Novel Anticancer Fused Pyrazole Derivatives as EGFR and VEGFR-2 Dual TK Inhibitors

Apatinib regulates the cell proliferation and apoptosis of liver cancer by regulation of VEGFR2/STAT3 signaling

(2019) Song Wen et al.   PATHOLOGY RESEARCH AND PRACTICE

Novel thienopyrimidine derivatives as dual EGFR and VEGFR-2 inhibitors: design, synthesis, anticancer activity and effect on cell cycle profile

(2019) Aml E.-S. Mghwary et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Identification of Novel Anti-Liver Cancer Small Molecules with Better Therapeutic Index than Sorafenib via Zebrafish Drug Screening Platform

(2019) Lin et al.   Cancers

Design and synthesis of novel pyridazinoquinazoline derivatives as potent VEGFR-2 inhibitors: In vitro and in vivo study

(2019) Marwa G. El-Gazzar et al.   BIOORGANIC CHEMISTRY

Novel thioureido-benzenesulfonamide derivatives with enaminone linker as potent anticancer, radiosensitizers and VEGFR2 inhibitors

(2018) Mostafa M. Ghorab et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anticancer Evaluation and Docking Study of New Bifunctional Phthalazine Derivatives

(2018) Marwa G. El-Gazzar et al.   CURRENT ORGANIC SYNTHESIS

Efficient procedure with new fused pyrimidinone derivatives, Schiff base ligand and its La and Gd complexes by green chemistry

(2018) Hala M. Aly et al.   Inorganic Chemistry Frontiers

Transitions From Heart Disease to Cancer as the Leading Cause of Death in US States, 1999–2016

(2018) Michael C. Harding et al.   Preventing Chronic Disease

A SAR Study: Evaluation of Bromo Derivatives of 8-Substituted Quinolines as Novel Anticancer Agents

(2017) Salih Okten et al.   Letters in Drug Design & Discovery

Synthesis, structural characterization and anticancer evaluation of pyrazole derivatives

(2017) Mohamed S. A. El-Gaby et al.   MEDICINAL CHEMISTRY RESEARCH

A green and clean pathway: one pot, multicomponent, and visible light assisted synthesis of pyrano[2,3-c]pyrazoles under catalyst-free and solvent-free conditions

(2017) Bhartendu Pati Tripathi et al.   NEW JOURNAL OF CHEMISTRY

Review: biologically active pyrazole derivatives

(2017) Anam Ansari et al.   NEW JOURNAL OF CHEMISTRY

Chemotherapy-induced peripheral neuropathy: Current status and progress

(2016) Jamie R. Brewer et al.   GYNECOLOGIC ONCOLOGY

Synthesis of bifunctional thieno[3,2-c]pyrazole, pyrazolothieno[2,3-d]pyrimidin derivatives and their antimicrobial activities

(2016) Hala M. Aly   Journal of the Iranian Chemical Society

Approved and Experimental Small-Molecule Oncology Kinase Inhibitor Drugs: A Mid-2016 Overview

(2016) Peter M. Fischer   MEDICINAL RESEARCH REVIEWS

Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids

(2016) Mostafa Ghorab et al.   MOLECULES

Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells

(2016) Cristina Florean et al.   Oncotarget

Small Molecules for Immunomodulation in Cancer: A Review

(2015) Vidhya Iyer   Anti-Cancer Agents in Medicinal Chemistry

Risk of extrapyramidal side effects comparing continuous vs. bolus intravenous metoclopramide administration: a systematic review and meta-analysis of randomised controlled trials

(2015) Iván Cavero-Redondo et al.   JOURNAL OF CLINICAL NURSING

Synthesis, Antimicrobial Evaluations, and DNA Photo Cleavage Studies of New Bispyranopyrazoles

(2015) Mohamad Yusuf et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis of 4H-chromenes promoted by NbCl5 through multicomponent reaction

(2015) Paula Beatriz Oshiro et al.   TETRAHEDRON LETTERS

A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method

(2015) Sethurajan Ambethkar et al.   Journal of Advanced Research

Small Molecule Substrate Phosphorylation Site Inhibitors of Protein Kinases: Approaches and Challenges

(2014) Meghan E. Breen et al.   ACS Chemical Biology

Multi-drug resistance in cancer chemotherapeutics: Mechanisms and lab approaches

(2014) Qiong Wu et al.   CANCER LETTERS

Small Heterocycles in Multicomponent Reactions

(2014) Benjamin H. Rotstein et al.   CHEMICAL REVIEWS

Synthesis of new class of spirocarbocycle derivatives by multicomponent domino reaction and their evaluation for antimicrobial, anticancer activity and molecular docking studies

(2014) N. Sudhapriya et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Highly efficient organocatalytic synthesis of diverse and densely functionalized 2-amino-3-cyano-4H-pyrans under mechanochemical ball milling

(2014) Mohammad G. Dekamin et al.   GREEN CHEMISTRY

A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma

(2014) Lei Zhong et al.   INTERNATIONAL JOURNAL OF CANCER

Medicinal attributes of pyrazolo[3,4-d]pyrimidines: A review

(2013) Monika Chauhan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chitosan: a highly efficient renewable and recoverable bio-polymer catalyst for the expeditious synthesis of α-amino nitriles and imines under mild conditions

(2013) Mohammad G. Dekamin et al.   GREEN CHEMISTRY

Novel 5-anilinoquinazoline-8-nitro derivatives as inhibitors of VEGFR-2 tyrosine kinase: synthesis, biological evaluation and molecular docking

(2013) Liang Xi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Novel Antitumor Acetamide, Pyrrole, Pyrrolopyrimidine, Thiocyanate, Hydrazone, Pyrazole, Isothiocyanate and Thiophene Derivatives Containing a Biologically Active Pyrazole Moiety

(2012) Saleh Alqasoumi et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

Novel Pyrazole Derivatives as Anticancer and Radiosensitizing Agents

(2012) H. Aly et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

Potassium phthalimide-N-oxyl: a novel, efficient, and simple organocatalyst for the one-pot three-component synthesis of various 2-amino-4H-chromene derivatives in water

(2012) Mohammad G. Dekamin et al.   TETRAHEDRON

Efficient one-pot preparation of novel fused chromeno[2,3-d]pyrimidine and pyrano[2,3-d]pyrimidine derivatives

(2011) Hala M. Aly et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel pyrrolidinone and pyrazolo[1,5-a][1,3,5]triazine derivatives bearing a biologically active sulfamoyl moiety as a new class of antitumor agents

(2011) Hala M. Aly   MONATSHEFTE FUR CHEMIE

A new catalytic mode of the modularly designed organocatalysts (MDOs): enantioselective synthesis of dihydropyrano[2,3-c]pyrazoles

(2011) Savitha Muramulla et al.   TETRAHEDRON LETTERS

Synthesis of novel pyrrole and pyrrolo[2,3-d]pyrimidine derivatives bearing sulfonamide moiety for evaluation as anticancer and radiosensitizing agents

(2010) Mostafa M. Ghorab et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Antitumor Activity of Some Novel Pyrazole and Thienopyrimidine Derivatives

(2009) Hala Aly   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes

(2008) S. A. Lang et al.   MOLECULAR CANCER THERAPEUTICS

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in ApcMin/+ mice

(2008) D. Alferez et al.   MOLECULAR CANCER THERAPEUTICS