Monodentately-coordinated bioactive moieties in multimodal half-sandwich organoruthenium anticancer agents

Synthesis and biological assessment of a ruthenium(II) cyclopentadienyl complex in breast cancer cells and on the development of zebrafish embryos

(2020) Golara Golbaghi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization, in silico and in vitro biological activity studies of Ru(II) (η6-p-cymene) complexes with novel N-dibenzosuberene substituted aroyl selenourea exhibiting Se type coordination

(2020) Moideen Musthafa et al.   RESEARCH ON CHEMICAL INTERMEDIATES

First insights into the novel class of organometallic compounds bearing a bidentate selenopyridone coordination motif: Synthesis, characterization, stability and biological investigations

(2020) Sophia Harringer et al.   INORGANICA CHIMICA ACTA

Ruthenium(II)–arene and triruthenium-carbonyl cluster complexes with new water-soluble phopsphites based on glucose: Synthesis, characterization and antiproliferative activity

(2020) Maria R. Gonchar et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Multiaction Platinum(IV) Prodrug Containing Thymidylate Synthase Inhibitor and Metabolic Modifier against Triple-Negative Breast Cancer

(2020) Nafees Muhammad et al.   INORGANIC CHEMISTRY

Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells

(2020) Marijana Pavlović et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis, characterization, antimicrobial and cytotoxic activity of novel half-sandwich Ru(II) arene complexes with benzoylthiourea derivatives

(2020) Dragiša Obradović et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Ruthenium(II) Complexes of Isothiazole Ligands: Crystal Structure, HSA/DNA Interactions, Cytotoxic Activity and Molecular Docking Simulations

(2020) Maja B. Djukić et al.   ChemistrySelect

Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?

(2019) Reece G. Kenny et al.   CHEMICAL REVIEWS

Structural Modifications of the Antiinflammatory Oxicam Scaffold and Preparation of Anticancer Organometallic Compounds

(2019) Adnan Ashraf et al.   ORGANOMETALLICS

Organoruthenium(II) Complexes Bearing an Aromatase Inhibitor: Synthesis, Characterization, in Vitro Biological Activity and in Vivo Toxicity in Zebrafish Embryos

(2019) Golara Golbaghi et al.   ORGANOMETALLICS

Coordination Chemistry of Organoruthenium Compounds with Benzoylthiourea Ligands and their Biological Properties

(2019) Shahida Parveen et al.   Chemistry-An Asian Journal

A Ru(II)-p-cymene compound bearing naproxen-pyridineamide. Synthesis, spectroscopic studies, computational analysis and in vitro anticancer activity against lung cells compared to Ru(II)-p-cymene-naproxen and the corresponding drug ligands

(2019) Julie Pauline Gaitan Tabares et al.   INORGANICA CHIMICA ACTA

NAMI-A and KP1019/1339, Two Iconic Ruthenium Anticancer Drug Candidates Face-to-Face: A Case Story in Medicinal Inorganic Chemistry

(2019) Enzo Alessio et al.   MOLECULES

Hexanuclear Zn(II) and Mononuclear Cu(II) Complexes containing imino phenol ligands: Exploitation of their Catalytic and Biological Perspectives

(2019) Shyam Sundar Mondal et al.   APPLIED ORGANOMETALLIC CHEMISTRY

A new 4-(pyridinyl)-4H-benzo[g]chromene-5,10-dione ruthenium(II) complex inducing senescence in 518A2 melanoma cells

(2019) Madeleine Gold et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Synthesis and Anticancer Activity of [RuCl2(η6-arene)(aroylthiourea)] Complexes—High Activity against the Human Neuroblastoma (IMR-32) Cancer Cell Line

(2019) Srividya Swaminathan et al.   ACS Omega

Conjugating Biotin to Ruthenium(II) Arene Units via Phosphine Ligand Functionalization

(2019) Lorenzo Biancalana et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

A new amido-phosphine of dichloroacetic acid as an active ligand for metals of pharmaceutical interest. Synthesis, characterization and tests of antiproliferative and pro-apoptotic activity

(2019) Lorenza Marvelli et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future

(2019) Sona Vodenkova et al.   PHARMACOLOGY & THERAPEUTICS

Synthesis and characterization of thiosemicarbazone-functionalized organoruthenium (II)-arene complexes: Investigation of antitumor characteristics in colorectal cancer cell lines

(2019) Elif Subasi et al.   Materials Science & Engineering C-Materials for Biological Applications

Anti-tumour active gold(i), palladium(ii) and ruthenium(ii) complexes with thio- and selenoureato ligands: a comparative study

(2018) Anja Molter et al.   DALTON TRANSACTIONS

Synthesis and Biological Evaluation of Organometallic Complexes Bearing Bis-1,8-naphthalimide Ligands

(2018) Wojciech Streciwilk et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction

(2018) Wojciech Streciwilk et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Clinical relevance of metronidazole and peripheral neuropathy: a systematic review of the literature

(2018) Tiffany A. Goolsby et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Bioactive ruthenium(II)-arene complexes containing modified 18β-glycyrrhetinic acid ligands

(2018) Yaqiong Kong et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

New (arene)ruthenium(II) complexes of 4‑aryl‑4 H ‑naphthopyrans with anticancer and anti-vascular activities

(2018) Florian Schmitt et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Anticancer Activity of Bifunctional Organometallic Ru(II) Arene Complexes Containing a 7-Hydroxycoumarin Group

(2018) Jian Zhao et al.   ORGANOMETALLICS

Enhanced Tumor Diagnostic and Therapeutic Effect of Mesoporous Silica Nanoparticle-Mediated Pre-targeted Strategy

(2018) Gaochao Lv et al.   PHARMACEUTICAL RESEARCH

Ru(II)-η 6 -benzene Complexes of Dibenzosuberenyl Appended Aroyl/Acylthiourea Ligands: In vitro Biomolecular Interaction Studies and Catalytic Transfer Hydrogenation

(2018) Gandhaveeti Rohini et al.   ChemistrySelect

Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells

(2018) Shingo Kozono et al.   Nature Communications

Metronidazole: an update on metabolism, structure–cytotoxicity and resistance mechanisms

(2017) Simon A Dingsdag et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Varying the metal to ethacrynic acid ratio in ruthenium(ii)/osmium(ii)- p -cymene conjugates

(2017) Emilia Păunescu et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Anticancer Ru( η 6 - p -cymene) complexes of 2-pyridinecarbothioamides: A structure–activity relationship study

(2017) Jahanzaib Arshad et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

New highly cytotoxic organic and organometallic bexarotene derivatives

(2017) Yulia N. Nosova et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Asymmetric hydrogenation of pro-chiral ketones catalyzed by chiral Ru(II)-benzene organometallic compounds containing amino acid based aroylthiourea ligands

(2017) M. Mary Sheeba et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Advances in the design of organometallic anticancer complexes

(2017) Pingyu Zhang et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Priviledged scaffolds for anti-infective activity: Imidazole and pyrazole based analogues

(2017) Kavit Patel et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

A review on metronidazole: an old warhorse in antimicrobial chemotherapy

(2017) David Leitsch   PARASITOLOGY

Naproxen derivatives: Synthesis, reactions, and biological applications

(2017) Y. A. Ammar et al.   SYNTHETIC COMMUNICATIONS

Insights into the in vitro Anticancer Effects of Diruthenium-1

(2016) Aneta Koceva-Chyła et al.   ChemMedChem

Thiolato-bridged dinuclear arene ruthenium complexes and their potential as anticancer drugs

(2016) Julien Furrer et al.   COORDINATION CHEMISTRY REVIEWS

The development of RAPTA compounds for the treatment of tumors

(2016) Benjamin S. Murray et al.   COORDINATION CHEMISTRY REVIEWS

Update on metal N-heterocyclic carbene complexes as potential anti-tumor metallodrugs

(2016) Wukun Liu et al.   COORDINATION CHEMISTRY REVIEWS

Coordination chemistry of thiazoles, isothiazoles and thiadiazoles

(2016) Luís M.T. Frija et al.   COORDINATION CHEMISTRY REVIEWS

Inorganic sulfur–nitrogen compounds: from gunpowder chemistry to the forefront of biological signaling

(2016) Miriam M. Cortese-Krott et al.   DALTON TRANSACTIONS

Half-sandwich RuCl2(η6-p-cymene) core complexes containing sulfur donor aroylthiourea ligands: DNA and protein binding, DNA cleavage and cytotoxic studies

(2016) Kumaramangalam Jeyalakshmi et al.   DALTON TRANSACTIONS

A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action

(2016) Jing-Jing Zhang et al.   DALTON TRANSACTIONS

Nonsteroidal Anti-inflammatory—Organometallic Anticancer Compounds

(2016) Emilia Păunescu et al.   INORGANIC CHEMISTRY

The synthesis, lipophilicity and cytotoxic effects of new ruthenium(II) arene complexes with chromone derivatives

(2016) Adam Pastuszko et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Anticancer activity of Ru- and Os(arene) compounds of a maleimide-functionalized bioactive pyridinecarbothioamide ligand

(2016) Muhammad Hanif et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Anticancer Activity and Modes of Action of (arene) ruthenium(II) Complexes Coordinated to C-, N-, and O-ligands

(2016) Bernhard Biersack   MINI-REVIEWS IN MEDICINAL CHEMISTRY

N,N′-Disubstituted thiourea and urea derivatives: design, synthesis, docking studies and biological evaluation against nitric oxide synthase

(2016) Mariem Chayah et al.   MedChemComm

Synergistic Anticancer Potential of Dichloroacetate and Estradiol Analogue Exerting their Effect via ROS-JNK-Bcl-2-Mediated Signalling Pathways

(2015) Xiao Xing Stander et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ferrocifen type anti cancer drugs

(2015) Gérard Jaouen et al.   CHEMICAL SOCIETY REVIEWS

Half-Sandwich Ruthenium(II) Biotin Conjugates as Biological Vectors to Cancer Cells

(2015) Maria V. Babak et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fighting Cancer with Transition Metal Complexes: From Naked DNA to Protein and Chromatin Targeting Strategies

(2015) Giulia Palermo et al.   ChemMedChem

Current developments of coumarin-based anti-cancer agents in medicinal chemistry

(2015) Saeed Emami et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzotriazole: An overview on its versatile biological behavior

(2015) I. Briguglio et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic-Acid-Modified Pyridine and Triphenylphosphine Ligands

(2015) Gabriele Agonigi et al.   INORGANIC CHEMISTRY

A new ruthenium cyclopentadienyl azole compound with activity on tumor cell lines and trypanosomatid parasites

(2015) Esteban Rodríguez Arce et al.   JOURNAL OF COORDINATION CHEMISTRY

Design, synthesis and anticancer activity of diam(m)ine platinum(II) complexes bearing a small-molecular cell apoptosis inducer dichloroacetate

(2015) Weiping Liu et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Silver(I), Gold(I) and Gold(III)-N-Heterocyclic carbene complexes of naphthyl substituted annelated ligand: Synthesis, structure and cytotoxicity

(2015) Tapastaru Samanta et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Development of drugs based on imidazole and benzimidazole bioactive heterocycles: recent advances and future directions

(2015) Monika Gaba et al.   MEDICINAL CHEMISTRY RESEARCH

Discovery of a dual-targeting organometallic ruthenium complex with high activity inducing early stage apoptosis of cancer cells

(2015) Jun Du et al.   Metallomics

A tunable library of substituted thiourea precursors to metal sulfide nanocrystals

(2015) M. P. Hendricks et al.   SCIENCE

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

(2015) Maria V. Babak et al.   Chemical Science

Cytotoxic peptide conjugates of dinuclear arene ruthenium trithiolato complexes

(2015) Federico Giannini et al.   MedChemComm

Molecular targets of aspirin and cancer prevention

(2014) L Alfonso et al.   BRITISH JOURNAL OF CANCER

Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond

(2014) Shu Xu et al.   IUBMB LIFE

Structure-based design of novel naproxen derivatives targeting monomeric nucleoprotein of Influenza A virus

(2014) Bogdan Tarus et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Ferrocene and (arene)ruthenium(II) complexes of the natural anticancer naphthoquinone plumbagin with enhanced efficacy against resistant cancer cells and a genuine mode of action

(2014) Cornelia Spoerlein-Guettler et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hybrids of Phenylsulfonylfuroxan and Coumarin as Potent Antitumor Agents

(2014) Ming-Ming Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

RutheniumII(η6-arene) Complexes of Thiourea Derivatives: Synthesis, Characterization and Urease Inhibition

(2014) Muhammad Hanif et al.   MOLECULES

Deprotonation-Induced Structural Changes in SNS-Pincer Ruthenium Complexes with Secondary Thioamide Groups

(2014) Yoko Komiyama et al.   ORGANOMETALLICS

Synthesis and Biological Evaluation of Organoruthenium Complexes with Azole Antifungal Agents. First Crystal Structure of a Tioconazole Metal Complex

(2014) Jakob Kljun et al.   ORGANOMETALLICS

Chiral (η6-p-Cymene)ruthenium(II) Complexes Containing Monodentate Acylthiourea Ligands for Efficient Asymmetric Transfer Hydrogenation of Ketones

(2014) Mani Mary Sheeba et al.   ORGANOMETALLICS

Ten-year Experience of Bexarotene Therapy for Cutaneous T-cell Lymphoma in Finland

(2013) L Väkevä et al.   ACTA DERMATO-VENEREOLOGICA

Glycyrrhetinic acid and its analogs: A new class of antifilarial agents

(2013) Komal Kalani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Naproxen Induces Cell-Cycle Arrest and Apoptosis in Human Urinary Bladder Cancer Cell Lines and Chemically Induced Cancers by Targeting PI3K

(2013) M.-S. Kim et al.   Cancer Prevention Research

DMSO-Mediated Ligand Dissociation: Renaissance for Biological Activity ofN-Heterocyclic-[Ru(η6-arene)Cl2] Drug Candidates

(2013) Malay Patra et al.   CHEMISTRY-A EUROPEAN JOURNAL

Liposomes, a promising strategy for clinical application of platinum derivatives

(2013) Sara Zalba et al.   Expert Opinion on Drug Delivery

Metal–drug synergy: new ruthenium(II) complexes of ketoconazole are highly active against Leishmania major and Trypanosoma cruzi and nontoxic to human or murine normal cells

(2013) Eva Iniguez et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Evaluation of naproxen and cromolyn activities against cancer cells viability, proliferation, apoptosis, p53 and gene expression of survivin and caspase-3

(2013) Tarek M. K. Motawi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Multi-targeted organometallic ruthenium(II)–arene anticancer complexes bearing inhibitors of poly(ADP-ribose) polymerase-1: A strategy to improve cytotoxicity

(2013) Zhigang Wang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Discovery of a Potential Anti-Inflammatory Agent: 3-Oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile

(2013) Ran You et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis of the Antitumor Antibiotic (±)-Streptonigrin: First- and Second-Generation Routes for de Novo Pyridine Formation Using Ring-Closing Metathesis

(2013) Timothy J. Donohoe et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis, X-ray structure, electrochemical properties and cytotoxic effects of new arene ruthenium(II) complexes

(2013) Adam Pastuszko et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Flavonoid-Metal Ion Complexes: A Novel Class of Therapeutic Agents

(2013) Stalin Selvaraj et al.   MEDICINAL RESEARCH REVIEWS

Highly cytotoxic diruthenium trithiolato complexes of the type [(η6-p-MeC6H4Pri)2Ru2(μ2-SR)3]+: synthesis, characterization, molecular structure and in vitro anticancer activity

(2013) Federico Giannini et al.   NEW JOURNAL OF CHEMISTRY

MEK in cancer and cancer therapy

(2013) Cindy Neuzillet et al.   PHARMACOLOGY & THERAPEUTICS

Re-Engineering Nature's Catalysts

(2013) A. R. H. Narayan et al.   SCIENCE

Novel metal(ii) arene 2-pyridinecarbothioamides: a rationale to orally active organometallic anticancer agents

(2013) Samuel M. Meier et al.   Chemical Science

Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes

(2013) Muhammad Hanif et al.   Frontiers in Chemistry

Redox activation of metal-based prodrugs as a strategy for drug delivery

(2012) Nora Graf et al.   ADVANCED DRUG DELIVERY REVIEWS

Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-Pyrano-[2,3-b]naphthoquinones with anticancer activity

(2012) Igor V. Magedov et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, characterization, molecular docking and cytotoxic activity of novel plumbagin hydrazones against breast cancer cells

(2012) Prasad Dandawate et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New substituted 4H-chromenes as anticancer agents

(2012) Shivaputra A. Patil et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder

(2012) Andrea Kurzwernhart et al.   CHEMICAL COMMUNICATIONS

Contemporary Challenges in the Design of Topoisomerase II Inhibitors for Cancer Chemotherapy

(2012) Christian Bailly   CHEMICAL REVIEWS

Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death

(2012) Alexey A. Nazarov et al.   DALTON TRANSACTIONS

Caffeine treatment disturbs the angiogenesis of zebrafish embryos

(2012) Chien-Hung Yeh et al.   DRUG AND CHEMICAL TOXICOLOGY

Arene-ruthenium(II) complexes containing 5-fluorouracil-1-methyl isonicotinate: Synthesis and characterization of their anticancer activity

(2012) Kuan-Guan Liu et al.   INORGANICA CHIMICA ACTA

NSAIDs induce apoptosis in nonproliferating ovarian cancer cells and inhibit tumor growth in vivo

(2012) Kristal Duncan et al.   IUBMB LIFE

Searching for New Chemotherapies for Tropical Diseases: Ruthenium–Clotrimazole Complexes Display High in Vitro Activity against Leishmania major and Trypanosoma cruzi and Low Toxicity toward Normal Mammalian Cells

(2012) Alberto Martínez et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Ruthenium(II)–Letrozole Complexes as Anticancer Therapeutics

(2012) Annie Castonguay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Chalcones with Anticancer Activities

(2012) Suvitha Syam et al.   MOLECULES

Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

(2012) Christian G. Hartinger et al.   ORGANOMETALLICS

Naphthalimide-Tagged Ruthenium–Arene Anticancer Complexes: Combining Coordination with Intercalation

(2012) Kelly J. Kilpin et al.   ORGANOMETALLICS

“Push effect” of sulfur coordination: promoting the breaking of C(sp2)–I bond by pincer thioimido-Pd(ii) complexes

(2012) Jing Liu et al.   Chemical Science

Prodrug-based intracellular delivery of anticancer agents

(2011) L. Bildstein et al.   ADVANCED DRUG DELIVERY REVIEWS

Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

(2011) Muhammad Hanif et al.   CHEMICAL COMMUNICATIONS

Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs

(2011) Alberta Bergamo et al.   DALTON TRANSACTIONS

A Potent Ruthenium(II) Antitumor Complex Bearing a Lipophilic Levonorgestrel Group

(2011) José Ruiz et al.   INORGANIC CHEMISTRY

Cytotoxic Bipyridines from the Marine-Derived ActinomyceteActinoalloteichus cyanogriseusWH1-2216-6

(2011) Peng Fu et al.   JOURNAL OF NATURAL PRODUCTS

Characterization of New Potential Anticancer Drugs Designed To Overcome Glutathione Transferase Mediated Resistance

(2011) Katarina Johansson et al.   MOLECULAR PHARMACEUTICS

(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2

(2011) Kelsey C Duggan et al.   Nature Chemical Biology

Novel one-pot process for the synthesis of 1,3-thiazoles via organocatalysed epoxidation of nitro-olefins

(2011) Katharina M. Weiß et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Apoptosis Inducing Effect of Plumbagin on Colonic Cancer Cells Depends on Expression of COX-2

(2011) Bharathi Raja Subramaniya et al.   PLoS One

Role of p53 in Cell Death and Human Cancers

(2011) Toshinori Ozaki et al.   Cancers

Functional Mimics of Glutathione Peroxidase: Bioinspired Synthetic Antioxidants

(2010) Krishna P. Bhabak et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis and in vitro Anticancer Activities of some Selenadiazole Derivatives

(2010) Daniel Plano et al.   ARCHIV DER PHARMAZIE

Thioether binding mediates monofunctional platinum antitumor reagents to trans configuration in DNA interactions

(2010) Guolin Ma et al.   CHEMICAL COMMUNICATIONS

Beyond catalysis: N-heterocyclic carbene complexes as components for medicinal, luminescent, and functional materials applications

(2010) Laszlo Mercs et al.   CHEMICAL SOCIETY REVIEWS

Osmium(ii)–versus ruthenium(ii)–arene carbohydrate-based anticancer compounds: similarities and differences

(2010) Muhammad Hanif et al.   DALTON TRANSACTIONS

(Arene)Ru(II) complexes of epidermal growth factor receptor inhibiting tyrphostins with enhanced selectivity and cytotoxicity in cancer cells

(2010) B. Biersack et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arene–Ru(II)–chloroquine complexes interact with DNA, induce apoptosis on human lymphoid cell lines and display low toxicity to normal mammalian cells

(2010) Alberto Martínez et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A New Class of Naphthalimide-Based Antitumor Agents That Inhibit Topoisomerase II and Induce Lysosomal Membrane Permeabilization and Apoptosis

(2010) Zhuo Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nuclear Permeable Ruthenium(II) β-Carboline Complexes Induce Autophagy To Antagonize Mitochondrial-Mediated Apoptosis

(2010) Caiping Tan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organometallic Anticancer Compounds

(2010) Gilles Gasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

Perspectives on medicinal properties of plumbagin and its analogs

(2010) Subhash Padhye et al.   MEDICINAL RESEARCH REVIEWS

The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

(2010) Raga Krishnakumar et al.   MOLECULAR CELL

(Arene)Cl2Ru(II) complexes with N-coordinated estrogen and androgen isonicotinates: Interaction with sex hormone binding globulin and anticancer activity

(2010) Rainer Schobert et al.   STEROIDS

Modulation of the Biological Properties of Aspirin by Formation of a Bioorganometallic Derivative

(2009) Ingo Ott et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rational Design of an Organometallic Glutathione Transferase Inhibitor

(2009) Wee Han Ang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biological activity of metal ions complexes of chromones, coumarins and flavones

(2009) Magdalena Grazul et al.   COORDINATION CHEMISTRY REVIEWS

Naphthalimides and Azonafides as Promising Anti-Cancer Agents

(2009) Laurent Ingrassia et al.   CURRENT MEDICINAL CHEMISTRY

Cytotoxicity of the traditional chinese medicine (TCM) plumbagin in its copper chemistry

(2009) Zhen-Feng Chen et al.   DALTON TRANSACTIONS

Synthesis, Characterization, and in vitro Antimalarial and Antitumor Activity of New Ruthenium(II) Complexes of Chloroquine

(2009) Chandima S. K. Rajapakse et al.   INORGANIC CHEMISTRY

Synthesis and Insect Antifeedant Activity of Plumbagin Derivatives with the Amino Acid Moiety

(2009) Thonthula Sreelatha et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents

(2009) Reen-Yen Kuo et al.   NATURAL PRODUCT REPORTS

Structure–activity relationship of antibacterial chalcones

(2008) Hugo Pereira Ávila et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bioorganometallic chemistry—from teaching paradigms to medicinal applications

(2008) Christian G. Hartinger et al.   CHEMICAL SOCIETY REVIEWS

In Vitro Anticancer Activity and Biologically Relevant Metabolization of Organometallic Ruthenium Complexes with Carbohydrate-Based Ligands

(2008) Isabella Berger et al.   CHEMISTRY-A EUROPEAN JOURNAL

Carbohydrate-Metal Complexes and their Potential as Anticancer Agents

(2008) Christian Hartinger et al.   CURRENT MEDICINAL CHEMISTRY

Inorganic chemical biology: from small metal complexes in biological systems to metalloproteins

(2008) Sheila S David et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Cell and Molecular Aspects of Human Intestinal Biotin Absorption

(2008) Hamid M. Said   JOURNAL OF NUTRITION

Antitumour metal compounds: more than theme and variations

(2007) Michael A. Jakupec et al.   DALTON TRANSACTIONS