Cerebral effects of ammonia in liver disease: current hypotheses

Update on cerebral uptake of blood ammonia

(2013) Michael Sørensen   METABOLIC BRAIN DISEASE

Astrocytic Control of Biosynthesis and Turnover of the Neurotransmitters Glutamate and GABA

(2013) Arne Schousboe et al.   Frontiers in Endocrinology

Kir4.1 channels mediate a depolarization of hippocampal astrocytes under hyperammonemic conditions in situ

(2012) Jonathan Stephan et al.   GLIA

Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake

(2012) Gitte Dam et al.   HEPATOLOGY

Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy

(2012) Cristina R. Bosoi et al.   METABOLIC BRAIN DISEASE

Chronic hyperammonemia, glutamatergic neurotransmission and neurological alterations

(2012) Marta Llansola et al.   METABOLIC BRAIN DISEASE

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Sweet Sixteen for ANLS

(2011) Luc Pellerin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy

(2011) Renata Leke et al.   JOURNAL OF NEUROCHEMISTRY

Absence of neuropsychological impairment in hyperammonaemia in healthy young adults; possible synergism in development of hepatic encephalopathy (HE) symptoms?

(2011) Daniel J. Wilkinson et al.   METABOLIC BRAIN DISEASE

Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy

(2011) Kakulavarapu V. Rama Rao et al.   NEUROCHEMISTRY INTERNATIONAL

Blood–Brain Barrier Permeability for Ammonia in Patients with Different Grades of Liver Fibrosis is Not Different from Healthy Controls

(2010) Annemarie Goldbecker et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure

(2010) Peter Nissen Bjerring et al.   JOURNAL OF HEPATOLOGY

Brain Aquaporin-4 in Experimental Acute Liver Failure

(2010) Kakulavarapu V. Rama Rao et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

No oxygen delivery limitation in hepatic encephalopathy

(2010) Albert Gjedde et al.   METABOLIC BRAIN DISEASE

Human 13N-ammonia PET studies: the importance of measuring 13N-ammonia metabolites in blood

(2010) Susanne Keiding et al.   METABOLIC BRAIN DISEASE

Altered glial–neuronal crosstalk: Cornerstone in the pathogenesis of hepatic encephalopathy

(2010) Roger F. Butterworth   NEUROCHEMISTRY INTERNATIONAL

Increase brain lactate in hepatic encephalopathy: Cause or consequence?

(2010) Christopher F. Rose   NEUROCHEMISTRY INTERNATIONAL

Detoxification of Ammonia in Mouse Cortical GABAergic Cell Cultures Increases Neuronal Oxidative Metabolism and Reveals an Emerging Role for Release of Glucose-Derived Alanine

(2010) Renata Leke et al.   NEUROTOXICITY RESEARCH

Hyperammonemia Increases GABAergic Tone in the Cerebellum but Decreases It in the Rat Cortex

(2009) Omar Cauli et al.   GASTROENTEROLOGY

Low Cerebral Oxygen Consumption and Blood Flow in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy

(2008) Peter Iversen et al.   GASTROENTEROLOGY

Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: Ibuprofen restores its motor activity

(2008) Omar Cauli et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Backflux of ammonia from brain to blood in human subjects with and without hepatic encephalopathy

(2008) Michael Sørensen et al.   METABOLIC BRAIN DISEASE

Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia

(2008) Lasse K. Bak et al.   METABOLIC BRAIN DISEASE

Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy

(2008) Omar Cauli et al.   METABOLIC BRAIN DISEASE

Cerebral Glutamine Concentration and Lactate–Pyruvate Ratio in Patients with Acute Liver Failure

(2008) Peter Nissen Bjerring et al.   Neurocritical Care