Perspectives on Biologically Active Camptothecin Derivatives

Development and validation of a sensitive LC-MS/MS method for simultaneous quantification of sinotecan and its active metabolite in human blood

(2014) Yang Yu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Design, Synthesis, Mechanisms of Action, and Toxicity of Novel 20(S)-Sulfonylamidine Derivatives of Camptothecin as Potent Antitumor Agents

(2014) Mei-Juan Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A New Strategy To Improve the Metabolic Stability of Lactone: Discovery of (20S,21S)-21-Fluorocamptothecins as Novel, Hydrolytically Stable Topoisomerase I Inhibitors

(2013) Zhenyuan Miao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of DNA Topoisomerase-1 in Spodoptera exigua for Toxicity Evaluation of Camptothecin and Hydoxy-Camptothecin

(2013) Lan Zhang et al.   PLoS One

Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents

(2012) Ying-Qian Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Biological Evaluation of 7-Alkenyl Homocamptothecins as Potent Topoisomerase I Inhibitors

(2012) Lingjian Zhu et al.   CHEMISTRY & BIODIVERSITY

Synthesis and biological evaluation of new homocamptothecin analogs

(2012) Yu Luo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and preliminary bioevaluation of novel E-ring modified acetal analog of camptothecin as cytotoxic agents

(2012) Lingjian Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Utility of Camptothecin as a Synergist of Bacillus thuringiensis var. kurstaki and Nucleopolyhedroviruses Against Trichoplusia ni and Spodoptera exigua

(2012) Shifeng Sun et al.   JOURNAL OF ECONOMIC ENTOMOLOGY

Synthesis, Spectroscopic, and Antimicrobial Activity Studies of Novel 10-Substituted Camptothecin Phosphorothioate Analogs

(2012) Abdel-Nasser M. A. Alaghaz et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Synthesis and antitumor activity of 10-arylcamptothecin derivatives

(2011) Yu Jiao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of novel 7-acyl homocamptothecins as Topoisomerase I inhibitors

(2011) Wenfeng Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and insecticidal activities of novel spin-labeled derivatives of camptothecin

(2011) Ying-Qian Liu et al.   HETEROATOM CHEMISTRY

14-Aminocamptothecins: Their Synthesis, Preclinical Activity, and Potential Use for Cancer Treatment

(2011) Jian-Xin Duan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effects of camptothecin and hydroxycamptothecin on insect cell lines Sf21 and IOZCAS-Spex-II

(2011) Lan Zhang et al.   PEST MANAGEMENT SCIENCE

Phosphate ester derivatives of homocamptothecin: Synthesis, solution stabilities and antitumor activities

(2010) Zhenyuan Miao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of 9-benzylideneamino derivatives of homocamptothecin as potent inhibitors of DNA topoisomerase I

(2010) Wei Guo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Insecticidal Activity of Camptothecin Against Nilaparvata lugens, Brevicoryne brassicae, and Chilo suppressalis

(2010) Jianyi Ma et al.   JOURNAL OF ECONOMIC ENTOMOLOGY

A Series of α-Amino Acid Ester Prodrugs of Camptothecin: In Vitro Hydrolysis and A549 Human Lung Carcinoma Cell Cytotoxicity

(2010) Manjeet Deshmukh et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Anti-HIV Actions of 7- and 10-Substituted Camptothecins

(2010) Yu-Ye Li et al.   MOLECULES

Anti-HSV activity of camptothecin analogues

(2010) Ying-Qian Liu et al.   NATURAL PRODUCT RESEARCH

Neurotoxic activity of a Topoisomerase-I inhibitor, camptothecin, in cultured cerebellar granule neurons

(2010) M. Uday Bhanu et al.   NEUROTOXICOLOGY

Synthesis of novel derivatives of camptothecin as potential insecticides

(2010) Ying-Qian Liu et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Synthesis of new camptothecin analogs with improved antitumor activities

(2009) Satoshi Niizuma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation

(2009) Mingzong Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and cytotoxic activity of 7-alkynyl camptothecin derivatives

(2009) Feng Xiao et al.   CHINESE CHEMICAL LETTERS

Semisynthesis, Biological Activity, and Molecular Modeling Studies of C-Ring-Modified Camptothecins†

(2009) Cristian Samorì et al.   JOURNAL OF MEDICINAL CHEMISTRY

Semi-synthesis and biological activity of γ-lactones analogs of camptothecin

(2008) Mingzong Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and cytotoxic activity of new 9-substituted camptothecins

(2008) Sabrina Dallavalle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel hexacyclic camptothecin derivatives. Part 1: Synthesis and cytotoxicity of camptothecins with an A-ring fused 1,3-oxazine ring

(2008) Sheng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antitumor activity of novel 20s-camptothecin analogues

(2008) Qingyong Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

First synthesis of novel spin-labeled derivatives of camptothecin as potential antineoplastic agents

(2008) Ying-Qian Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effects of isocamptothecin, a novel camptothecin analogue, on proliferation, apoptosis and telomerase activity in HaCaT cells

(2008) Jingrong Lin et al.   EXPERIMENTAL DERMATOLOGY

Topoisomerase inhibitors as anti-arthritic agents

(2008) J. K. Jackson et al.   INFLAMMATION RESEARCH

Benzyl Ether-Linked Glucuronide Derivative of 10-Hydroxycamptothecin Designed for Selective Camptothecin-Based Anticancer Therapy

(2008) Yu-Ling Leu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thiocamptothecin†

(2008) Cristian Samorì et al.   JOURNAL OF MEDICINAL CHEMISTRY