Extracellular Vesicles in Blood: Sources, Effects, and Applications

Extracellular Vesicles and Exosomes: Insights From Exercise Science

(2021) Joshua P. Nederveen et al.   Frontiers in Physiology

Extracellular vesicle microRNA in early versus late pregnancy with birth outcomes in the MADRES study

(2021) Caitlin G Howe et al.   Epigenetics

A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos

(2021) Stephanie Rankin-Turner et al.   ADVANCED DRUG DELIVERY REVIEWS

Cellular senescence contributes to age‐dependent changes in circulating extracellular vesicle cargo and function

(2020) Faisal J. Alibhai et al.   AGING CELL

Protein Profile Changes in Circulating Placental Extracellular Vesicles in Term and Preterm Births: A Longitudinal Study

(2020) Ramkumar Menon et al.   ENDOCRINOLOGY

Unique microRNA Signals in Plasma Exosomes from Pregnancies Complicated by Preeclampsia

(2020) Hui Li et al.   HYPERTENSION

Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson’s Disease: Results from the EXosomes in PArkiNson’s Disease (EXPAND) Study

(2020) Anna Picca et al.   Journal of Clinical Medicine

MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments

(2020) Joshua A. Welsh et al.   Journal of Extracellular Vesicles

Extracellular Vesicles in Feto–Maternal Crosstalk and Pregnancy Disorders

(2020) Danilo Buca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19

(2020) Vikram Sengupta et al.   STEM CELLS AND DEVELOPMENT

Natural-Killer-Derived Extracellular Vesicles: Immune Sensors and Interactors

(2020) Cristina Federici et al.   Frontiers in Immunology

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

(2020) Ayuko Hoshino et al.   CELL

Synaptic and complement markers in extracellular vesicles in multiple sclerosis

(2020) Pavan Bhargava et al.   Multiple Sclerosis Journal

Plasma exosomes characterization reveals a perioperative protein signature in older patients undergoing different types of on-pump cardiac surgery

(2020) Alessandro Carrozzo et al.   GeroScience

Expression Analysis of Muscle-Specific miRNAs in Plasma-Derived Extracellular Vesicles from Patients with Chronic Obstructive Pulmonary Disease

(2020) Sara Carpi et al.   Diagnostics

Measuring Extracellular Vesicles by Conventional Flow Cytometry: Dream or Reality?

(2020) Donatella Lucchetti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Natural IgM antibodies inhibit microvesicle-driven coagulation and thrombosis

(2020) Georg Obermayer et al.   BLOOD

Delivery of muscle-derived exosomal miRNAs induced by HIIT improves insulin sensitivity through down-regulation of hepatic FoxO1 in mice

(2020) Carlos Castaño et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MiR-124 Enriched Exosomes Promoted the M2 Polarization of Microglia and Enhanced Hippocampus Neurogenesis After Traumatic Brain Injury by Inhibiting TLR4 Pathway

(2019) Yongxiang Yang et al.   NEUROCHEMICAL RESEARCH

Microvesicles from human adipose stem cells promote wound healing by optimizing cellular functions via AKT and ERK signaling pathways

(2019) Sen Ren et al.   Stem Cell Research & Therapy

Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition

(2019) Carine Z. J. Lim et al.   Nature Communications

Blockage of transferred exosome‐shuttled miR‐494 inhibits melanoma growth and metastasis

(2019) Jingjing Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Extracellular Vesicles Long RNA Sequencing Reveals Abundant mRNA, circRNA, and lncRNA in Human Blood as Potential Biomarkers for Cancer Diagnosis

(2019) Yuchen Li et al.   CLINICAL CHEMISTRY

Longterm Exercise-Derived Exosomal miR-342-5p: A Novel Exerkine for Cardioprotection

(2019) Zuoxu Hou et al.   CIRCULATION RESEARCH

Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

(2019) Sadanand Fulzele et al.   Aging-US

Manufacturing and characterization of extracellular vesicles from umbilical cord–derived mesenchymal stromal cells for clinical testing

(2019) Eva Rohde et al.   CYTOTHERAPY

Extracellular Vesicle as a Source of Alzheimer’s Biomarkers: Opportunities and Challenges

(2019) Seongju Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Involvement of Extracellular Vesicles in Vascular-Related Functions in Cancer Progression and Metastasis

(2019) Shinsuke Kikuchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

New windows into the brain: Central nervous system-derived extracellular vesicles in blood

(2019) Min Shi et al.   PROGRESS IN NEUROBIOLOGY

Advances in therapeutic applications of extracellular vesicles

(2019) Oscar P. B. Wiklander et al.   Science Translational Medicine

Plasma‑derived exosomal miR‑183 associates with protein kinase activity and may serve as a novel predictive biomarker of myocardial ischemic injury

(2019) Xingxing Zhao et al.   Experimental and Therapeutic Medicine

Differences in the cargos and functions of exosomes derived from six cardiac cell types: a systematic review

(2019) Ming-yue Xu et al.   Stem Cell Research & Therapy

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

The Role of Extracellular Vesicles in Viral Infection and Transmission

(2019) Lorena Urbanelli et al.   Vaccines

T cells and immune functions of plasma extracellular vesicles are differentially modulated from adults to centenarians

(2019) Ainhoa Alberro et al.   Aging-US

Analyzing bacterial extracellular vesicles in human body fluids by orthogonal biophysical separation and biochemical characterization

(2019) Joeri Tulkens et al.   Nature Protocols

Serum Small Extracellular Vesicles Proteome of Tuberculosis Patients Demonstrated Deregulated Immune Response

(2019) Rakesh Arya et al.   Proteomics Clinical Applications

Involvement of serum-derived exosomes of elderly patients with bone loss in failure of bone remodeling via alteration of exosomal bone-related proteins

(2018) Yong Xie et al.   AGING CELL

Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells

(2018) Marthe F.S. Lindenbergh et al.   Annual Review of Immunology

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise

(2018) Martin Whitham et al.   Cell Metabolism

Dissecting the biochemical architecture and morphological release pathways of the human platelet extracellular vesiculome

(2018) Silvia H. De Paoli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

New Technologies for Analysis of Extracellular Vesicles

(2018) Huilin Shao et al.   CHEMICAL REVIEWS

Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance

(2018) Weikan Wang et al.   FASEB JOURNAL

In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation

(2018) Jing Jing Li et al.   Journal of Neuroinflammation

Standardization of extracellular vesicle measurements by flow cytometry through vesicle diameter approximation

(2018) E. van der Pol et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Absolute sizing and label-free identification of extracellular vesicles by flow cytometry

(2018) Edwin van der Pol et al.   Nanomedicine-Nanotechnology Biology and Medicine

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extracellular vesicles induce protective immunity against Trichuris muris

(2018) R. K. Shears et al.   PARASITE IMMUNOLOGY

The role of extracellular vesicles when innate meets adaptive

(2018) Tom Groot Kormelink et al.   Seminars in Immunopathology

Plasma exosomes induced by remote ischaemic preconditioning attenuate myocardial ischaemia/reperfusion injury by transferring miR-24

(2018) Wen Minghua et al.   Cell Death & Disease

Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy

(2018) Sukrutha Chettimada et al.   Scientific Reports

Differential Interaction of Platelet-Derived Extracellular Vesicles with Leukocyte Subsets in Human Whole Blood

(2018) René Weiss et al.   Scientific Reports

Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures

(2018) Oscar P. B. Wiklander et al.   Frontiers in Immunology

The First Dose of Fingolimod Affects Circulating Extracellular Vesicles in Multiple Sclerosis Patients

(2018) Matías Sáenz-Cuesta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction

(2018) Joeri Tulkens et al.   GUT

Therapeutic Potential of Extracellular Vesicles for Demyelinating Diseases; Challenges and Opportunities

(2018) Iñaki Osorio-Querejeta et al.   Frontiers in Molecular Neuroscience

Rheumatoid Arthritis Patients With Circulating Extracellular Vesicles Positive for IgM Rheumatoid Factor Have Higher Disease Activity

(2018) Onno J. Arntz et al.   Frontiers in Immunology

Exosome levels in human body fluids: A tumor marker by themselves?

(2017) Francesco Cappello et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Manufacturing of Human Extracellular Vesicle-Based Therapeutics for Clinical Use

(2017) Mario Gimona et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases

(2017) David Rufino-Ramos et al.   JOURNAL OF CONTROLLED RELEASE

Plasma-derived exosomes contribute to inflammation via the TLR9-NF-κB pathway in chronic heart failure patients

(2017) Wei Ye et al.   MOLECULAR IMMUNOLOGY

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes

(2017) Shengli Li et al.   NUCLEIC ACIDS RESEARCH

Isolation of exosomes from whole blood by integrating acoustics and microfluidics

(2017) Mengxi Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy

(2017) Katherine S. Yang et al.   Science Translational Medicine

Progress in Exosome Isolation Techniques

(2017) Pin Li et al.   Theranostics

The ESCRT-III pathway facilitates cardiomyocyte release of cBIN1-containing microparticles

(2017) Bing Xu et al.   PLOS BIOLOGY

Exosomes and Metabolic Function in Mice Exposed to Alternating Dark-Light Cycles Mimicking Night Shift Work Schedules

(2017) Abdelnaby Khalyfa et al.   Frontiers in Physiology

Endothelial Extracellular Vesicles—Promises and Challenges

(2017) Carina Hromada et al.   Frontiers in Physiology

Second generation multiple reaction monitoring assays for enhanced detection of ultra-low abundance Mycobacterium tuberculosis peptides in human serum

(2017) Carolina Mehaffy et al.   Clinical Proteomics

Nanoplasmonic quantification of tumour-derived extracellular vesicles in plasma microsamples for diagnosis and treatment monitoring

(2017) Kai Liang et al.   Nature Biomedical Engineering

Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes

(2017) Erez Eitan et al.   Scientific Reports

Plasma exosomal miR-223 expression regulates inflammatory responses during cardiac surgery with cardiopulmonary bypass

(2017) Kin-Shing Poon et al.   Scientific Reports

Extracellular vesicles for drug delivery

(2016) Pieter Vader et al.   ADVANCED DRUG DELIVERY REVIEWS

Vesicular Galectin-3 levels decrease with donor age and contribute to the reduced osteo-inductive potential of human plasma derived extracellular vesicles

(2016) Sylvia Weilner et al.   Aging-US

Peripheral blood microvesicles secretion is influenced by storage time, temperature, and anticoagulants

(2016) Lukas Wisgrill et al.   CYTOMETRY PART A

Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

High levels of circulating extracellular vesicles with altered expression and function during pregnancy

(2016) Fabiola da Silva Nardi et al.   IMMUNOBIOLOGY

Subcutaneous injection of exosomes reduces symptom severity and mortality induced by Echinostoma caproni infection in BALB/c mice

(2016) Maria Trelis et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress

(2016) Akiko Eguchi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Plasma levels of endothelial and B-cell-derived microparticles are restored by fingolimod treatment in multiple sclerosis patients

(2016) Anna Zinger et al.   Multiple Sclerosis Journal

Increased levels of circulating platelet derived microparticles in Crohn's disease patients

(2016) Georgios Tziatzios et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Plasma levels of endothelial and B-cell-derived microparticles are restored by fingolimod treatment in multiple sclerosis patients

(2016) Anna Zinger et al.   Multiple Sclerosis Journal

Coronary Artery-Bypass-Graft Surgery Increases the Plasma Concentration of Exosomes Carrying a Cargo of Cardiac MicroRNAs: An Example of Exosome Trafficking Out of the Human Heart with Potential for Cardiac Biomarker Discovery

(2016) Costanza Emanueli et al.   PLoS One

Combining Exosomes Derived from Immature DCs with Donor Antigen-Specific Treg Cells Induces Tolerance in a Rat Liver Allograft Model

(2016) Ben Ma et al.   Scientific Reports

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Extracellular vesicles shuffling intercellular messages: for good or for bad

(2015) Alessandra Lo Cicero et al.   CURRENT OPINION IN CELL BIOLOGY

Fluorescence triggering: A general strategy for enumerating and phenotyping extracellular vesicles by flow cytometry

(2015) Nicolas Arraud et al.   CYTOMETRY PART A

Elevated Abundance, Size, and MicroRNA Content of Plasma Extracellular Vesicles in Viremic HIV-1+ Patients

(2015) Audrey Hubert et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Exosome secretion by eosinophils: A possible role in asthma pathogenesis

(2015) Carla Mazzeo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury

(2015) Jose M. Vicencio et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mast cells, basophils and B cell connection network

(2015) Sonia Merluzzi et al.   MOLECULAR IMMUNOLOGY

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

Age- and sex-specific differences in blood-borne microvesicles from apparently healthy humans

(2015) Callie M Gustafson et al.   Biology of Sex Differences

Methods for extracellular vesicles isolation in a hospital setting

(2015) Matías Sáenz-Cuesta   Frontiers in Immunology

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

(2015) Benjamin Besse et al.   OncoImmunology

Muscle Releases Alpha-Sarcoglycan Positive Extracellular Vesicles Carrying miRNAs in the Bloodstream

(2015) Michele Guescini et al.   PLoS One

Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

(2014) Min Shi et al.   ACTA NEUROPATHOLOGICA

Adiponectin is partially associated with exosomes in mouse serum

(2014) Worrawalan Phoonsawat et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circulating microparticles reflect treatment effects and clinical status in multiple sclerosis

(2014) Matías Sáenz-Cuesta et al.   Biomarkers in Medicine

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Benchtop isolation and characterization of functional exosomes by sequential filtration

(2014) Mitja L. Heinemann et al.   JOURNAL OF CHROMATOGRAPHY A

Quantitative Proteomics of Extracellular Vesicles Released from Human Monocyte-Derived Macrophages upon β-Glucan Stimulation

(2014) Wojciech Cypryk et al.   JOURNAL OF PROTEOME RESEARCH

Extracellular vesicles from blood plasma: determination of their morphology, size, phenotype and concentration

(2014) N. Arraud et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy

(2014) Suchismita Sarker et al.   Journal of Translational Medicine

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

(2014) J. Mark Cooper et al.   MOVEMENT DISORDERS

A Gestational Profile of Placental Exosomes in Maternal Plasma and Their Effects on Endothelial Cell Migration

(2014) Carlos Salomon et al.   PLoS One

Circulating Extracellular Vesicles with Specific Proteome and Liver MicroRNAs Are Potential Biomarkers for Liver Injury in Experimental Fatty Liver Disease

(2014) Davide Povero et al.   PLoS One

Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets

(2014) Annika Pienimaeki-Roemer et al.   TRANSFUSION

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

MiR-34, SIRT1, and p53: The feedback loop

(2011) Munekazu Yamakuchi et al.   CELL CYCLE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation

(2010) Rumiko Ogawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circulating CD31+/Annexin V+ microparticles correlate with cardiovascular outcomes

(2010) J.-M. Sinning et al.   EUROPEAN HEART JOURNAL

Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration

(2010) Julia Esser et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exosomal-like vesicles with immune-modulatory features are present in human plasma and can induce CD4+ T-cell apoptosis in vitro

(2010) Yana Ren et al.   TRANSFUSION

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

(2008) Shengming Dai et al.   MOLECULAR THERAPY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

T Lymphocytes are Targets for Platelet- and Trophoblast-Derived Microvesicles During Pregnancy

(2008) E. Pap et al.   PLACENTA

Detection of microRNA Expression in Human Peripheral Blood Microvesicles

(2008) Melissa Piper Hunter et al.   PLoS One