Design, synthesis, and molecular docking of novel 2‐arylbenzothiazole multiangiokinase inhibitors targeting breast cancer

New 2,4‐disubstituted‐2‐thiopyrimidines as VEGFR‐2 inhibitors: Design, synthesis, and biological evaluation

(2019) Heba T. Abdel‐Mohsen et al.   ARCHIV DER PHARMAZIE

Discovery of novel pyrimidine-based benzothiazole derivatives as potent cyclin-dependent kinase 2 inhibitors with anticancer activity

(2019) Peng-Cheng Diao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel potent substituted 4-amino-2-thiopyrimidines as dual VEGFR-2 and BRAF kinase inhibitors

(2019) Heba T. Abdel-Mohsen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pyrazolo-benzothiazole hybrids: Synthesis, anticancer properties and evaluation of antiangiogenic activity using in vitro VEGFR-2 kinase and in vivo transgenic zebrafish model

(2019) Velma Ganga Reddy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel 2-arylbenzothiazole DNA gyrase inhibitors: Synthesis, antimicrobial evaluation, QSAR and molecular docking studies

(2019) Iman A.Y. Ghannam et al.   BIOORGANIC CHEMISTRY

Targeting FGFR pathway in breast cancer

(2018) J. Perez-Garcia et al.   BREAST

Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer

(2018) Navid Sobhani et al.   Cells

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Type IIA - Type IIB protein tyrosine kinase inhibitors hybridization as an efficient approach for potent multikinase inhibitor development: Design, synthesis, anti-proliferative activity, multikinase inhibitory activity and molecular modeling of novel indolinone-based ureides and amides

(2018) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, molecular docking and cytotoxic evaluation of novel 2-furybenzimidazoles as VEGFR-2 inhibitors

(2017) Mona A. Abdullaziz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

FGFR-targeted therapeutics for the treatment of breast cancer

(2017) Antonella De Luca et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Triple Angiokinase Inhibitor Nintedanib Directly Inhibits Tumor Cell Growth and Induces Tumor Shrinkage via Blocking Oncogenic Receptor Tyrosine Kinases

(2017) Frank Hilberg et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Discovery of a Nanomolar Multikinase Inhibitor (KST016366): A New Benzothiazole Derivative with Remarkable Broad-Spectrum Antiproliferative Activity

(2016) Ashraf Kareem El-Damasy et al.   ChemMedChem

Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives

(2016) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, conformational assignment, and anti-inflammatory activities of N-arylidene-2-(4-chloro-2-(2-substituted phenoxy)phenyl)acetic acid hydrazides

(2016) Afraz Nakhostin et al.   MEDICINAL CHEMISTRY RESEARCH

Classification of small molecule protein kinase inhibitors based upon the structures of their drug-enzyme complexes

(2016) Robert Roskoski   PHARMACOLOGICAL RESEARCH

VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis

(2016) Chandran S. Abhinand et al.   Journal of Cell Communication and Signaling

Recent Advances in the Chemistry and Biology of Benzothiazoles

(2015) Rupinder K. Gill et al.   ARCHIV DER PHARMAZIE

Multi-Kinase Inhibitors

(2015) Laura Garuti et al.   CURRENT MEDICINAL CHEMISTRY

A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry

(2015) Rangappa S. Keri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

KLIFS: a structural kinase-ligand interaction database

(2015) Albert J. Kooistra et al.   NUCLEIC ACIDS RESEARCH

Targeting Angiogenesis in Cancer Therapy: Moving Beyond Vascular Endothelial Growth Factor

(2015) Y. Zhao et al.   ONCOLOGIST

Expression and prognostic significance of VEGFR-2 in breast cancer

(2015) Ji-Dong Yan et al.   PATHOLOGY RESEARCH AND PRACTICE

Profile of nintedanib in the treatment of solid tumors: the evidence to date

(2015) Niranjan Awasthi et al.   OncoTargets and Therapy

Benzothiazoles: How Relevant in Cancer Drug Design Strategy?

(2014) Meenakshi Singh et al.   Anti-Cancer Agents in Medicinal Chemistry

Multi-target angiokinase inhibitors to fight resistance

(2014) Oriol Casanovas et al.   CELL CYCLE

iLOGP: A Simple, Robust, and Efficient Description of n-Octanol/Water Partition Coefficient for Drug Design Using the GB/SA Approach

(2014) Antoine Daina et al.   Journal of Chemical Information and Modeling

Structural Insights into FGFR Kinase Isoform Selectivity: Diverse Binding Modes of AZD4547 and Ponatinib in Complex with FGFR1 and FGFR4

(2014) Julie A. Tucker et al.   STRUCTURE

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

Targeted inhibition of VEGF receptor 2: an update on ramucirumab

(2013) Jeffrey Melson Clarke et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

KLIFS: A Knowledge-Based Structural Database To Navigate Kinase–Ligand Interaction Space

(2013) Oscar P. J. van Linden et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of Amide Bond Conformers for a Novel Heterocyclic Template of N-acylhydrazone Derivatives

(2013) Alexandra Lopes et al.   MOLECULES

Synthesis and Conformational Assignment of N-(E)-Stilbenyloxymethylenecarbonyl-Substituted Hydrazones of Acetone ando-(m- andp-) Chloro- (nitro-) benzaldehydes by Means of and NMR Spectroscopy

(2013) Przemysław Patorski et al.   Journal of Spectroscopy

Sorafenib for Treatment of Hepatocellular Carcinoma: A Systematic Review

(2012) Bingru Xie et al.   DIGESTIVE DISEASES AND SCIENCES

Recent advances on structural modifications of benzothiazoles and their conjugate systems as potential chemotherapeutics

(2012) Kamal Ahmed et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Medicinal significance of benzothiazole scaffold: an insight view

(2012) Prabodh Chander Sharma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors

(2012) M. McTigue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling

(2011) Arvin C. Dar et al.   Annual Review of Biochemistry

E-3810 Is a Potent Dual Inhibitor of VEGFR and FGFR that Exerts Antitumor Activity in Multiple Preclinical Models

(2011) Ezia Bello et al.   CANCER RESEARCH

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Bevacizumab in the Treatment of Metastatic Breast Cancer: Friend or Foe?

(2011) Alberto J. Montero et al.   Current Oncology Reports

Vascular endothelial growth factor receptor-2 in breast cancer

(2010) Shanchun Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, anticancer activity and docking of some substituted benzothiazoles as tyrosine kinase inhibitors

(2010) Hemal A. Bhuva et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Recent Advances in the Development of Multi-Kinase Inhibitors

(2008) Martin Krug et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY