Recent advances in, and challenges of, anti-angiogenesis agents for tumor chemotherapy based on vascular normalization

Design, synthesis, and molecular docking of novel 2‐arylbenzothiazole multiangiokinase inhibitors targeting breast cancer

(2020) Heba T. Abdel‐Mohsen et al.   ARCHIV DER PHARMAZIE

The inhibition profiles of 4'‐acylpyrrole–5‐fluoroindolin‐2‐ones with a C‐3' side chain for VEGFR2, PDGFR‐β, and FGFR‐1 protein kinases

(2020) Jiann‐Jyh Huang et al.   JOURNAL OF THE CHINESE CHEMICAL SOCIETY

Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles

(2020) Heba T. Abdel-Mohsen et al.   MOLECULES

Novel Anticancer Fused Pyrazole Derivatives as EGFR and VEGFR-2 Dual TK Inhibitors

(2020) Nashwa M. Saleh et al.   Frontiers in Chemistry

Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2

(2020) Ikumi Kuriwaki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and molecular docking study of new pyrazole derivatives as potent anti-breast cancer agents targeting VEGFR-2 kinase

(2020) Dina H. Dawood et al.   BIOORGANIC CHEMISTRY

Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors

(2020) Erica Banks et al.   Science Translational Medicine

Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple-angiokinase inhibitor for cancer therapy

(2020) Yuqin Yao et al.   Acta Pharmaceutica Sinica B

Novel VEGFR‐2 inhibitors with an N ‐acylhydrazone scaffold

(2020) Fernanda P. Pauli et al.   ARCHIV DER PHARMAZIE

Structural modifications of indolinones bearing a pyrrole moiety and discovery of a multi-kinase inhibitor with potent antitumor activity

(2020) Mingze Qin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of N-substituted-3-phenyl-1,6-naphthyridinone derivatives bearing quinoline moiety as selective type II c-Met kinase inhibitors against VEGFR-2

(2020) Hongchuang Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors

(2020) Soha R. Abd El Hadi et al.   BIOORGANIC CHEMISTRY

Evolutionary chemical binding similarity approach integrated with 3D-QSAR method for effective virtual screening

(2020) Prasannavenkatesh Durai et al.   BMC BIOINFORMATICS

Exploration of carbamide derived pyrimidine-thioindole conjugates as potential VEGFR-2 inhibitors with anti-angiogenesis effect

(2020) Sravani Sana et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of new quinazolin-4(3H)-ones as VEGFR-2 inhibitors: Design, synthesis, and anti-proliferative evaluation

(2020) Ibrahim.H. Eissa et al.   BIOORGANIC CHEMISTRY

Design and synthesis of new 1,6-dihydropyrimidin-2-thio derivatives targeting VEGFR-2: Molecular docking and antiproliferative evaluation

(2020) Adel A. Marzouk et al.   BIOORGANIC CHEMISTRY

Selective VEGFR-2 inhibitors: Synthesis of pyridine derivatives, cytotoxicity and apoptosis induction profiling

(2020) Amal AbdelHaleem et al.   BIOORGANIC CHEMISTRY

Design, synthesis, molecular docking and anticancer evaluations of 5-benzylidenethiazolidine-2,4-dione derivatives targeting VEGFR-2 enzyme

(2020) Khaled El-Adl et al.   BIOORGANIC CHEMISTRY

Synthesis and evaluation of new thiourea derivatives as antitumor and antiangiogenic agents

(2020) Wenjing Bai et al.   TETRAHEDRON LETTERS

Pyrrolo[2,3-b]pyridine-3-one derivatives as novel fibroblast growth factor receptor 4 inhibitors for the treatment of hepatocellular carcinoma

(2020) Qiaomei Jin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of novel indolyl-1,2,4-triazole hybrids as potent vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors with potential anti-renal cancer activity

(2020) Sami A. Al-Hussain et al.   BIOORGANIC CHEMISTRY

Novel 2-indolinone thiazole hybrids as sunitinib analogues: Design, synthesis, and potent VEGFR-2 inhibition with potential anti-renal cancer activity

(2020) Huda K. Mahmoud et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and optimization of novel pyrazole-benzimidazole CPL304110, as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1–3)

(2020) Abdellah Yamani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel benzimidazole derivatives as anti-cervical cancer agents of potential multi-targeting kinase inhibitory activity

(2020) Eman A. Abd El-Meguid et al.   Arabian Journal of Chemistry

Probing 2 H ‐Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors

(2019) Jens Schoene et al.   ChemMedChem

Protein–ligand interaction-guided discovery of novel VEGFR-2 inhibitors

(2019) Yanmin Zhang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Molecular dynamics simulation and 3D-pharmacophore analysis of new quinoline-based analogues with dual potential against EGFR and VEGFR-2

(2019) Neda Fayyazi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1

(2019) Chenlong Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Imaging the Dynamic Interaction Between Sprouting Microvessels and the Extracellular Matrix

(2019) Adam Rauff et al.   Frontiers in Physiology

Design, synthesis, molecular modeling, in vivo studies and anticancer evaluation of quinazolin-4(3H)-one derivatives as potential VEGFR-2 inhibitors and apoptosis inducers

(2019) Hazem A. Mahdy et al.   BIOORGANIC CHEMISTRY

Design, synthesis, biological evaluation and molecular modeling study of new thieno[2,3-d]pyrimidines with anti-proliferative activity on pancreatic cancer cell lines

(2019) Mohamed S.H. Salem et al.   BIOORGANIC CHEMISTRY

Design, synthesis and biological evaluation of novel 1H-1,2,4-triazole, benzothiazole and indazole-based derivatives as potent FGFR1 inhibitors viafragment-based virtual screening

(2019) Jian Liu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

AT-533, a novel Hsp90 inhibitor, inhibits breast cancer growth and HIF-1α/VEGF/VEGFR-2-mediated angiogenesis in vitro and in vivo

(2019) Peng-Chao Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Discovery of 4,6-pyrimidinediamine derivatives as novel dual EGFR/FGFR inhibitors aimed EGFR/FGFR1-positive NSCLC

(2019) Zixin Xie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hypoxia: Overview on Hypoxia-Mediated Mechanisms with a Focus on the Role of HIF Genes

(2019) Alexandru Andrei Tirpe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

EphB4 mediates resistance to antiangiogenic therapy in experimental glioma

(2018) Christian Uhl et al.   ANGIOGENESIS

Hematopoietic growth factors and tumor angiogenesis

(2018) Domenico Ribatti et al.   CANCER LETTERS

Discovery of novel anti-angiogenesis agents. Part 9: Multiplex inhibitors suppressing compensatory activations of RTKs

(2018) Yuanyuan Shan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of novel anti-angiogenesis agents. Part 10: Multi-target inhibitors of VEGFR-2, Tie-2 and EphB4 incorporated with 1,2,3-triazol

(2018) Xiaoyan Pan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

FGF-dependent metabolic control of vascular development

(2017) Pengchun Yu et al.   NATURE

PFKFB3 promotes proliferation, migration and angiogenesis in nasopharyngeal carcinoma

(2017) Miao Gu et al.   Journal of Cancer

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis

(2015) Masaki Inada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity

(2015) Elisa Nuti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intermittent Hypoxia Selects for Genotypes and Phenotypes That Increase Survival, Invasion, and Therapy Resistance

(2015) Daniel Verduzco et al.   PLoS One

COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models

(2014) L. Xu et al.   Science Translational Medicine

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

(2013) Rakesh K. Jain   JOURNAL OF CLINICAL ONCOLOGY

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

(2011) Shom Goel et al.   PHYSIOLOGICAL REVIEWS

Overlooking Evolution: A Systematic Analysis of Cancer Relapse and Therapeutic Resistance Research

(2011) C. Athena Aktipis et al.   PLoS One

Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer

(2010) Wei Yu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Adverse effects of anticancer agents that target the VEGF pathway

(2009) Helen X. Chen et al.   Nature Reviews Clinical Oncology

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL