Design, Synthesis and Biological Evaluation of 4-Amino-N-(4-aminophenyl)benzamide Analogues of Quinoline-Based SGI-1027 as Inhibitors of DNA Methylation

Structure–activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1

(2013) Swarna A. Gamage et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular Modeling and Virtual Screening of DNA Methyltransferase Inhibitors

(2013) Jose L. Medina-Franco et al.   CURRENT PHARMACEUTICAL DESIGN

Docking of a novel DNA methyltransferase inhibitor identified from high-throughput screening: insights to unveil inhibitors in chemical databases

(2013) José L. Medina-Franco et al.   MOLECULAR DIVERSITY

Development of a universal radioactive DNA methyltransferase inhibition test for high-throughput screening and mechanistic studies

(2013) Christina Gros et al.   NUCLEIC ACIDS RESEARCH

Molecular Modeling Studies of the Novel Inhibitors of DNA Methyltransferases SGI-1027 and CBC12: Implications for the Mechanism of Inhibition of DNMTs

(2013) Jakyung Yoo et al.   PLoS One

Mechanisms of DNA methylation and demethylation in mammals

(2012) Ghislain Auclair et al.   BIOCHIMIE

DNA methylation inhibitors in cancer: Recent and future approaches

(2012) Christina Gros et al.   BIOCHIMIE

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Towards the Chemoinformatic-Based Identification of DNA Methyltransferase Inhibitors: 2D- and 3D-Similarity Profile of Screening Libraries

(2012) Jakyung Yoo et al.   Current Computer-Aided Drug Design

Inhibitors of DNA Methyltransferases: Insights from Computational Studies

(2012) J. Yoo et al.   CURRENT MEDICINAL CHEMISTRY

DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies

(2012) Jacques Fahy et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation

(2012) J. Song et al.   SCIENCE

C5-DNA Methyltransferase Inhibitors: From Screening to Effects on Zebrafish Embryo Development

(2011) Alexandre Ceccaldi et al.   CHEMBIOCHEM

Advances in the computational development of DNA methyltransferase inhibitors

(2011) José L. Medina-Franco et al.   DRUG DISCOVERY TODAY

Homology modeling, docking and structure-based pharmacophore of inhibitors of DNA methyltransferase

(2011) Jakyung Yoo et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1)

(2011) K. Takeshita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non-Small Cell Lung Cancer

(2011) R. A. Juergens et al.   Cancer Discovery

Structure and Function of Mammalian DNA Methyltransferases

(2010) Renata Zofia Jurkowska et al.   CHEMBIOCHEM

Natural products as DNA methyltransferase inhibitors: a computer-aided discovery approach

(2010) Jose L. Medina-Franco et al.   MOLECULAR DIVERSITY

Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation

(2010) J. Song et al.   SCIENCE

A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation

(2009) J. Datta et al.   CANCER RESEARCH

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

DNA Methylation Predicts Survival and Response to Therapy in Patients With Myelodysplastic Syndromes

(2009) Lanlan Shen et al.   JOURNAL OF CLINICAL ONCOLOGY

The Use of Formamidine Protection for the Derivatization of Aminobenzoic Acids

(2008) Paul E. Zhichkin et al.   JOURNAL OF ORGANIC CHEMISTRY

DNA methylation landscapes: provocative insights from epigenomics

(2008) Miho M. Suzuki et al.   NATURE REVIEWS GENETICS

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE

Mammalian DNA Methyltransferases: A Structural Perspective

(2008) Xiaodong Cheng et al.   STRUCTURE