Molecular cancer cell responses to solid compressive stress and interstitial fluid pressure

Investigating the influence of physiologically relevant hydrostatic pressure on CHO cell batch culture

(2021) Menglin Shang et al.   Scientific Reports

Circulating prostate cancer cells have differential resistance to fluid shear stress-induced cell death

(2021) Jacob M. Hope et al.   JOURNAL OF CELL SCIENCE

Extra-cellular matrix in multicellular aggregates acts as a pressure sensor controlling cell proliferation and motility

(2021) Monika E Dolega et al.   eLife

Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance

(2020) Jose L. Orgaz et al.   CANCER CELL

Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement

(2020) Helen K. Matthews et al.   DEVELOPMENTAL CELL

Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation

(2020) Devon L. Moose et al.   Cell Reports

Targeting Tissue Stiffness in Metastasis: Mechanomedicine Improves Cancer Therapy

(2020) Jian Zhang et al.   CANCER CELL

Correlating nuclear morphology and external force with combined atomic force microscopy and light sheet imaging separates roles of chromatin and lamin A/C in nuclear mechanics

(2020) Chad M. Hobson et al.   MOLECULAR BIOLOGY OF THE CELL

Nuclear Deformation Causes DNA Damage by Increasing Replication Stress

(2020) Pragya Shah et al.   CURRENT BIOLOGY

Solid stress-induced migration is mediated by GDF15 through Akt pathway activation in pancreatic cancer cells

(2019) Maria Kalli et al.   Scientific Reports

Regulation of Cell Behavior by Hydrostatic Pressure

(2019) Shaobao Liu et al.   Applied Mechanics Reviews

Repair of nuclear ruptures requires barrier-to-autointegration factor

(2019) Charles T. Halfmann et al.   JOURNAL OF CELL BIOLOGY

Mechanics of nuclear membranes

(2019) Ashutosh Agrawal et al.   JOURNAL OF CELL SCIENCE

Nuclear envelope deformation controls cell cycle progression in response to mechanical force

(2019) Julien Aureille et al.   EMBO REPORTS

Early-Stage Dynamics in Vascular Endothelial Cells Exposed to Hydrostatic Pressure

(2019) Daisuke Yoshino et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

High stretchability, strength, and toughness of living cells enabled by hyperelastic vimentin intermediate filaments

(2019) Jiliang Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular regulation of antitumor immunity

(2019) Lance L. Munn et al.   SCIENCE

Emerging Concepts and Tools in Cell Mechanomemory

(2019) Tanmay P. Lele et al.   ANNALS OF BIOMEDICAL ENGINEERING

Vimentin protects cells against nuclear rupture and DNA damage during migration

(2019) Alison E. Patteson et al.   JOURNAL OF CELL BIOLOGY

Rho-mediated signaling promotes BRAF inhibitor resistance in de-differentiated melanoma cells

(2019) S. A. Misek et al.   ONCOGENE

Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making

(2019) Matthew R. Zanotelli et al.   Nature Communications

Hybrid collagen alginate hydrogel as a platform for 3D tumor spheroid invasion

(2018) Chun Liu et al.   Acta Biomaterialia

Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration

(2018) Maria Kalli et al.   ANNALS OF BIOMEDICAL ENGINEERING

On the Origin of Microtubules’ High-Pressure Sensitivity

(2018) Mimi Gao et al.   BIOPHYSICAL JOURNAL

Elevated hydrostatic pressure promotes ameloblastoma cell invasion through up-regulation of MMP-2 and MMP-9 expression via Wnt/β-catenin signalling

(2018) Zinan Yang et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Mitotic cells generate protrusive extracellular forces to divide in three-dimensional microenvironments

(2018) Sungmin Nam et al.   Nature Physics

The effect of the rate of hydrostatic pressure depressurization on cells in culture

(2018) Ellen Tworkoski et al.   PLoS One

Mechanical principles of nuclear shaping and positioning

(2018) Tanmay P. Lele et al.   JOURNAL OF CELL BIOLOGY

Compressive force induces reversible chromatin condensation and cell geometry dependent transcriptional response

(2018) Karthik Damodaran et al.   MOLECULAR BIOLOGY OF THE CELL

Local, transient tensile stress on the nuclear membrane causes membrane rupture

(2018) Qiao Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Tissue Force Programs Cell Fate and Tumor Aggression

(2017) Jason J. Northey et al.   Cancer Discovery

Nuclear envelope rupture is induced by actin-based nucleus confinement

(2016) Emily M. Hatch et al.   JOURNAL OF CELL BIOLOGY

Elevated hydrostatic pressure enhances the motility and enlarges the size of the lung cancer cells through aquaporin upregulation mediated by caveolin-1 and ERK1/2 signaling

(2016) Y-C Kao et al.   ONCOGENE

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading

(2015) Yuan Li et al.   BIOPHYSICAL JOURNAL

Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness

(2015) Lena A. Lautscham et al.   BIOPHYSICAL JOURNAL

Tumor-Induced Pressure in the Bone Microenvironment Causes Osteocytes to Promote the Growth of Prostate Cancer Bone Metastases

(2015) Joseph L. Sottnik et al.   CANCER RESEARCH

Endothelial Cell Response Under Hydrostatic Pressure Condition Mimicking Pressure Therapy

(2015) Daisuke Yoshino et al.   Cellular and Molecular Bioengineering

Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell

(2015) Srujana Neelam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement

(2015) Barbara Sorce et al.   Nature Communications

Hydrostatic Pressure Does Not Cause Detectable Changes in Survival of Human Retinal Ganglion Cells

(2015) Andrew Osborne et al.   PLoS One

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

Compressive Stress Inhibits Proliferation in Tumor Spheroids through a Volume Limitation

(2014) Morgan Delarue et al.   BIOPHYSICAL JOURNAL

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

Releasing Pressure in Tumors: What Do We Know So Far and Where Do We Go from Here? A Review

(2014) A. B. Ariffin et al.   CANCER RESEARCH

Mechanotransduction of fluid stresses governs 3D cell migration

(2014) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyaluronan, fluid pressure and stromal resistance in pancreas cancer

(2013) P P Provenzano et al.   BRITISH JOURNAL OF CANCER

High interstitial fluid pressure promotes tumor cell proliferation and invasion in oral squamous cell carcinoma

(2013) TAO YU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

(2013) Rakesh K. Jain   JOURNAL OF CLINICAL ONCOLOGY

Mechanical Stress Impairs Mitosis Progression in Multi-Cellular Tumor Spheroids

(2013) Annaïck Desmaison et al.   PLoS One

Keratins significantly contribute to cell stiffness and impact invasive behavior

(2013) K. Seltmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

(2013) Vikash P. Chauhan et al.   Nature Communications

Delivery of molecular and cellular medicine to solid tumors

(2012) Rakesh K. Jain   ADVANCED DRUG DELIVERY REVIEWS

Modulation of Invasive Phenotype by Interstitial Pressure-Driven Convection in Aggregates of Human Breast Cancer Cells

(2012) Joe Tien et al.   PLoS One

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Culturing of Cartilage Tissue: The Significance of Hydrostatic Pressure

(2012) Cristina Correia et al.   TISSUE ENGINEERING PART A

Mild Elevation of Body Temperature Reduces Tumor Interstitial Fluid Pressure and Hypoxia and Enhances Efficacy of Radiotherapy in Murine Tumor Models

(2011) A. Sen et al.   CANCER RESEARCH

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Interstitial flow influences direction of tumor cell migration through competing mechanisms

(2011) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of high hydrostatic pressure on the expression of glutamine synthetase in rat retinal Müller cells cultured in vitro

(2011) JUN YU et al.   Experimental and Therapeutic Medicine

Microtubule depolymerization at high pressure

(2010) Masayoshi Nishiyama et al.   Annals of the New York Academy of Sciences

Effects of cyclic hydraulic pressure on osteocytes

(2010) Chao Liu et al.   BONE

Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding

(2010) Martin P. Stewart et al.   NATURE

Contribution of the Cytoskeleton to the Compressive Properties and Recovery Behavior of Single Cells

(2009) Gidon Ofek et al.   BIOPHYSICAL JOURNAL

Pressure-Induced Changes in the Structure and Function of the Kinesin-Microtubule Complex

(2009) Masayoshi Nishiyama et al.   BIOPHYSICAL JOURNAL

Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells

(2009) Gang Cheng et al.   PLoS One

Force amplification response of actin filaments under confined compression

(2009) G. W. Greene et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blebs lead the way: how to migrate without lamellipodia

(2008) Guillaume Charras et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY