The Role of Extracellular Vesicles in Viral Infection and Transmission

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Insight into the Role of Extracellular Vesicles in Lysosomal Storage Disorders

(2019) Brunella Tancini et al.   Genes

Extracellular Vesicles From KSHV-Infected Cells Stimulate Antiviral Immune Response Through Mitochondrial DNA

(2019) Hyungtaek Jeon et al.   Frontiers in Immunology

Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells

(2018) Marthe F.S. Lindenbergh et al.   Annual Review of Immunology

An Exosome-Based Vaccine Platform Imparts Cytotoxic T Lymphocyte Immunity Against Viral Antigens

(2018) Simona Anticoli et al.   Biotechnology Journal

Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer

(2018) Rahul Bhome et al.   CANCER LETTERS

Exosomes and Ectosomes in Intercellular Communication

(2018) Jacopo Meldolesi   CURRENT BIOLOGY

Extracellular Vesicles as Conveyors of Membrane-Derived Bioactive Lipids in Immune System

(2018) Krizia Sagini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer

(2018) Amrita Datta et al.   Scientific Reports

An Exosome-Based Vaccine Platform Imparts Cytotoxic T Lymphocyte Immunity Against Viral Antigens

(2018) Simona Anticoli et al.   Biotechnology Journal

Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris

(2018) Sarah Caruso et al.   Frontiers in Immunology

Herpesviruses and MicroRNAs: New Pathogenesis Factors in Oral Infection and Disease?

(2018) Afsar R. Naqvi et al.   Frontiers in Immunology

Oncogenic H-Ras Expression Induces Fatty Acid Profile Changes in Human Fibroblasts and Extracellular Vesicles

(2018) Krizia Sagini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells

(2018) Scott A. Hinger et al.   Cell Reports

Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis

(2017) Helena Costa Verdera et al.   JOURNAL OF CONTROLLED RELEASE

Herpesviruses hijack host exosomes for viral pathogenesis

(2017) Sara Sadeghipour et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Collective Infectious Units in Viruses

(2017) Rafael Sanjuán   TRENDS IN MICROBIOLOGY

Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling

(2017) Qiyu Wang et al.   Nature Communications

RNA in extracellular vesicles

(2017) Kyoung Mi Kim et al.   Wiley Interdisciplinary Reviews-RNA

Extracellular vesicles released by fibroblasts undergoing H-Ras induced senescence show changes in lipid profile

(2017) Sandra Buratta et al.   PLoS One

TAX1BP1 downregulation by EBV-miR-BART15-3p enhances chemosensitivity of gastric cancer cells to 5-FU

(2016) Hoyun Choi et al.   ARCHIVES OF VIROLOGY

Dendritic cell–derived exosomes for cancer therapy

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of chronic inflammatory and immune processes by extracellular vesicles

(2016) Paul D. Robbins et al.   JOURNAL OF CLINICAL INVESTIGATION

CD63 Regulates Epstein-Barr Virus LMP1 Exosomal Packaging, Enhancement of Vesicle Production, and Noncanonical NF-κB Signaling

(2016) Stephanie N. Hurwitz et al.   JOURNAL OF VIROLOGY

Extracellular Vesicles Exploit Viral Entry Routes for Cargo Delivery

(2016) Helena M. van Dongen et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Extracellular vesicles and viruses: Are they close relatives?

(2016) Esther Nolte-‘t Hoen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-H28 and miR-H29 expressed late in productive infection are exported and restrict HSV-1 replication and spread in recipient cells

(2016) Zhiyuan Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of microRNAs in the Pathogenesis of Herpesvirus Infection

(2016) Diogo Piedade et al.   Viruses-Basel

Extracellular Vesicles Including Exosomes Regulate Innate Immune Responses to Hepatitis B Virus Infection

(2016) Takahisa Kouwaki et al.   Frontiers in Immunology

Syntenin and syndecan in the biogenesis of exosomes

(2015) Véronique Friand et al.   BIOLOGY OF THE CELL

Extracellular vesicles shuffling intercellular messages: for good or for bad

(2015) Alessandra Lo Cicero et al.   CURRENT OPINION IN CELL BIOLOGY

ESCRTs are everywhere

(2015) J. H. Hurley   EMBO JOURNAL

The Nuclear DNA Sensor IFI16 Acts as a Restriction Factor for Human Papillomavirus Replication through Epigenetic Modifications of the Viral Promoters

(2015) Irene Lo Cigno et al.   JOURNAL OF VIROLOGY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Latent HIV-1 is activated by exosomes from cells infected with either replication-competent or defective HIV-1

(2015) Claudia Arenaccio et al.   Retrovirology

Viruses transfer the antiviral second messenger cGAMP between cells

(2015) A. Bridgeman et al.   SCIENCE

Transmission of innate immune signaling by packaging of cGAMP in viral particles

(2015) Matteo Gentili et al.   SCIENCE

Exosome Biogenesis, Regulation, and Function in Viral Infection

(2015) Marta Alenquer et al.   Viruses-Basel

Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function

(2015) Jian Zhang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Induction and transport of Wnt 5a during macrophage-induced malignant invasion is mediated by two types of extracellular vesicles

(2015) Kerstin Menck et al.   Oncotarget

EVpedia: a community web portal for extracellular vesicles research

(2014) D.-K. Kim et al.   BIOINFORMATICS

Exosomes and other extracellular vesicles in host-pathogen interactions

(2014) J. S. Schorey et al.   EMBO REPORTS

Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery

(2014) Tian Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytomegalovirus-Infected Human Endothelial Cells Can Stimulate Allogeneic CD4+ Memory T Cells by Releasing Antigenic Exosomes

(2014) J. D. Walker et al.   JOURNAL OF IMMUNOLOGY

Exosomes Derived from Burkitt's Lymphoma Cell Lines Induce Proliferation, Differentiation, and Class-Switch Recombination in B Cells

(2014) C. Gutzeit et al.   JOURNAL OF IMMUNOLOGY

Virion-Independent Transfer of Replication-Competent Hepatitis C Virus RNA between Permissive Cells

(2014) Andrea Longatti et al.   JOURNAL OF VIROLOGY

Exosomes from Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Cells License Quiescent CD4+ T Lymphocytes To Replicate HIV-1 through a Nef- and ADAM17-Dependent Mechanism

(2014) C. Arenaccio et al.   JOURNAL OF VIROLOGY

Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes

(2014) M Aga et al.   ONCOGENE

Epstein-Barr Virus-Encoded Small RNAs (EBERs) Are Present in Fractions Related to Exosomes Released by EBV-Transformed Cells

(2014) Waqar Ahmed et al.   PLoS One

Novel HIV-1 MiRNAs Stimulate TNFα Release in Human Macrophages via TLR8 Signaling Pathway

(2014) Mark A. Bernard et al.   PLoS One

Nef Neutralizes the Ability of Exosomes from CD4+ T Cells to Act as Decoys during HIV-1 Infection

(2014) Julianne V. de Carvalho et al.   PLoS One

Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs

(2014) Maria Kalamvoki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90

(2014) Terence N. Bukong et al.   PLoS Pathogens

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

(2013) Michel Record et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ALG-2-interacting Tubby-like protein superfamily member PLSCR3 is secreted by an exosomal pathway and taken up by recipient cultured cells

(2013) Tatsutoshi Inuzuka et al.   BIOSCIENCE REPORTS

Virus Budding and the ESCRT Pathway

(2013) Jörg Votteler et al.   Cell Host & Microbe

Exosomes Derived from HIV-1-infected Cells Contain Trans-activation Response Element RNA

(2013) Aarthi Narayanan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

(2013) Johnny C. Akers et al.   JOURNAL OF NEURO-ONCOLOGY

Constitutive Interferon-Inducible Protein 16-Inflammasome Activation during Epstein-Barr Virus Latency I, II, and III in B and Epithelial Cells

(2013) M. A. Ansari et al.   JOURNAL OF VIROLOGY

Exosomes Derived from Epstein-Barr Virus-Infected Cells Are Internalized via Caveola-Dependent Endocytosis and Promote Phenotypic Modulation in Target Cells

(2013) A. Nanbo et al.   JOURNAL OF VIROLOGY

Epstein-Barr Virus-Encoded MicroRNA BART15-3p Promotes Cell Apoptosis Partially by Targeting BRUCE

(2013) H. Choi et al.   JOURNAL OF VIROLOGY

Role of the Phosphatidylserine Receptor TIM-1 in Enveloped-Virus Entry

(2013) S. Moller-Tank et al.   JOURNAL OF VIROLOGY

Kaposi's Sarcoma-Associated Herpesvirus Latency in Endothelial and B Cells Activates Gamma Interferon-Inducible Protein 16-Mediated Inflammasomes

(2013) V. V. Singh et al.   JOURNAL OF VIROLOGY

Epstein-Barr Virus Encoded dUTPase Containing Exosomes Modulate Innate and Adaptive Immune Responses in Human Dendritic Cells and Peripheral Blood Mononuclear Cells

(2013) Maria Eugenia Ariza et al.   PLoS One

Human placental trophoblasts confer viral resistance to recipient cells

(2013) E. Delorme-Axford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells

(2013) V. Ramakrishnaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of B-cell exosome proteins by gamma herpesvirus infection

(2013) D. G. Meckes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hrs- and CD63-Dependent Competing Mechanisms Make Different Sized Endosomal Intraluminal Vesicles

(2013) James R. Edgar et al.   TRAFFIC

Viral Membrane Fusion and Nucleocapsid Delivery into the Cytoplasm are Distinct Events in Some Flaviviruses

(2013) Adel M. Nour et al.   PLoS Pathogens

Systemically Circulating Viral and Tumor-Derived MicroRNAs in KSHV-Associated Malignancies

(2013) Pauline E. Chugh et al.   PLoS Pathogens

Signaling Pathways in Exosomes Biogenesis, Secretion and Fate

(2013) Lorena Urbanelli et al.   Genes

Phospholipidomics reveals differences in glycerophosphoserine profiles of hypothermically stored red blood cells and microvesicles

(2012) Beatriz Bicalho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Short-Range Exosomal Transfer of Viral RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Innate Immunity

(2012) Marlène Dreux et al.   Cell Host & Microbe

Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers

(2012) C. D'Souza-Schorey et al.   GENES & DEVELOPMENT

Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1  Production

(2012) M. Haneklaus et al.   JOURNAL OF IMMUNOLOGY

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

(2012) Hina Kalra et al.   PLOS BIOLOGY

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

Interaction and uptake of exosomes by ovarian cancer cells

(2011) Cristina Escrevente et al.   BMC CANCER

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation

(2011) Frederik J Verweij et al.   EMBO JOURNAL

The cell biology of receptor-mediated virus entry

(2011) Joe Grove et al.   JOURNAL OF CELL BIOLOGY

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway

(2011) Keiichi Tamai et al.   VIROLOGY

Genetic Characterization of HIV Type 1 Nef-Induced Vesicle Secretion

(2010) Syed A. Ali et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV Type 1 Nef Is Released from Infected Cells in CD45+ Microvesicles and Is Present in the Plasma of HIV-Infected Individuals

(2010) A.D. Raymond et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Exosomes and retroviruses: the chicken or the egg?

(2010) Nuria Izquierdo-Useros et al.   CELLULAR MICROBIOLOGY

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

(2010) Arthit Chairoungdua et al.   JOURNAL OF CELL BIOLOGY

Exosomes Containing Glycoprotein 350 Released by EBV-Transformed B Cells Selectively Target B Cells through CD21 and Block EBV Infection In Vitro

(2010) H. Vallhov et al.   JOURNAL OF IMMUNOLOGY

Pivotal Advance: The promotion of soluble DC-SIGN release by inflammatory signals and its enhancement of cytomegalovirus-mediated cis -infection of myeloid dendritic cells

(2010) N. Plazolles et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human Ago2 Is Required for Efficient MicroRNA 122 Regulation of Hepatitis C Virus RNA Accumulation and Translation

(2010) J. A. Wilson et al.   JOURNAL OF VIROLOGY

HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription

(2010) Nanhai He et al.   MOLECULAR CELL

Human tumor virus utilizes exosomes for intercellular communication

(2010) D. G. Meckes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages

(2009) C. Barres et al.   BLOOD

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Novel MHC Class I Structures on Exosomes

(2009) S. Lynch et al.   JOURNAL OF IMMUNOLOGY

The Herpes Simplex Virus-1 Encoded Glycoprotein B Diverts HLA-DR into the Exosome Pathway

(2009) Sebastian Temme et al.   JOURNAL OF IMMUNOLOGY

HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits

(2009) Weifeng Xu et al.   NATURE IMMUNOLOGY

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

(2008) J. Klibi et al.   BLOOD

Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway

(2008) N. Izquierdo-Useros et al.   BLOOD

EBV MicroRNAs in Primary Lymphomas and Targeting of CXCL-11 by ebv-mir-BHRF1-3

(2008) T. Xia et al.   CANCER RESEARCH

Exosomes Packaging APOBEC3G Confer Human Immunodeficiency Virus Resistance to Recipient Cells

(2008) A. K. Khatua et al.   JOURNAL OF VIROLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

HIV-1 Nef Targets MHC-I and CD4 for Degradation Via a Final Common β-COP–Dependent Pathway in T Cells

(2008) Malinda R. Schaefer et al.   PLoS Pathogens