer

(2017) Nadia Harbeck et al.   LANCET

Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma

(2017) Joaquim Bellmunt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Type Iγ phosphatidylinositol phosphate kinase regulates PD-L1 expression by activating NF-κB

(2017) Junli Xue et al.   Oncotarget

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

Macropinocytosis of Nab-paclitaxel Drives Macrophage Activation in Pancreatic Cancer

(2017) Jane Cullis et al.   Cancer Immunology Research

A brief look at the role of monocyte chemoattractant protein-1 (CCL2) in the pathophysiology of psoriasis

(2017) Shadi Behfar et al.   CYTOKINE

Treatment Outcome of Low-dose Interleukin-2 Therapy in Patients with Metastatic Renal Cell Carcinoma

(2016) YUTA TAKEZAWA et al.   ANTICANCER RESEARCH

Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways

(2016) Jiao Liu et al.   CANCER LETTERS

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

(2016) Alan L. Chang et al.   CANCER RESEARCH

FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling

(2016) Xuguang Yang et al.   CANCER RESEARCH

Heterogeneous Stromal Signaling within the Tumor Microenvironment Controls the Metastasis of Pancreatic Cancer

(2016) Agnieszka A. Rucki et al.   CANCER RESEARCH

Myeloid-Derived Suppressor Cell Subset Accumulation in Renal Cell Carcinoma Parenchyma Is Associated with Intratumoral Expression of IL1β, IL8, CXCL5, and Mip-1α

(2016) Yana G. Najjar et al.   CLINICAL CANCER RESEARCH

Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial

(2016) Roy S Herbst et al.   LANCET

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial

(2016) Timothy M Nywening et al.   LANCET ONCOLOGY

Identification of an atypical monocyte and committed progenitor involved in fibrosis

(2016) Takashi Satoh et al.   NATURE

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

CCL2/CCR2 axis is associated with postoperative survival and recurrence of patients with non-metastatic clear-cell renal cell carcinoma

(2016) Zewei Wang et al.   Oncotarget

Targeting the CCL2-CCR2 signaling axis in cancer metastasis

(2016) Su Yin Lim et al.   Oncotarget

CCL2 as a potential therapeutic target for clear cell renal cell carcinoma

(2016) Ryuichiro Arakaki et al.   Cancer Medicine

The Role of Myeloid-Derived Suppressor Cells in Patients with Solid Tumors: A Meta-Analysis

(2016) Shuo Zhang et al.   PLoS One

wRAPping Up Early Monocyte and Neutrophil Recruitment in Atherogenesis via AnnexinA1/FPR2 Signaling

(2015) M. J. Butcher et al.   CIRCULATION RESEARCH

Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients

(2015) K. Kurose et al.   CLINICAL CANCER RESEARCH

CCL2-CCR2 Signaling in Disease Pathogenesis

(2015) Tracy O’Connor et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

The Chemokine CCL2 Increases Prostate Tumor Growth and Bone Metastasis through Macrophage and Osteoclast Recruitment

(2015) Kosuke Mizutani et al.   NEOPLASIA

Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

(2014) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

Macrophage Polarization in Inflammatory Diseases

(2014) Yan-Cun Liu et al.   International Journal of Biological Sciences

CCL2 Shapes Macrophage Polarization by GM-CSF and M-CSF: Identification of CCL2/CCR2-Dependent Gene Expression Profile

(2014) E. Sierra-Filardi et al.   JOURNAL OF IMMUNOLOGY

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

(2014) Theerawut Chanmee et al.   Cancers

Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases

(2013) Shambhunath Bose et al.   ARCHIVES OF PHARMACAL RESEARCH

Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis

(2013) D. E. Sanford et al.   CLINICAL CANCER RESEARCH

Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2-induced STAT3 activation

(2013) Kouji Izumi et al.   EMBO Molecular Medicine

Host immunity contributes to the anti-melanoma activity of BRAF inhibitors

(2013) Deborah A. Knight et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating Fibrocytes Prepare the Lung for Cancer Metastasis by Recruiting Ly-6C+ Monocytes Via CCL2

(2013) H. W. van Deventer et al.   JOURNAL OF IMMUNOLOGY

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Autocrine CCL2 promotes cell migration and invasion via PKC activation and tyrosine phosphorylation of paxillin in bladder cancer cells

(2012) Hsiao-Ying Chiu et al.   CYTOKINE

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer

(2012) Kenneth J. Pienta et al.   INVESTIGATIONAL NEW DRUGS

CCL2/CCR2 Chemokine Signaling Coordinates Survival and Motility of Breast Cancer Cells through Smad3 Protein- and p42/44 Mitogen-activated Protein Kinase (MAPK)-dependent Mechanisms

(2012) Wei Bin Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiogenesis and immunity: a bidirectional link potentially relevant for the monitoring of antiangiogenic therapy and the development of novel therapeutic combination with immunotherapy

(2011) Eric Tartour et al.   CANCER AND METASTASIS REVIEWS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Pancreatic cancer

(2011) Audrey Vincent et al.   LANCET

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity

(2010) Suzanne Ostrand-Rosenberg   CANCER IMMUNOLOGY IMMUNOTHERAPY

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemokines and chemokine receptors: new insights into cancer-related inflammation

(2010) Gwendal Lazennec et al.   TRENDS IN MOLECULAR MEDICINE

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL