Aberrant Excitatory–Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer’s Disease

Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model

(2018) Archie A Khan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20-APP transgenic and wild-type mice

(2018) Cheril Tapia-Rojas et al.   JOURNAL OF NEUROCHEMISTRY

Synaptic mechanism in Alzheimer’s disease: a selective degeneration of an excitatory synaptic pathway in the CA1 hippocampus that controls spatial learning and memory in Alzheimer’s disease

(2018) X Yang et al.   MOLECULAR PSYCHIATRY

Diazepam-induced loss of inhibitory synapses mediated by PLCδ/ Ca2+/calcineurin signalling downstream of GABAA receptors

(2018) Martin W. Nicholson et al.   MOLECULAR PSYCHIATRY

Evidence of Wnt/β-catenin alterations in brain and bone of a tauopathy mouse model of Alzheimer's disease

(2018) Christine M. Dengler-Crish et al.   NEUROBIOLOGY OF AGING

The Role of Fluoxetine in Activating Wnt/β-Catenin Signaling and Repressing β-Amyloid Production in an Alzheimer Mouse Model

(2018) Min Huang et al.   Frontiers in Aging Neuroscience

Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease

(2018) NibaldoC Inestrosa et al.   Neural Regeneration Research

A role for APP in Wnt signalling links synapse loss with β-amyloid production

(2018) Christina Elliott et al.   Translational Psychiatry

Sodium selenate activated Wnt/β-catenin signaling and repressed amyloid-β formation in a triple transgenic mouse model of Alzheimer's disease

(2017) Na Jin et al.   EXPERIMENTAL NEUROLOGY

Hippocampal GABAergic Inhibitory Interneurons

(2017) Kenneth A. Pelkey et al.   PHYSIOLOGICAL REVIEWS

Altered Synapse Stability in the Early Stages of Tauopathy

(2017) Johanna S. Jackson et al.   Cell Reports

Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult Hippocampus

(2016) Aude Marzo et al.   CURRENT BIOLOGY

Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-β (Aβ)42peptides

(2016) Cheril Tapia-Rojas et al.   JOURNAL OF NEUROCHEMISTRY

A novel mechanism of memory loss in Alzheimer’s disease mice via the degeneration of entorhinal–CA1 synapses

(2016) X Yang et al.   MOLECULAR PSYCHIATRY

Gamma frequency entrainment attenuates amyloid load and modifies microglia

(2016) Hannah F. Iaccarino et al.   NATURE

Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders

(2016) Wen Zhang et al.   NATURE NEUROSCIENCE

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

Cognitive deficits in single App knock-in mouse models

(2016) Akira Masuda et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Impairments of neural circuit function in Alzheimer's disease

(2016) Marc Aurel Busche et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A novel function for Wnt signaling modulating neuronal firing activity and the temporal structure of spontaneous oscillation in the entorhinal–hippocampal circuit

(2015) Carolina A. Oliva et al.   EXPERIMENTAL NEUROLOGY

Activation of the Wnt/β-catenin pathway represses the transcription of the β-amyloid precursor protein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter

(2015) Callum Parr et al.   FASEB JOURNAL

Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease

(2015) Kaoru Yamamoto et al.   Cell Reports

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer’s Disease

(2014) Chia-Chen Liu et al.   NEURON

Regulating Wnt signaling: a strategy to prevent neurodegeneration and induce regeneration

(2014) K. Harvey et al.   Journal of Molecular Cell Biology

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

(2014) S. A. Purro et al.   Journal of Molecular Cell Biology

Wnt signaling in the nervous system and in Alzheimer's disease

(2014) N. C. Inestrosa et al.   Journal of Molecular Cell Biology

Wnt signaling: Role in LTP, neural networks and memory

(2013) Carolina A. Oliva et al.   AGEING RESEARCH REVIEWS

Distribution of CaMKIIα expression in the brain in vivo, studied by CaMKIIα-GFP mice

(2013) Xinjun Wang et al.   BRAIN RESEARCH

Krüppel-like Factor 8 Ameliorates Alzheimer's Disease by Activating β-Catenin

(2013) Ran Yi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

(2013) Usman A Khan et al.   NATURE NEUROSCIENCE

Wnts in action: from synapse formation to synaptic maintenance

(2013) Ellen M. Dickins et al.   Frontiers in Cellular Neuroscience

Wnts in adult brain: from synaptic plasticity to cognitive deficiencies

(2013) Carolina A. Oliva et al.   Frontiers in Cellular Neuroscience

The regulation and deregulation of Wnt signaling by PARK genes in health and disease

(2013) D. C. Berwick et al.   Journal of Molecular Cell Biology

The APP intracellular domain (AICD) inhibits Wnt signalling and promotes neurite outgrowth

(2012) Fangfang Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Wnt signaling regulates experience-dependent synaptic plasticity in the adult nervous system

(2012) Michael Jensen et al.   CELL CYCLE

WNTs in synapse formation and neuronal circuitry

(2012) Mikyoung Park et al.   EMBO JOURNAL

The Secreted Wnt Antagonist Dickkopf-1 Is Required for Amyloid  -Mediated Synaptic Loss

(2012) S. A. Purro et al.   JOURNAL OF NEUROSCIENCE

Bidirectional Relationship between Functional Connectivity and Amyloid-  Deposition in Mouse Brain

(2012) A. W. Bero et al.   JOURNAL OF NEUROSCIENCE

Interneuron dysfunction in psychiatric disorders

(2012) Oscar Marín   NATURE REVIEWS NEUROSCIENCE

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

(2012) Arnold Bakker et al.   NEURON

GABAA Receptor Subtype-Selective Modulators. I. α2/α3-Selective Agonists as Non-Sedating Anxiolytics

(2011) John R. Atack   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Regulation of NMDA-Receptor Synaptic Transmission by Wnt Signaling

(2011) W. Cerpa et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons

(2010) Bernardo Rudy et al.   Developmental Neurobiology

Wnt-5a occludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons

(2010) Waldo Cerpa et al.   Molecular Neurodegeneration

Physiology of neuronal–glial networking

(2010) Alexei Verkhratsky   NEUROCHEMISTRY INTERNATIONAL

Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline

(2010) J. L. O'Brien et al.   NEUROLOGY

Lithium Improves Hippocampal Neurogenesis, Neuropathology and Cognitive Functions in APP Mutant Mice

(2010) Anna Fiorentini et al.   PLoS One

Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease

(2010) J J Rodríguez et al.   Cell Death & Disease

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model of Alzheimer's disease

(2009) E M Toledo et al.   MOLECULAR PSYCHIATRY

Emerging roles of Wnts in the adult nervous system

(2009) Nibaldo C. Inestrosa et al.   NATURE REVIEWS NEUROSCIENCE

Diminished perisomatic GABAergic terminals on cortical neurons adjacent to amyloid plaques

(2009) Virginia Garcia-Marin   Frontiers in Neuroanatomy

The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease

(2008) Nibaldo C Inestrosa et al.   Molecular Neurodegeneration

Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex

(2008)   NATURE REVIEWS NEUROSCIENCE

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE

Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations

(2008) T. Klausberger et al.   SCIENCE