Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila Model

Ask1 and Akt act synergistically to promote ROS-dependent regeneration in Drosophila

(2019) Paula Santabárbara-Ruiz et al.   PLoS Genetics

Wingless modulates activator protein-1-mediated tumor invasion

(2019) Shiping Zhang et al.   ONCOGENE

JNK signaling in cancer cell survival

(2019) Qinghua Wu et al.   MEDICINAL RESEARCH REVIEWS

Lic regulates JNK-mediated cell death in Drosophila

(2019) Yihao Sun et al.   CELL PROLIFERATION

Drosophila jumu modulates apoptosis via a JNK-dependent pathway and is required for other processes in wing development

(2019) Xiao Chun Wang et al.   APOPTOSIS

Elimination of oncogenic cells that regulate epithelial homeostasis in Drosophila

(2019) Shizue Ohsawa   DEVELOPMENT GROWTH & DIFFERENTIATION

Oncogenic Notch Triggers Neoplastic Tumorigenesis in a Transition-Zone-like Tissue Microenvironment

(2019) Sheng-An Yang et al.   DEVELOPMENTAL CELL

Modeling Cancer with Flies and Fish

(2019) Ross L. Cagan et al.   DEVELOPMENTAL CELL

Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network

(2019) Peter M. U. Ung et al.   PLoS Computational Biology

JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress

(2019) Andrea Cosolo et al.   eLife

Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila

(2019) Carlos Camilleri-Robles et al.   Genes

A personalized platform identifies trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer

(2019) Erdem Bangi et al.   Science Advances

Strip and Cka negatively regulate JNK signalling during Drosophila spermatogenesis

(2019) John E. La Marca et al.   DEVELOPMENT

Dynamic MAPK signaling activity underlies a transition from growth arrest to proliferation in Drosophila scribble mutant tumors

(2019) Tiantian Ji et al.   Disease Models & Mechanisms

The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila

(2019) Jean-Philippe Parvy et al.   eLife

Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression

(2019) Mingli Li et al.   Cell Death & Disease

Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration

(2019) Marta Portela et al.   PLOS BIOLOGY

Tankyrase regulates apoptosis by activating JNK signaling in Drosophila

(2018) Ying Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deltex interacts with Eiger and consequently influences the cell death in Drosophila melanogaster

(2018) Debdeep Dutta et al.   CELLULAR SIGNALLING

Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila

(2018) Mitsuko Katsukawa et al.   CURRENT BIOLOGY

A Drosophila Tumor Suppressor Gene Prevents Tonic TNF Signaling through Receptor N-Glycosylation

(2018) Geert de Vreede et al.   DEVELOPMENTAL CELL

Advances in Engineering the Fly Genome with the CRISPR-Cas System

(2018) Ethan Bier et al.   GENETICS

Src Cooperates with Oncogenic Ras in Tumourigenesis via the JNK and PI3K Pathways in Drosophila epithelial Tissue

(2018) Carole Poon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Drosophila bendless catalyzes K63-linked polyubiquitination and is involved in the response to DNA damage

(2018) Zhiqiang Bai et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

A whole-animal platform to advance a clinical kinase inhibitor into new disease space

(2018) Masahiro Sonoshita et al.   Nature Chemical Biology

JNK and Yorkie drive tumor progression by generating polyploid giant cells in Drosophila

(2018) Bojie Cong et al.   ONCOGENE

Short-term activation of the Jun N-terminal kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis

(2018) Noelia Pinal et al.   Nature Communications

Yorkie and JNK Control Tumorigenesis in Drosophila Cells with Cytokinesis Failure

(2018) Stephan U. Gerlach et al.   Cell Reports

Signalling crosstalk during early tumorigenesis in the absence of Polycomb silencing

(2018) Jorge V. Beira et al.   PLoS Genetics

Modelling Cooperative Tumorigenesis in Drosophila

(2018) Helena E. Richardson et al.   Biomed Research International

Advances in Engineering the Fly Genome with the CRISPR-Cas System

(2018) Ethan Bier et al.   GENETICS

The Hippo Signaling Network and its Biological Functions

(2018) Jyoti R. Misra et al.   Annual Review of Genetics

Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues

(2018) Najate Benhra et al.   DEVELOPMENTAL CELL

Polarity protein Canoe mediates overproliferation via modulation of JNK, Ras-MAPK and Hippo signalling

(2018) Zhiwei Ma et al.   CELL PROLIFERATION

Epithelial cells release adenosine to promote local TNF production in response to polarity disruption

(2018) Ingrid Poernbacher et al.   Nature Communications

The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition

(2017) Masatoshi Yamamoto et al.   NATURE

Hippo signaling promotes JNK-dependent cell migration

(2017) Xianjue Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feedback amplification loop drives malignant growth in epithelial tissues

(2017) Mariana Muzzopappa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Drosophila Duox maturation factor is a key component of a positive feedback loop that sustains regeneration signaling

(2017) Sumbul Jawed Khan et al.   PLoS Genetics

Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila

(2017) Ernesto Pérez et al.   eLife

JNK, p38, ERK, and SGK1 Inhibitors in Cancer

(2017) Jonas Cicenas et al.   Cancers

GLYAT regulates JNK-mediated cell death in Drosophila

(2017) Pu Ren et al.   Scientific Reports

An Ectopic Network of Transcription Factors Regulated by Hippo Signaling Drives Growth and Invasion of a Malignant Tumor Model

(2016) Mardelle Atkins et al.   CURRENT BIOLOGY

Slit-Robo Repulsive Signaling Extrudes Tumorigenic Cells from Epithelia

(2016) John Vaughen et al.   DEVELOPMENTAL CELL

Functional exploration of colorectal cancer genomes using Drosophila

(2016) Erdem Bangi et al.   Nature Communications

Localized JNK signaling regulates organ size during development

(2016) Helen Rankin Willsey et al.   eLife

In vivo genetic dissection of tumor growth and the Warburg effect

(2016) Cheng-Wei Wang et al.   eLife

JNK signaling is converted from anti- to pro-tumor pathway by Ras-mediated switch of Warts activity

(2015) Masato Enomoto et al.   DEVELOPMENTAL BIOLOGY

Interplay amongDrosophilatranscription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy

(2015) Eva Külshammer et al.   Disease Models & Mechanisms

The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth

(2015) Ditte S. Andersen et al.   NATURE

Rho1–Wnd signaling regulates loss-of-cell polarity-induced cell invasion in Drosophila

(2015) X Ma et al.   ONCOGENE

Impaired Hippo signaling promotes Rho1–JNK-dependent growth

(2015) Xianjue Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma

(2015) Rachel Ramsdale et al.   Science Signaling

Wallenda regulates JNK-mediated cell death in Drosophila

(2015) X Ma et al.   Cell Death & Disease

Active JNK-dependent secretion of Drosophila Tyrosyl-tRNA synthetase by loser cells recruits haemocytes during cell competition

(2015) Sergio Casas-Tintó et al.   Nature Communications

Toll pathway modulates TNF-induced JNK-dependent cell death inDrosophila

(2015) Chenxi Wu et al.   Open Biology

The transcriptional response to tumorigenic polarity loss in Drosophila

(2015) Brandon D Bunker et al.   eLife

The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma

(2015) Rachel Ramsdale et al.   Science Signaling

BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila

(2015) Karen Doggett et al.   PLoS One

Recent Progress in the Design, Study, and Development of c-Jun N-Terminal Kinase Inhibitors as Anticancer Agents

(2014) Abdellah Messoussi et al.   CHEMISTRY & BIOLOGY

Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila

(2014) Kyoko Takino et al.   DEVELOPMENTAL BIOLOGY

The Dpp/TGFβ-Dependent Corepressor Schnurri Protects Epithelial Cells from JNK-Induced Apoptosis in Drosophila Embryos

(2014) Jorge V. Beira et al.   DEVELOPMENTAL CELL

The Drosophila TNF ortholog Eiger: Emerging physiological roles and evolution of the TNF system

(2014) Tatsushi Igaki et al.   SEMINARS IN IMMUNOLOGY

Mitochondrial defects trigger proliferation of neighbouring cells via a senescence-associated secretory phenotype in Drosophila

(2014) Mai Nakamura et al.   Nature Communications

A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila

(2014) Dariel Ashton-Beaucage et al.   PLOS BIOLOGY

dUev1a modulates TNF-JNK mediated tumor progression and cell death in Drosophila

(2013) Xianjue Ma et al.   DEVELOPMENTAL BIOLOGY

In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling

(2013) P. Khoo et al.   Disease Models & Mechanisms

Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium

(2013) A. G. Petzoldt et al.   Disease Models & Mechanisms

Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion

(2013) Vivek A Rudrapatna et al.   EMBO REPORTS

A Jnk–Rho–Actin remodeling positive feedback network directs Src-driven invasion

(2013) V A Rudrapatna et al.   ONCOGENE

De-Regulation of JNK and JAK/STAT Signaling in ESCRT-II Mutant Tissues Cooperatively Contributes to Neoplastic Tumorigenesis

(2013) Sarah E. Woodfield et al.   PLoS One

Ajuba Family Proteins Link JNK to Hippo Signaling

(2013) G. Sun et al.   Science Signaling

Src42A modulates tumor invasion and cell death via Ben/dUev1a-mediated JNK activation in Drosophila

(2013) X Ma et al.   Cell Death & Disease

Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway

(2013) Ainhoa Pérez-Garijo et al.   eLife

Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila

(2012) Masato Enomoto et al.   EMBO REPORTS

Regulating cell morphogenesis: The drosophila jun N-terminal kinase pathway

(2012) Luis Daniel Ríos-Barrera et al.   GENESIS

The actin cross-linker Filamin/Cheerio mediates tumor malignancy downstream of JNK signaling

(2012) E. Kulshammer et al.   JOURNAL OF CELL SCIENCE

The Kelch Repeat Protein KLHDC10 Regulates Oxidative Stress-Induced ASK1 Activation by Suppressing PP5

(2012) Yusuke Sekine et al.   MOLECULAR CELL

Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila

(2012) Shizue Ohsawa et al.   NATURE

Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

(2012) Arvin C. Dar et al.   NATURE

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Group choreography: mechanisms orchestrating the collective movement of border cells

(2012) Denise J. Montell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A non-cell-autonomous tumor suppressor role for Stat in eliminating oncogenic scribble cells

(2012) M C Schroeder et al.   ONCOGENE

PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation

(2012) Haitao Qing et al.   TUMOR BIOLOGY

The Apical Polarity Protein Network in Drosophila Epithelial Cells: Regulation of Polarity, Junctions, Morphogenesis, Cell Growth, and Survival

(2011) Ulrich Tepass   Annual Review of Cell and Developmental Biology

Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling

(2011) Karen Doggett et al.   BMC DEVELOPMENTAL BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A dp53/JNK-dependant feedback amplification loop is essential for the apoptotic response to stress in Drosophila

(2011) E Shlevkov et al.   CELL DEATH AND DIFFERENTIATION

Elimination of Oncogenic Neighbors by JNK-Mediated Engulfment in Drosophila

(2011) Shizue Ohsawa et al.   DEVELOPMENTAL CELL

Identification of Novel Ras-Cooperating Oncogenes inDrosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis

(2011) Anthony M. Brumby et al.   GENETICS

Tumor suppression by cell competition through regulation of the Hippo pathway

(2011) C.-L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy

(2010) Francesca Froldi et al.   BMC BIOLOGY

The dark side of fly TNF

(2010) Marcos Vidal   CELL CYCLE

Lgl, the SWH pathway and tumorigenesis: It’s a matter of context and competition!

(2010) Nicola A Grzeschik et al.   CELL CYCLE

Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors

(2010) Gongping Sun et al.   DEVELOPMENTAL BIOLOGY

Oncogenic Ras Diverts a Host TNF Tumor Suppressor Activity into Tumor Promoter

(2010) Julia B. Cordero et al.   DEVELOPMENTAL CELL

A Targeted UAS-RNAi Screen in Drosophila Larvae Identifies Wound Closure Genes Regulating Distinct Cellular Processes

(2010) C. Lesch et al.   GENETICS

Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane

(2010) Amanda L. Neisch et al.   JOURNAL OF CELL BIOLOGY

Regulation of mixed-lineage kinase activation in JNK-dependent morphogenesis

(2010) R. A. Garlena et al.   JOURNAL OF CELL SCIENCE

Interaction between Ras V12 and scribbled clones induces tumour growth and invasion

(2010) Ming Wu et al.   NATURE

A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway

(2010) J. Menendez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo RNAi: Today and Tomorrow

(2010) N. Perrimon et al.   Cold Spring Harbor Perspectives in Biology

Involvement of Lgl and Mahjong/VprBP in Cell Competition

(2010) Yoichiro Tamori et al.   PLOS BIOLOGY

scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

(2009) Gregory R Leong et al.   BMC BIOLOGY

Intrinsic Tumor Suppression and Epithelial Maintenance by Endocytic Activation of Eiger/TNF Signaling in Drosophila

(2009) Tatsushi Igaki et al.   DEVELOPMENTAL CELL

Apoptosis in Drosophila: compensatory proliferation and undead cells

(2009) Francisco A. Martin et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

A Drosophila Model for EGFR-Ras and PI3K-Dependent Human Glioma

(2009) Renee D. Read et al.   PLoS Genetics

A Quantitative RNAi Screen for JNK Modifiers Identifies Pvr as a Novel Regulator of Drosophila Immune Signaling

(2009) David Bond et al.   PLoS Pathogens

Regulation of Cell Adhesion and Collective Cell Migration by Hindsight and Its Human Homolog RREB1

(2008) Mariana Melani et al.   CURRENT BIOLOGY

JNK Signaling Controls Border Cell Cluster Integrity and Collective Cell Migration

(2008) Flora Llense et al.   CURRENT BIOLOGY

An innate immune response of blood cells to tumors and tissue damage in Drosophila

(2008) J. C. Pastor-Pareja et al.   Disease Models & Mechanisms