STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation

Sulindac has strong antifibrotic effects by suppressing STAT3-related miR-21

(2015) Xue Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Quantitative proteomics reveals ELP2 as a regulator to the inhibitory effect of TNF-α on osteoblast differentiation

(2015) Chang-Peng Xu et al.   Journal of Proteomics

IL-27 alleviates the bleomycin-induced pulmonary fibrosis by regulating the Th17 cell differentiation

(2015) Zhaoxing Dong et al.   BMC Pulmonary Medicine

Alveolar Epithelium: Beyond the Barrier

(2014) Zea Borok   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Gene of the month: Interleukin 6 (IL-6)

(2014) Parvin Ataie-Kachoie et al.   JOURNAL OF CLINICAL PATHOLOGY

Mechanisms of Oncostatin M-Induced Pulmonary Inflammation and Fibrosis

(2014) A. Mozaffarian et al.   JOURNAL OF IMMUNOLOGY

Blockade of IL-6TransSignaling Attenuates Pulmonary Fibrosis

(2014) Thanh-Thuy T. Le et al.   JOURNAL OF IMMUNOLOGY

Arsenic trioxide prevents rat pulmonary fibrosis via miR-98 overexpression

(2014) Shu-Yan Gao et al.   LIFE SCIENCES

The burden of idiopathic pulmonary fibrosis: An unmet public health need

(2014) Augustine S. Lee et al.   RESPIRATORY MEDICINE

Sesamin Induces Cell Cycle Arrest and Apoptosis through the Inhibition of Signal Transducer and Activator of Transcription 3 Signalling in Human Hepatocellular Carcinoma Cell Line HepG2

(2013) Pengyi Deng et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Stat3 Activation Links a C/EBPδ to Myostatin Pathway to Stimulate Loss of Muscle Mass

(2013) Liping Zhang et al.   Cell Metabolism

STAT1/3 and ERK1/2 Synergistically Regulate Cardiac Fibrosis Induced by High Glucose

(2013) Bin Dai et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Transforming Growth Factor-β (TGF-β)-mediated Connective Tissue Growth Factor (CTGF) Expression in Hepatic Stellate Cells Requires Stat3 Signaling Activation

(2013) Yan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT3-Mediated Signaling Dysregulates Lung Fibroblast-Myofibroblast Activation and Differentiation in UIP/IPF

(2012) Dmitri V. Pechkovsky et al.   AMERICAN JOURNAL OF PATHOLOGY

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

(2012) Robert J. J. O'Donoghue et al.   EMBO Molecular Medicine

Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model

(2012) Bhuvanesh Dave et al.   PLoS One

Hypoxia-inducible factor-1α mediates TGF-β-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis

(2011) Manabu Ueno et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis

(2011) Harold A. Chapman   Annual Review of Physiology

Involvement of STAT3-regulated hepatic soluble factors in attenuation of stellate cell activity and liver fibrogenesis in mice

(2011) Minoru Shigekawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor

(2011) M. S. Redell et al.   BLOOD

Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition

(2011) Daniel J. Schneider et al.   FASEB JOURNAL

Interleukin-6 Contributes to Inflammation and Remodeling in a Model of Adenosine Mediated Lung Injury

(2011) Mesias Pedroza et al.   PLoS One

Suppression of Expression of Heat Shock Protein 70 by Gefitinib and Its Contribution to Pulmonary Fibrosis

(2011) Takushi Namba et al.   PLoS One

Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis

(2010) Amber L. Degryse et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice

(2010) Ken-Ichiro Tanaka et al.   BIOCHEMICAL PHARMACOLOGY

Signal Transducer and Activator of Transcription 3 Protects From Liver Injury and Fibrosis in a Mouse Model of Sclerosing Cholangitis

(2010) Markus Mair et al.   GASTROENTEROLOGY

Alterations in Adenosine Metabolism and Signaling in Patients with Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

(2010) Yang Zhou et al.   PLoS One

Resistance to Bleomycin-Induced Lung Fibrosis in MMP-8 Deficient Mice Is Mediated by Interleukin-10

(2010) Emilio García-Prieto et al.   PLoS One

Contribution of Epithelial-derived Fibroblasts to Bleomycin-induced Lung Fibrosis

(2009) Harikrishna Tanjore et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Incidence, Prevalence, and Clinical Course of Idiopathic Pulmonary Fibrosis

(2009) Evans R. Fernández Pérez et al.   CHEST

SH2 domain binding to phosphopeptide ligands: potential for drug targeting

(2009) Moses et al.   Frontiers in Bioscience-Landmark

Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation

(2009) Xuejun Xu et al.   PLoS One

Single and repeated bleomycin intratracheal instillations lead to different biomechanical changes in lung tissue

(2009) M. Pinart et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations

(2009) Pravitt Gourh et al.   ARTHRITIS RESEARCH & THERAPY

Standardized quantification of pulmonary fibrosis in histological samples

(2008) Ralf-Harto Hübner et al.   BIOTECHNIQUES

Role of Interleukin-6 in Bleomycin-Induced Lung Inflammatory Changes in Mice

(2007) Fumitake Saito et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

(2007) Antje Moeller et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY