Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via NRF2/ARE/NF-κB signal pathway

Dl-3-n-Butylphthalide Alleviates Hippocampal Neuron Damage in Chronic Cerebral Hypoperfusion via Regulation of the CNTF/CNTFRα/JAK2/STAT3 Signaling Pathways

(2021) Wenxian Li et al.   Frontiers in Aging Neuroscience

Participation of Amyloid and Tau Protein in Post-Ischemic Neurodegeneration of the Hippocampus of a Nature Identical to Alzheimer's Disease

(2021) Ryszard Pluta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ferroptosis and its potential as a therapeutic target

(2021) Hanshu Yuan et al.   BIOCHEMICAL PHARMACOLOGY

Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation, apoptosis, and pyroptosis

(2021) Yaling Zheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ferroptosis: An emerging therapeutic target in stroke

(2021) Yibo Liu et al.   JOURNAL OF NEUROCHEMISTRY

Reduction in pericyte coverage leads to blood–brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion

(2021) Zhengyu Sun et al.   Fluids and Barriers of the CNS

Ferroptosis and traumatic brain injury

(2021) Zhiwen Geng et al.   BRAIN RESEARCH BULLETIN

Physical exercise modulates the astrocytes polarization, promotes myelin debris clearance and remyelination in chronic cerebral hypoperfusion rats

(2021) Ting Jiang et al.   LIFE SCIENCES

Transcription factors in ferroptotic cell death

(2020) Chongshan Dai et al.   CANCER GENE THERAPY

Grafted Neural Progenitor Cells Persist in the Injured Site and Differentiate Neuronally in a Rodent Model of Cardiac Arrest-Induced Global Brain Ischemia

(2020) Patricia Meyer et al.   STEM CELLS AND DEVELOPMENT

The Involvement of Canonical Wnt Signaling in Memory Impairment Induced by Chronic Cerebral Hypoperfusion in Mice

(2020) Min-Soo Kim et al.   Translational Stroke Research

Iron Metabolism, Ferroptosis, and the Links With Alzheimer’s Disease

(2020) Nao Yan et al.   Frontiers in Neuroscience

Transcranial Direct Current Stimulation Ameliorates Cognitive Impairment via Modulating Oxidative Stress, Inflammation, and Autophagy in a Rat Model of Vascular Dementia

(2020) Tao Guo et al.   Frontiers in Neuroscience

Inhibition of Ferroptosis Alleviates Early Brain Injury After Subarachnoid Hemorrhage In Vitro and In Vivo via Reduction of Lipid Peroxidation

(2020) Yuchen Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Update on the Neurobiology of Vascular Cognitive Impairment: From Lab to Clinic

(2020) Luisa Vinciguerra et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases

(2020) Xiaohua Song et al.   Frontiers in Neuroscience

Preventive and Therapeutic Strategies in Alzheimer's Disease: Focus on Oxidative Stress, Redox Metals, and Ferroptosis

(2020) Germán Plascencia-Villa et al.   ANTIOXIDANTS & REDOX SIGNALING

Fabricating an Electroactive Injectable Hydrogel Based on Pluronic-Chitosan/Aniline-Pentamer Containing Angiogenic Factor for Functional Repair of the Hippocampus Ischemia Rat Model

(2020) Melika Nourbakhsh et al.   Materials Science & Engineering C-Materials for Biological Applications

Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells

(2020) Yiran Sun et al.   MOLECULAR NEUROBIOLOGY

Ferroptosis in Neurological Diseases

(2020) Jia-Xin Ren et al.   Frontiers in Cellular Neuroscience

Exploring the Use of Dimethyl Fumarate as Microglia Modulator for Neurodegenerative Diseases Treatment

(2020) Maria Rosito et al.   Antioxidants

Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats

(2020) Yixin Li et al.   BRAIN RESEARCH

Long-term effects of experimental carotid stenosis on hippocampal infarct pathology, neurons and glia and amelioration by environmental enrichment

(2020) William Stevenson et al.   BRAIN RESEARCH BULLETIN

In the temporal organization of episodic memory, the hippocampus supports the experience of elapsed time

(2020) Marta Sabariego et al.   HIPPOCAMPUS

Characterization of Tauopathy in a Rat Model of Post-Stroke Dementia Combining Acute Infarct and Chronic Cerebral Hypoperfusion

(2020) Dong Bin Back et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FTH1 Inhibits Ferroptosis Through Ferritinophagy in the 6-OHDA Model of Parkinson’s Disease

(2020) Ye Tian et al.   Neurotherapeutics

Time as the fourth dimension in the hippocampus

(2020) Jean-Paul Banquet et al.   PROGRESS IN NEUROBIOLOGY

Cholinergic Dysfunction Involvement in Chronic Cerebral Hypoperfusion-Induced Impairment of Medial Septum–dCA1 Neurocircuit in Rats

(2020) Yi Xu et al.   Frontiers in Cellular Neuroscience

Computational repositioning of dimethyl fumarate for treating alcoholic liver disease

(2020) Ye Zhang et al.   Cell Death & Disease

Iron Metabolism in Ferroptosis

(2020) Xin Chen et al.   Frontiers in Cell and Developmental Biology

Acyl‐CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis

(2020) Xiao‐feng Qu et al.   CNS Neuroscience & Therapeutics

Green tea derivative (−)-epigallocatechin-3-gallate (EGCG) confers protection against ionizing radiation-induced intestinal epithelial cell death both in vitro and in vivo

(2020) Li-Wei Xie et al.   FREE RADICAL BIOLOGY AND MEDICINE

Recent advances in iron homeostasis and regulation - a focus on epigenetic regulation and stroke

(2020) Honglian Shi et al.   FREE RADICAL RESEARCH

Syringin exerts neuroprotective effects in a rat model of cerebral ischemia through the FOXO3a/NF-κB pathway

(2020) Junyi Tan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ferroptosis Mechanisms Involved in Neurodegenerative Diseases

(2020) Cadiele Oliana Reichert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dimethyl Fumarate Attenuates Lung Inflammation and Oxidative Stress Induced by Chronic Exposure to Diesel Exhaust Particles in Mice

(2020) Isabella Cattani-Cavalieri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment

(2020) Emma Sigfridsson et al.   Journal of Neuroinflammation

Galangin attenuated cerebral ischemia-reperfusion injury by inhibition of ferroptosis through activating the SLC7A11/GPX4 axis in gerbils

(2020) Xue Guan et al.   LIFE SCIENCES

AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia

(2020) Luting Poh et al.   MOLECULAR PSYCHIATRY

An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

(2020) Sarmistha Saha et al.   MOLECULES

Ferroptosis, a Regulated Neuronal Cell Death Type After Intracerebral Hemorrhage

(2020) Qinqin Bai et al.   Frontiers in Cellular Neuroscience

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Tripchlorolide May Improve Spatial Cognition Dysfunction and Synaptic Plasticity after Chronic Cerebral Hypoperfusion

(2019) Zhao-Hui Yao et al.   NEURAL PLASTICITY

Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease

(2019) Sau May Wong et al.   NEUROLOGY

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

Lasting spatial learning and memory deficits following chronic cerebral hypoperfusion are associated with hippocampal mitochondrial aging in rats

(2019) He Jing et al.   NEUROSCIENCE

Prostaglandin E1 Alleviates Cognitive Dysfunction in Chronic Cerebral Hypoperfusion Rats by Improving Hemodynamics

(2019) Xiaomei Xie et al.   Frontiers in Neuroscience

Sodium Dichloroacetate Stimulates Angiogenesis by Improving Endothelial Precursor Cell Function in an AKT/GSK-3β/Nrf2 Dependent Pathway in Vascular Dementia Rats

(2019) Hui Zhao et al.   Frontiers in Pharmacology

Honokiol Attenuates the Memory Impairments, Oxidative Stress, Neuroinflammation, and GSK-3β Activation in Vascular Dementia Rats

(2019) Si Guo et al.   JOURNAL OF ALZHEIMERS DISEASE

Treatment with dimethyl fumarate reduces the formation and rupture of intracranial aneurysms: Role of Nrf2 activation

(2019) Crissey L Pascale et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sestrin2 overexpression attenuates focal cerebral ischemic injury in rat by increasing Nrf2/HO-1 pathway-mediated angiogenesis

(2019) Peng Wang et al.   NEUROSCIENCE

Comprehensive Evaluation of White Matter Damage and Neuron Death and Whole-Transcriptome Analysis of Rats With Chronic Cerebral Hypoperfusion

(2019) Wenxian Li et al.   Frontiers in Cellular Neuroscience

Reactive Gliosis Contributes to Nrf2-Dependent Neuroprotection by Pretreatment with Dimethyl Fumarate or Korean Red Ginseng Against Hypoxic-Ischemia: Focus on Hippocampal Injury

(2019) Lei Liu et al.   MOLECULAR NEUROBIOLOGY

The Emerging Roles of Ferroptosis in Vascular Cognitive Impairment

(2019) Nao Yan et al.   Frontiers in Neuroscience

The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation

(2019) Xueying Guan et al.   LIFE SCIENCES

Carvacrol suppresses learning and memory dysfunction and hippocampal damages caused by chronic cerebral hypoperfusion

(2019) Azadeh Shahrokhi Raeini et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Mumefural Ameliorates Cognitive Impairment in Chronic Cerebral Hypoperfusion via Regulating the Septohippocampal Cholinergic System and Neuroinflammation

(2019) Jihye Bang et al.   Nutrients

Protection of blood-brain barrier as a potential mechanism for enriched environments to improve cognitive impairment caused by chronic cerebral hypoperfusion

(2019) Changhua Qu et al.   BEHAVIOURAL BRAIN RESEARCH

Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling

(2019) Magdalena Banach-Orłowska et al.   Cell Communication and Signaling

The Cannabinoid Receptor Agonist WIN55,212-2 Ameliorates Hippocampal Neuronal Damage After Chronic Cerebral Hypoperfusion Possibly Through Inhibiting Oxidative Stress and ASK1-p38 Signaling

(2019) Da-Peng Wang et al.   NEUROTOXICITY RESEARCH

FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia

(2018) Xin Jiang et al.   BEHAVIOURAL BRAIN RESEARCH

Neuroprotective Effect of Duloxetine on Chronic Cerebral Hypoperfusion-Induced Hippocampal Neuronal Damage

(2018) Jin-A Park et al.   Biomolecules & Therapeutics

Neuroprotective effect of Nrf2 activator dimethyl fumarate, on the hippocampal neurons in chemical kindling model in rat

(2018) Neha Singh et al.   EPILEPSY RESEARCH

Targeting crosstalk between Nuclear factor (erythroid-derived 2)-like 2 and Nuclear factor kappa beta pathway by Nrf2 activator dimethyl fumarate in epileptogenesis

(2018) Neha Singh et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Dimethyl Fumarate Attenuates Neuroinflammation and Neurobehavioral Deficits Induced by Experimental Traumatic Brain Injury

(2018) Giovanna Casili et al.   JOURNAL OF NEUROTRAUMA

HMGB1 Neutralization Attenuates Hippocampal Neuronal Death and Cognitive Impairment in Rats with Chronic Cerebral Hypoperfusion via Suppressing Inflammatory Responses and Oxidative Stress

(2018) Yue Hei et al.   NEUROSCIENCE

13 reasons why the brain is susceptible to oxidative stress

(2018) James Nathan Cobley et al.   Redox Biology

Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy

(2018) Antonio Cuadrado et al.   Redox Biology

Vascular cognitive impairment

(2018) Wiesje M. van der Flier et al.   Nature Reviews Disease Primers

Striking while the iron is hot: Iron metabolism and Ferroptosis in neurodegeneration

(2018) Shashank Masaldan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Limb Ischemic Conditioning Improved Cognitive Deficits via eNOS-Dependent Augmentation of Angiogenesis after Chronic Cerebral Hypoperfusion in Rats

(2018) Changhong Ren et al.   Aging and Disease

CZ-7, a new derivative of Claulansine F, ameliorates 2VO-induced vascular dementia in rats through a Nrf2-mediated antioxidant responses

(2018) Dan-dan Liu et al.   ACTA PHARMACOLOGICA SINICA

Effects of Cannabidiol on Diabetes Outcomes and Chronic Cerebral Hypoperfusion Comorbidities in Middle-Aged Rats

(2018) Amanda Nunes Santiago et al.   NEUROTOXICITY RESEARCH

Pretreatment with Korean red ginseng or dimethyl fumarate attenuates reactive gliosis and confers sustained neuroprotection against cerebral hypoxic-ischemic damage by an Nrf2-dependent mechanism

(2018) Lei Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Role of Autophagy in the Correlation Between Neuron Damage and Cognitive Impairment in Rat Chronic Cerebral Hypoperfusion

(2017) Wenying Zou et al.   MOLECULAR NEUROBIOLOGY

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Fumarate modulates the immune/inflammatory response and rescues nerve cells and neurological function after stroke in rats

(2016) Ruihe Lin et al.   Journal of Neuroinflammation

Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease

(2016) Mak Adam Daulatzai   JOURNAL OF NEUROSCIENCE RESEARCH

Molecular Mechanisms of Vascular Dementia: What Can Be Learned from Animal Models of Chronic Cerebral Hypoperfusion?

(2016) Si-Qi Du et al.   MOLECULAR NEUROBIOLOGY

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Effects of melatonin on cognitive impairment and hippocampal neuronal damage in a rat model of chronic cerebral hypoperfusion

(2016) CHOONG HYUN LEE et al.   Experimental and Therapeutic Medicine

Dimethyl Fumarate and Monomethyl Fumarate Promote Post-Ischemic Recovery in Mice

(2016) Yang Yao et al.   Translational Stroke Research

Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia

(2016) Raman Saggu et al.   Acta Neuropathologica Communications

Dimethyl Fumarate Protects Neural Stem/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1/2 MAPK Pathway

(2015) Qin Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage

(2015) Loretta O. Iniaghe et al.   NEUROBIOLOGY OF DISEASE

BMSCs transplantation improves cognitive impairment via up-regulation of hippocampal GABAergic system in a rat model of chronic cerebral hypoperfusion

(2015) Q. Long et al.   NEUROSCIENCE

Effects of alpha-lipoic acid on spatial learning and memory, oxidative stress, and central cholinergic system in a rat model of vascular dementia

(2015) Ran-ran Zhao et al.   NEUROSCIENCE LETTERS

Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A

(2015) Yanhong Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimethyl Fumarate Protects Brain From Damage Produced by Intracerebral Hemorrhage by Mechanism Involving Nrf2

(2015) Xiurong Zhao et al.   STROKE

Neurobehavioral and Imaging Correlates of Hippocampal Atrophy in a Mouse Model of Vascular Cognitive Impairment

(2015) Kristen L. Zuloaga et al.   Translational Stroke Research

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

From Chronic Cerebral Hypoperfusion to Alzheimer-Like Brain Pathology and Neurodegeneration

(2014) Yang Zhao et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neurohistological and behavioral changes following the four-vessel occlusion/internal carotid artery model of chronic cerebral hypoperfusion: Comparison between normotensive and spontaneously hypertensive rats

(2013) Cássia Valério Romanini et al.   BEHAVIOURAL BRAIN RESEARCH

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-κB pathways in diabetic neuropathy

(2013) Veera Ganesh Yerra et al.   Redox Biology

Disrupted Iron Metabolism and Ensuing Oxidative Stress may Mediate Cognitive Dysfunction Induced by Chronic Cerebral Hypoperfusion

(2012) Yunxia Li et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Key Neuroanatomical Structures for Post-Stroke Cognitive Impairment

(2012) Rebecca Grysiewicz et al.   Current Neurology and Neuroscience Reports

Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion

(2012) Zhanbo Feng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment

(2011) Fernanda Cechetti et al.   BRAIN RESEARCH BULLETIN

An enriched environment reverses the synaptic plasticity deficit induced by chronic cerebral hypoperfusion

(2011) Hong Zhu et al.   NEUROSCIENCE LETTERS

CA1 neurons in the human hippocampus are critical for autobiographical memory, mental time travel, and autonoetic consciousness

(2011) T. Bartsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regional Ischemic Vulnerability of the Brain to Hypoperfusion

(2011) Seyedmehdi Payabvash et al.   STROKE

Structural Features of Ischemic Damage in the Hippocampus

(2009) Alexander G. Nikonenko et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology