Discovery of novel indolyl-1,2,4-triazole hybrids as potent vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors with potential anti-renal cancer activity

Synthesis of a New Series of Nitrogen/Sulfur Heterocycles by Linking Four Rings: Indole; 1,2,4-Triazole; Pyridazine; and Quinoxaline

(2020) Ahmed T. A. Boraei et al.   MOLECULES

Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity

(2020) Thoraya A. Farghaly et al.   BIOORGANIC CHEMISTRY

Synthesis of Coumarin‐Analogues: Analytical, Spectral, Conformational, MOE‐Docking and Antimicrobial Studies

(2020) Abrar Bayazeed et al.   ChemistrySelect

Novel 2-indolinone thiazole hybrids as sunitinib analogues: Design, synthesis, and potent VEGFR-2 inhibition with potential anti-renal cancer activity

(2020) Huda K. Mahmoud et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Azoloquinazolines and substituted benzothiazepine as antimicrobial agents

(2019) Asmaa F. Kassem et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Introducing of acyclonucleoside analogues tethered 1,2,4-triazole as anticancer agents with dual epidermal growth factor receptor kinase and microtubule inhibitors

(2019) Mohamed Reda Aouad et al.   BIOORGANIC CHEMISTRY

Discovery of novel functionalized 1,2,4-triazoles as PARP-1 inhibitors in breast cancer: Design, synthesis and antitumor activity evaluation

(2019) Ahmed T.A. Boraei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New azoloazine derivatives as antimicrobial agents: Synthesis under microwave irradiations, structure elucidation, and antimicrobial activity

(2019) Asmaa F. Kassem et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update

(2019) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018

(2018) J. Ferlay et al.   EUROPEAN JOURNAL OF CANCER

Synthesis and antitumor activity of novel [1,2,4,5]-tetrazepino[6,7-b]indole derivatives: Marine natural productHyrtioreticuline C and D analogues

(2018) Zeinab A. Muhammad et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Design, selective alkylation and X-ray crystal structure determination of dihydro-indolyl-1,2,4-triazole-3-thione and its 3-benzylsulfanyl analogue as potent anticancer agents

(2017) Ahmed T.A. Boraei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The evolution of anti-angiogenic therapy for kidney cancer

(2017) Chung-Han Lee et al.   Nature Reviews Nephrology

Kinase Inhibitor Indole Derivatives as Anticancer Agents: A Patent Review

(2017) Anuj K. Rathi et al.   Recent Patents on Anti-Cancer Drug Discovery

Incidence and mortality of kidney cancer: temporal patterns and global trends in 39 countries

(2017) Martin C. S. Wong et al.   Scientific Reports

Recent Developments on 1,2,4-Triazole Nucleus in Anticancer Compounds: A Review

(2016) Ramandeep Kaur et al.   Anti-Cancer Agents in Medicinal Chemistry

Design, synthesis and biological evaluation of novel 3-alkylsulfanyl-4-amino-1,2,4-triazole derivatives

(2016) Pei-Liang Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent developments in second and third line therapy of metastatic renal cell carcinoma

(2016) Maria Giuseppa Vitale et al.   Expert Review of Anticancer Therapy

2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008–2014)

(2015) Alberto Leoni et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids

(2014) Kunal Nepali et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Renal cell carcinoma

(2014) E. Jonasch et al.   BMJ-British Medical Journal

Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents

(2013) Rania Hamdy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of N-(4-hydroxy-3-mercaptonaphthalen-1-yl)amides as inhibitors of angiogenesis and tumor growth

(2013) Fuming Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, molecular modeling, and biological evaluation of 1,2,4-triazole derivatives containing pyridine as potential anti-tumor agents

(2012) Yan-Bin Zhang et al.   MEDICINAL CHEMISTRY RESEARCH

Indolinones as Promising Scaffold as Kinase Inhibitors: A Review

(2012) C. R. Prakash et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors

(2012) M. McTigue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent developments in kidney cancer

(2011) Michael J. Leveridge et al.   CUAJ-Canadian Urological Association Journal

Discovery of Dual VEGFR-2 and Tubulin Inhibitors with in Vivo Efficacy

(2010) Eugene L. Piatnitski Chekler et al.   ACS Medicinal Chemistry Letters

Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?

(2009) Kristy J. Gotink et al.   ANGIOGENESIS

Synthesis, tautomerism, and antimicrobial, anti-HCV, anti-SSPE, antioxidant, and antitumor activities of arylazobenzosuberones

(2009) Thoraya A. Farghaly et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting Angiogenesis in Renal Cell Carcinoma

(2008) Georgios Lainakis et al.   CURRENT CANCER DRUG TARGETS