A New Strategy To Improve the Metabolic Stability of Lactone: Discovery of (20S,21S)-21-Fluorocamptothecins as Novel, Hydrolytically Stable Topoisomerase I Inhibitors

Title
A New Strategy To Improve the Metabolic Stability of Lactone: Discovery of (20S,21S)-21-Fluorocamptothecins as Novel, Hydrolytically Stable Topoisomerase I Inhibitors
Authors
Keywords
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Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 56, Issue 20, Pages 7902-7910
Publisher
American Chemical Society (ACS)
Online
2013-09-26
DOI
10.1021/jm400906z

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