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Title
STAT3 and its targeting inhibitors in osteosarcoma
Authors
Keywords
-
Journal
CELL PROLIFERATION
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2020-12-31
DOI
10.1111/cpr.12974
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Note: Only part of the references are listed.- Glaucocalyxin A-induced oxidative stress inhibits the activation of STAT3 signaling pathway and suppresses osteosarcoma progression in vitro and in vivo
- (2019) Min Mao et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- LncRNA BLACAT1 accelerates the proliferation and migration of osteosarcoma cells through regulating STAT3
- (2019) Zhou Dong et al. PATHOLOGY RESEARCH AND PRACTICE
- Curcumin inhibits the proliferation and invasion of MG-63 cells through inactivation of the p-JAK2/p-STAT3 pathway
- (2019) Yuanjue Sun et al. OncoTargets and Therapy
- The Induction of Ferroptosis by Impairing STAT3/Nrf2/GPx4 Signaling Enhances the Sensitivity of Osteosarcoma Cells to Cisplatin
- (2019) Qiang Liu et al. CELL BIOLOGY INTERNATIONAL
- Prohibitin 1 interacts with signal transducer and activator of transcription 3 in T-helper 17 cells
- (2019) Junling Zhang et al. IMMUNOLOGY LETTERS
- Catalpol suppresses osteosarcoma cell proliferation through blocking epithelial-mesenchymal transition (EMT) and inducing apoptosis
- (2018) Lei Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Apatinib inhibits migration and invasion as well as PD-L1 expression in osteosarcoma by targeting STAT3
- (2018) Bingxin Zheng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- MicroRNA-140 suppresses osteosarcoma tumor growth by enhancing anti-tumor immune response and blocking mTOR signaling
- (2018) Xianglu Ji et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells
- (2018) Zhong Wu et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- STAT3 isoforms: Alternative fates in cancer?
- (2018) Petra Aigner et al. CYTOKINE
- Targeting the IL-6/JAK/STAT3 signalling axis in cancer
- (2018) Daniel E. Johnson et al. Nature Reviews Clinical Oncology
- PARK2 inhibits osteosarcoma cell growth through the JAK2/STAT3/VEGF signaling pathway
- (2018) Zhong Lei et al. Cell Death & Disease
- Resveratrol eliminates cancer stem cells of osteosarcoma by STAT3 pathway inhibition
- (2018) Lihua Peng et al. PLoS One
- The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies
- (2018) Loukik Arora et al. Cancers
- Role of the HDAC6/STAT3 pathway in regulating PD-L1 expression in osteosarcoma cell lines
- (2018) Ajimu Keremu et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Tumor-associated macrophages promote lung metastasis and induce epithelial-mesenchymal transition in osteosarcoma by activating the COX-2/STAT3 axis
- (2018) Yu Han et al. CANCER LETTERS
- Structure-based virtual screening for the identification of high affinity small molecule towards STAT3 for the clinical treatment of Osteosarcoma
- (2018) Ravina Khandelwal et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Chlorogenic acid inhibits osteosarcoma carcinogenesis via suppressing the STAT3/Snail pathway
- (2018) Fang Zhang et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells
- (2018) Dongqing Zuo et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Do STAT3 inhibitors have potential in the future for cancer therapy?
- (2017) Andrea L.A. Wong et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- E2F1 silencing inhibits migration and invasion of osteosarcoma cells via regulating DDR1 expression
- (2017) Zhaofeng Wang et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy
- (2017) Pablo Angulo et al. Journal of Hematology & Oncology
- Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3
- (2017) T Zhang et al. ONCOGENE
- Irisin reverses the IL-6 induced epithelial-mesenchymal transition in osteosarcoma cell migration and invasion through the STAT3/Snail signaling pathway
- (2017) Gang Kong et al. ONCOLOGY REPORTS
- Apatinib promotes autophagy and apoptosis through VEGFR2/STAT3/BCL-2 signaling in osteosarcoma
- (2017) Kuisheng Liu et al. Cell Death & Disease
- Cucurbitacin B inhibits cell proliferation and induces apoptosis in human osteosarcoma cells via modulation of the JAK2/STAT3 and MAPK pathways
- (2017) Zhi-Ren Zhang et al. Experimental and Therapeutic Medicine
- Ameloblastin induces tumor suppressive phenotype and enhances chemosensitivity to doxorubicin via Src-Stat3 inactivation in osteosarcoma
- (2017) Toshinori Ando et al. Scientific Reports
- Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma
- (2017) Peter Y. Yu et al. PLoS One
- Targeting Inflammation in Cancer Prevention and Therapy
- (2016) J. Todoric et al. Cancer Prevention Research
- STAT3 inhibitor, cucurbitacin I, is a novel therapeutic agent for osteosarcoma
- (2016) Toru Oi et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Gene silencing of USP1 by lentivirus effectively inhibits proliferation and invasion of human osteosarcoma cells
- (2016) Jinbo Liu et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Sinomenine prevents metastasis of human osteosarcoma cells via S phase arrest and suppression of tumor-related neovascularization and osteolysis through the CXCR4-STAT3 pathway
- (2016) TAO XIE et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition
- (2016) Tao Zhang et al. Cell Death & Disease
- Prognostic role of STAT3 in solid tumors: a systematic review and meta-analysis
- (2016) Pin Wu et al. Oncotarget
- 4-Methoxydalbergione suppresses growth and induces apoptosis in human osteosarcoma cells in vitro and in vivo xenograft model through down-regulation of the JAK2/STAT3 pathway
- (2016) Kyung-Ran Park et al. Oncotarget
- Mesenchymal stem cells promote osteosarcoma cell survival and drug resistance through activation of STAT3
- (2016) Bing Tu et al. Oncotarget
- Leukemia inhibitory factor promotes tumor growth and metastasis in human osteosarcoma via activating STAT3
- (2015) Bin Liu et al. APMIS
- The role of STAT3 in autophagy
- (2015) Liangkun You et al. Autophagy
- Enhanced T-Cell Immunity to Osteosarcoma Through Antibody Blockade of PD-1/PD-L1 Interactions
- (2015) Danielle M. Lussier et al. JOURNAL OF IMMUNOTHERAPY
- Ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells through inhibition of STAT3 and activation of caspase-3/9
- (2015) MIN XIONG et al. ONCOLOGY REPORTS
- Suppression of cancer relapse and metastasis by inhibiting cancer stemness
- (2015) Youzhi Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Novel Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Activities and Exhibits Potent Growth-Suppressive Activity in Human Cancer Cells
- (2015) Li Lin et al. NEOPLASIA
- Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
- (2014) Kodappully Sivaraman Siveen et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Correlation between ERK1 and STAT3 expression and chemoresistance in patients with conventional osteosarcoma
- (2014) Sébastien Salas et al. BMC CANCER
- Cells of origin in osteosarcoma: Mesenchymal stem cells or osteoblast committed cells?
- (2014) Anthony J. Mutsaers et al. BONE
- TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells
- (2014) Bi-Sheng Liu et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Changes in Signal Transducer and Activator of Transcription 3 (STAT3) Dynamics Induced by Complexation with Pharmacological Inhibitors of Src Homology 2 (SH2) Domain Dimerization
- (2014) Diana Resetca et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CD271+ Osteosarcoma Cells Display Stem-Like Properties
- (2014) Jiguang Tian et al. PLoS One
- Unraveling the novel anti-osteosarcoma function of coptisine and its mechanisms
- (2014) Di Yu et al. TOXICOLOGY LETTERS
- A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation
- (2013) X. Zhang et al. CANCER RESEARCH
- Np63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis
- (2013) H. K. Bid et al. CANCER RESEARCH
- EMT transcription factors: implication in osteosarcoma
- (2013) Guoqiong Yang et al. MEDICAL ONCOLOGY
- Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells
- (2013) Hasita Horlad et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Stat3-coordinated Lin-28–let-7–HMGA2 and miR-200–ZEB1 circuits initiate and maintain oncostatin M-driven epithelial–mesenchymal transition
- (2013) L Guo et al. ONCOGENE
- STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor
- (2013) Y. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway
- (2013) Yanwu Liu et al. TOXICOLOGY
- Notch Signaling is Associated with ALDH Activity and an Aggressive Metastatic Phenotype in Murine Osteosarcoma Cells
- (2013) Xiaodong Mu et al. Frontiers in Oncology
- Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells
- (2012) Zan Chen et al. ACTA PHARMACOLOGICA SINICA
- Biologic activity of the novel small molecule STAT3 inhibitor LLL12 against canine osteosarcoma cell lines
- (2012) Jason I Couto et al. BMC Veterinary Research
- STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma
- (2012) Bing Tu et al. CANCER LETTERS
- STAT3 Protein Interacts with Class O Forkhead Transcription Factors in the Cytoplasm and Regulates Nuclear/Cytoplasmic Localization of FoxO1 and FoxO3a Proteins in CD4+T Cells
- (2012) Hyun-Mee Oh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SC-1, a sorafenib derivative, shows anti-tumor effects in osteogenic sarcoma cells
- (2012) Chen-Ti Wang et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Cytoplasmic STAT3 Represses Autophagy by Inhibiting PKR Activity
- (2012) Shensi Shen et al. MOLECULAR CELL
- A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
- (2012) Pontus Boström et al. NATURE
- Template-based protein structure modeling using the RaptorX web server
- (2012) Morten Källberg et al. Nature Protocols
- Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts
- (2012) X. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Columbamine suppresses the proliferation and neovascularization of metastatic osteosarcoma U2OS cells with low cytotoxicity
- (2012) Meimei Bao et al. TOXICOLOGY LETTERS
- Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines
- (2011) Stacey L Fossey et al. BMC CANCER
- The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines
- (2011) Stacey L Fossey et al. BMC CANCER
- YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo
- (2011) Shu Tian et al. CANCER SCIENCE
- Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice
- (2011) Grace-Ifeyinwa Onimoe et al. INVESTIGATIONAL NEW DRUGS
- Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species
- (2011) Karol Szczepanek et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cytoprotection by the modulation of mitochondrial electron transport chain: The emerging role of mitochondrial STAT3
- (2011) Karol Szczepanek et al. MITOCHONDRION
- MicroRNA-199a-3p Is Downregulated in Human Osteosarcoma and Regulates Cell Proliferation and Migration
- (2011) Z. Duan et al. MOLECULAR CANCER THERAPEUTICS
- Clinical value of signal transducers and activators of transcription 3 (STAT3) gene expression in human osteosarcoma
- (2010) Yu-Cai Wang et al. ACTA HISTOCHEMICA
- Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms
- (2010) A. Quintas-Cardama et al. BLOOD
- Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway
- (2010) Keinosuke Ryu et al. BMC CANCER
- Human mesenchymal stem cells promote growth of osteosarcoma: Involvement of interleukin-6 in the interaction between human mesenchymal stem cells and Saos-2
- (2010) Zhen-Yu Bian et al. CANCER SCIENCE
- Immunity, Inflammation, and Cancer
- (2010) Sergei I. Grivennikov et al. CELL
- Characterization of molecular recognition of STAT3 SH2 domain inhibitors through molecular simulation
- (2010) In-Hee Park et al. JOURNAL OF MOLECULAR RECOGNITION
- Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis
- (2010) Keinosuke Ryu et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells
- (2010) Li Lin et al. Molecular Cancer
- Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis
- (2010) Srdan Verstovsek et al. NEW ENGLAND JOURNAL OF MEDICINE
- Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance
- (2010) Honoki ONCOLOGY REPORTS
- Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma
- (2010) Jarkko T. Korpi et al. SURGICAL ONCOLOGY-OXFORD
- Phase 2 study of CEP-701, an orally available JAK2 inhibitor, in patients with primary or post-polycythemia vera/essential thrombocythemia myelofibrosis
- (2009) F. P. S. Santos et al. BLOOD
- Characterization of STAT3 activation and expression in canine and human osteosarcoma
- (2009) Stacey L Fossey et al. BMC CANCER
- Interleukin-6 Modulates the Expression of the Bone Morphogenic Protein Receptor Type II Through a Novel STAT3–microRNA Cluster 17/92 Pathway
- (2009) Matthias Brock et al. CIRCULATION RESEARCH
- The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines
- (2009) Jennifer K. McCleese et al. INTERNATIONAL JOURNAL OF CANCER
- The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling
- (2009) L Lin et al. ONCOGENE
- Function of Mitochondrial Stat3 in Cellular Respiration
- (2009) J. Wegrzyn et al. SCIENCE
- The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer
- (2008) Willscott E. Naugler et al. TRENDS IN MOLECULAR MEDICINE
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