Treatment with dimethyl fumarate reduces the formation and rupture of intracranial aneurysms: Role of Nrf2 activation

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

(2018) Michael D. Kornberg et al.   SCIENCE

Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy

(2018) Antonio Cuadrado et al.   Redox Biology

Dimethyl fumarate treatment after traumatic brain injury prevents depletion of antioxidative brain glutathione and confers neuroprotection

(2017) Tobias Krämer et al.   JOURNAL OF NEUROCHEMISTRY

Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease

(2016) M. Ahuja et al.   JOURNAL OF NEUROSCIENCE

Nrf2 Weaves an Elaborate Network of Neuroprotection Against Stroke

(2016) Shuai Jiang et al.   MOLECULAR NEUROBIOLOGY

Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2

(2016) Ulf Schulze-Topphoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimethyl Fumarate and Monomethyl Fumarate Promote Post-Ischemic Recovery in Mice

(2016) Yang Yao et al.   Translational Stroke Research

Utilization of Dimethyl Fumarate and Related Molecules for Treatment of Multiple Sclerosis, Cancer, and Other Diseases

(2016) Zaidoon Al-Jaderi et al.   Frontiers in Immunology

RhoA Proteolysis Regulates the Actin Cytoskeleton in Response to Oxidative Stress

(2016) Marie-Pier Girouard et al.   PLoS One

Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury

(2016) Takashi Ashino et al.   Scientific Reports

Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation

(2016) Victoria A. McGuire et al.   Scientific Reports

Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS

(2015) Benedetta Parodi et al.   ACTA NEUROPATHOLOGICA

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dimethylfumarate protects against TNF-α-induced secretion of inflammatory cytokines in human endothelial cells

(2015) Simon Gerhardt et al.   Journal of Inflammation-London

Monomethyl fumarate promotes Nrf2-dependent neuroprotection in retinal ischemia-reperfusion

(2015) Hongkwan Cho et al.   Journal of Neuroinflammation

Dimethylfumarate alleviates early brain injury and secondary cognitive deficits after experimental subarachnoid hemorrhage via activation of Keap1-Nrf2-ARE system

(2015) Yizhi Liu et al.   JOURNAL OF NEUROSURGERY

Inflammatory Mediators in Vascular Disease: Identifying Promising Targets for Intracranial Aneurysm Research

(2015) David M. Sawyer et al.   MEDIATORS OF INFLAMMATION

Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage

(2015) Loretta O. Iniaghe et al.   NEUROBIOLOGY OF DISEASE

Molecular Mechanisms of the Formation and Progression of Intracranial Aneurysms

(2015) Hiroharu KATAOKA   NEUROLOGIA MEDICO-CHIRURGICA

Dimethyl Fumarate Protects Brain From Damage Produced by Intracerebral Hemorrhage by Mechanism Involving Nrf2

(2015) Xiurong Zhao et al.   STROKE

Novel High-Throughput In Vitro Model for Identifying Hemodynamic-Induced Inflammatory Mediators of Cerebral Aneurysm Formation

(2014) Kamil W. Nowicki et al.   HYPERTENSION

Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation

(2014) Antonio Cuadrado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Proteome of Mouse Cerebral Arteries

(2014) AmanPreet Badhwar et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE

(2014) Hui Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Dimethylfumarate attenuates restenosis after acute vascular injury by cell-specific and Nrf2-dependent mechanisms

(2014) Chang Joo Oh et al.   Redox Biology

Redox-Sensitive Transcription Factor Nrf2 Regulates Vascular Smooth Muscle Cell Migration and Neointimal Hyperplasia

(2013) Takashi Ashino et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Role of Oxidative Stress in Cerebral Aneurysm Formation and Rupture

(2013) Robert Starke et al.   CURRENT NEUROVASCULAR RESEARCH

Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes

(2013) Oliver Soehnlein et al.   EMBO Molecular Medicine

TNF-α Induces Phenotypic Modulation in Cerebral Vascular Smooth Muscle Cells: Implications for Cerebral Aneurysm Pathology

(2013) Muhammad S Ali et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Early modulation of the transcription factor Nrf2 in rodent striatal slices by quinolinic acid, a toxic metabolite of the kynurenine pathway

(2013) A.L. Colín-González et al.   NEUROSCIENCE

Regulation of CCL5 Expression in Smooth Muscle Cells Following Arterial Injury

(2012) Huan Liu et al.   PLoS One

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells

(2011) Kamran Ghoreschi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells

(2011) Yuexi Wang et al.   PROTEOMICS

Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases

(2010) Nicole F. Villeneuve et al.   ANTIOXIDANTS & REDOX SIGNALING

Discovering transcriptional modules by Bayesian data integration

(2010) Richard S. Savage et al.   BIOINFORMATICS

Nicotinic acid– and monomethyl fumarate–induced flushing involves GPR109A expressed by keratinocytes and COX-2–dependent prostanoid formation in mice

(2010) Julien Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

Critical Roles of Macrophages in the Formation of Intracranial Aneurysm

(2010) Yasuhisa Kanematsu et al.   STROKE

Signaling Through Rho GTPase Pathway as Viable Drug Target

(2009) Qun Lu et al.   CURRENT MEDICINAL CHEMISTRY

Elastase-Induced Intracranial Aneurysms in Hypertensive Mice

(2009) Yoshitsugu Nuki et al.   HYPERTENSION

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Risk of recurrent subarachnoid haemorrhage, death, or dependence and standardised mortality ratios after clipping or coiling of an intracranial aneurysm in the International Subarachnoid Aneurysm Trial (ISAT): long-term follow-up

(2009) Andrew J Molyneux et al.   LANCET NEUROLOGY