Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis

Combining Ceftriaxone with Doxycycline and Daptomycin Reduces Mortality, Neuroinflammation, Brain Damage and Hearing Loss in Infant Rat Pneumococcal Meningitis

(2019) Lukas Muri et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis

(2018) Lukas Muri et al.   Journal of Neuroinflammation

Global, regional, and national burden of meningitis, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Joseph Raymond Zunt et al.   LANCET NEUROLOGY

pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion

(2017) Federico Iovino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Brain-derived neurotrophic factor reduces inflammation and hippocampal apoptosis in experimental Streptococcus pneumoniae meningitis

(2017) Danfeng Xu et al.   Journal of Neuroinflammation

Therapeutic potential of brain-derived neurotrophic factor (BDNF) and a small molecular mimics of BDNF for traumatic brain injury

(2017) Dong Sun et al.   Neural Regeneration Research

Metformin protects the brain against ischemia/reperfusion injury through PI3K/Akt1/JNK3 signaling pathways in rats

(2017) Xu-Hua Ge et al.   PHYSIOLOGY & BEHAVIOR

Host–pathogen interactions in bacterial meningitis

(2016) Kelly S. Doran et al.   ACTA NEUROPATHOLOGICA

Inhibition of Hippocampal Regeneration by Adjuvant Dexamethasone in Experimental Infant Rat Pneumococcal Meningitis

(2016) Lia Bally et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice

(2016) Wilma Helena Oliveira et al.   BRAIN RESEARCH

Metformin Attenuates Cognitive Impairments in Hypoxia–Ischemia Neonatal Rats via Improving Remyelination

(2016) Boxiang Qi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

ESCMID guideline: diagnosis and treatment of acute bacterial meningitis

(2016) D. van de Beek et al.   CLINICAL MICROBIOLOGY AND INFECTION

Exogenous BDNF increases neurogenesis in the hippocampus in experimental Streptococcus pneumoniae meningitis

(2016) Di Lian et al.   JOURNAL OF NEUROIMMUNOLOGY

Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation

(2016) Yinbing Pan et al.   Journal of Neuroinflammation

The Severity of Infection Determines the Localization of Damage and Extent of Sensorineural Hearing Loss in Experimental Pneumococcal Meningitis

(2016) M. Perny et al.   JOURNAL OF NEUROSCIENCE

Metformin Protects Auditory Hair Cells from Gentamicin-Induced Toxicity in vitro

(2015) Andrea Glutz et al.   AUDIOLOGY AND NEURO-OTOLOGY

Bacterial meningitis: insights into pathogenesis and evaluation of new treatment options: a perspective from experimental studies

(2015) Fabian D Liechti et al.   Future Microbiology

Tumor Necrosis Factor-α-Induced Ototoxicity in Mouse Cochlear Organotypic Culture

(2015) Qian Wu et al.   PLoS One

Activating Endogenous Neural Precursor Cells Using Metformin Leads to Neural Repair and Functional Recovery in a Model of Childhood Brain Injury

(2015) Parvati Dadwal et al.   Stem Cell Reports

Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation

(2015) Michael Fatt et al.   Stem Cell Reports

Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke

(2014) Qin Jin et al.   BRAIN BEHAVIOR AND IMMUNITY

Neurogenesis in the Normal Ageing Hippocampus: A Mini-Review

(2014) D�sir�e R.M. Seib et al.   GERONTOLOGY

Platelet Endothelial Cell Adhesion Molecule-1, a Putative Receptor for the Adhesion of Streptococcus pneumoniae to the Vascular Endothelium of the Blood-Brain Barrier

(2014) Federico Iovino et al.   INFECTION AND IMMUNITY

Matrix Metalloproteinase Inhibition Lowers Mortality and Brain Injury in Experimental Pneumococcal Meningitis

(2014) Fabian D. Liechti et al.   INFECTION AND IMMUNITY

Neuroprotective effect of metformin in MPTP-induced Parkinson’s disease in mice

(2014) S.P. Patil et al.   NEUROSCIENCE

Metformin promotes focal angiogenesis and neurogenesis in mice following middle cerebral artery occlusion

(2014) Yanqun Liu et al.   NEUROSCIENCE LETTERS

Bacterial Invasion of the Inner Ear in Association With Pneumococcal Meningitis

(2014) Martin Nue Møller et al.   OTOLOGY & NEUROTOLOGY

Streptococcus pneumoniae Interacts with pIgR Expressed by the Brain Microvascular Endothelium but Does Not Co-Localize with PAF Receptor

(2014) Federico Iovino et al.   PLoS One

The Mood-Stabilizer Lithium Prevents Hippocampal Apoptosis and Improves Spatial Memory in Experimental Meningitis

(2014) Fabian D. Liechti et al.   PLoS One

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Adjunctive Daptomycin Attenuates Brain Damage and Hearing Loss More Efficiently than Rifampin in Infant Rat Pneumococcal Meningitis

(2012) Denis Grandgirard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An Old Drug for New Ideas: Metformin Promotes Adult Neurogenesis and Spatial Memory Formation

(2012) Matthew B. Potts et al.   Cell Stem Cell

Metformin Activates an Atypical PKC-CBP Pathway to Promote Neurogenesis and Enhance Spatial Memory Formation

(2012) Jing Wang et al.   Cell Stem Cell

Effectiveness of Metformin on Weight Loss in Non-Diabetic Individuals with Obesity

(2012) C. Seifarth et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice

(2012) Layla K. Mahdi et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of vaccines on bacterial meningitis worldwide

(2012) Peter B McIntyre et al.   LANCET

Pathogenesis and Pathophysiology of Pneumococcal Meningitis

(2011) B. B. Mook-Kanamori et al.   CLINICAL MICROBIOLOGY REVIEWS

Neurogenesis in Adult Human Brain after Traumatic Brain Injury

(2011) WeiMing Zheng et al.   JOURNAL OF NEUROTRAUMA

Neonatal inflammatory pain increases hippocampal neurogenesis in rat pups

(2011) Ana Teresa F.S. Leslie et al.   NEUROSCIENCE LETTERS

Attenuation of Cerebrospinal Fluid Inflammation by the Nonbacteriolytic Antibiotic Daptomycin versus That by Ceftriaxone in Experimental Pneumococcal Meningitis

(2010) D. Grandgirard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tracking the transcriptional host response from the acute to the regenerative phase of experimental pneumococcal meningitis

(2010) Matthias Wittwer et al.   BMC INFECTIOUS DISEASES

Global and regional risk of disabling sequelae from bacterial meningitis: a systematic review and meta-analysis

(2010) Karen Edmond et al.   LANCET INFECTIOUS DISEASES

Long-term Sequelae of Childhood Bacterial Meningitis

(2010) Aruna Chandran et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Metformin Attenuated the Autoimmune Disease of the Central Nervous System in Animal Models of Multiple Sclerosis

(2009) N. Nath et al.   JOURNAL OF IMMUNOLOGY

Review: Pathophysiology and treatment of bacterial meningitis

(2009) Olaf Hoffman et al.   Therapeutic Advances in Neurological Disorders