Inhibitory synapse loss and accumulation of amyloid beta in inhibitory presynaptic terminals in Alzheimer's disease

Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease

(2021) Julie C. Lauterborn et al.   Nature Communications

Amyloid-Beta1-42 -Induced Increase in GABAergic Tonic Conductance in Mouse Hippocampal CA1 Pyramidal Cells

(2020) Beatriz Calvo-Flores Guzmán et al.   MOLECULES

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

(2020) Martí Colom-Cadena et al.   Alzheimers Research & Therapy

Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model

(2020) Masafumi Shimojo et al.   JOURNAL OF NEUROSCIENCE

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

(2020) Gill Livingston et al.   LANCET

Three-dimensional analysis of synaptic organization in the hippocampal CA1 field in Alzheimer’s disease

(2020) Marta Montero-Crespo et al.   BRAIN

Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer’s disease amyloidosis

(2019) Jan-Oliver Hollnagel et al.   PLoS One

Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration

(2019) Christopher M. Henstridge et al.   Frontiers in Cellular Neuroscience

Role of GirK Channels in Long-Term Potentiation of Synaptic Inhibition in an In Vivo Mouse Model of Early Amyloid-β Pathology

(2019) Irene Sánchez-Rodríguez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aberrant Excitatory–Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer’s Disease

(2019) Alexandra L Petrache et al.   CEREBRAL CORTEX

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease

(2019) Eleanor K. Pickett et al.   Cell Reports

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

(2019) Raphael Hesse et al.   Acta Neuropathologica Communications

Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer’s disease patients

(2018) M. Domínguez-Álvaro et al.   Acta Neuropathologica Communications

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

(2018) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Epileptic activity in Alzheimer's disease: causes and clinical relevance

(2017) Keith A Vossel et al.   LANCET NEUROLOGY

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease

(2017) Hongjun Fu et al.   NEURON

Impaired expression of GABA transporters in the human Alzheimer’s disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus

(2017) Tessa E. Fuhrer et al.   NEUROSCIENCE

Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer’s disease: analysis of Osaka mutation-knockin mice

(2017) Tomohiro Umeda et al.   Acta Neuropathologica Communications

Synaptic pathology: A shared mechanism in neurological disease

(2016) Christopher M. Henstridge et al.   AGEING RESEARCH REVIEWS

Biphasic Alteration of the Inhibitory Synapse Scaffold Protein Gephyrin in Early and Late Stages of an Alzheimer Disease Model

(2016) Eva Kiss et al.   AMERICAN JOURNAL OF PATHOLOGY

Non-Fibrillar Oligomeric Amyloid-β within Synapses

(2016) Eleanor K. Pickett et al.   JOURNAL OF ALZHEIMERS DISEASE

Calcium channel blockade attenuates abnormal synaptic transmission in the dentate gyrus elicited by entorhinal amyloidopathy

(2016) Hamid Gholami Pourbadie et al.   SYNAPSE

Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse

(2015) Christopher M. Henstridge et al.   Acta Neuropathologica Communications

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Age-Related Changes to Layer 3 Pyramidal Cells in the Rhesus Monkey Visual Cortex

(2013) J. I. Luebke et al.   CEREBRAL CORTEX

Studying synapses in human brain with array tomography and electron microscopy

(2013) Kevin R Kay et al.   Nature Protocols

Altered synapses and gliotransmission in Alzheimer's disease and AD model mice

(2013) Stanislaw Mitew et al.   NEUROBIOLOGY OF AGING

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

(2012) Robert M. Koffie et al.   BRAIN

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diminished perisomatic GABAergic terminals on cortical neurons adjacent to amyloid plaques

(2009) Virginia Garcia-Marin   Frontiers in Neuroanatomy

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Gender differences in human cortical synaptic density

(2008) L. Alonso-Nanclares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA