N ‐acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages

TIMER2.0 for analysis of tumor-infiltrating immune cells

(2020) Taiwen Li et al.   NUCLEIC ACIDS RESEARCH

A single-cell landscape of high-grade serous ovarian cancer

(2020) Benjamin Izar et al.   NATURE MEDICINE

Ammonia inhibits energy metabolism in astrocytes in a rapid and glutamate dehydrogenase 2-dependent manner

(2020) Leonie Drews et al.   Disease Models & Mechanisms

Glufosinate constrains synchronous and metachronous metastasis by promoting anti‐tumor macrophages

(2020) Alessio Menga et al.   EMBO Molecular Medicine

Determining cell type abundance and expression from bulk tissues with digital cytometry

(2019) Aaron M. Newman et al.   NATURE BIOTECHNOLOGY

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

(2019) Francesca Finotello et al.   Genome Medicine

Pro-inflammatory monocyte profile in patients with major depressive disorder and suicide behaviour and how ketamine induces anti-inflammatory M2 macrophages by NMDAR and mTOR

(2019) Wanda Nowak et al.   EBioMedicine

Monoamine oxidase-dependent histamine catabolism accounts for post-ischemic cardiac redox imbalance and injury

(2018) Veronica Costiniti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Glutamine Synthetase: Localization Dictates Outcome

(2018) Alessandra Castegna et al.   Genes

Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors

(2018) Jin-Bao Zhang et al.   Cell Reports

SLC25A26overexpression impairs cell function via mtDNA hypermethylation and rewiring of methyl metabolism

(2017) Alessio Menga et al.   FEBS Journal

Metabolism and TAM functions-it takes two to tango

(2017) Massimiliano Mazzone et al.   FEBS Journal

Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment

(2017) Thomas Worzfeld et al.   MOLECULAR & CELLULAR PROTEOMICS

Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation

(2017) Wei Lü et al.   SCIENCE

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

(2017) Erika M. Palmieri et al.   Cell Reports

N-Acetylaspartate Metabolism Outside the Brain: Lipogenesis, Histone Acetylation, and Cancer

(2017) Juliane G. Bogner-Strauss   Frontiers in Endocrinology

Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines

(2016) Daniel R. Sappington et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mechanism of NMDA Receptor Inhibition and Activation

(2016) Shujia Zhu et al.   CELL

RhoC GTPase Is a Potent Regulator of Glutamine Metabolism andN-Acetylaspartate Production in Inflammatory Breast Cancer Cells

(2016) Michelle L. Wynn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Increased n-acetylaspartate Levels in Cancer

(2016) Behrouz Zand et al.   JNCI-Journal of the National Cancer Institute

N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes

(2016) A. Prokesch et al.   Scientific Reports

Role of Increased n-acetylaspartate Levels in Cancer

(2016) Behrouz Zand et al.   JNCI-Journal of the National Cancer Institute

Bioelectric modulation of macrophage polarization

(2016) Chunmei Li et al.   Scientific Reports

Acetylation of human mitochondrial citrate carrier modulates mitochondrial citrate/malate exchange activity to sustain NADPH production during macrophage activation

(2015) Erika M. Palmieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non-Small Cell Lung Cancer and Its Potential as a Circulating Biomarker

(2015) T.-F. Lou et al.   Cancer Prevention Research

Lactate promotes glutamine uptake and metabolism in oxidative cancer cells

(2015) Jhudit Pérez-Escuredo et al.   CELL CYCLE

Prediction of high- and low-affinity quinol-analogue-binding sites in theaa3andbo3terminal oxidases fromBacillus subtilisandEscherichia coli

(2014) Fabrizio Bossis et al.   BIOCHEMICAL JOURNAL

Glutamine synthetase desensitizes differentiated adipocytes to proinflammatory stimuli by raising intracellular glutamine levels

(2014) Erika Mariana Palmieri et al.   FEBS LETTERS

Molecular bases of NMDA receptor subtype-dependent properties

(2014) Nathan G. Glasgow et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cerebral effects of ammonia in liver disease: current hypotheses

(2014) Peter Ott et al.   METABOLIC BRAIN DISEASE

Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer

(2014) L. Yang et al.   Molecular Systems Biology

NMDA receptor structures reveal subunit arrangement and pore architecture

(2014) Chia-Hsueh Lee et al.   NATURE

Molecular level activation insights from a NR2A/NR2B agonist

(2013) Weng IeongTou et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Inhibition of tumor growth and metastasis by a self-therapeutic nanoparticle

(2013) R. R. Arvizo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A physical sciences network characterization of non-tumorigenic and metastatic cells

(2013)   Scientific Reports

Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration

(2012) Christine A. Caneba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain

(2012) Angela M. Kaindl et al.   ANNALS OF NEUROLOGY

Global Profiling Strategies for Mapping Dysregulated Metabolic Pathways in Cancer

(2012) Daniel I. Benjamin et al.   Cell Metabolism

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

(2012) Anne Le et al.   Cell Metabolism

Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy

(2012) Kristan E. van der Vos et al.   NATURE CELL BIOLOGY

Differences in Metabolism of Fiber Tract Alterations in Gliomas

(2012) Andreas Stadlbauer et al.   NEUROSURGERY

Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis

(2012) Dania Daye et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Staging recurrent ovarian cancer with 18FDG PET/CT

(2012) SANJA DRAGOSAVAC et al.   Oncology Letters

Role of Glutamine in Cancer: Therapeutic and Imaging Implications

(2011) K. N. Rajagopalan et al.   JOURNAL OF NUCLEAR MEDICINE

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

(2011) D. Gaglio et al.   Molecular Systems Biology

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

(2011) Katie M. Vance et al.   Nature Communications

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

pGenTHREADER and pDomTHREADER: new methods for improved protein fold recognition and superfamily discrimination

(2009) Anna Lobley et al.   BIOINFORMATICS

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE