JNK Signaling in Drosophila Aging and Longevity

FOXO Regulates Neuromuscular Junction Homeostasis During Drosophila Aging

(2021) Allison Birnbaum et al.   Frontiers in Aging Neuroscience

JNK Pathway in CNS Pathologies

(2021) Teresa de los Reyes Corrales et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biodiversity-based development and evolution: the emerging research systems in model and non-model organisms

(2021) Long Zhao et al.   Science China-Life Sciences

Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways

(2021) Christina Wagner et al.   Cell Reports

The Emerging Roles of JNK Signaling in Drosophila Stem Cell Homeostasis

(2021) Salvador C. Herrera et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila Model

(2020) John E. La Marca et al.   Frontiers in Cell and Developmental Biology

Apoptosis inhibition mitigates aging effects in Drosophila melanogaster

(2020) Hiroaki Kidera et al.   GENETICA

JNK-dependent intestinal barrier failure disrupts host–microbe homeostasis during tumorigenesis

(2020) Jun Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of c‐Jun N‐terminal Kinase Enhances Senescence in Joint Tissues and Increases the Severity of Age‐Related Osteoarthritis in Mice

(2020) Richard F. Loeser et al.   Arthritis & Rheumatology

Differential activation of eMI by distinct forms of cellular stress

(2020) Ana Mesquita et al.   Autophagy

Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut

(2020) Alexandra Vaccaro et al.   CELL

JNK signaling in Drosophila immunity and homeostasis

(2020) Ghada Tafesh-Edwards et al.   IMMUNOLOGY LETTERS

Drosophila Caliban preserves intestinal homeostasis and lifespan through regulating mitochondrial dynamics and redox state in enterocytes

(2020) Zhaoxia Dai et al.   PLoS Genetics

Pro-apoptotic and pro-proliferation functions of the JNK pathway of Drosophila : roles in cell competition, tumorigenesis and regeneration

(2019) Noelia Pinal et al.   Open Biology

JNK modifies neuronal metabolism to promote proteostasis and longevity

(2019) Lifen Wang et al.   AGING CELL

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

(2019) Anju Singh et al.   MOLECULES

Ets21c Governs Tissue Renewal, Stress Tolerance, and Aging in the Drosophila Intestine

(2019) Juliane Mundorf et al.   Cell Reports

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Control of Intestinal Cell Fate by Dynamic Mitotic Spindle Repositioning Influences Epithelial Homeostasis and Longevity

(2019) Daniel Jun-Kit Hu et al.   Cell Reports

New insights on Drosophila antimicrobial peptide function in host defense and beyond

(2019) Mark Austin Hanson et al.   CURRENT OPINION IN IMMUNOLOGY

Stress resistance and lifespan enhanced by downregulation of antimicrobial peptide genes in the Imd pathway

(2018) Yuh-Ru Lin et al.   Aging-US

Overexpression of antimicrobial peptides contributes to aging through cytotoxic effects in Drosophila tissues

(2018) Marziyeh Badinloo et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

Tankyrase regulates apoptosis by activating JNK signaling in Drosophila

(2018) Ying Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

JIP3 knockout protects mice against high fat diet-induced liver injury

(2018) Xiao-jun Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overexpression of dJmj differentially affects intestinal stem cells and differentiated enterocytes

(2018) Dang Ngoc Anh Suong et al.   CELLULAR SIGNALLING

Correction: Fat body glycogen serves as a metabolic safeguard for the maintenance of sugar levels inDrosophila(doi:10.1242/dev.158865)

(2018) Takayuki Yamada et al.   DEVELOPMENT

MKK4 from Litopenaeus vannamei is a regulator of p38 MAPK kinase and involved in anti-bacterial response

(2018) Sheng Wang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

A bidirectional relationship between sleep and oxidative stress in Drosophila

(2018) Vanessa M. Hill et al.   PLOS BIOLOGY

Nubbin isoform antagonism governs Drosophila intestinal immune homeostasis

(2018) Bo G. Lindberg et al.   PLoS Pathogens

PpV, acting via the JNK pathway, represses apoptosis during normal development of Drosophila wing

(2018) Chunli Chi et al.   APOPTOSIS

Tankyrase Mediates K63-Linked Ubiquitination of JNK to Confer Stress Tolerance and Influence Lifespan in Drosophila

(2018) Ping Li et al.   Cell Reports

Cap-n-Collar Promotes Tissue Regeneration by Regulating ROS and JNK Signaling in the Drosophila melanogaster Wing Imaginal Disc

(2017) Amanda R. Brock et al.   GENETICS

Glial Draper Rescues Aβ Toxicity in aDrosophilaModel of Alzheimer's Disease

(2017) Arpita Ray et al.   JOURNAL OF NEUROSCIENCE

Molecular Mechanisms of Sleep Homeostasis in Flies and Mammals

(2017) Ravi Allada et al.   Cold Spring Harbor Perspectives in Biology

Minocycline treatment increases resistance to oxidative stress and extends lifespan in Drosophila via FOXO

(2017) Gang Jun Lee et al.   Oncotarget

Cap-n-Collar Promotes Tissue Regeneration by Regulating ROS and JNK Signaling in the Drosophila melanogaster Wing Imaginal Disc

(2017) Amanda R. Brock et al.   GENETICS

Drosophila as a model for ageing

(2017) Matthew D.W. Piper et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Intrinsic JNK-MAPK pathway involvement requires daf-16-mediated immune response during Shigella flexneri infection in C. elegans

(2016) Shanmugam Marudhupandiyan et al.   IMMUNOLOGIC RESEARCH

KIF1A inhibition immortalizes brain stem cells but blocks BDNF-mediated neuronal migration

(2016) Aurelie Carabalona et al.   NATURE NEUROSCIENCE

G6PD protects from oxidative damage and improves healthspan in mice

(2016) Sandrina Nóbrega-Pereira et al.   Nature Communications

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Identification of Neurons with a Privileged Role in Sleep Homeostasis in Drosophila melanogaster

(2015) Glen Seidner et al.   CURRENT BIOLOGY

Enteroendocrine cells are generated from stem cells through a distinct progenitor in the adult Drosophila posterior midgut

(2015) X. Zeng et al.   DEVELOPMENT

Interplay amongDrosophilatranscription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy

(2015) Eva Külshammer et al.   Disease Models & Mechanisms

Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency

(2015) Z. Guo et al.   SCIENCE

The canonical Wg signaling modulates Bsk-mediated cell death in Drosophila

(2015) S Zhang et al.   Cell Death & Disease

ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration

(2015) Paula Santabárbara-Ruiz et al.   PLoS Genetics

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan

(2014) Linlin Guo et al.   CELL

The role of mitochondria in fungal aging

(2014) Dominik Bernhardt et al.   CURRENT OPINION IN MICROBIOLOGY

Domain Specificity of MAP3K Family Members, MLK and Tak1, for JNK Signaling in Drosophila

(2014) Beth Stronach et al.   GENETICS

The Drosophila TNF ortholog Eiger: Emerging physiological roles and evolution of the TNF system

(2014) Tatsushi Igaki et al.   SEMINARS IN IMMUNOLOGY

Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology

(2014) N. A. Broderick et al.   mBio

Caspase Inhibition in Select Olfactory Neurons Restores Innate Attraction Behavior in Aged Drosophila

(2014) Takahiro Chihara et al.   PLoS Genetics

The influence of skeletal muscle on systemic aging and lifespan

(2013) Fabio Demontis et al.   AGING CELL

The Digestive Tract ofDrosophila melanogaster

(2013) Bruno Lemaitre et al.   Annual Review of Genetics

E93 predominantly transduces 20-hydroxyecdysone signaling to induce autophagy and caspase activity in Drosophila fat body

(2013) Hanhan Liu et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Serine Proteolytic Pathway Activation Reveals an Expanded Ensemble of Wound Response Genes in Drosophila

(2013) Rachel A. Patterson et al.   PLoS One

Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain

(2012) Hua Bai et al.   AGING CELL

Regulating cell morphogenesis: The drosophila jun N-terminal kinase pathway

(2012) Luis Daniel Ríos-Barrera et al.   GENESIS

WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression

(2012) M. A. Bogoyevitch et al.   JOURNAL OF CELL SCIENCE

CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model

(2012) Min-Ji Kang et al.   NATURE CELL BIOLOGY

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family

(2012) Jenna L. Riffell et al.   NATURE REVIEWS DRUG DISCOVERY

Mitogen-activated Protein Kinase Phosphatase (Mkp)-1 Protects Mice against Acetaminophen-induced Hepatic Injury

(2012) Lyn M. Wancket et al.   TOXICOLOGIC PATHOLOGY

Pan-neuronal knockdown of the c-Jun N-terminal Kinase (JNK) results in a reduction in sleep and longevity in Drosophila

(2011) Kazuhiro Takahama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Docking interactions of the JNK scaffold protein WDR62

(2011) Ksenya Cohen-Katsenelson et al.   BIOCHEMICAL JOURNAL

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Oxidative stress in synapse development and function

(2011) Valerie J. Milton et al.   Developmental Neurobiology

Oxidative stress induces overgrowth of the Drosophila neuromuscular junction

(2011) V. J. Milton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dyrk1A Positively Stimulates ASK1-JNK Signaling Pathway during Apoptotic Cell Death

(2011) Hyoung Kyoung Choi et al.   Experimental Neurobiology

Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs

(2010) Enrique Blanco et al.   BMC DEVELOPMENTAL BIOLOGY

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Mitochondrial DNA mutations in disease and aging

(2010) Douglas C. Wallace   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The Role of Mitochondria in Drosophila Aging

(2010) Jaehyoung Cho et al.   EXPERIMENTAL GERONTOLOGY

Regulation of Drosophila lifespan by JNK signaling

(2010) Benoit Biteau et al.   EXPERIMENTAL GERONTOLOGY

Regulation of mixed-lineage kinase activation in JNK-dependent morphogenesis

(2010) R. A. Garlena et al.   JOURNAL OF CELL SCIENCE

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila

(2010) Benoît Biteau et al.   PLoS Genetics

Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut

(2009) Huaqi Jiang et al.   CELL

JNK/FOXO-mediated Neuronal Expression of Fly Homologue of Peroxiredoxin II Reduces Oxidative Stress and Extends Life Span

(2009) Kyu-Sun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy

(2009) Hai Wu et al.   MECHANISMS OF DEVELOPMENT

JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut

(2008) Benoît Biteau et al.   Cell Stem Cell