JNK modifies neuronal metabolism to promote proteostasis and longevity

Drosophila Insulin-Like Peptides DILP2 and DILP5 Differentially Stimulate Cell Signaling and Glycogen Phosphorylase to Regulate Longevity

(2018) Stephanie Post et al.   Frontiers in Endocrinology

Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress

(2017) Ivan Gusarov et al.   Nature Communications

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans

(2015) Niki Chondrogianni et al.   FASEB JOURNAL

Protein Quality Control under Oxidative Stress Conditions

(2015) Jan-Ulrik Dahl et al.   JOURNAL OF MOLECULAR BIOLOGY

Tipping the metabolic scales towards increased longevity in mammals

(2015) Celine E. Riera et al.   NATURE CELL BIOLOGY

Enhanced Neuronal Glucose Transporter Expression Reveals Metabolic Choice in a HD Drosophila Model

(2015) Marie Thérèse Besson et al.   PLoS One

Kinetics of Precursor Labeling in Stable Isotope Labeling in Cell Cultures (SILAC) Experiments

(2014) Tian Zhang et al.   ANALYTICAL CHEMISTRY

Knockdown expression of eukaryotic initiation factor 5 C-terminal domain containing protein extends lifespan in Drosophila melanogaster

(2014) Daoyong Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Gene Ontology Consortium: going forward

(2014)   NUCLEIC ACIDS RESEARCH

Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation

(2014) Andrei S Avanesov et al.   eLife

Perturbed Glucose Metabolism: Insights into Multiple Sclerosis Pathogenesis

(2014) Deepali Mathur et al.   Frontiers in Neurology

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

(2012) David Vilchez et al.   NATURE

Advantages and Limitations of Different p62-Based Assays for Estimating Autophagic Activity in Drosophila

(2012) Karolina Pircs et al.   PLoS One

Reduced neuronal expression of ribose-5-phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity inDrosophila

(2011) Ching-Tzu Wang et al.   AGING CELL

JNK regulates FoxO-dependent autophagy in neurons

(2011) P. Xu et al.   GENES & DEVELOPMENT

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

(2011) Silvestre Alavez et al.   NATURE

Aging as an Event of Proteostasis Collapse

(2011) R. C. Taylor et al.   Cold Spring Harbor Perspectives in Biology

Metabolic Networks of Longevity

(2010) Riekelt H. Houtkooper et al.   CELL

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

Heat shock proteins and Drosophila aging

(2010) John Tower   EXPERIMENTAL GERONTOLOGY

Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network

(2010) Linda Partridge et al.   EXPERIMENTAL GERONTOLOGY

Regulation of Drosophila lifespan by JNK signaling

(2010) Benoit Biteau et al.   EXPERIMENTAL GERONTOLOGY

Increased energy metabolism rescues glia-induced pathology in a Drosophila model of Huntington's disease

(2010) Marie-Thérèse Besson et al.   HUMAN MOLECULAR GENETICS

Basic Leucine Zipper Protein Cnc-C Is a Substrate and Transcriptional Regulator of the Drosophila 26S Proteasome

(2010) K. B. Grimberg et al.   MOLECULAR AND CELLULAR BIOLOGY

Analysis of proteome dynamics in the mouse brain

(2010) J. C. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila

(2009) Jason Karpac et al.   AGING CELL

JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy

(2009) Hai Wu et al.   MECHANISMS OF DEVELOPMENT

Insulin and JNK: optimizing metabolic homeostasis and lifespan

(2009) Jason Karpac et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

ProteoWizard: open source software for rapid proteomics tools development

(2008) Darren Kessner et al.   BIOINFORMATICS

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

(2008) Kristan K. Steffen et al.   CELL

Use of stable isotopes to examine how dietary restriction extends Drosophila lifespan

(2008) Diane M. O'Brien et al.   CURRENT BIOLOGY

Overexpression of Glucose-6-phosphate Dehydrogenase Extends the Life Span ofDrosophila melanogaster

(2008) Susan K. Legan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ref(2)P, theDrosophila melanogasterhomologue of mammalian p62, is required for the formation of protein aggregates in adult brain

(2008) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY

The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: A review

(2008) M. M. C. Wamelink et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Cerebrospinal fluid evidence of increased extra-mitochondrial glucose metabolism implicates mitochondrial dysfunction in multiple sclerosis disease progression

(2008) William T. Regenold et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Realized immune response is enhanced in long-lived puc and chico mutants but is unaffected by dietary restriction

(2007) Sergiy Libert et al.   MOLECULAR IMMUNOLOGY