Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway

Hiding in Plain Sight: Interleukin-11 Emerges as a Master Regulator of Fibrosis, Tissue Integrity, and Stromal Inflammation

(2020) Stuart A. Cook et al.   Annual Review of Medicine

TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency

(2020) Haiyun Chen et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future

(2020) Maria C. Basil et al.   Cell Stem Cell

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy

(2020) Peter M George et al.   Lancet Respiratory Medicine

Vascular dysfunction in aged mice contributes to persistent lung fibrosis

(2020) Nunzia Caporarello et al.   AGING CELL

Contributions of alveolar epithelial cell quality control to pulmonary fibrosis

(2020) Jeremy Katzen et al.   JOURNAL OF CLINICAL INVESTIGATION

Studies on the Use of Flagellin as an Immunostimulant and Vaccine Adjuvant in Fish Aquaculture

(2019) Eakapol Wangkahart et al.   Frontiers in Immunology

Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study

(2019) Madeleine K D Scott et al.   Lancet Respiratory Medicine

Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis

(2019) Anissa A. Widjaja et al.   GASTROENTEROLOGY

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

(2019) Christopher S. Smillie et al.   CELL

Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis

(2019) Christina Morse et al.   EUROPEAN RESPIRATORY JOURNAL

Emerging roles for Interleukin-11 in disease

(2019) Paul M. Nguyen et al.   GROWTH FACTORS

Modeling of Fibrotic Lung Disease Using 3D Organoids Derived from Human Pluripotent Stem Cells

(2019) Alexandros Strikoudis et al.   Cell Reports

Roles of interleukin-11 during acute bacterial pneumonia

(2019) Katrina E. Traber et al.   PLoS One

A Phase 2 Randomized Controlled Study of Tralokinumab in Subjects with Idiopathic Pulmonary Fibrosis

(2018) Joseph M. Parker et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL11RA- related Crouzon-like autosomal recessive craniosynostosis in ten new patients: resemblances and differences

(2018) E. Brischoux-Boucher et al.   CLINICAL GENETICS

Pathogenic stromal cells as therapeutic targets in joint inflammation

(2018) Stephanie G. Dakin et al.   Nature Reviews Rheumatology

Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice

(2018) Maria Agthe et al.   Cell Reports

Idiopathic pulmonary fibrosis

(2017) Luca Richeldi et al.   LANCET

IL11 is a crucial determinant of cardiovascular fibrosis

(2017) Sebastian Schafer et al.   NATURE

Idiopathic pulmonary fibrosis

(2017) Fernando J. Martinez et al.   Nature Reviews Disease Primers

Therapeutic Effect of Recombinant Mutated Interleukin 11 in the Mouse Model of Tuberculosis

(2016) Galina Shepelkova et al.   JOURNAL OF INFECTIOUS DISEASES

Diagnostic value of exome and whole genome sequencing in craniosynostosis

(2016) Kerry A Miller et al.   JOURNAL OF MEDICAL GENETICS

A Novel Genomic Signature with Translational Significance for Human Idiopathic Pulmonary Fibrosis

(2015) Yasmina Bauer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review

(2015) John Hutchinson et al.   EUROPEAN RESPIRATORY JOURNAL

Comparative analysis of differential gene expression in kidney tissues of moribund and surviving crucian carp (Carassius auratus gibelio) in response to cyprinid herpesvirus 2 infection

(2014) Lijuan Xu et al.   ARCHIVES OF VIROLOGY

Lack of Oncostatin M Receptor β Leads to Adipose Tissue Inflammation and Insulin Resistance by Switching Macrophage Phenotype

(2013) Tadasuke Komori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Th17 cytokines induce pro-fibrotic cytokines release from human eosinophils

(2013) Saleh Al-Muhsen et al.   RESPIRATORY RESEARCH

Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease

(2013) Gisela E Lindahl et al.   RESPIRATORY RESEARCH

Mutations in the interleukin receptorIL11RAcause autosomal recessive Crouzon-like craniosynostosis

(2013) Katharina Keupp et al.   Molecular Genetics & Genomic Medicine

Prednisone, Azathioprine, andN-Acetylcysteine for Pulmonary Fibrosis

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Inactivation of IL11 Signaling Causes Craniosynostosis, Delayed Tooth Eruption, and Supernumerary Teeth

(2011) Pekka Nieminen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Interleukin-6 Promotes Pulmonary Emphysema Associated with Apoptosis in Mice

(2011) Saleela M. Ruwanpura et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

MEK-ERK Pathway Modulation Ameliorates Pulmonary Fibrosis Associated with Epidermal Growth Factor Receptor Activation

(2011) Satish K. Madala et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44

(2011) Yuejuan Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-11 Drives Early Lung Inflammation during Mycobacterium tuberculosis Infection in Genetically Susceptible Mice

(2011) Marina A. Kapina et al.   PLoS One

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling pathways in the epithelial origins of pulmonary fibrosis

(2010) William D. Hardie et al.   CELL CYCLE

gp130 at the nexus of inflammation, autoimmunity, and cancer

(2010) J. S. Silver et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-17F-induced IL-11 release in bronchial epithelial cells via MSK1-CREB pathway

(2009) Mio Kawaguchi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Oxidative stress in the pathogenesis of diffuse lung diseases: A review

(2009) E. Bargagli et al.   RESPIRATORY MEDICINE

Endogenous IL-11 Signaling Is Essential in Th2- and IL-13–Induced Inflammation and Mucus Production

(2008) Chun Geun Lee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY