Article
Biochemistry & Molecular Biology
Niki Sarri, Kehuan Wang, Maria Tsioumpekou, Casimiro Castillejo-Lopez, Johan Lennartsson, Carl-Henrik Heldin, Natalia Papadopoulos
Summary: Interaction between platelet-derived growth factors (PDGF) and their receptors leads to receptor activation and internalization, which is regulated by deubiquitinating enzymes. Deubiquitination of the receptors affects receptor trafficking and stability, as well as downstream signaling and transcription through STAT3, resulting in dysregulated cell proliferation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Veterinary Sciences
Laura C. Setyo, Shannon L. Donahoe, Patrick L. Shearer, Penghao Wang, Mark B. Krockenberger
Summary: This study found that tyrosine kinases, including VEGFR2 and PDGFR-beta, are present in canine urothelial carcinomas (UCs). The expression of CDK4 in UC cells is weaker compared to normal and cystitis bladder samples. The overexpression of VEGFR2 suggests that it may serve as a potential therapeutic target in UC.
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
(2023)
Article
Cell Biology
Sang Hyun Seo, Kyung Joo Cho, Hye Jung Park, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Jae Hee Cheon, Jong In Yook, Man-Deuk Kim, Dong Jin Joo, Seung Up Kim
Summary: This study found that DKK1 is overexpressed in patients with hepatocellular carcinoma (HCC), and inhibiting DKK1 can enhance the anti-tumor efficacy of sorafenib in HCC. By regulating the activity of GSK3 beta and inhibiting the PI3K/Akt and Wnt/β-catenin pathways, a new therapeutic strategy for HCC has been identified.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Urology & Nephrology
Michaela A. A. Fuchs, Katharina A. E. Broeker, Julia Schrankl, Nicolai Burzlaff, Carsten Willam, Charlotte Wagner, Armin Kurtz
Summary: The study revealed that TGFβ1 signaling in resident interstitial cells plays a role in promoting profibrotic gene expression and downregulating erythropoietin production during kidney fibrosis, while not affecting the development of myofibroblasts. Expanding our understanding of the specific contributions of TGFβ1 in kidney fibrosis may lead to potential therapeutic targets for preventing or treating the condition.
KIDNEY INTERNATIONAL
(2021)
Article
Cell Biology
Joon Sung Park, Jungyuen Choi, Longxing Cao, Jyotidarsini Mohanty, Yoshihisa Suzuki, Andy Park, David Baker, Joseph Schlessinger, Sangwon Lee
Summary: The mini-protein mb7 is found to bind with high affinity to the c-isoforms of FGFR, inhibiting cellular signaling induced by specific FGFs and blocking interaction between FGFR with Klotho proteins. This makes mb7 an antagonist of the metabolic hormones FGF19 and FGF21, providing insights and strategies for developing therapeutics for diseases caused by aberrantly activated FGFRs.
Article
Oncology
Adria Bernat-Peguera, Juan Navarro-Ventura, Laura Lorenzo-Sanz, Victoria da Silva-Diz, Mattia Bosio, Luis Palomero, Rosa M. Penin, Diana Perez Sidelnikova, Josep Oriol Bermejo, Miren Taberna, Noelia Vilarino, Josep M. Piulats, Ricard Mesia, Joan Maria Vinals, Eva Gonzalez-Suarez, Salvador Capella-Gutierrez, Alberto Villanueva, Francesc Vinals, Purificacion Munoz
Summary: EGFR-targeted therapy may be effective for treating cSCCs conserving epithelial traits, but resistance may occur in tumors with the E545K PIK3CA-activating mutation. Some initially responding tumors develop resistance after long-term treatment, induced by bypassing from EGFR signaling to FGFR signaling. Pharmacologic inhibition of FGFR signaling can overcome resistance to EGFR inhibitors.
CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Christopher J. Fritschi, Saumya Anang, Zhen Gong, Mohammadjavad Mohammadi, Jonathan Richard, Catherine Bourassa, Kenny T. Severino, Hannah Richter, Derek Yang, Hung -Ching Chen, Ta-Jung Chiu, Michael S. Seaman, Navid Madani, Cameron Abrams, Andres Finzi, Wayne A. Hendrickson, Joseph G. Sodroski, Amos B. Smith
Summary: Binding of HIV-1 to host cell receptors CD4 and CCR5/CXCR4 causes conformational changes in the viral envelope protein, promoting virus entry. CD4-mimetic compounds (CD4mcs) are small molecules that induce inactivating conformational changes in the viral envelope, making it susceptible to neutralization and ADCC. Novel CD4mcs based on an indoline scaffold demonstrate increased potency and breadth against HIV-1 variants, making them potential candidates for antiviral therapy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biology
Yeaji Kim, Dong Young Kim, Haiying Zhang, Cho-Rong Bae, Daehyeon Seong, Yeomyung Kim, Jaewhan Song, Young-Myeong Kim, Young-Guen Kwon
Summary: This study investigates the role of DIXDC1 in vasculature and its involvement in the crosstalk between VEGF/VEGFR2 and Wnt/beta-catenin signaling pathways. The results demonstrate that DIXDC1 is crucial in vascular development and pathological angiogenesis, acting as a mediator between the two signaling pathways.
Article
Biology
Csongor G. Lengyel, Sadaqat Hussain, Andreas Seeber, Sara Jamil Nidhamalddin, Dario Trapani, Baker S. Habeeb, Essam Elfaham, Syed Ayub Mazher, Fahmi Seid, Shah Z. Khan, Khalid El Bairi, Andrew Odhiambo, Sara C. Altuna, Angelica Petrillo
Summary: Gastric cancer is the third leading cause of cancer-related death worldwide. Late diagnosis and lack of screening programs are major challenges. Novel diagnostic techniques and molecular pathways, such as the FGFR pathway, have been identified to improve survival in gastric cancer patients.
Article
Cell Biology
Yifan Feng, Xi Yang, Jinhai Huang, Minqian Shen, Liyang Wang, Xiuping Chen, Yuanzhi Yuan, Chunqiong Dong, Xiaoping Ma, Fei Yuan
Summary: This study elucidated the relationship between the reprogramming of glutamine metabolism in macrophages and the development of alkali burn-induced corneal neovascularization (CoNV). GLS1 inhibition or glutamine deprivation prevented alkali-induced CoNV by inhibiting the infiltration and M2 polarization of macrophages. These findings suggest that pharmacological GLS1 inhibition could be a feasible and effective treatment strategy for chemical burn-related CoNV in humans.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Xinjiang Cai, Yan Zhao, Yang Yang, Xiuju Wu, Li Zhang, Jocelyn A. Ma, Jaden Ji, Kristina I. Bostrom, Yucheng Yao
Summary: Glycogen synthase kinase-3 beta (GSK3 beta) inhibition or endothelial-specific deletion of GSK3 beta reduces atherosclerotic calcification. The changes in beta-catenin and SMAD1 induced by GSK3 beta inhibition in the aortas of Apoe(-/-) mice are similar to Mgp(-/-) mice. This suggests that GSK3 beta inhibition reduces vascular calcification in atherosclerotic lesions through a similar mechanism to that in Mgp(-/-) mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shuai Wang, Xiaoning Liu, Zeqi Meng, Qi Feng, Yanling Lin, Honglin Niu, Chao Yu, Yanhong Zong, Lingling Guo, Weiwei Yang, Yuehua Ma, Wenjun Zhang, Chenyang Li, Yunran Yang, Wenjuan Wang, Xurui Gao, Yaxin Hu, Chao Liu, Lei Nie
Summary: DCBLD2 is a transmembrane protein that regulates PDGFR-beta endocytosis, and its inhibition of receptor endocytosis can regulate the phenotypic conversion of VSMCs and arterial wall proliferation, making it a potential therapeutic target for cardiovascular diseases.
Article
Oncology
Yingfeng Shi, Jinqing Li, Hui Chen, Yan Hu, Lunxian Tang, Yi Wang, Xiujuan Zang, Xiaoyan Ma, Guansen Huang, Xun Zhou, Min Tao, Zexin Lv, Si Chen, Andong Qiu, Shougang Zhuang, Na Liu
Summary: The catalytic subunit of polycomb repressive complex 2 (PRC2), EZH2, plays an important role in peritoneal fibrosis and angiogenesis. Inhibition of EZH2 can alleviate chlorhexidine gluconate-induced peritoneal fibrosis in mice and reduce the expression of vascular markers by regulating the Wnt1/β-catenin and IL-6/STAT3 pathways. These findings suggest that EZH2 may be a novel therapeutic target for preventing peritoneal angiogenesis in patients with peritoneal dialysis.
JOURNAL OF PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Evan Flietner, Zhi Wen, Adhithi Rajagopalan, Oisun Jung, Lyndsay Watkins, Joshua Wiesner, Xiaona You, Yun Zhou, Yuqian Sun, Brock Kingstad-Bakke, Natalie S. Callander, Alan Rapraeger, M. Suresh, Fotis Asimakopoulos, Jing Zhang
Summary: This study found that ponatinib has moderate killing activity against multiple myeloma (MM) and strong synergism with trametinib (Tra) in vitro. However, ponatinib inhibits T cell function, which may partially counteract its synergistic killing effect with Tra in vivo.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Ji Pang, Guorui Li, Hai Qian, Yan Wu, Yongchang Chen
Summary: The study focuses on the secretory protein kinase in recent years, particularly investigating the effect of secretory PKG II on PDGFR beta. It was found that secretory PKG II can reverse the cell migration, invasion, and proliferation induced by PDGF-BB. Furthermore, the study demonstrates that secretory PKG II inhibits PDGFR beta activation by phosphorylating Ser254 site.
CELL BIOLOGY INTERNATIONAL
(2022)
