mTOR Signaling in the Inner Ear as Potential Target to Treat Hearing Loss
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
mTOR Signaling in the Inner Ear as Potential Target to Treat Hearing Loss
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 12, Pages 6368
Publisher
MDPI AG
Online
2021-06-15
DOI
10.3390/ijms22126368
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Metformin Alleviates Cisplatin-Induced Ototoxicity by Autophagy Induction Possibly via the AMPK/FOXO3a Pathway
- (2021) Zhengrong Liang et al. JOURNAL OF NEUROPHYSIOLOGY
- Improved Speech Intelligibility in Subjects With Stable Sensorineural Hearing Loss Following Intratympanic Dosing of FX-322 in a Phase 1b Study
- (2021) Will J. McLean et al. OTOLOGY & NEUROTOLOGY
- Rapamycin Added to Diet in Late Mid-Life Delays Age-Related Hearing Loss in UMHET4 Mice
- (2021) Richard A. Altschuler et al. Frontiers in Cellular Neuroscience
- AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control
- (2020) Asier González et al. Cell Metabolism
- mTOR at the nexus of nutrition, growth, ageing and disease
- (2020) Grace Y. Liu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Presbycusis: An Update on Cochlear Mechanisms and Therapies
- (2020) Jing Wang et al. Journal of Clinical Medicine
- Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss
- (2020) Jingjing Zhao et al. Aging-US
- A phase I/IIa double blind single institute trial of low dose sirolimus for Pendred syndrome/DFNB4
- (2020) Masato Fujioka et al. MEDICINE
- Autophagy is Required for Remodeling in Postnatal Developing Ribbon Synapses of Cochlear Inner Hair Cells
- (2020) Wei Xiong et al. NEUROSCIENCE
- Cochlear Implantation in Adults
- (2020) Matthew L. Carlson NEW ENGLAND JOURNAL OF MEDICINE
- LIN28B/let-7control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling
- (2020) Xiao-Jun Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulin-Like Growth Factor 1 on the Maintenance of Ribbon Synapses in Mouse Cochlear Explant Cultures
- (2020) Li Gao et al. Frontiers in Cellular Neuroscience
- Disruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in mice
- (2020) Han Zhou et al. Cell Death & Disease
- Regulation of mTORC2 Signaling
- (2020) Wenxiang Fu et al. Genes
- The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2
- (2019) Joanna R. Kovalski et al. MOLECULAR CELL
- The Antioxidative Role of Autophagy in Hearing Loss
- (2019) Bin Ye et al. Frontiers in Neuroscience
- Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR
- (2019) Bin Ye et al. Autophagy
- Rapamycin Protects Spiral Ganglion Neurons from Gentamicin-Induced Degeneration In Vitro
- (2019) Shasha Guo et al. JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
- Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis
- (2019) Lukas Muri et al. Journal of Neuroinflammation
- AMPK directly activates mTORC2 to promote cell survival during acute energetic stress
- (2019) Dubek Kazyken et al. Science Signaling
- Structural basis for the docking of mTORC1 on the lysosomal surface
- (2019) Kacper B. Rogala et al. SCIENCE
- Therapeutic effects of metformin for noise induced hearing loss
- (2019) Özge Gedik et al. AMERICAN JOURNAL OF OTOLARYNGOLOGY
- Renewed proliferation in adult mouse cochlea and regeneration of hair cells
- (2019) Yilai Shu et al. Nature Communications
- Cryo-EM structure of human mTOR complex 2
- (2018) Xizi Chen et al. CELL RESEARCH
- Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes
- (2018) Kuang Shen et al. NATURE
- Architecture of the human mTORC2 core complex
- (2018) Edward Stuttfeld et al. eLife
- Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea
- (2018) R.A. Altschuler et al. HEARING RESEARCH
- Tuberous sclerosis complex–mediated mTORC1 overactivation promotes age-related hearing loss
- (2018) Xiaolong Fu et al. JOURNAL OF CLINICAL INVESTIGATION
- Toward Cochlear Therapies
- (2018) Jing Wang et al. PHYSIOLOGICAL REVIEWS
- Estimating the concentration of therapeutic range using disease-specific iPS cells: Low-dose rapamycin therapy for Pendred syndrome
- (2018) Makoto Hosoya et al. Regenerative Therapy
- An update on drug design strategies to prevent acquired sensorineural hearing loss
- (2017) Daniel Bodmer Expert Opinion on Drug Discovery
- Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms
- (2017) M. Charles Liberman et al. HEARING RESEARCH
- mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
- (2017) Yuchao Gu et al. MOLECULAR CELL
- SZT2 dictates GATOR control of mTORC1 signalling
- (2017) Min Peng et al. NATURE
- KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
- (2017) Rachel L. Wolfson et al. NATURE
- Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea
- (2017) Celia Zhang et al. NEUROSCIENCE
- SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway
- (2017) Xin Gu et al. SCIENCE
- Protein Synthesis Inhibition and Activation of the c-Jun N-Terminal Kinase Are Potential Contributors to Cisplatin Ototoxicity
- (2017) Brian D. Nicholas et al. Frontiers in Cellular Neuroscience
- Sesn2/AMPK/mTOR signaling mediates balance between survival and apoptosis in sensory hair cells under stress
- (2017) Daniel Bodmer et al. Cell Death & Disease
- Autophagy is essential for hearing in mice
- (2017) Chisato Fujimoto et al. Cell Death & Disease
- Autophagic flux, a possible mechanism for delayed gentamicin-induced ototoxicity
- (2017) Yeon Ju Kim et al. Scientific Reports
- Cochlear Cell Modeling Using Disease-Specific iPSCs Unveils a Degenerative Phenotype and Suggests Treatments for Congenital Progressive Hearing Loss
- (2017) Makoto Hosoya et al. Cell Reports
- The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss
- (2017) Lourdes Rodríguez-de la Rosa et al. Frontiers in Aging Neuroscience
- The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
- (2016) Lynne Chantranupong et al. CELL
- PRICKLE1 Contributes to Cancer Cell Dissemination through Its Interaction with mTORC2
- (2016) Avais M. Daulat et al. DEVELOPMENTAL CELL
- Noise-Induced Loss of Hair Cells and Cochlear Synaptopathy Are Mediated by the Activation of AMPK
- (2016) K. Hill et al. JOURNAL OF NEUROSCIENCE
- mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
- (2016) I. Ben-Sahra et al. SCIENCE
- Activation of PI3K signaling prevents aminoglycoside-induced hair cell death in the murine cochlea
- (2016) Azadeh Jadali et al. Biology Open
- Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness
- (2015) Sharen E. McKay et al. AMERICAN JOURNAL OF PATHOLOGY
- Autophagy Attenuates Noise-Induced Hearing Loss by Reducing Oxidative Stress
- (2015) Hu Yuan et al. ANTIOXIDANTS & REDOX SIGNALING
- Metformin Protects Auditory Hair Cells from Gentamicin-Induced Toxicity in vitro
- (2015) Andrea Glutz et al. AUDIOLOGY AND NEURO-OTOLOGY
- Sensory hair cell development and regeneration: similarities and differences
- (2015) P. J. Atkinson et al. DEVELOPMENT
- Insulin-like growth factor 1: A novel treatment for the protection or regeneration of cochlear hair cells
- (2015) Kohei Yamahara et al. HEARING RESEARCH
- Increased Sensitivity to Noise-Induced Hearing Loss by Blockade of Endogenous PI3K/Akt Signaling
- (2015) Jun Chen et al. JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
- SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
- (2015) Manuele Rebsamen et al. NATURE
- Architecture of human mTOR complex 1
- (2015) C. H. S. Aylett et al. SCIENCE
- Sestrin2 is a leucine sensor for the mTORC1 pathway
- (2015) R. L. Wolfson et al. SCIENCE
- Regulation of mTORC1 by PI3K signaling
- (2015) Christian C. Dibble et al. TRENDS IN CELL BIOLOGY
- PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex
- (2015) P. Liu et al. Cancer Discovery
- All Akt Isoforms (Akt1, Akt2, Akt3) Are Involved in Normal Hearing, but Only Akt2 and Akt3 Are Involved in Auditory Hair Cell Survival in the Mammalian Inner Ear
- (2015) Yves Brand et al. PLoS One
- Rapamycin alleviates cisplatin-induced ototoxicity in vivo
- (2014) Bin Fang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment
- (2014) Takayuki Nakagawa et al. BMC Medicine
- Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
- (2014) Suchithra Menon et al. CELL
- Where is mTOR and what is it doing there?
- (2014) Charles Betz et al. JOURNAL OF CELL BIOLOGY
- Making new contacts: the mTOR network in metabolism and signalling crosstalk
- (2014) Mitsugu Shimobayashi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo
- (2014) Naoki Oishi et al. NEUROSCIENCE LETTERS
- Sound Strategies for Hearing Restoration
- (2014) G. S. G. Geleoc et al. SCIENCE
- Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells
- (2013) Kathrin Thedieck et al. CELL
- WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation
- (2013) Emel Esen et al. Cell Metabolism
- mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
- (2013) Masahiro Morita et al. Cell Metabolism
- A brief history of hair cell regeneration research and speculations on the future
- (2013) Edwin W. Rubel et al. HEARING RESEARCH
- Protective Effect of Metformin Against Cisplatin-Induced Ototoxicity in an Auditory Cell Line
- (2013) Jiwon Chang et al. JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
- Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases
- (2013) Constance S. Petit et al. JOURNAL OF CELL BIOLOGY
- A Novel Role of Cytosolic Protein Synthesis Inhibition in Aminoglycoside Ototoxicity
- (2013) S. P. Francis et al. JOURNAL OF NEUROSCIENCE
- Age-Related Cochlear Synaptopathy: An Early-Onset Contributor to Auditory Functional Decline
- (2013) Y. Sergeyenko et al. JOURNAL OF NEUROSCIENCE
- Insulin-like growth factor 1 inhibits hair cell apoptosis and promotes the cell cycle of supporting cells by activating different downstream cascades after pharmacological hair cell injury in neonatal mice
- (2013) Yushi Hayashi et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
- (2013) Zhi-Yang Tsun et al. MOLECULAR CELL
- mTOR is a key modulator of ageing and age-related disease
- (2013) Simon C. Johnson et al. NATURE
- Conditional Deletion of Pten Leads to Defects in Nerve Innervation and Neuronal Survival in Inner Ear Development
- (2013) Hyung Jin Kim et al. PLoS One
- Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1
- (2013) I. Ben-Sahra et al. SCIENCE
- Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis
- (2013) A. M. Robitaille et al. SCIENCE
- A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1
- (2013) L. Bar-Peled et al. SCIENCE
- MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
- (2012) Jose A. Martina et al. Autophagy
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
- (2012) Carmine Settembre et al. EMBO JOURNAL
- AMP-activated protein kinase in BK-channel regulation and protection against hearing loss following acoustic overstimulation
- (2012) Michael Föller et al. FASEB JOURNAL
- Atoh1, an Essential Transcription Factor in Neurogenesis and Intestinal and Inner Ear Development: Function, Regulation, and Context Dependency
- (2012) Joanna Mulvaney et al. JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
- TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
- (2012) Christian C. Dibble et al. MOLECULAR CELL
- YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29
- (2012) Karen Tumaneng et al. NATURE CELL BIOLOGY
- Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion
- (2012) Yeon Ja Choi et al. PLoS One
- The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
- (2012) A. Roczniak-Ferguson et al. Science Signaling
- The serine/threonine kinase ULK1 is a target of multiple phosphorylation events
- (2011) Markus Bach et al. BIOCHEMICAL JOURNAL
- mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
- (2011) Timothy R. Peterson et al. CELL
- mTOR signaling in disease
- (2011) Eva Dazert et al. CURRENT OPINION IN CELL BIOLOGY
- Protective role of antidiabetic drug metformin against gentamicin induced apoptosis in auditory cell line
- (2011) Hak Hyun Jung et al. HEARING RESEARCH
- Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate
- (2011) Xiaoqing Gan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Redox Regulates Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity by Modulating the TSC1/TSC2-Rheb GTPase Pathway
- (2011) Sei Yoshida et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- Rapamycin passes the torch: a new generation of mTOR inhibitors
- (2011) Don Benjamin et al. NATURE REVIEWS DRUG DISCOVERY
- mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
- (2011) R. Zoncu et al. SCIENCE
- Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
- (2011) Y. Yu et al. SCIENCE
- The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
- (2011) P. P. Hsu et al. SCIENCE
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
- (2010) Yasemin Sancak et al. CELL
- Multi-mechanisms are involved in reactive oxygen species regulation of mTORC1 signaling
- (2010) Ming Li et al. CELLULAR SIGNALLING
- mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
- (2010) Won Jun Oh et al. EMBO JOURNAL
- Generation and characterization of Atoh1-Cre knock-in mouse line
- (2010) Hua Yang et al. GENESIS
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
- (2010) D. F. Egan et al. SCIENCE
- 4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila
- (2009) Brian M. Zid et al. CELL
- PTEN attenuates PIP3/Akt signaling in the cochlea of the aging CBA/J mouse
- (2009) Su-Hua Sha et al. HEARING RESEARCH
- ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
- (2009) Ian G. Ganley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Adding Insult to Injury: Cochlear Nerve Degeneration after "Temporary" Noise-Induced Hearing Loss
- (2009) S. G. Kujawa et al. JOURNAL OF NEUROSCIENCE
- Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
- (2009) Nao Hosokawa et al. MOLECULAR BIOLOGY OF THE CELL
- ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
- (2009) Chang Hwa Jung et al. MOLECULAR BIOLOGY OF THE CELL
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- (2009) David E. Harrison et al. NATURE
- The nuts and bolts of AGC protein kinases
- (2009) Laura R. Pearce et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
- (2008) Juan M. García-Martínez et al. BIOCHEMICAL JOURNAL
- Regulation of TORC1 by Rag GTPases in nutrient response
- (2008) Eunjung Kim et al. NATURE CELL BIOLOGY
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started