FOXO Regulates Neuromuscular Junction Homeostasis During Drosophila Aging

Involvement of p38 MAPK in Synaptic Function and Dysfunction

(2020) Chiara Falcicchia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dying Neurons Utilize Innate Immune Signaling to Prime Glia for Phagocytosis during Development

(2019) Colleen N. McLaughlin et al.   DEVELOPMENTAL CELL

Age-Dependent Changes in Transcription Factor FOXO Targeting in Female Drosophila

(2019) Allison Birnbaum et al.   Frontiers in Genetics

A hormone receptor pathway cell-autonomously delays neuron morphological aging by suppressing endocytosis

(2019) Claire E. Richardson et al.   PLOS BIOLOGY

TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2

(2019) Kai Chang et al.   Autophagy

Neuromuscular Junction Formation, Aging, and Disorders

(2018) Lei Li et al.   Annual Review of Physiology

A cAMP/PKA/Kinesin-1 Axis Promotes the Axonal Transport of Mitochondria in Aging Drosophila Neurons

(2018) Alessio Vagnoni et al.   CURRENT BIOLOGY

Keeping Neurons Young and Foxy: FoxOs Promote Neuronal Plasticity

(2018) Colleen N. McLaughlin et al.   TRENDS IN GENETICS

Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS

(2018) Katherine L. Gibbs et al.   Cell Death & Disease

Blocking p38 Signaling Reduces the Activation of Pro-inflammatory Cytokines and the Phosphorylation of p38 in the Habenula and Reverses Depressive-Like Behaviors Induced by Neuroinflammation

(2018) Ya-wei Zhao et al.   Frontiers in Pharmacology

FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

(2018) Iris Schäffner et al.   NEURON

Levels of Par-1 kinase determine the localization of Bruchpilot at the Drosophila neuromuscular junction synapses

(2018) Kara R. Barber et al.   Scientific Reports

The role of mitochondrial ROS in the aging brain

(2017) Rhoda Stefanatos et al.   FEBS LETTERS

Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?

(2017) Kurt J. De Vos et al.   NEUROBIOLOGY OF DISEASE

The age factor in axonal repair after spinal cord injury: A focus on neuron-intrinsic mechanisms

(2017) Cédric G. Geoffroy et al.   NEUROSCIENCE LETTERS

Presynaptic Aβ40 prevents synapse addition in the adult Drosophila neuromuscular junction

(2017) Begoña López-Arias et al.   PLoS One

Neuronal-Glial Interactions Maintain Chronic Neuropathic Pain after Spinal Cord Injury

(2017) Young S. Gwak et al.   NEURAL PLASTICITY

Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders

(2017) Natalia Salvadores et al.   Frontiers in Neuroscience

Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

(2016) Daniel J. Colacurcio et al.   AGEING RESEARCH REVIEWS

FoxO regulates microtubule dynamics and polarity to promote dendrite branching in Drosophila sensory neurons

(2016) James C. Sears et al.   DEVELOPMENTAL BIOLOGY

A Toll receptor–FoxO pathway represses Pavarotti/MKLP1 to promote microtubule dynamics in motoneurons

(2016) Colleen N. McLaughlin et al.   JOURNAL OF CELL BIOLOGY

Traumatic Axonal Injury: Mechanisms and Translational Opportunities

(2016) Ciaran S. Hill et al.   TRENDS IN NEUROSCIENCES

Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery

(2016) Rebekah Elizabeth Mahoney et al.   eLife

Transient Pinning and Pulling: A Mechanism for Bending Microtubules

(2016) Ian A. Kent et al.   PLoS One

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

(2015) Rute Martins et al.   AGING CELL

Autophagy in stress and disease

(2015) M Chiara Maiuri et al.   CELL DEATH AND DIFFERENTIATION

AgingDrosophila melanogasterdisplay altered pre- and postsynaptic ultrastructure at adult neuromuscular junctions

(2015) Nicole Wagner et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Axonal transport declines with age in two distinct phases separated by a period of relative stability

(2015) Stefan Milde et al.   NEUROBIOLOGY OF AGING

Aging in Sensory and Motor Neurons Results in Learning Failure in Aplysia californica

(2015) Andrew T. Kempsell et al.   PLoS One

Neurodegenerative lysosomal disorders: A continuum from development to late age

(2014) Ralph A. Nixon et al.   Autophagy

Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration

(2014) Lihong Zhan et al.   HUMAN MOLECULAR GENETICS

Anterograde Activin Signaling Regulates Postsynaptic Membrane Potential and GluRIIA/B Abundance at the Drosophila Neuromuscular Junction

(2014) Myung-Jun Kim et al.   PLoS One

An assay to image neuronal microtubule dynamics in mice

(2014) Tatjana Kleele et al.   Nature Communications

The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle

(2014) Marta Gonzalez-Freire et al.   Frontiers in Aging Neuroscience

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Functional Aging in the Nervous System Contributes to Age-Dependent Motor Activity Decline in C. elegans

(2013) Jie Liu et al.   Cell Metabolism

FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra

(2013) Emilda Pino et al.   HUMAN MOLECULAR GENETICS

Independent Pathways Downstream of the Wnd/DLK MAPKKK Regulate Synaptic Structure, Axonal Transport, and Injury Signaling

(2013) S. Klinedinst et al.   JOURNAL OF NEUROSCIENCE

JNK-Interacting Protein 3 Mediates the Retrograde Transport of Activated c-Jun N-Terminal Kinase and Lysosomes

(2013) Catherine M. Drerup et al.   PLoS Genetics

Development and plasticity of the Drosophila larval neuromuscular junction

(2013) Kaushiki P. Menon et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Aging and muscle

(2012) Todd M. Manini et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Signaling and aging at the neuromuscular synapse: lessons learnt from neuromuscular diseases

(2012) Anna Rostedt Punga et al.   CURRENT OPINION IN PHARMACOLOGY

FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption

(2012) Inna V. Nechipurenko et al.   JOURNAL OF CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

JNK regulates FoxO-dependent autophagy in neurons

(2011) P. Xu et al.   GENES & DEVELOPMENT

Spontaneous Age-Related Neurite Branching in Caenorhabditis elegans

(2011) E. M. H. Tank et al.   JOURNAL OF NEUROSCIENCE

Oxidative stress induces overgrowth of the Drosophila neuromuscular junction

(2011) V. J. Milton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

(2010) Nirmala Hariharan et al.   CIRCULATION RESEARCH

Activin signaling functions upstream of Gbb to regulate synaptic growth at the Drosophila neuromuscular junction

(2010) J.E. Ellis et al.   DEVELOPMENTAL BIOLOGY

A FOXO-Pak1 transcriptional pathway controls neuronal polarity

(2010) L. de la Torre-Ubieta et al.   GENES & DEVELOPMENT

FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis

(2009) Ji-hye Paik et al.   Cell Stem Cell

Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly, and axon degeneration

(2009) Min D. Tang-Schomer et al.   FASEB JOURNAL

Unc-51 Controls Active Zone Density and Protein Composition by Downregulating ERK Signaling

(2009) Y. P. Wairkar et al.   JOURNAL OF NEUROSCIENCE

Age-related changes in brain energetics and phospholipid metabolism

(2009) Brent P. Forester et al.   NMR IN BIOMEDICINE

Rab GTPases and their roles in brain neurons and glia

(2008) Ee Ling Ng et al.   BRAIN RESEARCH REVIEWS

FoxO transcription factors in the maintenance of cellular homeostasis during aging

(2008) Dervis AM Salih et al.   CURRENT OPINION IN CELL BIOLOGY

TGF  signals regulate axonal development through distinct Smad-independent mechanisms

(2008) J. Ng   DEVELOPMENT

A PI3-Kinase–Mediated Negative Feedback Regulates Neuronal Excitability

(2008) Eric Howlett et al.   PLoS Genetics