SMC 5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability

Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage

(2019) Kelvin W. Pond et al.   PLoS Genetics

Replication stress induces accumulation of FANCD2 at central region of large fragile genes

(2018) Yusuke Okamoto et al.   NUCLEIC ACIDS RESEARCH

The concerted roles of FANCM and Rad52 in the protection of common fragile sites

(2018) Hailong Wang et al.   Nature Communications

Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites

(2018) Xiao P. Peng et al.   PLoS Genetics

Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites

(2018) Takuya Abe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Smc5/6 Complex: New and Old Functions of the Enigmatic Long-Distance Relative

(2018) Luis Aragón   Annual Review of Genetics

FANCD2 protects genome stability by recruiting RNA processing enzymes to resolve R-loops during mild replication stress

(2018) Yusuke Okamoto et al.   FEBS Journal

A journey with common fragile sites: From S phase to telophase

(2018) Michelle Debatisse et al.   GENES CHROMOSOMES & CANCER

BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II–DNA complexes

(2018) Hiroyuki Sasanuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ESCO1/2's roles in chromosome structure and interphase chromatin organization

(2017) Ryotaro Kawasumi et al.   GENES & DEVELOPMENT

A never-ending story: the steadily growing family of the FA and FA-like genes

(2017) Anna Gueiderikh et al.   GENETICS AND MOLECULAR BIOLOGY

CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis

(2017) Remi Sonneville et al.   NATURE CELL BIOLOGY

PARPi focus the spotlight on replication fork protection in cancer

(2017) Katharina Schlacher   NATURE CELL BIOLOGY

FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells

(2017) Constanze Pentzold et al.   NUCLEIC ACIDS RESEARCH

Specialized interfaces of Smc5/6 control hinge stability and DNA association

(2017) Aaron Alt et al.   Nature Communications

Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease

(2016) Saskia N. van der Crabben et al.   JOURNAL OF CLINICAL INVESTIGATION

FANCD2 Facilitates Replication through Common Fragile Sites

(2016) Advaitha Madireddy et al.   MOLECULAR CELL

The Fanconi anaemia pathway: new players and new functions

(2016) Raphael Ceccaldi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromatin determinants of the inner-centromere rely on replication factors with functions that impart cohesion

(2016) Takuya Abe et al.   Oncotarget

Functions and regulation of the multitasking FANCM family of DNA motor proteins

(2015) Xiaoyu Xue et al.   GENES & DEVELOPMENT

Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines

(2015) Nguyen Ngoc Hoa et al.   GENES TO CELLS

Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance

(2015) Jodi M Saunus et al.   JOURNAL OF PATHOLOGY

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen

(2015) Lucas B. Pontel et al.   MOLECULAR CELL

Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance

(2015) Demis Menolfi et al.   MOLECULAR CELL

The mechanism of DNA replication termination in vertebrates

(2015) James M. Dewar et al.   NATURE

Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA

(2015) Katerina Zabrady et al.   NUCLEIC ACIDS RESEARCH

Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells

(2015) Emilie Renaud et al.   NUCLEIC ACIDS RESEARCH

Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

(2015) M. Raschle et al.   SCIENCE

Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes

(2015) Jan J. Palecek et al.   STRUCTURE

Development of a Targeted Flip-in System in Avian DT40 Cells

(2015) Kaori Kobayashi et al.   PLoS One

Loss ofCaenorhabditis elegansBRCA1 Promotes Genome Stability During Replication insmc-5Mutants

(2014) Stefanie Wolters et al.   GENETICS

Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance

(2014) Felicity Payne et al.   JOURNAL OF CLINICAL INVESTIGATION

The maintenance of chromosome structure: positioning and functioning of SMC complexes

(2014) Kristian Jeppsson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression

(2014) Spencer W. Luebben et al.   NUCLEIC ACIDS RESEARCH

Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae

(2014) W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

(2013) F. Ann Ran et al.   CELL

FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling

(2013) Gérald Lossaint et al.   MOLECULAR CELL

A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair

(2013) J. Tomida et al.   NUCLEIC ACIDS RESEARCH

An expanded tool kit for the auxin-inducible degron system in budding yeast

(2013) Magdalena Morawska et al.   YEAST

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Evaluation of associations between common variation in mitotic regulatory pathways and risk of overall and high grade breast cancer

(2011) Kristen N. Stevens et al.   BREAST CANCER RESEARCH AND TREATMENT

Roles of Vertebrate Smc5 in Sister Chromatid Cohesion and Homologous Recombinational Repair

(2011) A. K. Stephan et al.   MOLECULAR AND CELLULAR BIOLOGY

Chromosome length influences replication-induced topological stress

(2011) Andreas Kegel et al.   NATURE

Replication Termination at Eukaryotic Chromosomes Is Mediated by Top2 and Occurs at Genomic Loci Containing Pausing Elements

(2010) Daniele Fachinetti et al.   MOLECULAR CELL

Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia

(2010) Adele Adamo et al.   MOLECULAR CELL

Monoubiquitylation in the Fanconi anemia DNA damage response pathway

(2009) A.F. Alpi et al.   DNA REPAIR

Smc5-Smc6-Dependent Removal of Cohesin from Mitotic Chromosomes

(2009) E. A. Outwin et al.   MOLECULAR AND CELLULAR BIOLOGY

The Saccharomyces cerevisiae Esc2 and Smc5-6 Proteins Promote Sister Chromatid Junction-mediated Intra-S Repair

(2009) Julie Sollier et al.   MOLECULAR BIOLOGY OF THE CELL

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

(2009) Valeria Naim et al.   NATURE CELL BIOLOGY

An auxin-based degron system for the rapid depletion of proteins in nonplant cells

(2009) Kohei Nishimura et al.   NATURE METHODS

The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

(2009) P. Knipscheer et al.   SCIENCE

Smc5/6: a link between DNA repair and unidirectional replication?

(2007) Johanne M. Murray et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY