Metronidazole: an update on metabolism, structure–cytotoxicity and resistance mechanisms
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Title
Metronidazole: an update on metabolism, structure–cytotoxicity and resistance mechanisms
Authors
Keywords
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Journal
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volume 73, Issue 2, Pages 265-279
Publisher
Oxford University Press (OUP)
Online
2017-09-04
DOI
10.1093/jac/dkx351
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Note: Only part of the references are listed.- nimH, a novel nitroimidazole resistance gene contributing to metronidazole resistance in Bacteroides fragilis
- (2017) Corentine Alauzet et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Reversion of antibiotic resistance inMycobacterium tuberculosisby spiroisoxazoline SMARt-420
- (2017) Nicolas Blondiaux et al. SCIENCE
- Antimicrobial susceptibility of Clostridium difficile isolated in Thailand
- (2017) Papanin Putsathit et al. Antimicrobial Resistance and Infection Control
- In VitroEvaluation of the Activity of Imipenem-Relebactam against 451 Recent Clinical Isolates of Bacteroides Group and Related Species
- (2016) David R. Snydman et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Differences in the Molecular Epidemiology and Antibiotic Susceptibility of Clostridium difficile Isolates in Pediatric and Adult Patients
- (2016) Larry K. Kociolek et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- A quasi-universal medium to break the aerobic/anaerobic bacterial culture dichotomy in clinical microbiology
- (2016) N. Dione et al. CLINICAL MICROBIOLOGY AND INFECTION
- Characterisation of Clostridium difficile strains isolated from Groote Schuur Hospital, Cape Town, South Africa
- (2016) B. Kullin et al. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
- Emergence and evolution of an international cluster of MDRBacteroides fragilisisolates
- (2016) József Sóki et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Clostridium difficileclade 5 in Australia: antimicrobial susceptibility profiling of PCR ribotypes of human and animal origin
- (2016) Daniel R. Knight et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Crystal structures of two nitroreductases from hypervirulent Clostridium difficile and functionally related interactions with the antibiotic metronidazole
- (2016) Bing Wang et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Lactate dehydrogenase activity in Bacteroides fragilis group strains with induced resistance to metronidazole
- (2016) Aleksandra Presečki Stanko et al. Journal of Global Antimicrobial Resistance
- Identification of antimicrobial resistance genes in multidrug-resistant clinical Bacteroides fragilis isolates by whole genome shotgun sequencing
- (2015) Thomas Vognbjerg Sydenham et al. ANAEROBE
- Recent evolution of antibiotic resistance in the anaerobes as compared to previous decades
- (2015) Lyudmila Boyanova et al. ANAEROBE
- Antibiotic susceptibility profiles of anaerobic pathogens in The Netherlands
- (2015) A.C.M. Veloo et al. ANAEROBE
- The prevalence of enterotoxin and antibiotic resistance genes in clinical and intestinal Bacteroides fragilis group isolates in Turkey
- (2015) Achille Aime Kangaba et al. ANAEROBE
- Evaluation of antibiotic susceptibility of Bacteroides, Prevotella and Fusobacterium species isolated from patients of the N. N. Blokhin Cancer Research Center, Moscow, Russia
- (2015) Irina I. Shilnikova et al. ANAEROBE
- The occurrence of antibiotic resistance genes in drug resistant Bacteroides fragilis isolates from Groote Schuur Hospital, South Africa
- (2015) Rosemary Meggersee et al. ANAEROBE
- First Hungarian case of an infection caused by multidrug-resistant Bacteroides fragilis strain
- (2015) Edit Urbán et al. ANAEROBE
- Analysis of Romanian Bacteroides isolates for antibiotic resistance levels and the corresponding antibiotic resistance genes
- (2015) Edit Székely et al. ANAEROBE
- U.S.-Based National Sentinel Surveillance Study for the Epidemiology of Clostridium difficile-Associated Diarrheal Isolates and Their Susceptibility to Fidaxomicin
- (2015) D. R. Snydman et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Metronidazole- and Carbapenem-Resistant Bacteroides thetaiotaomicron Isolated in Rochester, Minnesota, in 2014
- (2015) Sapna P. Sadarangani et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Anaerobic blood culture isolates in a Norwegian university hospital: identification by MALDI-TOF MS vs 16S rRNA sequencing and antimicrobial susceptibility profiles
- (2015) Nina Handal et al. APMIS
- Metronidazole-triazole conjugates: Activity against Clostridium difficile and parasites
- (2015) Angie M. Jarrad et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Antibiotic susceptibility profiles of Prevotella species in The Netherlands
- (2015) A.C.M. Veloo et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- The aerobic activity of metronidazole against anaerobic bacteria
- (2015) Niokhor Dione et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Characterisation of a multidrug-resistant Bacteroides fragilis isolate recovered from blood of a patient in Denmark using whole-genome sequencing
- (2015) Nina Ank et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Loss of Microbiota-Mediated Colonization Resistance toClostridium difficileInfection With Oral Vancomycin Compared With Metronidazole
- (2015) Brittany B. Lewis et al. JOURNAL OF INFECTIOUS DISEASES
- Gut biogeography of the bacterial microbiota
- (2015) Gregory P. Donaldson et al. NATURE REVIEWS MICROBIOLOGY
- Metronidazole-Induced Encephalopathy: Not Always a Reversible Situation
- (2015) Kyle Hobbs et al. Neurocritical Care
- Clostridium difficile Infection
- (2015) Daniel A. Leffler et al. NEW ENGLAND JOURNAL OF MEDICINE
- Amino acid-linked porphyrin-nitroimidazole antibiotics targeting Porphyromonas gingivalis
- (2015) Simon A. Dingsdag et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Multicenter Study of Antimicrobial Susceptibility of Anaerobic Bacteria in Korea in 2012
- (2015) Yangsoon Lee et al. Annals of Laboratory Medicine
- Escherichia coli pyruvate:flavodoxin oxidoreductase, YdbK - regulation of expression and biological roles in protection against oxidative stress
- (2015) Takayuki Nakayama et al. GENES & GENETIC SYSTEMS
- In vitro activity of MCB3681 against Clostridium difficile strains
- (2014) Mamun-Ur Rashid et al. ANAEROBE
- Vancomycin, Metronidazole, or Tolevamer for Clostridium difficile Infection: Results From Two Multinational, Randomized, Controlled Trials
- (2014) Stuart Johnson et al. CLINICAL INFECTIOUS DISEASES
- Use of MALDI-TOF/MS for routine detection of cfiA gene-positive Bacteroides fragilis strains
- (2014) Viktor Sándor Fenyvesi et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Deficiency of the ferrous iron transporter FeoAB is linked with metronidazole resistance in Bacteroides fragilis
- (2014) Yaligara Veeranagouda et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- A study on Nim expression in Bacteroides fragilis
- (2014) D. Leitsch et al. MICROBIOLOGY-SGM
- The prevalence of antibiotic resistance genes in Bacteroides fragilis group strains isolated in different European countries
- (2013) Zsuzsa Eitel et al. ANAEROBE
- Two Multidrug-Resistant Clinical Isolates of Bacteroides fragilis Carry a Novel Metronidazole ResistancenimGene (nimJ)
- (2013) Fasahath Husain et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome
- (2013) Corinne Ferrier Maurice et al. CELL
- Antimicrobial Resistance and Prevalence of Resistance Genes of Obligate Anaerobes Isolated From Periodontal Abscesses
- (2013) Yi Xie et al. JOURNAL OF PERIODONTOLOGY
- Characterization of a Stable, Metronidazole-Resistant Clostridium difficile Clinical Isolate
- (2013) Tarah Lynch et al. PLoS One
- Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity
- (2013) Y. Miyamoto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Morphological, biochemical, physiological and molecular aspects of the response of Fusobacterium nucleatum exposed to subinhibitory concentrations of antimicrobials
- (2012) Job Alves de Souza Filho et al. ANAEROBE
- Amixicile, a Novel Inhibitor of Pyruvate:Ferredoxin Oxidoreductase, Shows Efficacy against Clostridium difficile in a Mouse Infection Model
- (2012) Cirle A. Warren et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Antimicrobial-Resistant Strains of Clostridium difficile from North America
- (2012) Fred C. Tenover et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Molecular analysis of the carbapenem and metronidazole resistance mechanisms of Bacteroides strains reported in a Europe-wide antibiotic resistance survey
- (2012) József Sóki et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Multidrug-resistant Bacteroides fragilis group on the rise in Europe?
- (2012) G. N. Hartmeyer et al. JOURNAL OF MEDICAL MICROBIOLOGY
- Antibiotic resistance and adhesion potential of Bacteroides fragilis clinical isolates from Cape Town, South Africa
- (2011) B.P.G.V. Galvão et al. ANAEROBE
- Multi-drug resistant Bacteroides fragilis recovered from blood and severe leg wounds caused by an improvised explosive device (IED) in Afghanistan
- (2011) Jeffrey E. Sherwood et al. ANAEROBE
- Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
- (2011) A.-P. Magiorakos et al. CLINICAL MICROBIOLOGY AND INFECTION
- Catabolic pathway for 2-nitroimidazole involves a novel nitrohydrolase that also confers drug resistance
- (2011) Yi Qu et al. ENVIRONMENTAL MICROBIOLOGY
- The role of Bacteroides fragilis RecQ DNA helicases in cell survival after metronidazole exposure
- (2011) Lynthia Paul et al. FEMS MICROBIOLOGY LETTERS
- Antibiotic Treatment Alters the Colonic Mucus Layer and Predisposes the Host to ExacerbatedCitrobacter rodentium-Induced Colitis
- (2011) M. Wlodarska et al. INFECTION AND IMMUNITY
- The antimicrobial resistance pattern of cultured human methanogens reflects the unique phylogenetic position of archaea
- (2011) B. Dridi et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- The Intestinal Microbiota Plays a Role in Salmonella-Induced Colitis Independent of Pathogen Colonization
- (2011) Rosana B. R. Ferreira et al. PLoS One
- Coupling of ferredoxin and heterodisulfide reduction via electron bifurcation in hydrogenotrophic methanogenic archaea
- (2011) A.-K. Kaster et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metronidazole-cerebellopathy associated with peripheral neuropathy, downbeat nystagmus, and bilateral ocular abduction deficit
- (2011) A. Etxeberria et al. REVUE NEUROLOGIQUE
- In VitroActivity of Ceftaroline against a Broad Spectrum of Recent Clinical Anaerobic Isolates
- (2010) David R. Snydman et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Biophysical characterization and mutational analysis of the antibiotic resistance protein NimA from Deinococcus radiodurans
- (2010) Hanna-Kirsti S. Leiros et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe: 20 years of experience
- (2010) E. Nagy et al. CLINICAL MICROBIOLOGY AND INFECTION
- Reshaping the gut microbiome with bacterial transplantation and antibiotic intake
- (2010) C. Manichanh et al. GENOME RESEARCH
- Long-term impacts of antibiotic exposure on the human intestinal microbiota
- (2010) C. Jernberg et al. MICROBIOLOGY-SGM
- Naturally-occurring nitro compounds
- (2010) Ronald Parry et al. NATURAL PRODUCT REPORTS
- Short-Term Antibiotic Treatment Has Differing Long-Term Impacts on the Human Throat and Gut Microbiome
- (2010) Hedvig E. Jakobsson et al. PLoS One
- Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile
- (2010) M. C. Rea et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bacteroides fragilis RecA protein overexpression causes resistance to metronidazole
- (2010) Laura S. Steffens et al. RESEARCH IN MICROBIOLOGY
- Metronidazole Resistance in Prevotella spp. and Description of a New nim Gene in Prevotella baroniae
- (2009) C. Alauzet et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- A Redox Basis for Metronidazole Resistance in Helicobacter pylori
- (2009) N. O. Kaakoush et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Overexpression of the rhamnose catabolism regulatory protein, RhaR: a novel mechanism for metronidazole resistance in Bacteroides thetaiotaomicron
- (2009) E. H. Patel et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance
- (2009) David Leitsch et al. MOLECULAR MICROBIOLOGY
- Porphyrin-linked nitroimidazole antibiotics targeting Porphyromonas gingivalis
- (2009) Benjamin C.-M. Yap et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- An AraC/XylS family transcriptional regulator homologue fromBacteroides fragilisis associated with cell survival following DNA damage
- (2008) Ana I. Casanueva et al. FEMS MICROBIOLOGY LETTERS
- Determination of Antibiotic Hypersensitivity among 4,000 Single-Gene-Knockout Mutants of Escherichia coli
- (2008) C. Tamae et al. JOURNAL OF BACTERIOLOGY
- Nitroreductase-mediated cell/tissue ablation in zebrafish: a spatially and temporally controlled ablation method with applications in developmental and regeneration studies
- (2008) Silvia Curado et al. Nature Protocols
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