Quinoline anticancer agents active on DNA and DNA-interacting proteins: From classical to emerging therapeutic targets

Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation

(2020) Clemens Zwergel et al.   Cancers

Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1

(2020) Ehab Ghazy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New Dual CK2/HDAC1 Inhibitors with Nanomolar Inhibitory Activity against Both Enzymes

(2020) Loganathan Rangasamy et al.   ACS Medicinal Chemistry Letters

Discovery of novel dual c-Met/HDAC inhibitors as a promising strategy for cancer therapy

(2020) Hao Hu et al.   BIOORGANIC CHEMISTRY

Development of a metabolically stable topoisomerase I poison as anticancer agent

(2020) Biswajit Kundu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

F10, a new camptothecin derivative, was identified as a new orally–bioavailable, potent antitumor agent

(2020) Shu Fan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quinoline-Based Molecules Targeting c-Met, EGF, and VEGF Receptors and the Proteins Involved in Related Carcinogenic Pathways

(2020) Annamaria Martorana et al.   MOLECULES

Epigenetic Targets and Their Inhibitors in Cancer Therapy

(2019) Le Zhao et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy

(2019) Sefan Asamitsu et al.   MOLECULES

Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poisons with Potent Anticancer Activity

(2019) Biswajit Kundu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and docking study of new quinoline derivatives as antitumor agents

(2019) Eman E. Nasr et al.   ARCHIV DER PHARMAZIE

Insights for the design of protein lysine methyltransferase G9a inhibitors

(2019) Mariasoosai Ramya Chandar Charles et al.   Future Medicinal Chemistry

Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3

(2019) Chuhui Huang et al.   ACS Medicinal Chemistry Letters

Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells

(2019) Clemens Zwergel et al.   Clinical Epigenetics

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

(2019) Yi-Ling Hsieh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Design, Synthesis and Anticancer Evaluation of New Substituted Thiophene-Quinoline Derivatives

(2019) Dina I.A. Othman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel 9-(2-(1-arylethylidene)hydrazinyl)acridine derivatives: Target Topoisomerase 1 and growth inhibition of HeLa cancer cells

(2019) Md Rafi Haider et al.   BIOORGANIC CHEMISTRY

Cisplatin: The first metal based anticancer drug

(2019) Sumit Ghosh   BIOORGANIC CHEMISTRY

A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade

(2019) Xiaoxia Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The roles of DNA, RNA and histone methylation in ageing and cancer

(2019) Ewa M. Michalak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Anticancer, antimicrobial activities of quinoline based hydrazone analogues: Synthesis, characterization and molecular docking

(2019) Kanubhai D Katariya et al.   BIOORGANIC CHEMISTRY

Fluorinated 3,6,9-trisubstituted acridine derivatives as DNA interacting agents and topoisomerase inhibitors with A549 antiproliferative activity

(2019) Patrik Nunhart et al.   BIOORGANIC CHEMISTRY

Design, synthesis, biological evaluation and molecular docking study of arylcarboxamido piperidine and piperazine-based hydroxamates as potential HDAC8 inhibitors with promising anticancer activity

(2019) Prakruti Trivedi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

RJT-101, a novel camptothecin derivative, is highly effective in the treatment of melanoma through DNA damage by targeting topoisomerase 1

(2019) Chengxiang Lian et al.   BIOCHEMICAL PHARMACOLOGY

Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening

(2019) M. Ramya Chandar Charles et al.   BIOCHIMIE

Synthesis and biological evaluation of 2-quinolineacrylamides

(2019) Shih-Wei Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological research of novel N-phenylbenzamide-4-methylamine acridine derivatives as potential topoisomerase I/II and apoptosis-inducing agents

(2019) Bin Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin

(2019) Cheng-Jie Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antiproliferative activity and DNA/RNA-binding properties of mono- and bis-(1,2,3-triazolyl)-appended benzimidazo[1,2-a]quinoline derivatives

(2019) Andrijana Meščić Macan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Topoisomerases as anticancer targets

(2018) Justine L. Delgado et al.   BIOCHEMICAL JOURNAL

Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity

(2018) Concepción Alonso et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quinoline based Pd(II) complexes: Synthesis, characterization and evaluation of DNA/protein binding, molecular docking and in vitro anticancer activity

(2018) Thangavel Thirunavukkarasu et al.   INORGANICA CHIMICA ACTA

Synthesis, characterization and cytotoxic activity of novel copper(II) complexes with aroylhydrazone derivatives of 2-Oxo-1,2-dihydrobenzo[ h ]quinoline-3-carbaldehyde

(2018) Eswaran Ramachandran et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

(2018) Hsueh-Yun Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Evaluation of Novel p-(methylthio)styryl Substituted Quindoline Derivatives as Neuroblastoma RAS (NRAS) Repressors via Specific Stabilizing the RNA G-Quadruplex

(2018) Wang Peng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy

(2018) Obdulia Rabal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, DNA binding and cytotoxic activity of pyrimido[4′,5′:4,5]thieno(2,3-b)quinoline with 9-hydroxy-4-(3-diethylaminopropylamino) and 8-methoxy-4-(3-diethylaminopropylamino) substitutions

(2018) Hulihalli N. KiranKumar et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy

(2018) Maria Cristina Manara et al.   MOLECULAR CANCER THERAPEUTICS

HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors

(2018) Rekha Sangwan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Drug Design and Identification of H2O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo

(2018) Peichen Pan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Medicinal chemistry of acridine and its analogues

(2018) Parteek Prasher et al.   MedChemComm

Copper(ii) complexes based on quinoline-derived Schiff-base ligands: synthesis, characterization, HSA/DNA binding ability, and anticancer activity

(2018) Kun Hu et al.   MedChemComm

The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells

(2018) Huang-Ju Tu et al.   Clinical Epigenetics

Synthesis and antitumor activity of novel substituted uracil-1′(N)-acetic acid ester derivatives of 20(S)-camptothecins

(2017) Di-Zao Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of quinoline derivatives as HDAC class I inhibitors

(2017) Chen Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An overview of quinoline as a privileged scaffold in cancer drug discovery

(2017) Robert Musiol   Expert Opinion on Drug Discovery

Anticancer Activity of Iridium(III) Complexes Based on a Pyrazole-Appended Quinoline-Based BODIPY

(2017) Rajendra Prasad Paitandi et al.   INORGANIC CHEMISTRY

Histone Deacetylase Inhibitors as Anticancer Drugs

(2017) Tomas Eckschlager et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines

(2017) Katharina Stenzel et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Disubstituted Quindoline Derivatives Inhibiting Burkitt’s Lymphoma Cell Proliferation by Impeding c-MYC Transcription

(2017) Hui-Yun Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry

(2017) De-Ying Zeng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antiproliferative activity of amino-substituted benzimidazo[1,2- $${\varvec{a}}$$ a ]quinolines as mesylate salts designed by 3D-QSAR analysis

(2017) Darko Vušak et al.   MOLECULAR DIVERSITY

Design, Synthesis and Biological Evaluation of New Substituted Diquinolinyl-Pyridine Ligands as Anticancer Agents by Targeting G-Quadruplex

(2017) Rabindra Das et al.   MOLECULES

Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives

(2017) Dong Lu et al.   ACS Medicinal Chemistry Letters

Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies

(2017) Edurne San José-Enériz et al.   Nature Communications

Three novel transition metal complexes of 6-methyl-2-oxo-quinoline-3-carbaldehyde thiosemicarbazone: synthesis, crystal structure, cytotoxicity, and mechanism of action

(2017) Bi-Qun Zou et al.   RSC Advances

Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile

(2016) Zarko V. Boskovic et al.   ACS Chemical Biology

Stabilization of G-quadruplex DNA and inhibition of Bcl-2 expression by a pyridostatin analog

(2016) Yun Feng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel benzoquinoline derivatives via unpredicted condensation of ethyl propiolate and naphthylamines: Synthesis and topoisomerase inhibition activity

(2016) Giovanni Marzaro et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives

(2016) Zi-Long Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Amino substituted benzimidazo[1,2- a ]quinolines: Antiproliferative potency, 3D QSAR study and DNA binding properties

(2016) Nataša Perin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2-(Phenylsulfonyl)quinoline N -hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase

(2016) Hsueh-Yun Lee et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antiproliferative activity of 9-benzylamino-6-chloro-2-methoxy-acridine derivatives as potent DNA-binding ligands and topoisomerase II inhibitors

(2016) Wei Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quinolino[3,4- b ]quinoxalines and pyridazino[4,3- c ]quinoline derivatives: Synthesis, inhibition of topoisomerase IIα, G-quadruplex binding and cytotoxic properties

(2016) Fausta Palluotto et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, cytotoxic activity, DNA binding and molecular docking studies of novel 9-anilinothiazolo[5,4-b]quinoline derivatives

(2016) Francisco J. Reyes-Rangel et al.   MEDICINAL CHEMISTRY RESEARCH

Design, synthesis and biological evaluation of tetracyclic azafluorenone derivatives with topoisomerase I inhibitory properties as potential anticancer agents

(2016) Tsung-Chih Chen et al.   Arabian Journal of Chemistry

Design, synthesis and preliminary bioactivity evaluations of substituted quinoline hydroxamic acid derivatives as novel histone deacetylase (HDAC) inhibitors

(2015) Lei Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

DNA intercalative 4-butylaminopyrimido[4′,5′:4,5]thieno(2,3-b)quinoline induces cell cycle arrest and apoptosis in leukemia cells

(2015) Heggodu G. RohitKumar et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Indolo[3,2-c]quinoline G-Quadruplex Stabilizers: a Structural Analysis of Binding to the Human Telomeric G-Quadruplex

(2015) João Lavrado et al.   ChemMedChem

The synthesis of indolo[2,3-b]quinoline derivatives with a guanidine group: Highly selective cytotoxic agents

(2015) Katarzyna Sidoryk et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting G-quadruplex nucleic acids with heterocyclic alkaloids and their derivatives

(2015) Yun-Xia Xiong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A review on anticancer potential of bioactive heterocycle quinoline

(2015) Obaid Afzal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Perspectives on Biologically Active Camptothecin Derivatives

(2015) Ying-Qian Liu et al.   MEDICINAL RESEARCH REVIEWS

5-Methoxyquinoline Derivatives as a New Class of EZH2 Inhibitors

(2015) Pu Xiang et al.   MOLECULES

Cell Cycle Arrest and Induction of Apoptosis in Colon Adenocarcinoma Cells by a DNA Intercalative Quinoline Derivative, 4-Morpholinopyrimido [4′,5′:4,5] Selenolo (2,3-b) Quinoline

(2015) Heggodu G. RohitKumar et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives

(2015) Hugo Brito et al.   PLoS One

HDAC Inhibitors as Novel Anti-Cancer Therapeutics

(2015) Cristabelle Souza et al.   Recent Patents on Anti-Cancer Drug Discovery

Towards Tris(diimine)–Ruthenium(II) and Bis(quinoline)–Re(I)(CO)3 Complexes as Photoactivated Anticancer Drug Candidates

(2015) Tanmaya Joshi et al.   SYNLETT

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines

(2015) João Lavrado et al.   Scientific Reports

Stabilization of VEGF G-quadruplex and inhibition of angiogenesis by quindoline derivatives

(2014) Yue Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors

(2014) Toshihiko Tashima et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Small-molecule quadruplex-targeted drug discovery

(2014) Stephan A. Ohnmacht et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Histone deacetylase inhibitors and cell death

(2014) Jing Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Design, Synthesis and Biological Evaluation of 4-Amino-N-(4-aminophenyl)benzamide Analogues of Quinoline-Based SGI-1027 as Inhibitors of DNA Methylation

(2014) Elodie Rilova et al.   ChemMedChem

G-Quadruplex Structures and Their Interaction Diversity with Ligands

(2014) Sulin Zhang et al.   ChemMedChem

Does Ligand Symmetry Play a Role in the Stabilization of DNA G-Quadruplex Host-Guest Complexes?

(2014) Antonino Lauria et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis and in vitro cytotoxic effect of 6-amino-substituted 11H- and 11Me-indolo[3,2-c]quinolines

(2014) Ning Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antiproliferative activity and DNA binding properties of novel 5-Aminobenzimidazo[1,2-a]quinoline-6-carbonitriles

(2014) Nataša Perin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in small organic molecules as DNA intercalating agents: Synthesis, activity, and modeling

(2014) Antonio Rescifina et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Acridine and its derivatives: a patent review (2009 – 2013)

(2014) Bin Zhang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

New Insights on the Mechanism of Quinoline-based DNA Methyltransferase Inhibitors

(2014) Christina Gros et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting DNA Methylation with Small Molecules: What’s Next?

(2014) Alexandre Erdmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, Mechanisms of Action, and Toxicity of Novel 20(S)-Sulfonylamidine Derivatives of Camptothecin as Potent Antitumor Agents

(2014) Mei-Juan Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells

(2014) Sergio Valente et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors

(2014) Nitipol Srimongkolpithak et al.   MedChemComm

TCH-1030 targeting on topoisomerase I induces S-phase arrest, DNA fragmentation, and cell death of breast cancer cells

(2013) Yu-Peng Liu et al.   BREAST CANCER RESEARCH AND TREATMENT

Synthesis, structure and in vitro pharmacological evaluation of a novel 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (2′-methylbenzoyl) hydrazone bridged copper(II) coordination polymer

(2013) Duraisamy Senthil Raja et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quinolone-based HDAC inhibitors

(2013) Gopalan Balasubramanian et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A New Strategy To Improve the Metabolic Stability of Lactone: Discovery of (20S,21S)-21-Fluorocamptothecins as Novel, Hydrolytically Stable Topoisomerase I Inhibitors

(2013) Zhenyuan Miao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of indeno[1,2- $$c$$ c ]quinoline derivatives as dual topoisomerases I/II inhibitors: Part 3

(2013) Chih-Hua Tseng et al.   MOLECULAR DIVERSITY

G-Quadruplex Structures in the Human Genome as Novel Therapeutic Targets

(2013) Joanna Bidzinska et al.   MOLECULES

On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs

(2013) Chyuan-Chuan Wu et al.   NUCLEIC ACIDS RESEARCH

Molecular Modeling Studies of the Novel Inhibitors of DNA Methyltransferases SGI-1027 and CBC12: Implications for the Mechanism of Inhibition of DNMTs

(2013) Jakyung Yoo et al.   PLoS One

Biological activity and DNA binding studies of 2-substituted benzimidazo[1,2-a]quinolines bearing different amino side chains

(2013) Nataša Perin et al.   MedChemComm

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Amsacrine as a Topoisomerase II Poison: Importance of Drug–DNA Interactions

(2012) Adam C. Ketron et al.   BIOCHEMISTRY

Benzofuroquinoline Derivatives Had Remarkable Improvement of their Selectivity for Telomeric G-Quadruplex DNA over Duplex DNA upon Introduction of Peptidyl Group

(2012) Yi Long et al.   BIOCONJUGATE CHEMISTRY

Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted 5H- and 6H-indolo[2,3-b]quinolines; structure–activity relationships of neocryptolepines and 6-methyl congeners

(2012) Li Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors

(2012) Wojciech Luniewski et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Phase I Pharmacokinetic and Pharmacodynamic Study of CHR-3996, an Oral Class I Selective Histone Deacetylase Inhibitor in Refractory Solid Tumors

(2012) U. Banerji et al.   CLINICAL CANCER RESEARCH

A novel water soluble ligand bridged cobalt(ii) coordination polymer of 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (isonicotinic) hydrazone: evaluation of the DNA binding, protein interaction, radical scavenging and anticancer activity

(2012) Duraisamy Senthil Raja et al.   DALTON TRANSACTIONS

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

(2012) Sebastian Müller et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Antineoplastic activity of the thiazolo[5,4-b]quinoline derivative D3CLP in K-562 cells is mediated through effector caspases activation

(2011) Ignacio González-Sánchez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, crystal structure and pharmacological evaluation of two new Cu(II) complexes of 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (benzoyl) hydrazone: A comparative investigation

(2011) Duraisamy Senthil Raja et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effect of N(4)-Phenyl Substitution in 2-Oxo-1,2-dihydroquinoline-3-carbaldehyde Semicarbazones on the Structure, DNA/Protein Interaction, and Antioxidative and Cytotoxic Activity of Cu(II) Complexes

(2011) Duraisamy Senthil Raja et al.   INORGANIC CHEMISTRY

DNA binding, protein interaction, radical scavenging and cytotoxic activity of 2-oxo-1,2-dihydroquinoline-3-carbaldehyde(2′-hydroxybenzoyl)hydrazone and its Cu(II) complexes: A structure activity relationship study

(2011) Duraisamy Senthil Raja et al.   INORGANICA CHIMICA ACTA

Structure–activity relationship study of copper(II) complexes with 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (4′-methylbenzoyl) hydrazone: synthesis, structures, DNA and protein interaction studies, antioxidative and cytotoxic activity

(2011) Duraisamy Senthil Raja et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Inhibition of Cell Proliferation by Quindoline Derivative (SYUIQ-05) through its Preferential Interaction withc-mycPromoter G-Quadruplex

(2011) Tian-Miao Ou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and c-Met Kinase Inhibition of 3,5-Disubstituted and 3,5,7-Trisubstituted Quinolines: Identification of 3-(4-Acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a Novel Anticancer Agent

(2011) Yuanxiang Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel DNA intercalator, 8-methoxy pyrimido[4′,5′:4,5]thieno (2,3-b)quinoline-4(3H)-one induces apoptosis in cancer cells, inhibits the tumor progression and enhances lifespan in mice with tumor

(2011) Sheetal Sharma et al.   MOLECULAR CARCINOGENESIS

Synthesis and antiproliferative evaluation of certain indolo[3,2-c]quinoline derivatives

(2010) Chih-Ming Lu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: Anticancer profile and G-quadruplex stabilization

(2010) João Lavrado et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Benzimidazole derivatives related to 2,3-acrylonitriles, benzimidazo[1,2-a]quinolines and fluorenes: Synthesis, antitumor evaluation in vitro and crystal structure determination

(2010) Marijana Hranjec et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Intercalative pyrimido[4′,5′:4,5]thieno(2,3-b)quinolines induce apoptosis in leukemic cells: a comparative study of methoxy and morpholino substitution

(2010) M. S. Shahabuddin et al.   INVESTIGATIONAL NEW DRUGS

Turning off Transcription of thebcl-2Gene by Stabilizing thebcl-2Promoter Quadruplex with Quindoline Derivatives

(2010) Xiao-Dong Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 2-(6-{[(6-Fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a Class I Selective Orally Active Histone Deacetylase Inhibitor

(2010) David Moffat et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antiproliferative Evaluation of Certain Indeno[1,2-c]quinoline Derivatives. Part 2

(2010) Chih-Hua Tseng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biological Activities of Quinoline Derivatives

(2010) Suresh Kumar et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

Synthesis, cytotoxic activity, DNA topoisomerase-II inhibition, molecular modeling and structure–activity relationship of 9-anilinothiazolo[5,4-b]quinoline derivatives

(2009) Marco A. Loza-Mejía et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation

(2009) J. Datta et al.   CANCER RESEARCH

Synthesis and Analysis of Potential DNA Intercalators Containing Quinoline-Glucose Hybrids

(2009) Wei Li et al.   Chemical Biology & Drug Design

Novel camptothecin derivatives as topoisomerase I inhibitors

(2009) Serena Basili et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

A novel DNA intercalator, butylamino-pyrimido[4′,5′:4,5]selenolo(2,3-b)quinoline, induces cell cycle arrest and apoptosis in leukemic cells

(2009) M. S. Shahabuddin et al.   INVESTIGATIONAL NEW DRUGS

Discovery of a Potent Class I Selective Ketone Histone Deacetylase Inhibitor with Antitumor Activity in Vivo and Optimized Pharmacokinetic Properties

(2009) Olaf Kinzel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

(2009) Feng Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

5-N-Methylated Quindoline Derivatives as Telomeric G-Quadruplex Stabilizing Ligands: Effects of 5-NPositive Charge on Quadruplex Binding Affinity and Cell Proliferation

(2008) Yu-Jing Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis of DNA Quadruplex Recognition by an Acridine Drug

(2008) Nancy H. Campbell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres

(2008) Raphaël Rodriguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis, cytotoxic evaluation, and DNA binding of novel thiazolo[5,4-b]quinoline derivatives

(2007) Marco A. Loza-Mejía et al.   BIOORGANIC & MEDICINAL CHEMISTRY